(Q21496631)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9DBY1

Zinc finger, RING/FYVE/PHD-type

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9DBY1

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

Zinc finger, RING-type, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9DBY1

ATPase binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9DBY1

metal ion binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9DBY1

1 reference

14 February 2019

protein binding

3 references

14 February 2019

The ER-associated degradation adaptor protein Sel1L regulates LPL secretion and lipid metabolism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9DBY1

14 February 2019

Dual regulation of the transcriptional activity of Nrf1 by β-TrCP- and Hrd1-dependent degradation mechanisms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9DBY1

14 February 2019

An E3 ubiquitin ligase, Synoviolin, is involved in the degradation of immature nicastrin, and regulates the production of amyloid beta-protein

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9DBY1

transferase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9DBY1

1 reference

14 February 2019

ubiquitin protein ligase activity

Human HRD1 protects against ER stress-induced apoptosis through ER-associated degradation

3 references

11 October 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9DBY1&geneProductId=UniProtKB:Q9DBY1

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9DBY1&geneProductId=UniProtKB:Q9DBY1

11 October 2018

11 October 2018

Dual regulation of the transcriptional activity of Nrf1 by β-TrCP- and Hrd1-dependent degradation mechanisms

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9DBY1&geneProductId=UniProtKB:Q9DBY1

unfolded protein binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9DBY1

ubiquitin-specific protease binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9DBY1

ubiquitin protein ligase activity

Human HRD1 protects against ER stress-induced apoptosis through ER-associated degradation

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9DBY1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9DBY1

14 February 2019

14 February 2019

Dual regulation of the transcriptional activity of Nrf1 by β-TrCP- and Hrd1-dependent degradation mechanisms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9DBY1

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9DBY1

integral component of membrane

cell component

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9DBY1

1 reference

14 February 2019

endoplasmic reticulum membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9DBY1

1 reference

14 February 2019

ubiquitin ligase complex

1 reference

14 February 2019

Human HRD1 protects against ER stress-induced apoptosis through ER-associated degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9DBY1

nucleoplasm

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9DBY1

smooth endoplasmic reticulum

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9DBY1

endoplasmic reticulum quality control compartment

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9DBY1&geneProductId=UniProtKB:Q9DBY1

1 reference

27 March 2018

membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9DBY1

1 reference

14 February 2019

Hrd1p ubiquitin ligase complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9DBY1

1 reference

14 February 2019

Derlin-1 retrotranslocation complex

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9DBY1

endomembrane system

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9DBY1

biological process

ERAD pathway

2 references

11 October 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9DBY1&geneProductId=UniProtKB:Q9DBY1

11 October 2018

SEL1L protein critically determines the stability of the HRD1-SEL1L endoplasmic reticulum-associated degradation (ERAD) complex to optimize the degradation kinetics of ERAD substrates

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9DBY1&geneProductId=UniProtKB:Q9DBY1

protein stabilization

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9DBY1

14 February 2019

SEL1L protein critically determines the stability of the HRD1-SEL1L endoplasmic reticulum-associated degradation (ERAD) complex to optimize the degradation kinetics of ERAD substrates

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9DBY1

protein polyubiquitination

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9DBY1&geneProductId=UniProtKB:Q9DBY1

1 reference

27 March 2018

in utero embryonic development

1 reference

14 February 2019

Essential role of synoviolin in embryogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9DBY1

multicellular organism development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9DBY1

1 reference

14 February 2019

endoplasmic reticulum unfolded protein response

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9DBY1&geneProductId=UniProtKB:Q9DBY1

1 reference

27 March 2018

protein K48-linked ubiquitination

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9DBY1

response to unfolded protein

1 reference

14 February 2019

Human HRD1 protects against ER stress-induced apoptosis through ER-associated degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9DBY1

retrograde protein transport, ER to cytosol

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9DBY1

protein catabolic process

1 reference

14 February 2019

Wolfram syndrome 1 gene negatively regulates ER stress signaling in rodent and human cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9DBY1

protein ubiquitination

ubiquitin-dependent ERAD pathway

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9DBY1&geneProductId=UniProtKB:Q9DBY1

4 references

27 March 2018

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9DBY1&geneProductId=UniProtKB:Q9DBY1

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9DBY1&geneProductId=UniProtKB:Q9DBY1

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9DBY1&geneProductId=UniProtKB:Q9DBY1

27 March 2018

ubiquitin-dependent ERAD pathway

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9DBY1

14 February 2019

SEL1L protein critically determines the stability of the HRD1-SEL1L endoplasmic reticulum-associated degradation (ERAD) complex to optimize the degradation kinetics of ERAD substrates

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9DBY1

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9DBY1

has part(s)

Zinc finger, RING-type

1 reference

InterPro Release 71.0