(Q21116665)

Protein kinase domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Protein kinase, ATP binding site, protein family

1 reference

based on heuristic

inferred from protein domain or family

Serine/threonine-protein kinase, active site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36507

1 reference

8 April 2019

nucleotide binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36507

1 reference

8 April 2019

protein kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36507

1 reference

8 April 2019

PDZ domain binding

1 reference

8 April 2019

Identification of mitogen-activated protein/extracellular signal-responsive kinase kinase 2 as a novel partner of the scaffolding protein human homolog of disc-large

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36507

scaffold protein binding

protein serine/threonine kinase activator activity

1 reference

8 April 2019

Cloning and characterization of two distinct human extracellular signal-regulated kinase activator kinases, MEK1 and MEK2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36507

metal ion binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36507

1 reference

8 April 2019

kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36507

1 reference

8 April 2019

protein binding

9 references

8 April 2019

Identification of interaction between MEK2 and A-Raf-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36507

8 April 2019

Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36507

8 April 2019

HiQuant: Rapid Postquantification Analysis of Large-Scale MS-Generated Proteomics Data.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36507

8 April 2019

A novel tandem affinity purification strategy for the efficient isolation and characterisation of native protein complexes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36507

8 April 2019

A proteome-scale map of the human interactome network

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36507

8 April 2019

Identification of mitogen-activated protein/extracellular signal-responsive kinase kinase 2 as a novel partner of the scaffolding protein human homolog of disc-large

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36507

8 April 2019

Disruption of CRAF-mediated MEK activation is required for effective MEK inhibition in KRAS mutant tumors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36507

8 April 2019

Toward an understanding of the protein interaction network of the human liver

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36507

8 April 2019

Tunable-combinatorial mechanisms of acquired resistance limit the efficacy of BRAF/MEK cotargeting but result in melanoma drug addiction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36507

protein serine/threonine/tyrosine kinase activity

1 reference

8 April 2019

The ERK signaling cascade--views from different subcellular compartments

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36507

protein tyrosine kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36507

1 reference

8 April 2019

MAP kinase kinase activity

1 reference

26 September 2017

Cloning and characterization of two distinct human extracellular signal-regulated kinase activator kinases, MEK1 and MEK2

http://www.ebi.ac.uk/QuickGO/annotations?protein=P36507&geneProductId=UniProtKB:P36507

protein serine/threonine kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36507

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36507

8 April 2019

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36507

MAP kinase kinase activity

1 reference

8 April 2019

The ERK signaling cascade--views from different subcellular compartments

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36507

Golgi apparatus

membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36507

1 reference

8 April 2019

focal adhesion

1 reference

8 April 2019

The ERK signaling cascade--views from different subcellular compartments

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36507

cell-cell junction

1 reference

8 April 2019

Identification of mitogen-activated protein/extracellular signal-responsive kinase kinase 2 as a novel partner of the scaffolding protein human homolog of disc-large

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36507

peroxisomal membrane

1 reference

26 September 2017

PEX14 is required for microtubule-based peroxisome motility in human cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P36507&geneProductId=UniProtKB:P36507

extracellular region

NAS

1 reference

8 April 2019

Cloning and characterization of two distinct human extracellular signal-regulated kinase activator kinases, MEK1 and MEK2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36507

NAS

early endosome

1 reference

8 April 2019

The ERK signaling cascade--views from different subcellular compartments

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36507

endoplasmic reticulum

1 reference

8 April 2019

Identification of mitogen-activated protein/extracellular signal-responsive kinase kinase 2 as a novel partner of the scaffolding protein human homolog of disc-large

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36507

mitochondrion

1 reference

8 April 2019

The ERK signaling cascade--views from different subcellular compartments

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36507

perinuclear region of cytoplasm

1 reference

8 April 2019

Identification of mitogen-activated protein/extracellular signal-responsive kinase kinase 2 as a novel partner of the scaffolding protein human homolog of disc-large

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36507

cytoplasmic side of plasma membrane

1 reference

8 April 2019

Identification of mitogen-activated protein/extracellular signal-responsive kinase kinase 2 as a novel partner of the scaffolding protein human homolog of disc-large

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36507

microtubule

1 reference

8 April 2019

Identification of mitogen-activated protein/extracellular signal-responsive kinase kinase 2 as a novel partner of the scaffolding protein human homolog of disc-large

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36507

nucleus

1 reference

8 April 2019

The ERK signaling cascade--views from different subcellular compartments

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36507

cytoplasm

http://www.ebi.ac.uk/QuickGO/annotations?protein=P36507&geneProductId=UniProtKB:P36507

1 reference

26 September 2017

cytosol

The ERK signaling cascade--views from different subcellular compartments

3 references

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P36507&geneProductId=UniProtKB:P36507

http://www.ebi.ac.uk/QuickGO/annotations?protein=P36507&geneProductId=UniProtKB:P36507

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P36507&geneProductId=UniProtKB:P36507

26 September 2017

plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?protein=P36507&geneProductId=UniProtKB:P36507

1 reference

26 September 2017

peroxisomal membrane

HDA

1 reference

8 April 2019

PEX14 is required for microtubule-based peroxisome motility in human cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36507

HDA

biological process

phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36507

1 reference

8 April 2019

regulation of early endosome to late endosome transport

1 reference

8 April 2019

The ERK signaling cascade--views from different subcellular compartments

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36507

peptidyl-serine autophosphorylation

1 reference

8 April 2019

Cloning and characterization of two distinct human extracellular signal-regulated kinase activator kinases, MEK1 and MEK2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36507

negative regulation of gene expression

IGI

1 reference

8 April 2019

Anthrax lethal toxin downregulates claudin-5 expression in human endothelial tight junctions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36507

positive regulation of protein serine/threonine kinase activity

IGI

1 reference

8 April 2019

Cloning and characterization of two distinct human extracellular signal-regulated kinase activator kinases, MEK1 and MEK2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36507

protein phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36507

1 reference

8 April 2019

peptidyl-tyrosine phosphorylation

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36507

regulation of Golgi inheritance

1 reference

8 April 2019

The ERK signaling cascade--views from different subcellular compartments

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36507

regulation of stress-activated MAPK cascade

1 reference

8 April 2019

The ERK signaling cascade--views from different subcellular compartments

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36507

MAPK cascade

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36507

1 reference

8 April 2019

ERK1 and ERK2 cascade

http://www.ebi.ac.uk/QuickGO/annotations?protein=P36507&geneProductId=UniProtKB:P36507

1 reference

26 September 2017

positive regulation of production of miRNAs involved in gene silencing by miRNA

1 reference

8 April 2019

MiR-92a mediates AZD6244 induced apoptosis and G1-phase arrest of lymphoma cells by targeting Bim

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36507

positive regulation of transcription, DNA-templated

1 reference

8 April 2019

MiR-92a mediates AZD6244 induced apoptosis and G1-phase arrest of lymphoma cells by targeting Bim

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36507

positive regulation of ERK1 and ERK2 cascade

1 reference

26 September 2017

MiR-92a mediates AZD6244 induced apoptosis and G1-phase arrest of lymphoma cells by targeting Bim

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P36507&geneProductId=UniProtKB:P36507

regulation of mitotic cell cycle

http://www.ebi.ac.uk/QuickGO/annotations?protein=P36507&geneProductId=UniProtKB:P36507

1 reference

26 September 2017

regulation of apoptotic process

http://www.ebi.ac.uk/QuickGO/annotations?protein=P36507&geneProductId=UniProtKB:P36507

1 reference

26 September 2017

signal transduction

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36507

stress-activated protein kinase signaling cascade

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36507

activation of protein kinase activity

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36507

physically interacts with

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

7921

IUPHAR/BPS Guide to PHARMACOLOGY

17 August 2016

1 reference

Guide to Pharmacology Ligand ID

7626

IUPHAR/BPS Guide to PHARMACOLOGY

17 August 2016

1 reference

Guide to Pharmacology Ligand ID

6495

English

17 August 2016

has part(s)

protein kinase domain

1 reference

protein kinase, ATP binding site

1 reference

serine/threonine-protein kinase, active site

1 reference

D08.811.913.696.620.682.700.565.200

Identifiers

MeSH descriptor ID

D048370

subject named as

MAP Kinase Kinase 2

0 references

MeSH tree code

0 references

D08.811.913.696.620.682.725.200.200

0 references

D12.776.476.563.565.200

0 references

D12.776.476.568.200.200

0 references

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

4 August 2016

1 reference

4 August 2016

inferred by common MeSH mappings on source and on Wikidata

1 reference

UMLS 2023