(Q21989450)

Protein kinase-like domain superfamily

1 reference

tyrosine-protein kinase, Ret receptor

1 reference

membrane protein

1 reference

inferred from GOA cell component → membrane

Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family

1 reference

Protein kinase domain, protein family

1 reference

Cadherin-like, protein family

1 reference

Protein kinase, ATP binding site, protein family

1 reference

Tyrosine-protein kinase, catalytic domain, protein family

1 reference

Tyrosine-protein kinase, active site, protein family

1 reference

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35546

1 reference

25 May 2022

1 reference

25 May 2022

1 reference

14 February 2019

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35546

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35546

protein kinase activity

1 reference

14 February 2019

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35546

4 references

14 February 2019

GFRAL is the receptor for GDF15 and is required for the anti-obesity effects of the ligand

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35546

14 February 2019

The candidate neuroprotective agent artemin induces autonomic neural dysplasia without preventing peripheral nerve dysfunction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35546

14 February 2019

Identification and characterization of GFRalpha-3, a novel Co-receptor belonging to the glial cell line-derived neurotrophic receptor family

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35546

14 February 2019

Ret is a multifunctional coreceptor that integrates diffusible- and contact-axon guidance signals

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35546

protein tyrosine kinase activity

IPI

2 references

2 references

transmembrane receptor protein tyrosine kinase activity

4 references

24 April 2018

Regulation of ureteric bud outgrowth by Pax2-dependent activation of the glial derived neurotrophic factor gene

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35546&geneProductId=UniProtKB:P35546

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35546&geneProductId=UniProtKB:P35546

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35546&geneProductId=UniProtKB:P35546

24 April 2018

GFRAL is the receptor for GDF15 and is required for the anti-obesity effects of the ligand

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35546&geneProductId=UniProtKB:P35546

transmembrane receptor protein tyrosine kinase activity

5 references

21 June 2018

Regulation of ureteric bud outgrowth by Pax2-dependent activation of the glial derived neurotrophic factor gene

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35546&geneProductId=UniProtKB:P35546

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35546&geneProductId=UniProtKB:P35546

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35546&geneProductId=UniProtKB:P35546

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35546&geneProductId=UniProtKB:P35546

21 June 2018

GFRAL is the receptor for GDF15 and is required for the anti-obesity effects of the ligand

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35546&geneProductId=UniProtKB:P35546

Regulation of ureteric bud outgrowth by Pax2-dependent activation of the glial derived neurotrophic factor gene

receptor tyrosine kinase

6 references

11 October 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35546&geneProductId=UniProtKB:P35546

11 October 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35546&geneProductId=UniProtKB:P35546

11 October 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35546&geneProductId=UniProtKB:P35546

11 October 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35546&geneProductId=UniProtKB:P35546

11 October 2018

GFRAL is the receptor for GDF15 and is required for the anti-obesity effects of the ligand

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35546&geneProductId=UniProtKB:P35546

11 October 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35546&geneProductId=UniProtKB:P35546

transmembrane signaling receptor activity

1 reference

7 November 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35546&geneProductId=UniProtKB:P35546

transmembrane receptor protein tyrosine kinase activity

6 references

14 February 2019

Regulation of ureteric bud outgrowth by Pax2-dependent activation of the glial derived neurotrophic factor gene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35546

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35546

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35546

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35546

14 February 2019

GFRAL is the receptor for GDF15 and is required for the anti-obesity effects of the ligand

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35546

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35546

integral component of membrane

cell component

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35546

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35546

2 references

3 references

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35546

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35546

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35546

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35546

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35546

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35546

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35546

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35546

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35546

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35546

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35546

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35546

1 reference

7 November 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35546&geneProductId=UniProtKB:P35546

integral component of plasma membrane

3 references

3 references

3 references

14 February 2019

Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35546

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35546

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35546

Distal ureter morphogenesis depends on epithelial cell remodeling mediated by vitamin A and Ret

biological process

ureteric bud development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35546

embryonic epithelial tube formation

2 references

21 June 2018

The neuronal scaffold protein Shank3 mediates signaling and biological function of the receptor tyrosine kinase Ret in epithelial cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35546&geneProductId=UniProtKB:P35546

21 June 2018

The neuronal scaffold protein Shank3 mediates signaling and biological function of the receptor tyrosine kinase Ret in epithelial cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35546&geneProductId=UniProtKB:P35546

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35546

transmembrane receptor protein tyrosine kinase signaling pathway

1 reference

7 November 2018

GFRalpha3 is an orphan member of the GDNF/neurturin/persephin receptor family

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35546&geneProductId=UniProtKB:P35546

neuron cell-cell adhesion

IGI

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35546

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35546

14 February 2019

RET modulates cell adhesion via its cleavage by caspase in sympathetic neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35546

anatomical structure morphogenesis

1 reference

14 February 2019

Regulation of ureteric bud outgrowth by Pax2-dependent activation of the glial derived neurotrophic factor gene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35546

nervous system development

TAS

1 reference

7 November 2018

Distinct roles for GFRalpha1 and GFRalpha2 signalling in different cranial parasympathetic ganglia in vivo

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35546&geneProductId=UniProtKB:P35546

1 reference

14 February 2019

The neuronal scaffold protein Shank3 mediates signaling and biological function of the receptor tyrosine kinase Ret in epithelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35546

1 reference

14 February 2019

c-ret regulates cholinergic properties in mouse sympathetic neurons: evidence from mutant mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35546

positive regulation of metanephric glomerulus development

1 reference

14 February 2019

Regulation of c-Ret in the developing kidney is responsive to Pax2 gene dosage

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35546

positive regulation of transcription, DNA-templated

1 reference

14 February 2019

Regulation of c-Ret in the developing kidney is responsive to Pax2 gene dosage

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35546

regulation of axonogenesis

1 reference

14 February 2019

A hierarchical NGF signaling cascade controls Ret-dependent and Ret-independent events during development of nonpeptidergic DRG neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35546

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35546

protein phosphorylation

1 reference

14 February 2019

enteric nervous system development

1 reference

14 February 2019

Multipotential progenitors of the mammalian enteric nervous system capable of colonising aganglionic bowel in organ culture

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35546

positive regulation of gene expression

1 reference

14 February 2019

Apolipoprotein B is a new target of the GDNF/RET and ET-3/EDNRB signalling pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35546

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35546

1 reference

14 February 2019

Nephric duct insertion is a crucial step in urinary tract maturation that is regulated by a Gata3-Raldh2-Ret molecular network in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35546

1 reference

14 February 2019

RET signaling is required for survival and normal function of nonpeptidergic nociceptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35546

retina development in camera-type eye

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35546

neural crest cell migration

1 reference

14 February 2019

Neural cells in the esophagus respond to glial cell line-derived neurotrophic factor and neurturin, and are RET-dependent

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35546

A hierarchical NGF signaling cascade controls Ret-dependent and Ret-independent events during development of nonpeptidergic DRG neurons

neuron differentiation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35546

positive regulation of cell size

1 reference

14 February 2019

A hierarchical NGF signaling cascade controls Ret-dependent and Ret-independent events during development of nonpeptidergic DRG neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35546

homophilic cell adhesion via plasma membrane adhesion molecules

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35546

Peyer's patch morphogenesis

1 reference

14 February 2019

Tyrosine kinase receptor RET is a key regulator of Peyer's patch organogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35546

peptidyl-tyrosine phosphorylation

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35546

activation of cysteine-type endopeptidase activity involved in apoptotic process

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35546

positive regulation of extrinsic apoptotic signaling pathway in absence of ligand

ISO

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35546

regulation of peptidyl-serine phosphorylation of STAT protein

ISO

1 reference

21 June 2018

GDNF family ligand dependent STAT3 activation is mediated by specific alternatively spliced isoforms of GFRα2 and RET

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35546&geneProductId=UniProtKB:P35546

positive regulation of peptidyl-serine phosphorylation of STAT protein

positive regulation of MAPK cascade

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35546&geneProductId=UniProtKB:P35546

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35546

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35546

glial cell-derived neurotrophic factor receptor signaling pathway

3 references

positive regulation of protein kinase B signaling

embryonic epithelial tube formation

1 reference

14 February 2019

The neuronal scaffold protein Shank3 mediates signaling and biological function of the receptor tyrosine kinase Ret in epithelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35546

negative regulation of signal transduction

IGI

1 reference

7 November 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35546&geneProductId=UniProtKB:P35546

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35546

positive regulation of peptidyl-serine phosphorylation of STAT protein

1 reference

14 February 2019

GDNF family ligand dependent STAT3 activation is mediated by specific alternatively spliced isoforms of GFRα2 and RET

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35546

negative regulation of apoptotic process

1 reference

7 November 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35546&geneProductId=UniProtKB:P35546

positive regulation of ERK1 and ERK2 cascade

1 reference

7 November 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35546&geneProductId=UniProtKB:P35546

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35546

positive regulation of MAPK cascade

3 references

positive regulation of protein kinase B signaling

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35546

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35546

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35546

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35546

1 reference

tyrosine-protein kinase, catalytic domain

1 reference

tyrosine-protein kinase, active site

1 reference

serine-threonine/tyrosine-protein kinase, catalytic domain

1 reference

protein kinase, ATP binding site

1 reference

protein kinase domain

1 reference