(Q22008845)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10052460%20AND%20SRC:MED&resulttype=core&format=json

11 November 2019

title

Structure of a HoxB1-Pbx1 heterodimer bound to DNA: role of the hexapeptide and a fourth homeodomain helix in complex formation (English)

1 reference

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11 November 2019

1 reference

GOA release 2020-03-11

Homeobox B1

1 reference

GOA release 2020-03-11

DNA binding

1 reference

GOA release 2020-03-11

C Wolberger

Wolberger

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10052460%20AND%20SRC:MED&resulttype=core&format=json

11 November 2019

D E Piper

D E

Piper

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10052460%20AND%20SRC:MED&resulttype=core&format=json

11 November 2019

A H Batchelor

series ordinal

author given names

A H

author last names

Batchelor

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10052460%20AND%20SRC:MED&resulttype=core&format=json

11 November 2019

C P Chang

series ordinal

author given names

C P

author last names

Chang

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10052460%20AND%20SRC:MED&resulttype=core&format=json

11 November 2019

M L Cleary

series ordinal

author given names

M L

author last names

Cleary

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10052460%20AND%20SRC:MED&resulttype=core&format=json

11 November 2019

language of work or name

English

0 references

publication date

1 February 1999

1 reference

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11 November 2019

1 reference

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11 November 2019

volume

1 reference

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11 November 2019

issue

1 reference

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11 November 2019

page(s)

587-597

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10052460%20AND%20SRC:MED&resulttype=core&format=json

The novel homeoprotein Prep1 modulates Pbx-Hox protein cooperativity

11 November 2019

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7 January 2021

The DNA binding specificity of Ultrabithorax is modulated by cooperative interactions with extradenticle, another homeoprotein.

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Comparison of X-ray and NMR structures for the Antennapedia homeodomain-DNA complex

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7 January 2021

Engrailed homeodomain-DNA complex at 2.2 A resolution: a detailed view of the interface and comparison with other engrailed structures

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A conserved C-terminal domain in PBX increases DNA binding by the PBX homeodomain and is not a primary site of contact for the YPWM motif of HOXA1

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Synergistic activation of a Drosophila enhancer by HOM/EXD and DPP signaling

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Extradenticle protein is a selective cofactor for the Drosophila homeotics: role of the homeodomain and YPWM amino acid motif in the interaction

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7 January 2021

Improved methods for building protein models in electron density maps and the location of errors in these models

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7 January 2021

A new homeobox gene contributes the DNA binding domain of the t(1;19) translocation protein in pre-B ALL

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7 January 2021

Crystal structure of an engrailed homeodomain-DNA complex at 2.8 A resolution: a framework for understanding homeodomain-DNA interactions

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7 January 2021

Oct-1 POU domain-DNA interactions: cooperative binding of isolated subdomains and effects of covalent linkage

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7 January 2021

Crystal structure of the Oct-1 POU domain bound to an octamer site: DNA recognition with tethered DNA-binding modules

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7 January 2021

The pentapeptide motif of Hox proteins is required for cooperative DNA binding with Pbx1, physically contacts Pbx1, and enhances DNA binding by Pbx1.

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7 January 2021

Meis1 and pKnox1 bind DNA cooperatively with Pbx1 utilizing an interaction surface disrupted in oncoprotein E2a-Pbx1

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7 January 2021

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7 January 2021

The definition of generalized helicoidal parameters and of axis curvature for irregular nucleic acids

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7 January 2021

Crystal structure of the MATa1/MAT alpha 2 homeodomain heterodimer bound to DNA

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7 January 2021

Structural determinants within Pbx1 that mediate cooperative DNA binding with pentapeptide-containing Hox proteins: proposal for a model of a Pbx1-Hox-DNA complex

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7 January 2021

Heterodimerization of Hox proteins with Pbx1 and oncoprotein E2a-Pbx1 generates unique DNA-binding specifities at nucleotides predicted to contact the N-terminal arm of the Hox homeodomain--demonstration of Hox-dependent targeting of E2a-Pbx1 in viv

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7 January 2021

Fusion with E2A converts the Pbx1 homeodomain protein into a constitutive transcriptional activator in human leukemias carrying the t(1;19) translocation

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7 January 2021

Both Pbx1 and E2A-Pbx1 bind the DNA motif ATCAATCAA cooperatively with the products of multiple murine Hox genes, some of which are themselves oncogenes.

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7 January 2021

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7 January 2021

Pbx Raises the DNA Binding Specificity but Not the Selectivity of Antennapedia Hox Proteins

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7 January 2021

The hexapeptide LFPWMR in Hoxb-8 is required for cooperative DNA binding with Pbx1 and Pbx2 proteins

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

Distinct HOX N-terminal arm residues are responsible for specificity of DNA recognition by HOX monomers and HOX.PBX heterodimers

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7 January 2021

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7 January 2021

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7 January 2021

NMR structure determination reveals that the homeodomain is connected through a flexible linker to the main body in the Drosophila Antennapedia protein

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7 January 2021

Nuclear magnetic resonance spectroscopy of a DNA complex with the uniformly 13C-labeled Antennapedia homeodomain and structure determination of the DNA-bound homeodomain.

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7 January 2021

extradenticle, a regulator of homeotic gene activity, is a homolog of the homeobox-containing human proto-oncogene pbx1.

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7 January 2021

Nuclear translocation of extradenticle requires homothorax, which encodes an extradenticle-related homeodomain protein

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7 January 2021

Hox homeodomain proteins exhibit selective complex stabilities with Pbx and DNA.

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7 January 2021

Elongation of helix III of the NK-2 homeodomain upon binding to DNA: a secondary structure study by NMR.

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7 January 2021

Engrailed (Gln50→Lys) homeodomain–DNA complex at 1.9 Å resolution: structural basis for enhanced affinity and altered specificity

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7 January 2021

extradenticle raises the DNA binding specificity of homeotic selector gene products

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7 January 2021

Pbx1 is converted into a transcriptional activator upon acquiring the N-terminal region of E2A in pre-B-cell acute lymphoblastoid leukemia

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7 January 2021

High resolution crystal structure of a paired (Pax) class cooperative homeodomain dimer on DNA

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7 January 2021

Crystal structure of a MAT alpha 2 homeodomain-operator complex suggests a general model for homeodomain-DNA interactions

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7 January 2021

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Identifiers

DOI

2 references

Consolidated OpenCitations Corpus – April 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10052460%20AND%20SRC:MED&resulttype=core&format=json

11 November 2019

1 reference

Consolidated OpenCitations Corpus – April 2017

2 references

Consolidated OpenCitations Corpus – April 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10052460%20AND%20SRC:MED&resulttype=core&format=json