(Q24304998)

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Alterations in thin filament regulation induced by a human cardiac troponin T mutant that causes dilated cardiomyopathy are distinct from those induced by troponin T mutants that cause hypertrophic cardiomyopathy

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Alterations in thin filament regulation induced by a human cardiac troponin T mutant that causes dilated cardiomyopathy are distinct from those induced by troponin T mutants that cause hypertrophic cardiomyopathy (English)

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Troponin T2, cardiac type

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GOA release 2020-03-11

positive regulation of ATP-dependent activity

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GOA release 2020-03-11

hypertrophic cardiomyopathy

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based on heuristic

inferred from title

dilated cardiomyopathy

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based on heuristic

inferred from title

Hugh Christian Watkins

7

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author name string

Paul Robinson

1

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Mahmooda Mirza

2

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Adam Knott

3

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Hassan Abdulrazzak

4

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Ruth Willott

5

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Steven Marston

6

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Charles Redwood

8

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language of work or name

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publication date

25 October 2002

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Journal of Biological Chemistry

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277

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43

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40710-6

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Mutations that alter the surface charge of alpha-tropomyosin are associated with dilated cardiomyopathy

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203446200

7 January 2021

based on heuristic

inferred from DOI database lookup

In vitro motility analysis of thin filaments from failing and non-failing human heart: troponin from failing human hearts induces slower filament sliding and higher Ca(2+) sensitivity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203446200

7 January 2021

based on heuristic

inferred from DOI database lookup

A simple method for automatic tracking of actin filaments in the motility assay.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203446200

7 January 2021

based on heuristic

inferred from DOI database lookup

[33] Assays for actin sliding movement over myosin-coated surfaces

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203446200

7 January 2021

based on heuristic

inferred from DOI database lookup

Kinetics of the Ca(2+), H(+), and Mg(2+) interaction with the ion-binding sites of the SR Ca-ATPase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203446200

7 January 2021

based on heuristic

inferred from DOI database lookup

Dynamics of the muscle thin filament regulatory switch: the size of the cooperative unit.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203446200

7 January 2021

based on heuristic

inferred from DOI database lookup

Altered contractile function in heart failure

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203446200

7 January 2021

based on heuristic

inferred from DOI database lookup

Alterations of cross-bridge kinetics in human atrial and ventricular myocardium

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203446200

7 January 2021

based on heuristic

inferred from DOI database lookup

Functional analysis of human cardiac troponin by the in vitro motility assay: comparison of adult, foetal and failing hearts

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203446200

7 January 2021

based on heuristic

inferred from DOI database lookup

Properties of mutant contractile proteins that cause hypertrophic cardiomyopathy

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203446200

7 January 2021

based on heuristic

inferred from DOI database lookup

The Genetic Basis for Cardiomyopathy

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203446200

7 January 2021

based on heuristic

inferred from DOI database lookup

The genetic basis for cardiomyopathy: from mutation identification to mechanistic paradigms

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203446200

7 January 2021

based on heuristic

inferred from DOI database lookup

Cardiomyopathies: from genetics to the prospect of treatment

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203446200

7 January 2021

based on heuristic

inferred from DOI database lookup

Altered regulation of cardiac muscle contraction by troponin T mutations that cause familial hypertrophic cardiomyopathy.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203446200

7 January 2021

based on heuristic

inferred from DOI database lookup

Separation and characterization of the two functional regions of troponin involved in muscle thin filament regulation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203446200

7 January 2021

based on heuristic

inferred from DOI database lookup

Troponin T: genetics, properties and function

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203446200

7 January 2021

based on heuristic

inferred from DOI database lookup

Cardiac and skeletal myopathies: can genotype explain phenotype?

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203446200

7 January 2021

based on heuristic

inferred from DOI database lookup

Mutations of TTN, encoding the giant muscle filament titin, cause familial dilated cardiomyopathy

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203446200

7 January 2021

based on heuristic

inferred from DOI database lookup

Two mutations in troponin I that cause hypertrophic cardiomyopathy have contrasting effects on cardiac muscle contractility

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203446200

7 January 2021

based on heuristic

inferred from DOI database lookup

Troponin I and troponin T interact with troponin C to produce different Ca2+-dependent effects on actin-tropomyosin filament motility

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203446200

7 January 2021

based on heuristic

inferred from DOI database lookup

The Frequency of Familial Dilated Cardiomyopathy in a Series of Patients with Idiopathic Dilated Cardiomyopathy

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203446200

7 January 2021

based on heuristic

inferred from DOI database lookup

Mutations in sarcomere protein genes as a cause of dilated cardiomyopathy

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203446200

7 January 2021

based on heuristic

inferred from DOI database lookup

Ca(2+)-desensitizing effect of a deletion mutation Delta K210 in cardiac troponin T that causes familial dilated cardiomyopathy.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203446200

7 January 2021

based on heuristic

inferred from DOI database lookup

Functional analyses of troponin T mutations that cause hypertrophic cardiomyopathy: insights into disease pathogenesis and troponin function

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203446200

7 January 2021

based on heuristic

inferred from DOI database lookup

Identification and mutagenesis of a highly conserved domain in troponin T responsible for troponin I binding: potential role for coiled coil interaction

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203446200

7 January 2021

based on heuristic

inferred from DOI database lookup

A direct regulatory role for troponin T and a dual role for troponin C in the Ca2+ regulation of muscle contraction

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203446200

7 January 2021

based on heuristic

inferred from DOI database lookup

Functional consequences of troponin T mutations found in hypertrophic cardiomyopathy

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203446200

7 January 2021

based on heuristic

inferred from DOI database lookup

Altered regulation of cardiac muscle contraction by troponin T mutations that cause familial hypertrophic cardiomyopathy

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203446200

7 January 2021

based on heuristic

inferred from DOI database lookup

Altered regulatory properties of human cardiac troponin I mutants that cause hypertrophic cardiomyopathy

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203446200

7 January 2021

based on heuristic

inferred from DOI database lookup

Many roads lead to a broken heart: the genetics of dilated cardiomyopathy

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203446200

7 January 2021

based on heuristic

inferred from DOI database lookup

Mutations in the gamma(2) subunit of AMP-activated protein kinase cause familial hypertrophic cardiomyopathy: evidence for the central role of energy compromise in disease pathogenesis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203446200

7 January 2021

based on heuristic

inferred from DOI database lookup

Cardiac troponin T mutations: correlation between the type of mutation and the nature of myofilament dysfunction in transgenic mice

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203446200

7 January 2021

based on heuristic

inferred from DOI database lookup

Actin mutations in dilated cardiomyopathy, a heritable form of heart failure

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203446200

7 January 2021

based on heuristic

inferred from DOI database lookup

Familial dilated cardiomyopathy in the United Kingdom

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203446200

7 January 2021

based on heuristic

inferred from DOI database lookup

Ca2+-sensitizing effects of the mutations at Ile-79 and Arg-92 of troponin T in hypertrophic cardiomyopathy

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203446200

7 January 2021

based on heuristic

inferred from DOI database lookup

Invited Review: pathophysiology of cardiac muscle contraction and relaxation as a result of alterations in thin filament regulation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203446200

7 January 2021

based on heuristic

inferred from DOI database lookup

Myofilament calcium regulation in human myocardium

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203446200

7 January 2021

based on heuristic

inferred from DOI database lookup

Origin of contractile dysfunction in heart failure: calcium cycling versus myofilaments

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203446200

7 January 2021

based on heuristic

inferred from DOI database lookup

Investigation of a truncated cardiac troponin T that causes familial hypertrophic cardiomyopathy: Ca(2+) regulatory properties of reconstituted thin filaments depend on the ratio of mutant to wild-type protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203446200

7 January 2021

based on heuristic

inferred from DOI database lookup

Effects of calcium, inorganic phosphate, and pH on isometric force in single skinned cardiomyocytes from donor and failing human hearts

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203446200

7 January 2021

based on heuristic

inferred from DOI database lookup

Novel cardiac troponin T mutation as a cause of familial dilated cardiomyopathy

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203446200

7 January 2021

based on heuristic

inferred from DOI database lookup

Myofibrillar calcium sensitivity of isometric tension is increased in human dilated cardiomyopathies: role of altered beta-adrenergically mediated protein phosphorylation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203446200

7 January 2021

based on heuristic

inferred from DOI database lookup

Dominant-negative effect of a mutant cardiac troponin T on cardiac structure and function in transgenic mice

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203446200

7 January 2021

based on heuristic

inferred from DOI database lookup

Cardiac troponin T mutations result in allele-specific phenotypes in a mouse model for hypertrophic cardiomyopathy

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203446200

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1074/JBC.M203446200

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

PubMed publication ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

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