(Q21992233)

Concanavalin A-like lectin/glucanase domain superfamily

1 reference

Thrombospondin type-1 (TSP1) repeat superfamily

1 reference

thrombospondin-1

1 reference

Thrombospondin, C-terminal domain, protein family

1 reference

Laminin G domain, protein family

1 reference

VWFC domain, protein family

1 reference

EGF-like calcium-binding domain, protein family

1 reference

EGF-like domain, protein family

1 reference

Thrombospondin, type 3-like repeat, protein family

1 reference

EGF-like, conserved site, protein family

1 reference

Thrombospondin type-1 (TSP1) repeat, protein family

1 reference

Thrombospondin, type 3 repeat, protein family

1 reference

1 reference

20 March 2016

language of work or name

1 reference

20 March 2016

language of work or name

English

molecular function

fibronectin binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35441

calcium ion binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35441

1 reference

14 February 2019

heparin binding

Thrombospondin 3 is a developmentally regulated heparin binding protein

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35441

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35441

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35441

14 February 2019

collagen V binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35441

phosphatidylserine binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35441

fibrinogen binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35441

low-density lipoprotein particle binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35441

integrin binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35441

protein binding

IPI

1 reference

14 February 2019

A thrombospondin-dependent pathway for a protective ER stress response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35441

fibroblast growth factor binding

IPI

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35441

laminin binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35441

extracellular matrix structural constituent

2 references

1 January 2018

Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35441&geneProductId=UniProtKB:P35441

1 January 2018

The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35441&geneProductId=UniProtKB:P35441

transforming growth factor beta binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35441

extracellular matrix structural constituent

The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35441

RCA

14 February 2019

Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35441

RCA

14 February 2019

The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35441

14 February 2019

Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35441

cell component

platelet alpha granule

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35441

secretory granule

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35441

fibrinogen complex

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35441

cell surface

1 reference

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35441&geneProductId=UniProtKB:P35441

extracellular exosome

1 reference

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35441&geneProductId=UniProtKB:P35441

external side of plasma membrane

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35441

extracellular space

4 references

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35441&geneProductId=UniProtKB:P35441

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35441&geneProductId=UniProtKB:P35441

31 October 2017

31 October 2017

Id1 regulates angiogenesis through transcriptional repression of thrombospondin-1

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35441&geneProductId=UniProtKB:P35441

31 October 2017

Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35441&geneProductId=UniProtKB:P35441

extracellular space

5 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35441&geneProductId=UniProtKB:P35441

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35441&geneProductId=UniProtKB:P35441

1 January 2018

1 January 2018

Id1 regulates angiogenesis through transcriptional repression of thrombospondin-1

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35441&geneProductId=UniProtKB:P35441

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35441&geneProductId=UniProtKB:P35441

1 January 2018

Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35441&geneProductId=UniProtKB:P35441

cytoplasm

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35441

extracellular matrix

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35441&geneProductId=UniProtKB:P35441

3 references

1 January 2018

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35441&geneProductId=UniProtKB:P35441

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35441&geneProductId=UniProtKB:P35441

collagen-containing extracellular matrix

3 references

1 January 2018

Comparative proteomic analysis of supportive and unsupportive extracellular matrix substrates for human embryonic stem cell maintenance

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35441&geneProductId=UniProtKB:P35441

1 January 2018

Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35441&geneProductId=UniProtKB:P35441

1 January 2018

The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35441&geneProductId=UniProtKB:P35441

extracellular space

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35441

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35441

14 February 2019

14 February 2019

Id1 regulates angiogenesis through transcriptional repression of thrombospondin-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35441

14 February 2019

Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35441

collagen-containing extracellular matrix

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35441

14 February 2019

Comparative proteomic analysis of supportive and unsupportive extracellular matrix substrates for human embryonic stem cell maintenance

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35441

14 February 2019

The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35441

14 February 2019

Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35441

positive regulation of extrinsic apoptotic signaling pathway via death domain receptors

biological process

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35441

growth plate cartilage development

Skeletal abnormalities in mice lacking extracellular matrix proteins, thrombospondin-1, thrombospondin-3, thrombospondin-5, and type IX collagen

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35441

14 February 2019

Skeletal abnormalities in mice lacking extracellular matrix proteins, thrombospondin-1, thrombospondin-3, thrombospondin-5, and type IX collagen

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35441

negative regulation of nitric oxide mediated signal transduction

1 reference

14 February 2019

Thrombospondin-1 inhibits endothelial cell responses to nitric oxide in a cGMP-dependent manner

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35441

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35441

positive regulation of protein kinase B signaling

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35441

negative regulation of fibrinolysis

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35441

negative regulation of plasminogen activation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35441

blood vessel morphogenesis

1 reference

14 February 2019

The ubiquitin ligase Nedd4-1 is required for heart development and is a suppressor of thrombospondin-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35441

negative regulation of blood vessel endothelial cell migration

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35441

engulfment of apoptotic cell

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35441

positive regulation of cell migration

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35441

endocardial cushion development

1 reference

14 February 2019

The ubiquitin ligase Nedd4-1 is required for heart development and is a suppressor of thrombospondin-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35441

outflow tract morphogenesis

1 reference

14 February 2019

The ubiquitin ligase Nedd4-1 is required for heart development and is a suppressor of thrombospondin-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35441

positive regulation of macrophage activation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35441

response to magnesium ion

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35441

sprouting angiogenesis

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35441

negative regulation of apoptotic process

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35441

response to glucose

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35441

positive regulation of translation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35441

response to endoplasmic reticulum stress

1 reference

14 February 2019

A thrombospondin-dependent pathway for a protective ER stress response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35441

positive regulation of angiogenesis

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35441

negative regulation of endothelial cell migration

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35441

negative regulation of cell-matrix adhesion

1 reference

14 February 2019

Thrombospondin-1 inhibits endothelial cell responses to nitric oxide in a cGMP-dependent manner

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35441

negative regulation of endothelial cell proliferation

positive regulation of endothelial cell migration

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35441

negative regulation of fibroblast growth factor receptor signaling pathway

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35441

response to calcium ion

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35441

negative regulation of long-chain fatty acid import across plasma membrane

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35441

response to unfolded protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35441

1 reference

14 February 2019

peptide cross-linking

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35441

positive regulation of endothelial cell apoptotic process

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35441

positive regulation of blood coagulation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35441

behavioral response to pain

1 reference

14 February 2019

Thrombospondin-4 contributes to spinal sensitization and neuropathic pain states

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35441

positive regulation of reactive oxygen species metabolic process

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35441

negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35441

positive regulation of chemotaxis

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35441

positive regulation of blood vessel endothelial cell migration

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35441

negative regulation of endothelial cell chemotaxis

1 reference

14 February 2019

Thrombospondin-1 inhibits endothelial cell responses to nitric oxide in a cGMP-dependent manner

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35441

negative regulation of cGMP-mediated signaling

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35441

negative regulation of dendritic cell antigen processing and presentation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35441

negative regulation of angiogenesis

Thrombospondin-1 inhibits endothelial cell responses to nitric oxide in a cGMP-dependent manner

4 references

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35441&geneProductId=UniProtKB:P35441

31 October 2017

Thrombospondin-1 inhibits endothelial cell responses to nitric oxide in a cGMP-dependent manner

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35441&geneProductId=UniProtKB:P35441

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35441&geneProductId=UniProtKB:P35441

31 October 2017

31 October 2017

Id1 regulates angiogenesis through transcriptional repression of thrombospondin-1

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35441&geneProductId=UniProtKB:P35441

cellular response to nitric oxide

1 reference

14 February 2019

Thrombospondin-1 inhibits endothelial cell responses to nitric oxide in a cGMP-dependent manner

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35441

positive regulation of phosphorylation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35441

inflammatory response

positive regulation of macrophage chemotaxis

3 references

1 reference

14 February 2019

Thrombospondin 1 promotes tumor macrophage recruitment and enhances tumor cell cytotoxicity of differentiated U937 cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35441

cell migration

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35441

positive regulation of fibroblast migration

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35441

negative regulation of interleukin-12 production

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35441

positive regulation of cell-substrate adhesion

1 reference

14 February 2019

Transcriptome-based systematic identification of extracellular matrix proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35441

positive regulation of cell population proliferation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35441

positive regulation of smooth muscle cell proliferation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35441

inflammatory response

4 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35441&geneProductId=UniProtKB:P35441

1 January 2018

Characterization of integrin beta6 and thrombospondin-1 double-null mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35441&geneProductId=UniProtKB:P35441

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35441&geneProductId=UniProtKB:P35441

1 January 2018

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35441&geneProductId=UniProtKB:P35441

response to mechanical stimulus

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35441

negative regulation of angiogenesis

Thrombospondin-1 inhibits endothelial cell responses to nitric oxide in a cGMP-dependent manner

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35441

14 February 2019

Thrombospondin-1 inhibits endothelial cell responses to nitric oxide in a cGMP-dependent manner

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35441

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35441

14 February 2019

14 February 2019

Id1 regulates angiogenesis through transcriptional repression of thrombospondin-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35441

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35441

positive regulation of transforming growth factor beta receptor signaling pathway

3 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35441&geneProductId=UniProtKB:P35441

1 January 2018

Thrombospondin-1 is a major activator of TGF-beta1 in vivo

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35441&geneProductId=UniProtKB:P35441

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35441&geneProductId=UniProtKB:P35441

positive regulation of transforming growth factor beta production

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35441

negative regulation of cell migration involved in sprouting angiogenesis

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35441

negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35441

negative regulation of sprouting angiogenesis

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35441

1 reference

Thrombospondin type-1 (TSP1) repeat

1 reference

VWFC domain

1 reference

Thrombospondin, C-terminal

1 reference

Thrombospondin, type 3-like repeat

1 reference

Laminin G domain

1 reference

EGF-like, conserved site

1 reference

EGF-like calcium-binding domain

1 reference

Thrombospondin, type 3 repeat

1 reference