(Q21495318)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O70405

Protein kinase-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O70405

membrane protein

1 reference

inferred from GOA cell component → membrane

Serine/threonine-protein kinase, C-terminal domain, protein family

1 reference

Protein kinase domain, protein family

1 reference

Protein kinase, ATP binding site, protein family

1 reference

Serine/threonine-protein kinase, active site, protein family

1 reference

1 reference

25 May 2022

1 reference

25 May 2022

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70405

1 reference

8 April 2019

nucleotide binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70405

1 reference

8 April 2019

protein kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70405

3 references

14 February 2019

14 February 2019

Identification of mouse ULK1, a novel protein kinase structurally related to C. elegans UNC-51

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70405

14 February 2019

A mouse serine/threonine kinase homologous to C. elegans UNC51 functions in parallel fiber formation of cerebellar granule neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70405

Hsp90 protein binding

1 reference

8 April 2019

Hsp90-Cdc37 chaperone complex regulates Ulk1- and Atg13-mediated mitophagy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70405

kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70405

1 reference

8 April 2019

protein serine/threonine kinase activity

5 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O70405&geneProductId=UniProtKB:O70405

24 April 2018

Hsp90-Cdc37 chaperone complex regulates Ulk1- and Atg13-mediated mitophagy

http://www.ebi.ac.uk/QuickGO/annotations?protein=O70405&geneProductId=UniProtKB:O70405

http://www.ebi.ac.uk/QuickGO/annotations?protein=O70405&geneProductId=UniProtKB:O70405

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O70405&geneProductId=UniProtKB:O70405

24 April 2018

24 April 2018

FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=O70405&geneProductId=UniProtKB:O70405

protein binding

9 references

8 April 2019

ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70405

8 April 2019

FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70405

8 April 2019

Hsp90-Cdc37 chaperone complex regulates Ulk1- and Atg13-mediated mitophagy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70405

8 April 2019

Role of Unc51.1 and its binding partners in CNS axon outgrowth

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70405

8 April 2019

Unc-51-like kinase 1/2-mediated endocytic processes regulate filopodia extension and branching of sensory axons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70405

8 April 2019

Huntingtin functions as a scaffold for selective macroautophagy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70405

8 April 2019

ULK1 translocates to mitochondria and phosphorylates FUNDC1 to regulate mitophagy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70405

8 April 2019

Phosphorylation of ULK1 by AMPK regulates translocation of ULK1 to mitochondria and mitophagy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70405

8 April 2019

Sestrin2 promotes Unc-51-like kinase 1 mediated phosphorylation of p62/sequestosome-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70405

protein kinase binding

1 reference

8 April 2019

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70405

GTPase binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70405

identical protein binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70405

protein-containing complex binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70405

protein serine/threonine kinase activity

6 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70405

8 April 2019

Hsp90-Cdc37 chaperone complex regulates Ulk1- and Atg13-mediated mitophagy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70405

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70405

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70405

8 April 2019

8 April 2019

FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70405

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70405

protein kinase activity

GSK3-TIP60-ULK1 signaling pathway links growth factor deprivation to autophagy

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70405

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70405

8 April 2019

8 April 2019

A mouse serine/threonine kinase homologous to C. elegans UNC51 functions in parallel fiber formation of cerebellar granule neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70405

8 April 2019

Identification of mouse ULK1, a novel protein kinase structurally related to C. elegans UNC-51

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70405

cell component

cytosol

3 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O70405&geneProductId=UniProtKB:O70405

http://www.ebi.ac.uk/QuickGO/annotations?protein=O70405&geneProductId=UniProtKB:O70405

24 April 2018

24 April 2018

ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagy

http://www.ebi.ac.uk/QuickGO/annotations?protein=O70405&geneProductId=UniProtKB:O70405

membrane

1 reference

24 April 2018

Role of Unc51.1 and its binding partners in CNS axon outgrowth

http://www.ebi.ac.uk/QuickGO/annotations?protein=O70405&geneProductId=UniProtKB:O70405

extrinsic component of omegasome membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70405

Atg1/ULK1 kinase complex

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70405

8 April 2019

ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70405

8 April 2019

Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70405

extrinsic component of phagophore assembly site membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70405

phagophore assembly site

http://www.ebi.ac.uk/QuickGO/annotations?protein=O70405&geneProductId=UniProtKB:O70405

3 references

24 April 2018

24 April 2018

ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagy

http://www.ebi.ac.uk/QuickGO/annotations?protein=O70405&geneProductId=UniProtKB:O70405

24 April 2018

p62 Targeting to the autophagosome formation site requires self-oligomerization but not LC3 binding

http://www.ebi.ac.uk/QuickGO/annotations?protein=O70405&geneProductId=UniProtKB:O70405

autophagosome

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70405

neuronal cell body

1 reference

8 April 2019

A mouse serine/threonine kinase homologous to C. elegans UNC51 functions in parallel fiber formation of cerebellar granule neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70405

extrinsic component of autophagosome membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70405

cytoplasmic vesicle membrane

1 reference

8 April 2019

Role of Unc51.1 and its binding partners in CNS axon outgrowth

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70405

guanyl-nucleotide exchange factor complex

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70405

axon

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70405

phagophore assembly site

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70405

4 references

8 April 2019

8 April 2019

ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70405

8 April 2019

p62 Targeting to the autophagosome formation site requires self-oligomerization but not LC3 binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70405

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70405

cytosol

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70405

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70405

8 April 2019

8 April 2019

ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70405

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70405

biological process

phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70405

1 reference

8 April 2019

regulation of cell death

1 reference

8 April 2019

Hsp90-Cdc37 chaperone complex regulates Ulk1- and Atg13-mediated mitophagy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70405

negative regulation of protein-containing complex assembly

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70405

cellular response to amino acid starvation

1 reference

8 April 2019

Hsp90-Cdc37 chaperone complex regulates Ulk1- and Atg13-mediated mitophagy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70405

receptor internalization

1 reference

8 April 2019

Unc-51-like kinase 1/2-mediated endocytic processes regulate filopodia extension and branching of sensory axons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70405

autophagosome assembly

1 reference

24 April 2018

ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagy

http://www.ebi.ac.uk/QuickGO/annotations?protein=O70405&geneProductId=UniProtKB:O70405

protein phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70405

1 reference

8 April 2019

negative regulation of collateral sprouting

1 reference

8 April 2019

Unc-51-like kinase 1/2-mediated endocytic processes regulate filopodia extension and branching of sensory axons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70405

regulation of neurotrophin TRK receptor signaling pathway

1 reference

8 April 2019

Unc-51-like kinase 1/2-mediated endocytic processes regulate filopodia extension and branching of sensory axons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70405

cellular response to nutrient levels

1 reference

8 April 2019

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70405

axon extension

1 reference

24 April 2018

Unc-51-like kinase 1/2-mediated endocytic processes regulate filopodia extension and branching of sensory axons

http://www.ebi.ac.uk/QuickGO/annotations?protein=O70405&geneProductId=UniProtKB:O70405

response to starvation

1 reference

8 April 2019

FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70405

regulation of gene expression

1 reference

8 April 2019

Hsp90-Cdc37 chaperone complex regulates Ulk1- and Atg13-mediated mitophagy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70405

radial glia guided migration of cerebellar granule cell

1 reference

8 April 2019

A mouse serine/threonine kinase homologous to C. elegans UNC51 functions in parallel fiber formation of cerebellar granule neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70405

protein autophosphorylation

3 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O70405&geneProductId=UniProtKB:O70405

24 April 2018

Identification of mouse ULK1, a novel protein kinase structurally related to C. elegans UNC-51

http://www.ebi.ac.uk/QuickGO/annotations?protein=O70405&geneProductId=UniProtKB:O70405

24 April 2018

A mouse serine/threonine kinase homologous to C. elegans UNC51 functions in parallel fiber formation of cerebellar granule neurons

http://www.ebi.ac.uk/QuickGO/annotations?protein=O70405&geneProductId=UniProtKB:O70405

Ras protein signal transduction

1 reference

8 April 2019

Role of Unc51.1 and its binding partners in CNS axon outgrowth

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70405

neuron projection development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70405

3 references

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70405

8 April 2019

A mouse serine/threonine kinase homologous to C. elegans UNC51 functions in parallel fiber formation of cerebellar granule neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70405

signal transduction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70405

1 reference

8 April 2019

cerebellar granule cell differentiation

1 reference

8 April 2019

A mouse serine/threonine kinase homologous to C. elegans UNC51 functions in parallel fiber formation of cerebellar granule neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70405

autophagy

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70405

8 April 2019

FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70405

8 April 2019

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70405

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70405

8 April 2019

macroautophagy

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70405

8 April 2019

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70405

8 April 2019

Hsp90-Cdc37 chaperone complex regulates Ulk1- and Atg13-mediated mitophagy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70405

mitophagy

1 reference

8 April 2019

Hsp90-Cdc37 chaperone complex regulates Ulk1- and Atg13-mediated mitophagy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70405

response to mitochondrial depolarisation

1 reference

8 April 2019

Hsp90-Cdc37 chaperone complex regulates Ulk1- and Atg13-mediated mitophagy

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70405

peptidyl-threonine phosphorylation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70405

positive regulation by symbiont of host autophagy

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70405

neuron projection regeneration

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70405

positive regulation of autophagosome assembly

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70405

regulation of autophagy

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70405

protein autophosphorylation

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70405

8 April 2019

A mouse serine/threonine kinase homologous to C. elegans UNC51 functions in parallel fiber formation of cerebellar granule neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70405

8 April 2019

Identification of mouse ULK1, a novel protein kinase structurally related to C. elegans UNC-51

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70405

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70405

positive regulation of autophagy

1 reference

8 April 2019

GSK3-TIP60-ULK1 signaling pathway links growth factor deprivation to autophagy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70405