(Q24603867)

title

The high spontaneous mutation rate: is it a health risk? (English)

0 references

The high spontaneous mutation rate: Is it a health risk? (English)

1 reference

https://api.crossref.org/works/10.1073/PNAS.94.16.8380

9 November 2024

J. F. Crow

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A9237985

full work available at URL

9 November 2024

language of work or name

English

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publication date

5 August 1997

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https://europepmc.org/articles/pmc33757?pdf=render

file format

Portable Document Format

online access status

open access

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A9237985

https://europepmc.org/articles/PMC33757

9 November 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A9237985

https://europepmc.org/articles/PMC33757?pdf=render

9 November 2024

file format

Portable Document Format

online access status

open access

content deliverer

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A9237985

https://pnas.org/doi/pdf/10.1073/pnas.94.16.8380

9 November 2024

1 reference

https://api.crossref.org/works/10.1073/PNAS.94.16.8380

Proceedings of the National Academy of Sciences of the United States of America

9 November 2024

published in

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volume

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issue

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page(s)

8380-6

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cites work

Prevalence and parental origin of de novo RET mutations in multiple endocrine neoplasia type 2A and familial medullary thyroid carcinoma. Le Groupe d'Etude des Tumeurs a Calcitonine

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Parent-of-origin effects in multiple endocrine neoplasia type 2B

7 April 2017

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Spontaneous mutation and parental age in humans

7 April 2017

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Paternal age and the risk of congenital heart defects

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33757

Efficiency of truncation selection

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33757

Selection differentials and selection coefficients

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33757

The mutational load with epistatic gene interactions in fitness

27 September 2017

1 reference

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27 September 2017

Our load of mutations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33757

THE GENETIC STRUCTURE OF NATURAL POPULATIONS OF DROSOPHILA MELANOGASTER. I. SPONTANEOUS MUTATION RATE OF POLYGENES CONTROLLING VIABILITY

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33757

Comparing mutational variabilities.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33757

Exclusive paternal origin of new mutations in Apert syndrome

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33757

High male:female ratio of germ-line mutations: an alternative explanation for postulated gestational lethality in males in X-linked dominant disorders

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33757

Spontaneous mutation as a risk factor

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33757

How much do we know about spontaneous human mutation rates?

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33757

Trinucleotide repeat length instability and age of onset in Huntington's disease

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33757

On the origin of deletions and point mutations in Duchenne muscular dystrophy: most deletions arise in oogenesis and most point mutations result from events in spermatogenesis

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33757

Mutations in the transmembrane domain of FGFR3 cause the most common genetic form of dwarfism, achondroplasia

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33757

The effects of spontaneous mutation on quantitative traits. I. Variances and covariances of life history traits

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33757

Contamination of the genome by very slightly deleterious mutations: why have we not died 100 times over?

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33757

Homozygous viability and fertility loads in Drosophila melanogaster

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33757

Mutation rate and dominance of genes affecting viability in Drosophila melanogaster

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33757

Mutation in human populations

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33757

Frequency and nature of specific-locus mutations induced in female mice by radiations and chemicals: a review

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33757

The occurrence of new mutants in the X-linked recessive Lesch-Nyhan disease

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33757

Spontaneous and ethyl methanesulfonate-induced mutations controlling viability in Drosophila melanogaster. II. Homozygous effect of polygenic mutations

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33757

Human aneuploidy: incidence, origin, and etiology

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33757

Nature of deleterious mutation load in Drosophila.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33757

Sex differences in mutational rate and mutational mechanism in the NF1 gene in neurofibromatosis type 1 patients.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33757

A study of parental age effects on the occurrence of fresh mutations for the Apert syndrome.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33757

A paternal wash in Apert syndrome

30 May 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.94.16.8380

Parental age at conception and offspring longevity

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.94.16.8380

Sex differences in mutation rate in higher primates estimated from AMG intron sequences

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33757

Factor VIII gene inversions in severe hemophilia A: results of an international consortium study.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33757

Mutation frequency in human blood cells increases with age

28 November 2018

1 reference

12 December 2020

The mutation rate of the gene for haemophilia, and its segregation ratios in males and females

1 reference

12 December 2020

Spontaneous mutation in man

1 reference

12 December 2020

Selection against harmful mutations in large sexual and asexual populations

1 reference

12 December 2020

https://api.crossref.org/works/10.1073%2FPNAS.94.16.8380

1 reference

7 January 2021

inferred from DOI database lookup

Advances in human genetics

Crow J F

1985

1 reference

https://api.crossref.org/works/10.1073/PNAS.94.16.8380

9 November 2024

Identifiers

1 reference

ADS bibcode

1997PNAS...94.8380C

0 references

1 reference

1 reference

1 reference