(Q24328752)

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Protein kinase C-zeta-induced phosphorylation of Ser318 in insulin receptor substrate-1 (IRS-1) attenuates the interaction with the insulin receptor and the tyrosine phosphorylation of IRS-1

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Protein kinase C-zeta-induced phosphorylation of Ser318 in insulin receptor substrate-1 (IRS-1) attenuates the interaction with the insulin receptor and the tyrosine phosphorylation of IRS-1 (English)

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phosphorylation

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protein kinase C zeta

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GOA release 2020-03-11

insulin receptor

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GOA release 2020-03-11

negative regulation of peptidyl-tyrosine phosphorylation

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GOA release 2020-03-11

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based on heuristic

inferred from title

Hubert Kalbacher

5

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Hans-Ulrich Häring

8

object named as

Hans-Ulrich Häring

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3

object named as

Cora Weigert

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Erwin Schleicher

7

object named as

Erwin D Schleicher

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author name string

Klaus Moeschel

1

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Alexander Beck

2

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Reiner Lammers

4

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Wolfgang Voelter

6

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Rainer Lehmann

9

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language of work or name

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publication date

11 June 2004

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Journal of Biological Chemistry

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279

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24

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25157-63

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Protein kinase C isoforms alpha, delta and theta require insulin receptor substrate-1 to inhibit the tyrosine kinase activity of the insulin receptor in human kidney embryonic cells (HEK 293 cells).

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402477200

7 January 2021

based on heuristic

inferred from DOI database lookup

Protein kinase recognition sequence motifs

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402477200

7 January 2021

based on heuristic

inferred from DOI database lookup

Molecular mechanisms of insulin receptor substrate protein-mediated modulation of insulin signalling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402477200

7 January 2021

based on heuristic

inferred from DOI database lookup

Identification of an in vitro insulin receptor substrate-1 phosphorylation site by negative-ion muLC/ES-API-CID-MS hybrid scan technique

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402477200

7 January 2021

based on heuristic

inferred from DOI database lookup

Protein kinase C modulation of insulin receptor substrate-1 tyrosine phosphorylation requires serine 612.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402477200

7 January 2021

based on heuristic

inferred from DOI database lookup

Role of IRS-2 in insulin and cytokine signalling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402477200

7 January 2021

based on heuristic

inferred from DOI database lookup

Crystal structure of the pleckstrin homology-phosphotyrosine binding (PH-PTB) targeting region of insulin receptor substrate 1

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402477200

7 January 2021

based on heuristic

inferred from DOI database lookup

The pleckstrin homology domain in insulin receptor substrate-1 sensitizes insulin signaling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402477200

7 January 2021

based on heuristic

inferred from DOI database lookup

Tumor necrosis factor alpha-induced phosphorylation of insulin receptor substrate-1 (IRS-1). Possible mechanism for suppression of insulin-stimulated tyrosine phosphorylation of IRS-1

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402477200

7 January 2021

based on heuristic

inferred from DOI database lookup

4PS/insulin receptor substrate (IRS)-2 is the alternative substrate of the insulin receptor in IRS-1-deficient mice

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402477200

7 January 2021

based on heuristic

inferred from DOI database lookup

The pleckstrin homology domain is the principal link between the insulin receptor and IRS-1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402477200

7 January 2021

based on heuristic

inferred from DOI database lookup

A molecular basis for insulin resistance. Elevated serine/threonine phosphorylation of IRS-1 and IRS-2 inhibits their binding to the juxtamembrane region of the insulin receptor and impairs their ability to undergo insulin-induced tyrosine phosphory

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402477200

7 January 2021

based on heuristic

inferred from DOI database lookup

Identification of enhanced serine kinase activity in insulin resistance

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402477200

7 January 2021

based on heuristic

inferred from DOI database lookup

The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307)

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402477200

7 January 2021

based on heuristic

inferred from DOI database lookup

Protein kinase C-zeta phosphorylates insulin receptor substrate-1 and impairs its ability to activate phosphatidylinositol 3-kinase in response to insulin.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402477200

7 January 2021

based on heuristic

inferred from DOI database lookup

Insulin stimulates PKCzeta -mediated phosphorylation of insulin receptor substrate-1 (IRS-1). A self-attenuated mechanism to negatively regulate the function of IRS proteins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402477200

7 January 2021

based on heuristic

inferred from DOI database lookup

Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402477200

7 January 2021

based on heuristic

inferred from DOI database lookup

Insulin receptor substrate-2 phosphorylation is necessary for protein kinase C zeta activation by insulin in L6hIR cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402477200

7 January 2021

based on heuristic

inferred from DOI database lookup

c-Jun N-terminal kinase (JNK) mediates feedback inhibition of the insulin signaling cascade

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402477200

7 January 2021

based on heuristic

inferred from DOI database lookup

Pleiotropic insulin signals are engaged by multisite phosphorylation of IRS-1

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402477200

7 January 2021

based on heuristic

inferred from DOI database lookup

High-efficiency transformation of mammalian cells by plasmid DNA

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402477200

7 January 2021

based on heuristic

inferred from DOI database lookup

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10.1074/JBC.M402477200

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