(Q21988969)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q61144

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

1 reference

25 May 2022

1 reference

25 May 2022

aspartic-type endopeptidase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

1 reference

14 February 2019

endopeptidase activity

Presenilin/gamma-secretase-dependent processing of beta-amyloid precursor protein regulates EGF receptor expression

3 references

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61144&geneProductId=UniProtKB:Q61144

27 March 2018

Presenilin-1 and presenilin-2 exhibit distinct yet overlapping gamma-secretase activities

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61144&geneProductId=UniProtKB:Q61144

27 March 2018

Amyloid precursor protein regulates brain apolipoprotein E and cholesterol metabolism through lipoprotein receptor LRP1

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61144&geneProductId=UniProtKB:Q61144

peptidase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

1 reference

14 February 2019

protein binding

IPI

hydrolase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

1 reference

14 February 2019

aspartic endopeptidase activity, intramembrane cleaving

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

1 reference

14 February 2019

endopeptidase activity

Presenilin-1 and presenilin-2 exhibit distinct yet overlapping gamma-secretase activities

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

14 February 2019

Presenilin/gamma-secretase-dependent processing of beta-amyloid precursor protein regulates EGF receptor expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

14 February 2019

Amyloid precursor protein regulates brain apolipoprotein E and cholesterol metabolism through lipoprotein receptor LRP1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

cell component

ciliary basal body

1 reference

14 February 2019

A role for the primary cilium in Notch signaling and epidermal differentiation during skin development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

cytosol

1 reference

14 February 2019

Profiles of amyloid precursor and presenilin 2-like proteins are correlated during development of the mouse hypothalamus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

centrosome

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

Golgi apparatus

endoplasmic reticulum membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

1 reference

14 February 2019

Golgi membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

1 reference

14 February 2019

plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61144&geneProductId=UniProtKB:Q61144

1 reference

10 September 2018

integral component of plasma membrane

TAS

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

nuclear inner membrane

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

soma

1 reference

27 March 2018

Immunohistochemical analysis of presenilin 2 expression in the mouse brain: distribution pattern and co-localization with presenilin 1 protein

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61144&geneProductId=UniProtKB:Q61144

Z discdkac

1 reference

27 March 2018

Presenilin 2 regulates the systolic function of heart by modulating Ca2+ signaling

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61144&geneProductId=UniProtKB:Q61144

endoplasmic reticulum

4 references

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61144&geneProductId=UniProtKB:Q61144

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61144&geneProductId=UniProtKB:Q61144

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61144&geneProductId=UniProtKB:Q61144

27 March 2018

27 March 2018

An alternative spliced mouse presenilin-2 mRNA encodes a novel gamma-secretase inhibitor

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61144&geneProductId=UniProtKB:Q61144

perinuclear region of cytoplasm

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

nucleus

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

kinetochore

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

mitochondrial inner membrane

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61144&geneProductId=UniProtKB:Q61144

1 reference

27 March 2018

lysosomal membrane

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61144&geneProductId=UniProtKB:Q61144

1 reference

27 March 2018

cell cortex

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

cell surface

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61144&geneProductId=UniProtKB:Q61144

1 reference

27 March 2018

axon

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61144&geneProductId=UniProtKB:Q61144

1 reference

27 March 2018

growth cone

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61144&geneProductId=UniProtKB:Q61144

1 reference

27 March 2018

neuromuscular junction

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61144&geneProductId=UniProtKB:Q61144

1 reference

27 March 2018

ciliary rootlet

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61144&geneProductId=UniProtKB:Q61144

1 reference

27 March 2018

dendritic shaft

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61144&geneProductId=UniProtKB:Q61144

1 reference

27 March 2018

membrane raft

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61144&geneProductId=UniProtKB:Q61144

1 reference

27 March 2018

membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

6 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

14 February 2019

14 February 2019

Presenilin-1 and presenilin-2 exhibit distinct yet overlapping gamma-secretase activities

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

14 February 2019

Spatial segregation of gamma-secretase and substrates in distinct membrane domains

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

14 February 2019

Profiles of amyloid precursor and presenilin 2-like proteins are correlated during development of the mouse hypothalamus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

14 February 2019

Cell-fate decisions in early T cell development: regulation by cytokine receptors and the pre-TCR

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

protein-containing complex

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

endoplasmic reticulum

apical plasma membrane

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

soma

integral component of presynaptic membrane

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

early endosome

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

synaptic vesicle

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

synaptic membrane

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

negative regulation of protein phosphorylation

biological process

1 reference

14 February 2019

Forebrain degeneration and ventricle enlargement caused by double knockout of Alzheimer's presenilin-1 and presenilin-2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

hair follicle development

1 reference

14 February 2019

Mice lacking both presenilin genes exhibit early embryonic patterning defects

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

myeloid leukocyte differentiation

1 reference

14 February 2019

Myeloproliferative disease in mice with reduced presenilin gene dosage: effect of gamma-secretase blockage

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

positive regulation of extrinsic apoptotic signaling pathway via death domain receptors

1 reference

14 February 2019

Requirement of the familial Alzheimer's disease gene PS2 for apoptosis. Opposing effect of ALG-3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

intracellular signal transduction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

1 reference

14 February 2019

skin morphogenesis

1 reference

14 February 2019

Presenilin modulates EGFR signaling and cell transformation by regulating the ubiquitin ligase Fbw7

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

cardiac muscle contraction

1 reference

14 February 2019

Presenilin 2 regulates the systolic function of heart by modulating Ca2+ signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

thymus development

1 reference

14 February 2019

Presenilins regulate alphabeta T cell development by modulating TCR signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

cell fate specification

1 reference

14 February 2019

gamma-secretase functions through Notch signaling to maintain skin appendages but is not required for their patterning or initial morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

negative regulation of protein-containing complex assembly

1 reference

27 March 2018

An alternative spliced mouse presenilin-2 mRNA encodes a novel gamma-secretase inhibitor

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61144&geneProductId=UniProtKB:Q61144

positive regulation of coagulation

1 reference

14 February 2019

Presenilin 1 and presenilin 2 have differential effects on the stability and maturation of nicastrin in Mammalian brain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

neuron cellular homeostasis

1 reference

14 February 2019

Partial loss of presenilin impairs age-dependent neuronal survival in the cerebral cortex

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

protein processing

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

14 February 2019

Release of a membrane-bound death domain by gamma-secretase processing of the p75NTR homolog NRADD

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

14 February 2019

negative regulation of apoptotic signaling pathway

1 reference

14 February 2019

Forebrain degeneration and ventricle enlargement caused by double knockout of Alzheimer's presenilin-1 and presenilin-2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

protein maturation

1 reference

14 February 2019

Presenilin 1 is required for maturation and cell surface accumulation of nicastrin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

negative regulation of transcription by RNA polymerase II

1 reference

14 February 2019

Presenilin modulates EGFR signaling and cell transformation by regulating the ubiquitin ligase Fbw7

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

negative regulation of protein binding

1 reference

27 March 2018

An alternative spliced mouse presenilin-2 mRNA encodes a novel gamma-secretase inhibitor

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61144&geneProductId=UniProtKB:Q61144

endoplasmic reticulum calcium ion homeostasis

1 reference

14 February 2019

Presenilin-1 mutations sensitize neurons to DNA damage-induced death by a mechanism involving perturbed calcium homeostasis and activation of calpains and caspase-12

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

amyloid-beta metabolic process

Presenilin-1 and presenilin-2 exhibit distinct yet overlapping gamma-secretase activities

2 references

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61144&geneProductId=UniProtKB:Q61144

27 March 2018

Mutant presenilin 2 transgenic mice. A large increase in the levels of Abeta 42 is presumably associated with the low density membrane domain that contains decreased levels of glycerophospholipids and sphingomyelin

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61144&geneProductId=UniProtKB:Q61144

proteolysis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

1 reference

14 February 2019

regulation of synaptic plasticity

1 reference

14 February 2019

Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

negative regulation of epidermal growth factor-activated receptor activity

1 reference

14 February 2019

Presenilin modulates EGFR signaling and cell transformation by regulating the ubiquitin ligase Fbw7

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

membrane protein ectodomain proteolysis

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

embryonic limb morphogenesis

1 reference

14 February 2019

Notch1 and 2 cooperate in limb ectoderm to receive an early Jagged2 signal regulating interdigital apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

locomotion

1 reference

14 February 2019

Forebrain degeneration and ventricle enlargement caused by double knockout of Alzheimer's presenilin-1 and presenilin-2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

negative regulation of ubiquitin-protein transferase activity

1 reference

14 February 2019

Presenilin modulates EGFR signaling and cell transformation by regulating the ubiquitin ligase Fbw7

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

hematopoietic progenitor cell differentiation

1 reference

14 February 2019

Myeloproliferative disease in mice with reduced presenilin gene dosage: effect of gamma-secretase blockage

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

1 reference

27 March 2018

Generation of anti-apoptotic presenilin-2 polypeptides by alternative transcription, proteolysis, and caspase-3 cleavage

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61144&geneProductId=UniProtKB:Q61144

regulation of epidermal growth factor-activated receptor activity

1 reference

14 February 2019

Presenilin/gamma-secretase-dependent processing of beta-amyloid precursor protein regulates EGF receptor expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

learning or memory

1 reference

14 February 2019

Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

positive regulation of apoptotic process

1 reference

14 February 2019

Notch1 and 2 cooperate in limb ectoderm to receive an early Jagged2 signal regulating interdigital apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

protein transport

1 reference

14 February 2019

Presenilin 1 is required for maturation and cell surface accumulation of nicastrin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

negative regulation of ubiquitin-dependent protein catabolic process

1 reference

14 February 2019

Presenilin modulates EGFR signaling and cell transformation by regulating the ubiquitin ligase Fbw7

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

forebrain development

1 reference

14 February 2019

Forebrain degeneration and ventricle enlargement caused by double knockout of Alzheimer's presenilin-1 and presenilin-2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

dorsal/ventral neural tube patterning

1 reference

14 February 2019

Mice lacking both presenilin genes exhibit early embryonic patterning defects

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

lung alveolus development

1 reference

14 February 2019

Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

regulation of protein binding

1 reference

14 February 2019

Amyloid precursor protein regulates brain apolipoprotein E and cholesterol metabolism through lipoprotein receptor LRP1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

T cell receptor signaling pathway

1 reference

14 February 2019

Presenilins regulate alphabeta T cell development by modulating TCR signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

1 reference

14 February 2019

Presenilin modulates EGFR signaling and cell transformation by regulating the ubiquitin ligase Fbw7

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

positive regulation of receptor recycling

1 reference

14 February 2019

Presenilin modulates EGFR signaling and cell transformation by regulating the ubiquitin ligase Fbw7

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

brain morphogenesis

1 reference

14 February 2019

Environment enrichment rescues the neurodegenerative phenotypes in presenilins-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

T cell activation involved in immune response

1 reference

14 February 2019

Presenilins regulate alphabeta T cell development by modulating TCR signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

Notch receptor processing

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

calcium ion transport

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

amyloid precursor protein catabolic process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

1 reference

14 February 2019

amyloid-beta metabolic process

Presenilin-1 and presenilin-2 exhibit distinct yet overlapping gamma-secretase activities

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144

regulation of calcium import into the mitochondrion

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61144&geneProductId=UniProtKB:Q61144

1 reference

14 January 2019

mitochondrion-endoplasmic reticulum membrane tethering

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61144&geneProductId=UniProtKB:Q61144

1 reference

14 January 2019