(Q24535918)

6 July 2017

title

Tyrosine phosphorylation acts as a molecular switch to full-scale activation of the eIF2alpha RNA-dependent protein kinase (English)

1 reference

Eukaryotic translation initiation factor 2 alpha kinase 2

6 July 2017

0 references

1 reference

identical protein binding

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

Qiaozhu Su

Qiaozhu

1 reference

6 July 2017

Shuo Wang

Shuo

Wang

1 reference

6 July 2017

Dionissios Baltzis

Dionissios

Baltzis

1 reference

6 July 2017

Li-Ke Qu

Li-Ke

1 reference

6 July 2017

Andrew Hoi-Tao Wong

Andrew Hoi-Tao

Wong

1 reference

6 July 2017

Antonis E Koromilas

Antonis E

Koromilas

1 reference

6 July 2017

language of work or name

English

0 references

publication date

22 December 2005

1 reference

Proceedings of the National Academy of Sciences of the United States of America

6 July 2017

published in

1 reference

6 July 2017

volume

103

1 reference

6 July 2017

1 reference

6 July 2017

page(s)

63-68

1 reference

Nck-1 antagonizes the endoplasmic reticulum stress-induced inhibition of translation

6 July 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1324992

Modulation of protein translation by Nck-1.

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1324992

Crystal structure of the cytoplasmic domain of the type I TGF beta receptor in complex with FKBP12

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1324992

The TGF beta receptor activation process: an inhibitor- to substrate-binding switch

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1324992

Structural basis for autoinhibition of the Ephb2 receptor tyrosine kinase by the unphosphorylated juxtamembrane region

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1324992

The conformational plasticity of protein kinases

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1324992

How cells respond to interferons

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1324992

The protein kinase family: conserved features and deduced phylogeny of the catalytic domains

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1324992

Triggering the interferon antiviral response through an IKK-related pathway

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1324992

Viruses and interferon: a fight for supremacy

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1324992

The interferon-induced double-stranded RNA-activated protein kinase PKR will phosphorylate serine, threonine, or tyrosine at residue 51 in eukaryotic initiation factor 2alpha

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1324992

Protein kinase catalytic domain sequence database: identification of conserved features of primary structure and classification of family members

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1324992

Gene-specific regulation by general translation factors

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1324992

Translational control in stress and apoptosis

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1324992

PKR and eIF2alpha: integration of kinase dimerization, activation, and substrate docking

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1324992

Structural modes of stabilization of permissive phosphorylation sites in protein kinases: distinct strategies in Ser/Thr and Tyr kinases

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1324992

Murine embryonic fibroblasts lacking TC-PTP display delayed G1 phase through defective NF-kappaB activation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1324992

Eph receptors and ephrin ligands: embryogenesis to tumorigenesis

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1324992

A dynamically tuned double-stranded RNA binding mechanism for the activation of antiviral kinase PKR.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1324992

The T-cell protein tyrosine phosphatase

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1324992

PKR, apoptosis and cancer

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1324992

GS domain mutations that constitutively activate T beta R-I, the downstream signaling component in the TGF-beta receptor complex

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1324992

Tumor-suppressor genes: news about the interferon connection

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1324992

Functional expression and RNA binding analysis of the interferon-induced, double-stranded RNA-activated, 68,000-Mr protein kinase in a cell-free system

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1324992

TIK, a novel serine/threonine kinase, is recognized by antibodies directed against phosphotyrosine

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1324992

Characterization of transgenic mice with targeted disruption of the catalytic domain of the double-stranded RNA-dependent protein kinase, PKR.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1324992

Structure of the double-stranded RNA-binding domain of the protein kinase PKR reveals the molecular basis of its dsRNA-mediated activation

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1324992

The double-stranded RNA-dependent protein kinase PKR: structure and function

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1324992

Malignant transformation by a mutant of the IFN-inducible dsRNA-dependent protein kinase

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1324992

Dominant negative function by an alternatively spliced form of the interferon-inducible protein kinase PKR.

30 May 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0508207103

Higher-Order Substrate Recognition of eIF2α by the RNA-Dependent Protein Kinase PKR

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0508207103

Mechanistic Link between PKR Dimerization, Autophosphorylation, and eIF2α Substrate Recognition

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0508207103

Functional characterization of pkr gene products expressed in cells from mice with a targeted deletion of the N terminus or C terminus domain of PKR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0508207103

21 January 2018

Identifiers

DOI

10.1073/PNAS.0508207103

1 reference

release_2lnau2wbgnccbbgast2sez4zqi

6 July 2017

0 references

0 references

PMC publication ID

1324992

1 reference

6 July 2017

1 reference