(Q21497256)

Neurogenic differentiation factor 1

1 reference

Neurogenic differentiation factor, domain of unknown function, protein family

1 reference

based on heuristic

inferred from protein domain or family

Myc-type, basic helix-loop-helix (bHLH) domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

RNA polymerase II cis-regulatory region sequence-specific DNA binding

1 reference

14 February 2019

Transactivation of the mouse sulfonylurea receptor I gene by BETA2/NeuroD

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60867

protein dimerization activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60867

1 reference

14 February 2019

chromatin binding

1 reference

14 February 2019

Neurogenin and NeuroD direct transcriptional targets and their regulatory enhancers

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60867

DNA-binding transcription activator activity, RNA polymerase II-specific

protein binding

5 references

14 February 2019

Identification of the bHLH factor Math6 as a novel component of the embryonic pancreas transcriptional network

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60867

14 February 2019

The basic helix-loop-helix protein BETA2 interacts with p300 to coordinate differentiation of secretin-expressing enteroendocrine cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60867

14 February 2019

EYA1 and SIX1 drive the neuronal developmental program in cooperation with the SWI/SNF chromatin-remodeling complex and SOX2 in the mammalian inner ear

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60867

14 February 2019

Retinoblastoma and the related pocket protein p107 act as coactivators of NeuroD1 to enhance gene transcription

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60867

14 February 2019

Structure of a dominant-negative helix-loop-helix transcriptional regulator suggests mechanisms of autoinhibition

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60867

transcription coactivator activity

4 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60867&geneProductId=UniProtKB:Q60867

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60867&geneProductId=UniProtKB:Q60867

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60867

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60867

sequence-specific DNA binding

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60867

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60867

14 February 2019

Neuronatin, a downstream target of BETA2/NeuroD1 in the pancreas, is involved in glucose-mediated insulin secretion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60867

14 February 2019

Developmental dependence on NurRE and EboxNeuro for expression of pituitary proopiomelanocortin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60867

E-box binding

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60867

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60867

14 February 2019

Regulation of neuroD2 expression in mouse brain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60867

protein heterodimerization activity

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60867

ISO

14 February 2019

Developmental dependence on NurRE and EboxNeuro for expression of pituitary proopiomelanocortin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60867

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60867

DNA-binding transcription factor activity, RNA polymerase II-specific

1 reference

11 October 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60867&geneProductId=UniProtKB:Q60867

cell component

nucleoplasm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60867

1 reference

14 February 2019

intracellular anatomical structure

TAS

2 references

24 April 2018

Neuronatin, a downstream target of BETA2/NeuroD1 in the pancreas, is involved in glucose-mediated insulin secretion

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60867&geneProductId=UniProtKB:Q60867

24 April 2018

Independent development of pancreatic alpha- and beta-cells from neurogenin3-expressing precursors: a role for the notch pathway in repression of premature differentiation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60867&geneProductId=UniProtKB:Q60867

nucleus

6 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60867

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60867

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60867

14 February 2019

Developmental dependence on NurRE and EboxNeuro for expression of pituitary proopiomelanocortin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60867

14 February 2019

Differential expression of alpha 3 and alpha 6 integrins in the developing mouse inner ear

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60867

14 February 2019

MafA is a glucose-regulated and pancreatic beta-cell-specific transcriptional activator for the insulin gene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60867

cytoplasm

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60867

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60867

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60867

14 February 2019

Developmental dependence on NurRE and EboxNeuro for expression of pituitary proopiomelanocortin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60867

anterior/posterior pattern specification

biological process

1 reference

14 February 2019

Preferential posterior cerebellum defect in BETA2/NeuroD1 knockout mice is the result of differential expression of BETA2/NeuroD1 along anterior-posterior axis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60867

regulation of neuron differentiation

1 reference

14 February 2019

EYA1 and SIX1 drive the neuronal developmental program in cooperation with the SWI/SNF chromatin-remodeling complex and SOX2 in the mammalian inner ear

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60867

signal transduction involved in regulation of gene expression

1 reference

14 February 2019

ER71 acts downstream of BMP, Notch, and Wnt signaling in blood and vessel progenitor specification

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60867

endocrine pancreas development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60867

3 references

14 February 2019

TAS

14 February 2019

Loss of BETA2/NeuroD leads to malformation of the dentate gyrus and epilepsy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60867

14 February 2019

Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2/neuroD-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60867

camera-type eye development

1 reference

14 February 2019

Math3 and NeuroD regulate amacrine cell fate specification in the retina

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60867

positive regulation of cell differentiation

transcription, DNA-templated

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60867&geneProductId=UniProtKB:Q60867

1 reference

24 April 2018

amacrine cell differentiation

1 reference

14 February 2019

Math3 and NeuroD regulate amacrine cell fate specification in the retina

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60867

multicellular organism development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60867

1 reference

14 February 2019

hindbrain development

1 reference

14 February 2019

Preferential posterior cerebellum defect in BETA2/NeuroD1 knockout mice is the result of differential expression of BETA2/NeuroD1 along anterior-posterior axis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60867

embryonic organ morphogenesis

1 reference

14 February 2019

Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2/neuroD-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60867

pancreatic A cell fate commitment

1 reference

14 February 2019

Genetic identification of a novel NeuroD1 function in the early differentiation of islet alpha, PP and epsilon cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60867

regulation of intestinal epithelial structure maintenance

1 reference

14 February 2019

The basic helix-loop-helix protein BETA2 interacts with p300 to coordinate differentiation of secretin-expressing enteroendocrine cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60867

positive regulation of apoptotic process

1 reference

14 February 2019

The basic helix-loop-helix protein BETA2 interacts with p300 to coordinate differentiation of secretin-expressing enteroendocrine cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60867

negative regulation of receptor signaling pathway via JAK-STAT

1 reference

14 February 2019

Expression of Disabled 1 suppresses astroglial differentiation in neural stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60867

negative regulation of type B pancreatic cell apoptotic process

1 reference

14 February 2019

Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2/neuroD-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60867

glucose homeostasis

1 reference

14 February 2019

Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2/neuroD-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60867

positive regulation of transcription, DNA-templated

enteroendocrine cell differentiation

1 reference

14 February 2019

Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2/neuroD-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60867

neuron development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60867

1 reference

14 February 2019

inner ear development

1 reference

14 February 2019

NeuroD-null mice are deaf due to a severe loss of the inner ear sensory neurons during development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60867

pancreatic PP cell fate commitment

1 reference

14 February 2019

Genetic identification of a novel NeuroD1 function in the early differentiation of islet alpha, PP and epsilon cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60867

regulation of transcription, DNA-templated

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60867

1 reference

14 February 2019

cell fate commitment

1 reference

14 February 2019

Math3 and NeuroD regulate amacrine cell fate specification in the retina

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60867

cell differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60867

1 reference

14 February 2019

dentate gyrus development

NeuroD is required for differentiation of the granule cells in the cerebellum and hippocampus

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60867

14 February 2019

Loss of BETA2/NeuroD leads to malformation of the dentate gyrus and epilepsy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60867

14 February 2019

Neuronal basic helix-loop-helix proteins (NEX and BETA2/Neuro D) regulate terminal granule cell differentiation in the hippocampus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60867

positive regulation of DNA-binding transcription factor activity

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60867

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60867

14 February 2019

Regulation of neuroD2 expression in mouse brain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60867

positive regulation of transcription by RNA polymerase II

8 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60867

ISO

14 February 2019

Neuronatin, a downstream target of BETA2/NeuroD1 in the pancreas, is involved in glucose-mediated insulin secretion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60867

14 February 2019

Retinoblastoma and the related pocket protein p107 act as coactivators of NeuroD1 to enhance gene transcription

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60867

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60867

14 February 2019

The basic helix-loop-helix protein BETA2 interacts with p300 to coordinate differentiation of secretin-expressing enteroendocrine cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60867

14 February 2019

Neurogenin and NeuroD direct transcriptional targets and their regulatory enhancers

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60867

14 February 2019

Transactivation of the mouse sulfonylurea receptor I gene by BETA2/NeuroD

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60867

14 February 2019

Identification of PCIF1, a POZ domain protein that inhibits PDX-1 (MODY4) transcriptional activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60867

transcription by RNA polymerase II

1 reference

24 April 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60867&geneProductId=UniProtKB:Q60867

positive regulation of neuron differentiation

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60867

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60867

14 February 2019

Neurogenin and NeuroD direct transcriptional targets and their regulatory enhancers

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60867

Neurogenic differentiation factor, domain of unknown function

has part(s)

1 reference

Myc-type, basic helix-loop-helix (bHLH) domain

1 reference