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Wikidata

(Q21172390)

English

kinase insert domain receptor

mammalian protein found in Homo sapiens

  • Fetal liver kinase 1
  • FLK-1
  • vascular endothelial growth factor receptor 2
  • kinase insert domain receptor (a type III receptor tyrosine kinase)
  • protein-tyrosine kinase receptor Flk-1
  • KDR
  • tyrosine kinase growth factor receptor
  • fetal liver kinase-1
  • soluble VEGFR2
In more languages
default for all languages
No label defined

No description defined

Statements

part of
molecular function
protein binding
determination method or standard
IPI
26 references
retrieved
1 January 2018
stated in
AIP1 functions as an endogenous inhibitor of VEGFR2-mediated signaling and inflammatory angiogenesis in mice
GOA
curator
UniProt
UniProt protein ID
P35968
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P35968&geneProductId=UniProtKB:P35968
determination method or standard
IPI
retrieved
1 January 2018
stated in
The Cell Adhesion Molecule Necl-4/CADM4 Serves as a Novel Regulator for Contact Inhibition of Cell Movement and Proliferation
GOA
curator
UniProt
UniProt protein ID
P35968
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P35968&geneProductId=UniProtKB:P35968
determination method or standard
IPI
retrieved
1 January 2018
stated in
Vascular endothelial cell growth-activated XBP1 splicing in endothelial cells is crucial for angiogenesis
GOA
curator
UniProt
UniProt protein ID
P35968
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P35968&geneProductId=UniProtKB:P35968
determination method or standard
IPI
retrieved
1 January 2018
stated in
Early VEGFR2 activation in response to flow is VEGF-dependent and mediated by MMP activity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P35968&geneProductId=UniProtKB:P35968
determination method or standard
IPI
retrieved
1 January 2018
stated in
Phosphorylation of Tyr1214 within VEGFR-2 triggers the recruitment of Nck and activation of Fyn leading to SAPK2/p38 activation and endothelial cell migration in response to VEGF
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P35968&geneProductId=UniProtKB:P35968
determination method or standard
IPI
retrieved
1 January 2018
stated in
VEGF inhibits tumor cell invasion and mesenchymal transition through a MET/VEGFR2 complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P35968&geneProductId=UniProtKB:P35968
determination method or standard
IPI
retrieved
1 January 2018
stated in
VEGF receptor 2/-3 heterodimers detected in situ by proximity ligation on angiogenic sprouts
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P35968&geneProductId=UniProtKB:P35968
determination method or standard
IPI
retrieved
1 January 2018
stated in
The neurotransmitter dopamine modulates vascular permeability in the endothelium
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P35968&geneProductId=UniProtKB:P35968
determination method or standard
IPI
retrieved
1 January 2018
stated in
A role for VEGF as a negative regulator of pericyte function and vessel maturation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P35968&geneProductId=UniProtKB:P35968
determination method or standard
IPI
retrieved
1 January 2018
stated in
Effective suppression of vascular network formation by combination of antibodies blocking VEGFR ligand binding and receptor dimerization
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P35968&geneProductId=UniProtKB:P35968
determination method or standard
IPI
retrieved
1 January 2018
stated in
Identification of the KDR tyrosine kinase as a receptor for vascular endothelial cell growth factor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P35968&geneProductId=UniProtKB:P35968
determination method or standard
IPI
retrieved
1 January 2018
stated in
Src homology 2 (SH2) domain containing protein tyrosine phosphatase-1 (SHP-1) dephosphorylates VEGF Receptor-2 and attenuates endothelial DNA synthesis, but not migration
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P35968&geneProductId=UniProtKB:P35968
determination method or standard
IPI
retrieved
1 January 2018
stated in
Src kinase becomes preferentially associated with the VEGFR, KDR/Flk-1, following VEGF stimulation of vascular endothelial cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P35968&geneProductId=UniProtKB:P35968
determination method or standard
IPI
retrieved
1 January 2018
stated in
Glycosaminoglycan modification of neuropilin-1 modulates VEGFR2 signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P35968&geneProductId=UniProtKB:P35968
determination method or standard
IPI
retrieved
1 January 2018
stated in
Analysis of protein-protein interactions in cross-talk pathways reveals CRKL protein as a novel prognostic marker in hepatocellular carcinoma
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P35968&geneProductId=UniProtKB:P35968
determination method or standard
IPI
retrieved
1 January 2018
stated in
New role for the protein tyrosine phosphatase DEP-1 in Akt activation and endothelial cell survival
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P35968&geneProductId=UniProtKB:P35968
determination method or standard
IPI
retrieved
1 January 2018
stated in
Structure of a VEGF-VEGF receptor complex determined by electron microscopy
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P35968&geneProductId=UniProtKB:P35968
determination method or standard
IPI
retrieved
1 January 2018
stated in
Endorepellin laminin-like globular 1/2 domains bind Ig3-5 of vascular endothelial growth factor (VEGF) receptor 2 and block pro-angiogenic signaling by VEGFA in endothelial cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P35968&geneProductId=UniProtKB:P35968
determination method or standard
IPI
retrieved
1 January 2018
stated in
Gremlin is a novel agonist of the major proangiogenic receptor VEGFR2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P35968&geneProductId=UniProtKB:P35968
determination method or standard
IPI
retrieved
1 January 2018
stated in
Blocking neuropilin-1 function has an additive effect with anti-VEGF to inhibit tumor growth
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P35968&geneProductId=UniProtKB:P35968
determination method or standard
IPI
retrieved
1 January 2018
stated in
Endorepellin, the angiostatic module of perlecan, interacts with both the α2β1 integrin and vascular endothelial growth factor receptor 2 (VEGFR2): a dual receptor antagonism
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P35968&geneProductId=UniProtKB:P35968
determination method or standard
IPI
retrieved
1 January 2018
stated in
Glycosylation-dependent lectin-receptor interactions preserve angiogenesis in anti-VEGF refractory tumors
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P35968&geneProductId=UniProtKB:P35968
determination method or standard
IPI
retrieved
1 January 2018
stated in
The VEGF-C/Flt-4 axis promotes invasion and metastasis of cancer cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P35968&geneProductId=UniProtKB:P35968
determination method or standard
IPI
retrieved
1 January 2018
stated in
Structural determinants of growth factor binding and specificity by VEGF receptor 2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P35968&geneProductId=UniProtKB:P35968
determination method or standard
IPI
retrieved
1 January 2018
stated in
Programmed cell death 6 (PDCD6) inhibits angiogenesis through PI3K/mTOR/p70S6K pathway by interacting of VEGFR-2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P35968&geneProductId=UniProtKB:P35968
determination method or standard
IPI
retrieved
1 January 2018
stated in
Targeted disruption of heparan sulfate interaction with hepatocyte and vascular endothelial growth factors blocks normal and oncogenic signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P35968&geneProductId=UniProtKB:P35968
determination method or standard
IPI
vascular endothelial growth factor-activated receptor activity
determination method or standard
IEA
IDA
6 references
retrieved
5 June 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P35968&geneProductId=UniProtKB:P35968
determination method or standard
IEA
retrieved
5 June 2018
stated in
A single autophosphorylation site on KDR/Flk-1 is essential for VEGF-A-dependent activation of PLC-gamma and DNA synthesis in vascular endothelial cells
GOA
curator
UniProt
UniProt protein ID
P35968
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P35968&geneProductId=UniProtKB:P35968
determination method or standard
IDA
retrieved
5 June 2018
stated in
Vascular endothelial growth factor (VEGF)-D and VEGF-A differentially regulate KDR-mediated signaling and biological function in vascular endothelial cells
GOA
curator
UniProt
UniProt protein ID
P35968
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P35968&geneProductId=UniProtKB:P35968
determination method or standard
IDA
retrieved
5 June 2018
stated in
Autophosphorylation of KDR in the kinase domain is required for maximal VEGF-stimulated kinase activity and receptor internalization
GOA
curator
UniProt
UniProt protein ID
P35968
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P35968&geneProductId=UniProtKB:P35968
determination method or standard
IDA
retrieved
5 June 2018
stated in
Role of alphavbeta3 integrin in the activation of vascular endothelial growth factor receptor-2.
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P35968&geneProductId=UniProtKB:P35968
determination method or standard
IDA
retrieved
5 June 2018
stated in
Identification of the KDR tyrosine kinase as a receptor for vascular endothelial cell growth factor
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P35968&geneProductId=UniProtKB:P35968
determination method or standard
IDA
protein tyrosine kinase activity
determination method or standard
IEA
EXP
IDA
7 references
retrieved
1 January 2018
stated in
GOA
curator
UniProt
UniProt protein ID
P35968
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P35968&geneProductId=UniProtKB:P35968
determination method or standard
IEA
retrieved
1 January 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P35968&geneProductId=UniProtKB:P35968
determination method or standard
IEA
retrieved
1 January 2018
stated in
Vascular endothelial growth factor receptor KDR tyrosine kinase activity is increased by autophosphorylation of two activation loop tyrosine residues
GOA
curator
UniProt
UniProt protein ID
P35968
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P35968&geneProductId=UniProtKB:P35968
determination method or standard
IDA
retrieved
1 January 2018
stated in
Biological activity and phosphorylation sites of the bacterially expressed cytosolic domain of the KDR VEGF-receptor
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P35968&geneProductId=UniProtKB:P35968
determination method or standard
EXP
retrieved
1 January 2018
stated in
Vascular endothelial growth factor receptor KDR tyrosine kinase activity is increased by autophosphorylation of two activation loop tyrosine residues
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P35968&geneProductId=UniProtKB:P35968
determination method or standard
EXP
retrieved
1 January 2018
stated in
VEGF receptor-2 Y951 signaling and a role for the adapter molecule TSAd in tumor angiogenesis
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P35968&geneProductId=UniProtKB:P35968
determination method or standard
EXP
retrieved
1 January 2018
stated in
Interactions of FLT-1 and KDR with phospholipase C gamma: identification of the phosphotyrosine binding sites
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P35968&geneProductId=UniProtKB:P35968
determination method or standard
EXP
vascular endothelial growth factor-activated receptor activity
determination method or standard
IBA
IDA
IEA
7 references
retrieved
1 January 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P35968&geneProductId=UniProtKB:P35968
determination method or standard
IEA
retrieved
1 January 2018
stated in
Autophosphorylation of KDR in the kinase domain is required for maximal VEGF-stimulated kinase activity and receptor internalization
GOA
curator
UniProt
UniProt protein ID
P35968
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P35968&geneProductId=UniProtKB:P35968
determination method or standard
IDA
retrieved
1 January 2018
stated in
Vascular endothelial growth factor (VEGF)-D and VEGF-A differentially regulate KDR-mediated signaling and biological function in vascular endothelial cells
GOA
curator
UniProt
UniProt protein ID
P35968
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P35968&geneProductId=UniProtKB:P35968
determination method or standard
IDA
retrieved
1 January 2018
stated in
A single autophosphorylation site on KDR/Flk-1 is essential for VEGF-A-dependent activation of PLC-gamma and DNA synthesis in vascular endothelial cells
GOA
curator
UniProt
UniProt protein ID
P35968
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P35968&geneProductId=UniProtKB:P35968
determination method or standard
IDA
retrieved
1 January 2018
stated in
Role of alphavbeta3 integrin in the activation of vascular endothelial growth factor receptor-2.
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P35968&geneProductId=UniProtKB:P35968
determination method or standard
IDA
retrieved
1 January 2018
stated in
Identification of the KDR tyrosine kinase as a receptor for vascular endothelial cell growth factor
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P35968&geneProductId=UniProtKB:P35968
determination method or standard
IDA
retrieved
1 January 2018
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P35968&geneProductId=UniProtKB:P35968
determination method or standard
IBA
cell component
biological process
cellular response to vascular endothelial growth factor stimulus
determination method or standard
IDA
IMP
5 references
retrieved
1 January 2018
stated in
Vascular endothelial growth factor (VEGF)-D and VEGF-A differentially regulate KDR-mediated signaling and biological function in vascular endothelial cells
GOA
curator
UniProt
UniProt protein ID
P35968
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P35968&geneProductId=UniProtKB:P35968
determination method or standard
IMP
retrieved
1 January 2018
stated in
AIP1 functions as an endogenous inhibitor of VEGFR2-mediated signaling and inflammatory angiogenesis in mice
GOA
curator
UniProt
UniProt protein ID
P35968
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P35968&geneProductId=UniProtKB:P35968
determination method or standard
IDA
retrieved
1 January 2018
stated in
Autophosphorylation of KDR in the kinase domain is required for maximal VEGF-stimulated kinase activity and receptor internalization
GOA
curator
UniProt
UniProt protein ID
P35968
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P35968&geneProductId=UniProtKB:P35968
determination method or standard
IDA
retrieved
1 January 2018
stated in
Vascular endothelial cell growth-activated XBP1 splicing in endothelial cells is crucial for angiogenesis
GOA
curator
UniProt
UniProt protein ID
P35968
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P35968&geneProductId=UniProtKB:P35968
determination method or standard
IDA
retrieved
1 January 2018
stated in
A single autophosphorylation site on KDR/Flk-1 is essential for VEGF-A-dependent activation of PLC-gamma and DNA synthesis in vascular endothelial cells
GOA
curator
UniProt
UniProt protein ID
P35968
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P35968&geneProductId=UniProtKB:P35968
determination method or standard
IDA
vascular endothelial growth factor receptor signaling pathway
determination method or standard
IEA
IDA
IMP
TAS
6 references
retrieved
10 September 2018
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P35968&geneProductId=UniProtKB:P35968
determination method or standard
TAS
retrieved
10 September 2018
stated in
Vascular endothelial cell growth-activated XBP1 splicing in endothelial cells is crucial for angiogenesis
GOA
curator
UniProt
UniProt protein ID
P35968
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P35968&geneProductId=UniProtKB:P35968
determination method or standard
IMP
retrieved
10 September 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P35968&geneProductId=UniProtKB:P35968
determination method or standard
IEA
retrieved
10 September 2018
stated in
Vascular endothelial growth factor (VEGF)-D and VEGF-A differentially regulate KDR-mediated signaling and biological function in vascular endothelial cells
GOA
curator
UniProt
UniProt protein ID
P35968
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P35968&geneProductId=UniProtKB:P35968
determination method or standard
IDA
retrieved
10 September 2018
stated in
A single autophosphorylation site on KDR/Flk-1 is essential for VEGF-A-dependent activation of PLC-gamma and DNA synthesis in vascular endothelial cells
GOA
curator
UniProt
UniProt protein ID
P35968
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P35968&geneProductId=UniProtKB:P35968
determination method or standard
IDA
retrieved
10 September 2018
stated in
Autophosphorylation of KDR in the kinase domain is required for maximal VEGF-stimulated kinase activity and receptor internalization
GOA
curator
UniProt
UniProt protein ID
P35968
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P35968&geneProductId=UniProtKB:P35968
determination method or standard
IDA
vascular endothelial growth factor receptor signaling pathway
determination method or standard
IBA
IDA
IEA
IMP
TAS
7 references
retrieved
1 January 2018
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P35968&geneProductId=UniProtKB:P35968
determination method or standard
TAS
retrieved
1 January 2018
stated in
Vascular endothelial cell growth-activated XBP1 splicing in endothelial cells is crucial for angiogenesis
GOA
curator
UniProt
UniProt protein ID
P35968
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P35968&geneProductId=UniProtKB:P35968
determination method or standard
IMP
retrieved
1 January 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P35968&geneProductId=UniProtKB:P35968
determination method or standard
IEA
retrieved
1 January 2018
stated in
Autophosphorylation of KDR in the kinase domain is required for maximal VEGF-stimulated kinase activity and receptor internalization
GOA
curator
UniProt
UniProt protein ID
P35968
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P35968&geneProductId=UniProtKB:P35968
determination method or standard
IDA
retrieved
1 January 2018
stated in
Vascular endothelial growth factor (VEGF)-D and VEGF-A differentially regulate KDR-mediated signaling and biological function in vascular endothelial cells
GOA
curator
UniProt
UniProt protein ID
P35968
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P35968&geneProductId=UniProtKB:P35968
determination method or standard
IDA
retrieved
1 January 2018
stated in
A single autophosphorylation site on KDR/Flk-1 is essential for VEGF-A-dependent activation of PLC-gamma and DNA synthesis in vascular endothelial cells
GOA
curator
UniProt
UniProt protein ID
P35968
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P35968&geneProductId=UniProtKB:P35968
determination method or standard
IDA
retrieved
1 January 2018
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P35968&geneProductId=UniProtKB:P35968
determination method or standard
IBA
physically interacts with
has part(s)

Identifiers

MeSH descriptor ID
D040301
subject named as
Vascular Endothelial Growth Factor Receptor-2
0 references
PDB structure ID
 
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                    Retrieved from "https://www.wikidata.org/w/index.php?title=Q21172390&oldid=2257708498"