(Q24630171)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10990461%20AND%20SRC:MED&resulttype=core&format=json

10 November 2019

title

Deficiency of T2K leads to apoptotic liver degeneration and impaired NF-kappaB-dependent gene transcription (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10990461%20AND%20SRC:MED&resulttype=core&format=json

10 November 2019

0 references

1 reference

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10990461%20AND%20SRC:MED&resulttype=core&format=json

10 November 2019

M Bonnard

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10990461%20AND%20SRC:MED&resulttype=core&format=json

10 November 2019

C Mirtsos

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10990461%20AND%20SRC:MED&resulttype=core&format=json

10 November 2019

S Suzuki

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10990461%20AND%20SRC:MED&resulttype=core&format=json

10 November 2019

K Graham

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10990461%20AND%20SRC:MED&resulttype=core&format=json

10 November 2019

J Huang

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10990461%20AND%20SRC:MED&resulttype=core&format=json

10 November 2019

M Ng

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10990461%20AND%20SRC:MED&resulttype=core&format=json

10 November 2019

A Itié

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10990461%20AND%20SRC:MED&resulttype=core&format=json

10 November 2019

A Wakeham

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10990461%20AND%20SRC:MED&resulttype=core&format=json

10 November 2019

A Shahinian

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10990461%20AND%20SRC:MED&resulttype=core&format=json

10 November 2019

A J Elia

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10990461%20AND%20SRC:MED&resulttype=core&format=json

10 November 2019

W Shillinglaw

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10990461%20AND%20SRC:MED&resulttype=core&format=json

10 November 2019

T W Mak

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10990461%20AND%20SRC:MED&resulttype=core&format=json

10 November 2019

Z Cao

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10990461%20AND%20SRC:MED&resulttype=core&format=json

10 November 2019

W C Yeh

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10990461%20AND%20SRC:MED&resulttype=core&format=json

10 November 2019

language of work or name

English

0 references

publication date

1 September 2000

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10990461%20AND%20SRC:MED&resulttype=core&format=json

10 November 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10990461%20AND%20SRC:MED&resulttype=core&format=json

10 November 2019

volume

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10990461%20AND%20SRC:MED&resulttype=core&format=json

10 November 2019

issue

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10990461%20AND%20SRC:MED&resulttype=core&format=json

10 November 2019

page(s)

4976-4985

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10990461%20AND%20SRC:MED&resulttype=core&format=json

IKKepsilon is part of a novel PMA-inducible IkappaB kinase complex

10 November 2019

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=314216

NF-kappaB activation by a signaling complex containing TRAF2, TANK and TBK1, a novel IKK-related kinase

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=314216

IKK-i, a novel lipopolysaccharide-inducible kinase that is related to IkappaB kinases

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=314216

Activation of phosphatidylinositol 3-kinase in response to interleukin-1 leads to phosphorylation and activation of the NF-kappaB p65/RelA subunit

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=314216

IKK1-deficient mice exhibit abnormal development of skin and skeleton

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=314216

IKK-gamma is an essential regulatory subunit of the IkappaB kinase complex

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=314216

IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=314216

IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=314216

Tumor necrosis factor (TNF)-mediated kinase cascades: bifurcation of nuclear factor-kappaB and c-jun N-terminal kinase (JNK/SAPK) pathways at TNF receptor-associated factor 2

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=314216

A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=314216

Casper is a FADD- and caspase-related inducer of apoptosis

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=314216

I-TRAF is a novel TRAF-interacting protein that regulates TRAF-mediated signal transduction

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=314216

TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=314216

IRAK: a kinase associated with the interleukin-1 receptor

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=314216

TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=314216

NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses

7 April 2017

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=314216

NAK is an IkappaB kinase-activating kinase

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=314216

TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=314216

The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=314216

Identification and characterization of an IkappaB kinase

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=314216

Stress-signalling kinase Sek1 protects thymocytes from apoptosis mediated by CD95 and CD3

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=314216

TRAF6 is a signal transducer for interleukin-1

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=314216

Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=314216

Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-κB

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=314216

Tumor necrosis factor receptor-associated factors (TRAFs)--a family of adapter proteins that regulates life and death

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=314216

Phosphorylation of NF-kappa B p65 by PKA stimulates transcriptional activity by promoting a novel bivalent interaction with the coactivator CBP/p300

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=314216

TRAF2-mediated activation of NF-kappa B by TNF receptor 2 and CD40

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=314216

Complementation cloning of NEMO, a component of the IkappaB kinase complex essential for NF-kappaB activation

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=314216

Early lethality, functional NF-kappaB activation, and increased sensitivity to TNF-induced cell death in TRAF2-deficient mice

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=314216

Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-kappaB activation prevents cell death

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=314216

An essential role for NF-kappaB in preventing TNF-alpha-induced cell death

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=314216

Female mice heterozygous for IKK gamma/NEMO deficiencies develop a dermatopathy similar to the human X-linked disorder incontinentia pigmenti

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=314216

Severe liver degeneration and lack of NF-kappaB activation in NEMO/IKKgamma-deficient mice

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=314216

Lineage-restricted function of nuclear factor kappaB-inducing kinase (NIK) in transducing signals via CD40.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=314216

Inhibition of interleukin-1-stimulated NF-kappaB RelA/p65 phosphorylation by mesalamine is accompanied by decreased transcriptional activity

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=314216

Gene targeting in the analysis of mammalian apoptosis and TNF receptor superfamily signaling

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=314216

The IKKbeta subunit of IkappaB kinase (IKK) is essential for nuclear factor kappaB activation and prevention of apoptosis

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=314216

NF-kappaB to the rescue: RELs, apoptosis and cellular transformation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=314216

Alymphoplasia is caused by a point mutation in the mouse gene encoding Nf-kappa b-inducing kinase

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=314216

Embryonic lethality, liver degeneration, and impaired NF-kappa B activation in IKK-beta-deficient mice

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=314216

Regulation of NF-kappaB RelA phosphorylation and transcriptional activity by p21(ras) and protein kinase Czeta in primary endothelial cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=314216

Modulation of tumor necrosis factor and interleukin-1-dependent NF-kappaB activity by mPLK/IRAK.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=314216

Effects of IL-1 receptor-associated kinase (IRAK) expression on IL-1 signaling are independent of its kinase activity

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=314216

Severe liver degeneration in mice lacking the IkappaB kinase 2 gene

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=314216

Activation of nuclear factor-kappaB-dependent transcription by tumor necrosis factor-alpha is mediated through phosphorylation of RelA/p65 on serine 529.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=314216

The transcriptional activity of NF-kappaB is regulated by the IkappaB-associated PKAc subunit through a cyclic AMP-independent mechanism

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=314216

Activation of SAPK/JNK by TNF receptor 1 through a noncytotoxic TRAF2-dependent pathway

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=314216

Abnormal morphogenesis but intact IKK activation in mice lacking the IKKalpha subunit of IkappaB kinase

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=314216

Limb and skin abnormalities in mice lacking IKKalpha

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=314216

TANK, a co-inducer with TRAF2 of TNF- and CD 40L-mediated NF-kappaB activation

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=314216

Impaired Negative Selection of T Cells in Hodgkin's Disease Antigen CD30–Deficient Mice

28 November 2018

1 reference

12 December 2020

Selective inhibition of E-selectin, vascular cell adhesion molecule-1, and intercellular adhesion molecule-1 expression by inhibitors of I kappa B-alpha phosphorylation

1 reference

12 December 2020

TRAF2 is essential for JNK but not NF-kappaB activation and regulates lymphocyte proliferation and survival

1 reference

12 December 2020

Activation of nuclear transcription factor NF-kappaB by interleukin-1 is accompanied by casein kinase II-mediated phosphorylation of the p65 subunit

1 reference

12 December 2020

Identifiers

DOI

10.1093/EMBOJ/19.18.4976

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10990461%20AND%20SRC:MED&resulttype=core&format=json

10 November 2019

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10990461%20AND%20SRC:MED&resulttype=core&format=json

10 November 2019

PubMed publication ID

10990461

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10990461%20AND%20SRC:MED&resulttype=core&format=json