(Q21100765)

English

Claudin 5

mammalian protein found in Homo sapiens

transmembrane protein deleted in velocardiofacial syndrome
transmembrane protein deleted in VCFS
TMDVCF
CLDN5
claudin-5

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Statements

1 reference

13 November 2019

1 reference

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/O00501

claudins

1 reference

Transporter Classification Database ID

1.H.1.1.16

retrieved

2 October 2019

based on heuristic

hierarchical database ID heuristic

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00501

determination method

IEA

apicolateral plasma membrane

1 reference

8 April 2019

Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00501

determination method

IDA

cortical actin cytoskeleton

1 reference

8 April 2019

Tumor necrosis factor disrupts claudin-5 endothelial tight junction barriers in two distinct NF-κB-dependent phases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00501

4 references

8 April 2019

Anthrax lethal toxin downregulates claudin-5 expression in human endothelial tight junctions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00501

8 April 2019

Tyrosine phosphorylation of VE-cadherin and claudin-5 is associated with TGF-β1-induced permeability of centrally derived vascular endothelium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00501

8 April 2019

Claudin-5 controls intercellular barriers of human dermal microvascular but not human umbilical vein endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00501

8 April 2019

SOX-18 controls endothelial-specific claudin-5 gene expression and barrier function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00501

determination method

IDA

integral component of membrane

4 references

8 April 2019

Identification, characterization, and precise mapping of a human gene encoding a novel membrane-spanning protein from the 22q11 region deleted in velo-cardio-facial syndrome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00501

8 April 2019

Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00501

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00501

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00501

determination method

IEA

bicellular tight junction

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00501

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00501

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00501

8 April 2019

Tumor necrosis factor disrupts claudin-5 endothelial tight junction barriers in two distinct NF-κB-dependent phases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00501

8 April 2019

Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00501

2 references

cell-cell junction assembly

1 reference

8 April 2019

Claudin-5 controls intercellular barriers of human dermal microvascular but not human umbilical vein endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00501

determination method

IMP

transforming growth factor beta receptor signaling pathway

1 reference

8 April 2019

Tyrosine phosphorylation of VE-cadherin and claudin-5 is associated with TGF-β1-induced permeability of centrally derived vascular endothelium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00501

determination method

IDA

outflow tract morphogenesis

1 reference

8 April 2019

Identification, characterization, and precise mapping of a human gene encoding a novel membrane-spanning protein from the 22q11 region deleted in velo-cardio-facial syndrome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00501

1 reference

8 April 2019

Identification, characterization, and precise mapping of a human gene encoding a novel membrane-spanning protein from the 22q11 region deleted in velo-cardio-facial syndrome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00501

determination method

TAS

positive regulation of establishment of endothelial barrier

1 reference

8 April 2019

Claudin-5 controls intercellular barriers of human dermal microvascular but not human umbilical vein endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00501

determination method

IMP

roof of mouth development

1 reference

8 April 2019

Identification, characterization, and precise mapping of a human gene encoding a novel membrane-spanning protein from the 22q11 region deleted in velo-cardio-facial syndrome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00501

determination method

TAS

calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00501

1 reference

8 April 2019

Identification, characterization, and precise mapping of a human gene encoding a novel membrane-spanning protein from the 22q11 region deleted in velo-cardio-facial syndrome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00501

determination method

TAS

regulation of bicellular tight junction assembly

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00501

determination method

TAS

has part(s)

Claudin, conserved site

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/O00501

Identifiers

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

Transporter Classification Database ID

1.H.1.1.16

2 references

stated in

Transporter Classification database

retrieved

13 March 2020

stated in

Transporter Classification database

retrieved

29 April 2020

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