(Q21981887)

Homeobox domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Homeobox protein SIX1, N-terminal SD domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Homeobox, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

sequence-specific DNA binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62232

3 references

14 February 2019

14 February 2019

The transcription factor Six2 activates expression of the Gdnf gene as well as its own promoter

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62232

14 February 2019

Identification and expression of six family genes in mouse retina

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62232

DNA-binding transcription factor activity

1 reference

14 February 2019

The transcription factor Six2 activates expression of the Gdnf gene as well as its own promoter

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62232

DNA-binding transcription activator activity, RNA polymerase II-specific

2 references

10 September 2018

The transcription factor Six2 activates expression of the Gdnf gene as well as its own promoter

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62232&geneProductId=UniProtKB:Q62232

14 February 2019

The transcription factor Six2 activates expression of the Gdnf gene as well as its own promoter

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62232

transcription factor binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

1 reference

14 February 2019

The transcription factor Six2 activates expression of the Gdnf gene as well as its own promoter

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62232

protein binding

3 references

14 February 2019

Molecular interaction and synergistic activation of a promoter by Six, Eya, and Dach proteins mediated through CREB binding protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62232

14 February 2019

Molecular effects of Eya1 domain mutations causing organ defects in BOR syndrome

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62232

14 February 2019

Sipl1 and Rbck1 are novel Eya1-binding proteins with a role in craniofacial development

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62232

protein-containing complex binding

1 reference

14 February 2019

A Hox-Eya-Pax complex regulates early kidney developmental gene expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62232

transcription cis-regulatory region binding

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62232

DNA-binding transcription activator activity, RNA polymerase II-specific

1 reference

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62232&geneProductId=UniProtKB:Q62232

DNA-binding transcription activator activity, RNA polymerase II-specific

DNA-binding transcription factor activity, RNA polymerase II-specific

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62232

cell component

nucleus

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62232&geneProductId=UniProtKB:Q62232

3 references

27 February 2018

27 February 2018

Identification and expression of six family genes in mouse retina

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62232&geneProductId=UniProtKB:Q62232

27 February 2018

The transcription factor Six2 activates expression of the Gdnf gene as well as its own promoter

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62232&geneProductId=UniProtKB:Q62232

nucleus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62232

4 references

14 February 2019

14 February 2019

The transcription factor Six2 activates expression of the Gdnf gene as well as its own promoter

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62232

14 February 2019

Identification and expression of six family genes in mouse retina

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62232

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62232

transcription regulator complex

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62232

embryonic skeletal system morphogenesis

biological process

1 reference

14 February 2019

Hoxa2 downregulates Six2 in the neural crest-derived mesenchyme

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62232

regulation of chondrocyte differentiation

1 reference

14 February 2019

Inactivation of Six2 in mouse identifies a novel genetic mechanism controlling development and growth of the cranial base

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62232

regulation of transcription, DNA-templated

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62232

1 reference

14 February 2019

positive regulation of chondrocyte proliferation

1 reference

14 February 2019

Inactivation of Six2 in mouse identifies a novel genetic mechanism controlling development and growth of the cranial base

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62232

chondrocyte differentiation

1 reference

14 February 2019

Inactivation of Six2 in mouse identifies a novel genetic mechanism controlling development and growth of the cranial base

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62232

protein import into nucleus

1 reference

14 February 2019

Pax6-dependence of Six3, Eya1 and Dach1 expression during lens and nasal placode induction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62232

kidney development

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62232&geneProductId=UniProtKB:Q62232

4 references

27 February 2018

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62232&geneProductId=UniProtKB:Q62232

27 February 2018

Six2 is required for suppression of nephrogenesis and progenitor renewal in the developing kidney

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62232&geneProductId=UniProtKB:Q62232

Ensembl genome database project

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62232&geneProductId=UniProtKB:Q62232

negative regulation of cell differentiation

1 reference

14 February 2019

Six2 is required for suppression of nephrogenesis and progenitor renewal in the developing kidney

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62232

mesenchymal stem cell maintenance involved in nephron morphogenesis

Six2 defines and regulates a multipotent self-renewing nephron progenitor population throughout mammalian kidney development

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62232

14 February 2019

Canonical Wnt9b signaling balances progenitor cell expansion and differentiation during kidney development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62232

14 February 2019

Osr1 acts downstream of and interacts synergistically with Six2 to maintain nephron progenitor cells during kidney organogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62232

14 February 2019

Six2 and Wnt regulate self-renewal and commitment of nephron progenitors through shared gene regulatory networks

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62232

mesenchymal to epithelial transition involved in metanephros morphogenesis

IEP

1 reference

14 February 2019

Initial differentiation of the metanephric mesenchyme is independent of WT1 and the ureteric bud

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62232

mesenchymal cell differentiation involved in kidney development

IEP

1 reference

14 February 2019

Six2 is required for suppression of nephrogenesis and progenitor renewal in the developing kidney

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62232

mesenchymal stem cell proliferation

1 reference

14 February 2019

Canonical Wnt9b signaling balances progenitor cell expansion and differentiation during kidney development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62232

regulation of branching involved in ureteric bud morphogenesis

1 reference

14 February 2019

Six2 is required for suppression of nephrogenesis and progenitor renewal in the developing kidney

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62232

multicellular organism development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62232

1 reference

14 February 2019

condensed mesenchymal cell proliferation

1 reference

14 February 2019

Stromal Fat4 acts non-autonomously with Dchs1/2 to restrict the nephron progenitor pool

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62232

nephron morphogenesis

1 reference

14 February 2019

Six2 is required for suppression of nephrogenesis and progenitor renewal in the developing kidney

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62232

nephron development

1 reference

14 February 2019

Six2 defines and regulates a multipotent self-renewing nephron progenitor population throughout mammalian kidney development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62232

middle ear morphogenesis

1 reference

14 February 2019

Hoxa2 downregulates Six2 in the neural crest-derived mesenchyme

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62232

embryonic digestive tract morphogenesis

1 reference

14 February 2019

Six2 activity is required for the formation of the mammalian pyloric sphincter

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62232

embryonic cranial skeleton morphogenesis

1 reference

14 February 2019

Inactivation of Six2 in mouse identifies a novel genetic mechanism controlling development and growth of the cranial base

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62232

regulation of ossification

1 reference

14 February 2019

Inactivation of Six2 in mouse identifies a novel genetic mechanism controlling development and growth of the cranial base

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62232

cell population proliferation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62232

4 references

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62232

14 February 2019

Inactivation of Six2 in mouse identifies a novel genetic mechanism controlling development and growth of the cranial base

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62232

Ensembl genome database project

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62232

metanephros development

1 reference

14 February 2019

Six2 is required for suppression of nephrogenesis and progenitor renewal in the developing kidney

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62232

mesodermal cell fate specification

1 reference

14 February 2019

A Hox-Eya-Pax complex regulates early kidney developmental gene expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62232

anterior/posterior axis specification

1 reference

14 February 2019

Six2 functions redundantly immediately downstream of Hoxa2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62232

cell migration

ISS

positive regulation of transcription by RNA polymerase II

1 reference

14 February 2019

The transcription factor Six2 activates expression of the Gdnf gene as well as its own promoter

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62232

transcription by RNA polymerase II

1 reference

27 February 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62232&geneProductId=UniProtKB:Q62232

kidney development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62232

5 references

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62232

14 February 2019

Six2 is required for suppression of nephrogenesis and progenitor renewal in the developing kidney

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62232

Ensembl genome database project

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62232

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62232

negative regulation of transcription, DNA-templated

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62232

anatomical structure development

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62232

1 reference

Homeobox, conserved site

1 reference

Homeobox protein SIX1, N-terminal SD domain

1 reference