(Q22003755)

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Overexpression of gamma-glutamylcysteine synthetase suppresses tumor necrosis factor-induced apoptosis and activation of nuclear transcription factor-kappa B and activator protein-1

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Overexpression of gamma-glutamylcysteine synthetase suppresses tumor necrosis factor-induced apoptosis and activation of nuclear transcription factor-kappa B and activator protein-1 (English)

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apoptotic process

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Glutamate-cysteine ligase catalytic subunit

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GOA release 2020-03-11

negative regulation of transcription, DNA-templated

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GOA release 2020-03-11

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based on heuristic

inferred from title

author name string

S K Manna

1

author given names

Sunil K

author last names

Manna

1 reference

Dimensions Publication ID

6 February 2023

M T Kuo

2

author given names

M Tien

author last names

Kuo

1 reference

Dimensions Publication ID

6 February 2023

B B Aggarwal

3

author given names

Bharat B

author last names

Aggarwal

1 reference

Dimensions Publication ID

6 February 2023

language of work or name

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publication date

29 July 1999

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18

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30

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4371-82

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An essential role for NF-kappaB in preventing TNF-alpha-induced cell death

1 reference

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21 January 2018

IkappaBalpha degradation and nuclear factor-kappaB DNA binding are insufficient for interleukin-1beta and tumor necrosis factor-alpha-induced kappaB-dependent transcription. Requirement for an additional activation pathway

1 reference

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21 January 2018

Protein oxidation in aging, disease, and oxidative stress

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202811

21 January 2018

Lipid peroxidation is involved in the activation of NF-kappaB by tumor necrosis factor but not interleukin-1 in the human endothelial cell line ECV304. Lack of involvement of H2O2 in NF-kappaB activation by either cytokine in both primary and transf

1 reference

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21 January 2018

Inhibition of the differentiation of human myeloid cell lines by redox changes induced through glutathione depletion

1 reference

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21 January 2018

Distinct effects of glutathione disulphide on the nuclear transcription factor kappa B and the activator protein-1.

1 reference

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21 January 2018

Cloning and nucleotide sequence of a full-length cDNA for human liver gamma-glutamylcysteine synthetase

1 reference

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21 January 2018

Direct evidence for tumor necrosis factor-induced mitochondrial reactive oxygen intermediates and their involvement in cytotoxicity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202811

21 January 2018

The oxidative metabolism of glutamine. A modulator of reactive oxygen intermediate-mediated cytotoxicity of tumor necrosis factor in L929 fibrosarcoma cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202811

21 January 2018

Correlation between sustained c-Jun N-terminal protein kinase activation and apoptosis induced by tumor necrosis factor-alpha in rat mesangial cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202811

21 January 2018

Tumor necrosis factor-alpha-induced cell killing and activation of transcription factor NF-kappaB are uncoupled in L929 cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202811

21 January 2018

Activation of CPP32-like protease in tumor necrosis factor-induced apoptosis is dependent on mitochondrial function

1 reference

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21 January 2018

Tumor necrosis factor-alpha-mediated decrease in glutathione increases the sensitivity of pulmonary vascular endothelial cells to H2O2

1 reference

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21 January 2018

Activation of the IkappaB alpha kinase complex by MEKK1, a kinase of the JNK pathway

1 reference

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21 January 2018

Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-kappaB activation prevents cell death

1 reference

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21 January 2018

On the discovery of glutathione.

1 reference

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21 January 2018

Tumor necrosis factor increases hepatocellular glutathione by transcriptional regulation of the heavy subunit chain of gamma-glutamylcysteine synthetase.

1 reference

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21 January 2018

Constitutive and beta-naphthoflavone-induced expression of the human gamma-glutamylcysteine synthetase heavy subunit gene is regulated by a distal antioxidant response element/TRE sequence

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202811

21 January 2018

Glutathione and the rate of cellular proliferation determine tumour cell sensitivity to tumour necrosis factor in vivo

1 reference

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21 January 2018

Cytokine-stimulated human immunodeficiency virus replication is inhibited by N-acetyl-L-cysteine

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202811

21 January 2018

Early activation of c-Jun N-terminal kinase and p38 kinase regulate cell survival in response to tumor necrosis factor alpha

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202811

21 January 2018

Distinct effects of thioredoxin and antioxidants on the activation of transcription factors NF-kappa B and AP-1.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202811

21 January 2018

Dithiocarbamates as potent inhibitors of nuclear factor kappa B activation in intact cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202811

21 January 2018

Rapid detection of octamer binding proteins with 'mini-extracts', prepared from a small number of cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202811

21 January 2018

Glutathione regulation of tumor necrosis factor-alpha-induced NF-kappa B activation in skeletal muscle-derived L6 cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202811

21 January 2018

Protein-tyrosine phosphatase inhibitors block tumor necrosis factor-dependent activation of the nuclear transcription factor NF-kappa B.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202811

21 January 2018

Intracellular thiols regulate activation of nuclear factor kappa B and transcription of human immunodeficiency virus

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202811

21 January 2018

Recent advances in tumor necrosis factor and CD40 signaling

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202811

21 January 2018

Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202811

21 January 2018

Suppression of TNF-alpha-induced apoptosis by NF-kappaB

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202811

21 January 2018

Two tumour necrosis factor receptors: structure and function.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202811

21 January 2018

TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-kappaB

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202811

21 January 2018

The level of intracellular glutathione is a key regulator for the induction of stress-activated signal transduction pathways including Jun N-terminal protein kinases and p38 kinase by alkylating agents

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202811

21 January 2018

Expression of multidrug resistance protein/GS-X pump and gamma-glutamylcysteine synthetase genes is regulated by oxidative stress.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202811

21 January 2018

Sequential reduction of mitochondrial transmembrane potential and generation of reactive oxygen species in early programmed cell death

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202811

21 January 2018

NF-κB-mediated Induction ofmdr1bExpression by Insulin in Rat Hepatoma Cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202811

21 January 2018

Separation of oxidant-initiated and redox-regulated steps in the NF-kappa B signal transduction pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202811

7 January 2021

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Interleukin-1 beta induces nuclear factor kappa B in epithelial cells independently of the production of reactive oxygen intermediates

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202811

7 January 2021

based on heuristic

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IkappaB alpha overexpression in human breast carcinoma MCF7 cells inhibits nuclear factor-kappaB activation but not tumor necrosis factor-alpha-induced apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202811

7 January 2021

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Early events in TNF signaling: a story of associations and dissociations.

1 reference

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7 January 2021

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Functions of glutathione and glutathione disulfide in immunology and immunopathology.

1 reference

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Regulation of mitogenesis by kinins in arterial smooth muscle cells

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Constitutive activation of NF-kappaB causes resistance to apoptosis in human cutaneous T cell lymphoma HuT-78 cells. Autocrine role of tumor necrosis factor and reactive oxygen intermediates

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202811

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JNK (c-Jun NH2-terminal kinase) is a target for antioxidants in T lymphocytes

1 reference

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7 January 2021

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Glutathione regulation of neutral sphingomyelinase in tumor necrosis factor-alpha-induced cell death

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202811

7 January 2021

based on heuristic

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Reactive oxygen species mediate cytokine activation of c-Jun NH2-terminal kinases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202811

7 January 2021

based on heuristic

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Overexpression of manganese superoxide dismutase suppresses tumor necrosis factor-induced apoptosis and activation of nuclear transcription factor-kappaB and activated protein-1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202811

7 January 2021

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inferred from DOI database lookup

H2O2 and antioxidants have opposite effects on activation of NF-kappa B and AP-1 in intact cells: AP-1 as secondary antioxidant-responsive factor.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202811

7 January 2021

based on heuristic

inferred from DOI database lookup

TNF-alpha induces peroxynitrite-mediated depletion of lung endothelial glutathione via protein kinase C.

1 reference

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7 January 2021

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Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1

1 reference

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7 January 2021

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Depletion of the mitochondrial electron transport abrogates the cytotoxic and gene-inductive effects of TNF.

1 reference

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7 January 2021

based on heuristic

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10.1038/SJ.ONC.1202811

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