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Wikidata

(Q21111353)

English

RAB5A, member RAS oncogene family

mammalian protein found in Homo sapiens

  • RAS-associated protein RAB5A
  • ras-related protein Rab-5A
  • RAB5A
  • rab5 GTP-Binding Proteins
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No label defined

No description defined

Statements

molecular function
protein binding
determination method or standard
IPI
24 references
retrieved
8 April 2019
stated in
Rab escort protein-1 is a multifunctional protein that accompanies newly prenylated rab proteins to their target membranes
GOA
curator
UniProt
UniProt protein ID
P20339
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339
determination method or standard
IPI
retrieved
8 April 2019
stated in
EEA1 links PI(3)K function to Rab5 regulation of endosome fusion
GOA
curator
UniProt
UniProt protein ID
P20339
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339
determination method or standard
IPI
retrieved
8 April 2019
stated in
Varp is a Rab21 guanine nucleotide exchange factor and regulates endosome dynamics
GOA
curator
UniProt
UniProt protein ID
P20339
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339
determination method or standard
IPI
retrieved
8 April 2019
stated in
Specific Rab GTPase-activating proteins define the Shiga toxin and epidermal growth factor uptake pathways
GOA
curator
UniProt
UniProt protein ID
P20339
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339
determination method or standard
IPI
retrieved
8 April 2019
stated in
Rab18 and a Rab18 GEF complex are required for normal ER structure
GOA
curator
UniProt
UniProt protein ID
P20339
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339
determination method or standard
IPI
retrieved
8 April 2019
stated in
The role of ceroid lipofuscinosis neuronal protein 5 (CLN5) in endosomal sorting
GOA
curator
UniProt
UniProt protein ID
P20339
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339
determination method or standard
IPI
retrieved
8 April 2019
stated in
APPL proteins link Rab5 to nuclear signal transduction via an endosomal compartment
GOA
curator
UniProt
UniProt protein ID
P20339
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339
determination method or standard
IPI
retrieved
8 April 2019
stated in
Structural basis of Rab5-Rabaptin5 interaction in endocytosis
GOA
curator
UniProt
UniProt protein ID
P20339
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339
determination method or standard
IPI
retrieved
8 April 2019
stated in
RabGEFs are a major determinant for specific Rab membrane targeting
GOA
curator
UniProt
UniProt protein ID
P20339
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339
determination method or standard
IPI
retrieved
8 April 2019
stated in
A novel ER-localized transmembrane protein, EMC6, interacts with RAB5A and regulates cell autophagy
GOA
curator
UniProt
UniProt protein ID
P20339
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339
determination method or standard
IPI
retrieved
8 April 2019
stated in
Abnormal alpha-synuclein interactions with rab3a and rabphilin in diffuse Lewy body disease.
GOA
curator
UniProt
UniProt protein ID
P20339
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339
determination method or standard
IPI
retrieved
8 April 2019
stated in
Structural basis of family-wide Rab GTPase recognition by rabenosyn-5
GOA
curator
UniProt
UniProt protein ID
P20339
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339
determination method or standard
IPI
retrieved
8 April 2019
stated in
The small GTPase Rab22 interacts with EEA1 and controls endosomal membrane trafficking
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339
determination method or standard
IPI
retrieved
8 April 2019
stated in
Structure of the APPL1 BAR-PH domain and characterization of its interaction with Rab5
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339
determination method or standard
IPI
retrieved
8 April 2019
stated in
Membrane targeting and activation of the Lowe syndrome protein OCRL1 by rab GTPases
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339
determination method or standard
IPI
retrieved
8 April 2019
stated in
EEA1 links PI(3)K function to Rab5 regulation of endosome fusion
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339
determination method or standard
IPI
retrieved
8 April 2019
stated in
A role of OCRL in clathrin-coated pit dynamics and uncoating revealed by studies of Lowe syndrome cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339
determination method or standard
IPI
retrieved
8 April 2019
stated in
The Rab5 effector Rabankyrin-5 regulates and coordinates different endocytic mechanisms
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339
determination method or standard
IPI
retrieved
8 April 2019
stated in
An AP-MS- and BioID-compatible MAC-tag enables comprehensive mapping of protein interactions and subcellular localizations.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339
determination method or standard
IPI
retrieved
8 April 2019
stated in
Defective relocalization of ALS2/alsin missense mutants to Rac1-induced macropinosomes accounts for loss of their cellular function and leads to disturbed amphisome formation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339
determination method or standard
IPI
retrieved
8 April 2019
stated in
The p85alpha subunit of phosphatidylinositol 3'-kinase binds to and stimulates the GTPase activity of Rab proteins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339
determination method or standard
IPI
retrieved
8 April 2019
stated in
A structural basis for Lowe syndrome caused by mutations in the Rab-binding domain of OCRL1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339
determination method or standard
IPI
retrieved
8 April 2019
stated in
Direct interaction of EEA1 with Rab5b
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339
determination method or standard
IPI
retrieved
8 April 2019
stated in
Central role for PICALM in amyloid-β blood-brain barrier transcytosis and clearance
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339
determination method or standard
IPI
GTPase activity
determination method or standard
IBA
IDA
IEA
TAS
7 references
retrieved
8 April 2019
stated in
The human Rab genes encode a family of GTP-binding proteins related to yeast YPT1 and SEC4 products involved in secretion
GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339
determination method or standard
TAS
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339
determination method or standard
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339
determination method or standard
IEA
retrieved
8 April 2019
stated in
Specific Rab GTPase-activating proteins define the Shiga toxin and epidermal growth factor uptake pathways
GOA
curator
UniProt
UniProt protein ID
P20339
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339
determination method or standard
IDA
retrieved
8 April 2019
stated in
Rab18 and a Rab18 GEF complex are required for normal ER structure
GOA
curator
UniProt
UniProt protein ID
P20339
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339
determination method or standard
IDA
retrieved
8 April 2019
stated in
Structural basis of Rab5-Rabaptin5 interaction in endocytosis
GOA
curator
UniProt
UniProt protein ID
P20339
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339
determination method or standard
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339
determination method or standard
IBA
cell component
early endosome
determination method or standard
IDA
IEA
TAS
8 references
retrieved
9 May 2017
stated in
Rabaptin-5 is a direct effector of the small GTPase Rab5 in endocytic membrane fusion
GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P20339
determination method or standard
TAS
retrieved
9 May 2017
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P20339
determination method or standard
IEA
retrieved
9 May 2017
stated in
Structural basis of Rab5-Rabaptin5 interaction in endocytosis
GOA
curator
UniProt
UniProt protein ID
P20339
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P20339
determination method or standard
IDA
retrieved
9 May 2017
stated in
Sac2/INPP5F is an inositol 4-phosphatase that functions in the endocytic pathway
GOA
curator
UniProt
UniProt protein ID
P20339
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P20339
determination method or standard
IDA
retrieved
9 May 2017
stated in
Specific Rab GTPase-activating proteins define the Shiga toxin and epidermal growth factor uptake pathways
GOA
curator
UniProt
UniProt protein ID
P20339
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P20339
determination method or standard
IDA
retrieved
9 May 2017
stated in
Hrs and SNX3 functions in sorting and membrane invagination within multivesicular bodies
GOA
curator
UniProt
UniProt protein ID
P20339
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P20339
determination method or standard
IDA
retrieved
9 May 2017
stated in
Cargo-selective endosomal sorting for retrieval to the Golgi requires retromer
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P20339
determination method or standard
IDA
retrieved
9 May 2017
stated in
The tumor susceptibility gene TMEM127 is mutated in renal cell carcinomas and modulates endolysosomal function
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P20339
determination method or standard
IDA
early endosome
determination method or standard
IBA
IDA
IEA
TAS
10 references
retrieved
8 April 2019
stated in
Rabaptin-5 is a direct effector of the small GTPase Rab5 in endocytic membrane fusion
GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339
determination method or standard
TAS
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339
determination method or standard
IEA
retrieved
8 April 2019
stated in
Hrs and SNX3 functions in sorting and membrane invagination within multivesicular bodies
GOA
curator
UniProt
UniProt protein ID
P20339
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339
determination method or standard
IDA
retrieved
8 April 2019
stated in
Biochemical characterization of APPL endosomes: the role of annexin A2 in APPL membrane recruitment
GOA
curator
UniProt
UniProt protein ID
P20339
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339
determination method or standard
IDA
retrieved
8 April 2019
stated in
Sac2/INPP5F is an inositol 4-phosphatase that functions in the endocytic pathway
GOA
curator
UniProt
UniProt protein ID
P20339
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339
determination method or standard
IDA
retrieved
8 April 2019
stated in
Specific Rab GTPase-activating proteins define the Shiga toxin and epidermal growth factor uptake pathways
GOA
curator
UniProt
UniProt protein ID
P20339
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339
determination method or standard
IDA
retrieved
8 April 2019
stated in
Structural basis of Rab5-Rabaptin5 interaction in endocytosis
GOA
curator
UniProt
UniProt protein ID
P20339
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339
determination method or standard
IDA
retrieved
8 April 2019
stated in
The tumor susceptibility gene TMEM127 is mutated in renal cell carcinomas and modulates endolysosomal function
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339
determination method or standard
IDA
retrieved
8 April 2019
stated in
Cargo-selective endosomal sorting for retrieval to the Golgi requires retromer
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339
determination method or standard
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339
determination method or standard
IBA
biological process

Identifiers

MeSH descriptor ID
D020696
subject named as
rab5 GTP-Binding Proteins
0 references
PDB structure ID
 
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