(Q21983361)

integrin alpha chain

1 reference

von Willebrand factor A-like domain superfamily

1 reference

Integrin alpha, N-terminal

1 reference

von Willebrand factor, type A, protein family

1 reference

Integrin alpha beta-propellor, protein family

1 reference

Integrin alpha-2, protein family

1 reference

FG-GAP repeat, protein family

1 reference

Integrin alpha chain, C-terminal cytoplasmic region, conserved site, protein family

1 reference

1 reference

20 March 2016

language of work or name

1 reference

20 March 2016

language of work or name

English

molecular function

heparin binding

1 reference

14 February 2019

Mac-1 (CD11b/CD18) and CD45 mediate the adhesion of hematopoietic progenitor cells to stromal cell elements via recognition of stromal heparan sulfate

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05555

protein binding

1 reference

4 April 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P05555

metal ion binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05555

1 reference

14 February 2019

heparan sulfate proteoglycan binding

1 reference

14 February 2019

Mac-1 (CD11b/CD18) and CD45 mediate the adhesion of hematopoietic progenitor cells to stromal cell elements via recognition of stromal heparan sulfate

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05555

heat shock protein binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05555

complement component C3b binding

1 reference

14 February 2019

Complement receptor 3 (CD11b/CD18) is implicated in the elimination of β-amyloid peptides

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05555

cargo receptor activity

protein heterodimerization activity

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05555

integral component of membrane

cell component

membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05555

1 reference

14 February 2019

integrin complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05555

1 reference

14 February 2019

extracellular exosome

1 reference

16 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05555&geneProductId=UniProtKB:P05555

external side of plasma membrane

16 references

14 February 2019

Augmented humoral and anaphylactic responses in Fc gamma RII-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05555

14 February 2019

Impaired IgG-dependent anaphylaxis and Arthus reaction in Fc gamma RIII (CD16) deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05555

14 February 2019

Mac-1 (CD11b/CD18) and CD45 mediate the adhesion of hematopoietic progenitor cells to stromal cell elements via recognition of stromal heparan sulfate

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05555

14 February 2019

Successful elimination of memory-type CD8+ T cell subsets by the administration of anti-Gr-1 monoclonal antibody in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05555

14 February 2019

The L1 adhesion molecule is a cellular ligand for VLA-5

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05555

14 February 2019

T lymphocytes amplify the anabolic activity of parathyroid hormone through Wnt10b signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05555

14 February 2019

The monoclonal antibody TER-119 recognizes a molecule associated with glycophorin A and specifically marks the late stages of murine erythroid lineage

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05555

14 February 2019

Dectin-1 is a major beta-glucan receptor on macrophages

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05555

14 February 2019

Serine protease inhibitors serpina1 and serpina3 are down-regulated in bone marrow during hematopoietic progenitor mobilization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05555

14 February 2019

A point mutation in the murine Hem1 gene reveals an essential role for Hematopoietic protein 1 in lymphopoiesis and innate immunity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05555

14 February 2019

Cellular mechanisms of fatal early-onset autoimmunity in mice with the T cell-specific targeting of transforming growth factor-beta receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05555

14 February 2019

Haploinsufficiency of SAMD9L, an endosome fusion facilitator, causes myeloid malignancies in mice mimicking human diseases with monosomy 7

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05555

14 February 2019

MicroRNAs enriched in hematopoietic stem cells differentially regulate long-term hematopoietic output

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05555

14 February 2019

Stroma-mediated dysregulation of myelopoiesis in mice lacking I kappa B alpha

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05555

14 February 2019

Distinct patterns of Fas cell surface expression during development of T- or B-lymphocyte lineages in normal, scid, and mutant mice lacking or overexpressing p53, bcl-2, or rag-2 genes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05555

14 February 2019

Contrasting effects of Sox17- and Sox18-sustained expression at the onset of blood specification

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05555

nucleus

1 reference

14 February 2019

Null mutation of calpain 3 (p94) in mice causes abnormal sarcomere formation in vivo and in vitro

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05555

extracellular space

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05555

plasma membrane

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05555

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05555

14 February 2019

14 February 2019

A novel role for the beta 2 integrin CD11b/CD18 in neutrophil apoptosis: a homeostatic mechanism in inflammation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05555

14 February 2019

Impaired mast cell development and innate immunity in Mac-1 (CD11b/CD18, CR3)-deficient mice.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05555

plasma membrane raft

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05555

membrane raft

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05555

1 reference

14 February 2019

integrin alphaM-beta2 complex

1 reference

14 February 2019

Complement receptor 3 (CD11b/CD18) is implicated in the elimination of β-amyloid peptides

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05555

leukocyte cell-cell adhesion

biological process

1 reference

14 February 2019

Heat stable antigen (mouse CD24) supports myeloid cell binding to endothelial and platelet P-selectin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05555

activated T cell proliferation

1 reference

14 February 2019

Deficiency of CD11b or CD11d results in reduced staphylococcal enterotoxin-induced T cell response and T cell phenotypic changes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05555

microglia development

1 reference

14 February 2019

Dynamic expression of Cx47 in mouse brain development and in the cuprizone model of myelin plasticity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05555

leukocyte migration involved in inflammatory response

1 reference

14 February 2019

The CXCR1/2 ligand NAP-2 promotes directed intravascular leukocyte migration through platelet thrombi

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05555

neutrophil chemotaxis

1 reference

14 February 2019

Relative contribution of LFA-1 and Mac-1 to neutrophil adhesion and migration

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05555

cell adhesion

Relative contribution of LFA-1 and Mac-1 to neutrophil adhesion and migration

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05555

14 February 2019

Adaptive immune response in JAM-C-deficient mice: normal initiation but reduced IgG memory

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05555

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05555

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05555

14 February 2019

integrin-mediated signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05555

1 reference

14 February 2019

cellular extravasation

1 reference

14 February 2019

Relative contribution of LFA-1 and Mac-1 to neutrophil adhesion and migration

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05555

microglial cell activation

1 reference

14 February 2019

Macrophage antigen complex-1 mediates reactive microgliosis and progressive dopaminergic neurodegeneration in the MPTP model of Parkinson's disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05555

neutrophil apoptotic process

1 reference

14 February 2019

A novel role for the beta 2 integrin CD11b/CD18 in neutrophil apoptosis: a homeostatic mechanism in inflammation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05555

phagocytosis

1 reference

14 February 2019

A novel role for the beta 2 integrin CD11b/CD18 in neutrophil apoptosis: a homeostatic mechanism in inflammation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05555

phagocytosis, engulfment

3 references

14 February 2019

Microglia sculpt postnatal neural circuits in an activity and complement-dependent manner

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05555

14 February 2019

Complement receptor 3 (CD11b/CD18) is implicated in the elimination of β-amyloid peptides

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05555

14 February 2019

Complement component C3 and complement receptor type 3 contribute to the phagocytosis and clearance of fibrillar Aβ by microglia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05555

positive regulation of neutrophil degranulation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05555

negative regulation of dopamine metabolic process

1 reference

14 February 2019

Macrophage antigen complex-1 mediates reactive microgliosis and progressive dopaminergic neurodegeneration in the MPTP model of Parkinson's disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05555

positive regulation of mast cell differentiation

1 reference

14 February 2019

Impaired mast cell development and innate immunity in Mac-1 (CD11b/CD18, CR3)-deficient mice.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05555

leukocyte adhesion to vascular endothelial cell

1 reference

14 February 2019

A novel role for the beta 2 integrin CD11b/CD18 in neutrophil apoptosis: a homeostatic mechanism in inflammation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05555

positive regulation of protein targeting to membrane

1 reference

14 February 2019

Macrophage antigen complex-1 mediates reactive microgliosis and progressive dopaminergic neurodegeneration in the MPTP model of Parkinson's disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05555

cell-cell adhesion

1 reference

14 February 2019

Dual interaction of JAM-C with JAM-B and alpha(M)beta2 integrin: function in junctional complexes and leukocyte adhesion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05555

complement-mediated synapse pruning

1 reference

14 February 2019

Microglia sculpt postnatal neural circuits in an activity and complement-dependent manner

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05555

vertebrate eye-specific patterning

1 reference

14 February 2019

Microglia sculpt postnatal neural circuits in an activity and complement-dependent manner

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05555

positive regulation of neuron death

1 reference

14 February 2019

Macrophage antigen complex-1 mediates reactive microgliosis and progressive dopaminergic neurodegeneration in the MPTP model of Parkinson's disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05555

positive regulation of oxidative stress-induced neuron death

1 reference

14 February 2019

Macrophage antigen complex-1 mediates reactive microgliosis and progressive dopaminergic neurodegeneration in the MPTP model of Parkinson's disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05555

positive regulation of microglial cell activation

1 reference

14 February 2019

Macrophage antigen complex-1 mediates reactive microgliosis and progressive dopaminergic neurodegeneration in the MPTP model of Parkinson's disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05555

positive regulation of microglial cell mediated cytotoxicity

1 reference

14 February 2019

Developmental neuronal death in hippocampus requires the microglial CD11b integrin and DAP12 immunoreceptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05555

cell surface receptor signaling pathway involved in cell-cell signaling

1 reference

14 February 2019

Microglia sculpt postnatal neural circuits in an activity and complement-dependent manner

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05555

positive regulation of prostaglandin-E synthase activity

1 reference

14 February 2019

Macrophage antigen complex-1 mediates reactive microgliosis and progressive dopaminergic neurodegeneration in the MPTP model of Parkinson's disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05555

forebrain development

1 reference

14 February 2019

Developmental neuronal death in hippocampus requires the microglial CD11b integrin and DAP12 immunoreceptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05555

positive regulation of superoxide anion generation

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05555

14 February 2019

Macrophage antigen complex-1 mediates reactive microgliosis and progressive dopaminergic neurodegeneration in the MPTP model of Parkinson's disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05555

14 February 2019

Developmental neuronal death in hippocampus requires the microglial CD11b integrin and DAP12 immunoreceptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05555

apoptotic signaling pathway

1 reference

14 February 2019

Developmental neuronal death in hippocampus requires the microglial CD11b integrin and DAP12 immunoreceptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05555

positive regulation of hippocampal neuron apoptotic process

1 reference

14 February 2019

Developmental neuronal death in hippocampus requires the microglial CD11b integrin and DAP12 immunoreceptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05555

Integrin alpha chain, C-terminal cytoplasmic region, conserved site

has part(s)

1 reference

von Willebrand factor, type A

1 reference

Integrin alpha-2

1 reference

FG-GAP repeat

1 reference

Integrin alpha beta-propellor

1 reference