(Q15328173)

Superoxide dismutase-like, copper/zinc binding domain superfamily

1 reference

Superoxide dismutase, copper/zinc binding domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Superoxide dismutase, copper/zinc, binding site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

oxidoreductase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

1 reference

14 February 2019

superoxide dismutase activity

In vitro photochemical cataract in mice lacking copper-zinc superoxide dismutase

21 references

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08228&geneProductId=UniProtKB:P08228

27 February 2018

Copper/zinc superoxide dismutase attenuates neuronal cell death by preventing extracellular signal-regulated kinase activation after transient focal cerebral ischemia in mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08228&geneProductId=UniProtKB:P08228

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08228&geneProductId=UniProtKB:P08228

27 February 2018

The nature of antioxidant defense mechanisms: a lesson from transgenic studies

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08228&geneProductId=UniProtKB:P08228

27 February 2018

Pivotal role of Cu,Zn-superoxide dismutase in endothelium-dependent hyperpolarization

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08228&geneProductId=UniProtKB:P08228

27 February 2018

Absence of CuZn superoxide dismutase leads to elevated oxidative stress and acceleration of age-dependent skeletal muscle atrophy

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08228&geneProductId=UniProtKB:P08228

27 February 2018

Targeted disruption of the mouse Sod I gene makes the hearts vulnerable to ischemic reperfusion injury

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08228&geneProductId=UniProtKB:P08228

27 February 2018

Motor neurons in Cu/Zn superoxide dismutase-deficient mice develop normally but exhibit enhanced cell death after axonal injury

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08228&geneProductId=UniProtKB:P08228

27 February 2018

Cellular response of antioxidant metalloproteins in Cu/Zn SOD transgenic mice exposed to hyperoxia

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08228&geneProductId=UniProtKB:P08228

27 February 2018

Increased superoxide and vascular dysfunction in CuZnSOD-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08228&geneProductId=UniProtKB:P08228

27 February 2018

Reduced fertility in female mice lacking copper-zinc superoxide dismutase

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08228&geneProductId=UniProtKB:P08228

27 February 2018

Exacerbation of delayed cell injury after transient global ischemia in mutant mice with CuZn superoxide dismutase deficiency

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08228&geneProductId=UniProtKB:P08228

27 February 2018

Targeted deletion of the cytosolic Cu/Zn-superoxide dismutase gene (Sod1) increases susceptibility to noise-induced hearing loss

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08228&geneProductId=UniProtKB:P08228

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08228&geneProductId=UniProtKB:P08228

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08228&geneProductId=UniProtKB:P08228

27 February 2018

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08228&geneProductId=UniProtKB:P08228

27 February 2018

Copper, zinc-superoxide dismutase protein but not mRNA is lower in copper-deficient mice and mice lacking the copper chaperone for superoxide dismutase

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08228&geneProductId=UniProtKB:P08228

27 February 2018

Complex III releases superoxide to both sides of the inner mitochondrial membrane

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08228&geneProductId=UniProtKB:P08228

27 February 2018

Developmental changes in murine brain antioxidant enzymes

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08228&geneProductId=UniProtKB:P08228

27 February 2018

Assignment of the gene for cytoplasmic glutamate-oxaloacetate transaminase to mouse chromosome 19 using chinese hamster x mouse somatic cell hybrids

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08228&geneProductId=UniProtKB:P08228

27 February 2018

Assignment of the gene for cytoplasmic superoxide dismutase ( Sod-1 ) to a region of chromosome 16 and of Hprt to a region of the X chromosome in the mouse

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08228&geneProductId=UniProtKB:P08228

zinc ion binding

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08228&geneProductId=UniProtKB:P08228

4 references

1 January 2018

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08228&geneProductId=UniProtKB:P08228

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08228&geneProductId=UniProtKB:P08228

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08228&geneProductId=UniProtKB:P08228

protein binding

3 references

14 February 2019

Transgenic mice with increased Cu/Zn-superoxide dismutase activity: animal model of dosage effects in Down syndrome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

14 February 2019

SOD1 mutations disrupt redox-sensitive Rac regulation of NADPH oxidase in a familial ALS model

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

14 February 2019

A Map of Human Mitochondrial Protein Interactions Linked to Neurodegeneration Reveals New Mechanisms of Redox Homeostasis and NF-κB Signaling

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

copper ion binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

4 references

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

protein phosphatase 2B binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

1 reference

14 February 2019

enzyme binding

1 reference

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08228&geneProductId=UniProtKB:P08228

superoxide dismutase activity

In vitro photochemical cataract in mice lacking copper-zinc superoxide dismutase

22 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

14 February 2019

Copper/zinc superoxide dismutase attenuates neuronal cell death by preventing extracellular signal-regulated kinase activation after transient focal cerebral ischemia in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

14 February 2019

Motor neurons in Cu/Zn superoxide dismutase-deficient mice develop normally but exhibit enhanced cell death after axonal injury

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

14 February 2019

Targeted deletion of the cytosolic Cu/Zn-superoxide dismutase gene (Sod1) increases susceptibility to noise-induced hearing loss

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

14 February 2019

Increased superoxide and vascular dysfunction in CuZnSOD-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

14 February 2019

Exacerbation of delayed cell injury after transient global ischemia in mutant mice with CuZn superoxide dismutase deficiency

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

14 February 2019

The nature of antioxidant defense mechanisms: a lesson from transgenic studies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

14 February 2019

Pivotal role of Cu,Zn-superoxide dismutase in endothelium-dependent hyperpolarization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

14 February 2019

Targeted disruption of the mouse Sod I gene makes the hearts vulnerable to ischemic reperfusion injury

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

14 February 2019

Cellular response of antioxidant metalloproteins in Cu/Zn SOD transgenic mice exposed to hyperoxia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

14 February 2019

Reduced fertility in female mice lacking copper-zinc superoxide dismutase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

14 February 2019

Absence of CuZn superoxide dismutase leads to elevated oxidative stress and acceleration of age-dependent skeletal muscle atrophy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

14 February 2019

Assignment of the gene for cytoplasmic superoxide dismutase ( Sod-1 ) to a region of chromosome 16 and of Hprt to a region of the X chromosome in the mouse

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

14 February 2019

Complex III releases superoxide to both sides of the inner mitochondrial membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

14 February 2019

Copper, zinc-superoxide dismutase protein but not mRNA is lower in copper-deficient mice and mice lacking the copper chaperone for superoxide dismutase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

14 February 2019

Assignment of the gene for cytoplasmic glutamate-oxaloacetate transaminase to mouse chromosome 19 using chinese hamster x mouse somatic cell hybrids

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

14 February 2019

Developmental changes in murine brain antioxidant enzymes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

superoxide dismutase copper chaperone activity

1 reference

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08228&geneProductId=UniProtKB:P08228

zinc ion binding

In vitro photochemical cataract in mice lacking copper-zinc superoxide dismutase

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

14 February 2019

14 February 2019

Nucleophosmin serves as a rate-limiting nuclear export chaperone for the Mammalian ribosome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

cytosol

3 references

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08228&geneProductId=UniProtKB:P08228

5 references

27 February 2018

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08228&geneProductId=UniProtKB:P08228

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08228&geneProductId=UniProtKB:P08228

27 February 2018

Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08228&geneProductId=UniProtKB:P08228

27 February 2018

A mitochondrial protein compendium elucidates complex I disease biology

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08228&geneProductId=UniProtKB:P08228

dendrite cytoplasm

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08228&geneProductId=UniProtKB:P08228

4 references

1 January 2018

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08228&geneProductId=UniProtKB:P08228

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08228&geneProductId=UniProtKB:P08228

1 January 2018

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08228&geneProductId=UniProtKB:P08228

myelin sheath

1 reference

27 February 2018

Proteolipid protein is required for transport of sirtuin 2 into CNS myelin

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08228&geneProductId=UniProtKB:P08228

extracellular matrix

3 references

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

dense core granule

1 reference

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08228&geneProductId=UniProtKB:P08228

secretory granule

1 reference

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08228&geneProductId=UniProtKB:P08228

extracellular region

1 reference

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08228&geneProductId=UniProtKB:P08228

neuron projection

1 reference

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08228&geneProductId=UniProtKB:P08228

lysosome

1 reference

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08228&geneProductId=UniProtKB:P08228

extracellular space

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08228&geneProductId=UniProtKB:P08228

5 references

27 February 2018

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08228&geneProductId=UniProtKB:P08228

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08228&geneProductId=UniProtKB:P08228

27 February 2018

Impaired extracellular secretion of mutant superoxide dismutase 1 associates with neurotoxicity in familial amyotrophic lateral sclerosis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08228&geneProductId=UniProtKB:P08228

27 February 2018

Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08228&geneProductId=UniProtKB:P08228

extracellular space

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08228&geneProductId=UniProtKB:P08228

6 references

1 January 2018

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08228&geneProductId=UniProtKB:P08228

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08228&geneProductId=UniProtKB:P08228

1 January 2018

Impaired extracellular secretion of mutant superoxide dismutase 1 associates with neurotoxicity in familial amyotrophic lateral sclerosis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08228&geneProductId=UniProtKB:P08228

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08228&geneProductId=UniProtKB:P08228

1 January 2018

Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08228&geneProductId=UniProtKB:P08228

cytoplasm

In vitro photochemical cataract in mice lacking copper-zinc superoxide dismutase

6 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08228&geneProductId=UniProtKB:P08228

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08228&geneProductId=UniProtKB:P08228

1 January 2018

1 January 2018

Nucleophosmin serves as a rate-limiting nuclear export chaperone for the Mammalian ribosome

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08228&geneProductId=UniProtKB:P08228

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08228&geneProductId=UniProtKB:P08228

1 January 2018

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08228&geneProductId=UniProtKB:P08228

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08228&geneProductId=UniProtKB:P08228

mitochondrion

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08228&geneProductId=UniProtKB:P08228

5 references

1 January 2018

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08228&geneProductId=UniProtKB:P08228

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08228&geneProductId=UniProtKB:P08228

1 January 2018

Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08228&geneProductId=UniProtKB:P08228

1 January 2018

A mitochondrial protein compendium elucidates complex I disease biology

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08228&geneProductId=UniProtKB:P08228

mitochondrial intermembrane space

protein-containing complex

1 reference

14 February 2019

Proteolipid protein is required for transport of sirtuin 2 into CNS myelin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

extracellular space

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

5 references

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

14 February 2019

Impaired extracellular secretion of mutant superoxide dismutase 1 associates with neurotoxicity in familial amyotrophic lateral sclerosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

14 February 2019

Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

nucleus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

5 references

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

mitochondrion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

6 references

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

14 February 2019

Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

14 February 2019

A mitochondrial protein compendium elucidates complex I disease biology

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

cytosol

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

4 references

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

negative regulation of neuron apoptotic process

biological process

1 reference

14 February 2019

Cu/Zn SOD deficiency potentiates hearing loss and cochlear pathology in aged 129,CD-1 mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

muscle cell cellular homeostasis

1 reference

14 February 2019

Absence of CuZn superoxide dismutase leads to elevated oxidative stress and acceleration of age-dependent skeletal muscle atrophy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

response to amphetamine

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

positive regulation of catalytic activity

1 reference

14 February 2019

c-kit delineates a distinct domain of progenitors in the developing kidney

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

response to organic substance

anterograde axonal transport

1 reference

14 February 2019

Effects of ALS-related SOD1 mutants on dynein- and KIF5-mediated retrograde and anterograde axonal transport

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

spermatogenesis

1 reference

14 February 2019

Accelerated impairment of spermatogenic cells in SOD1-knockout mice under heat stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

heart contraction

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

14 February 2019

Targeted disruption of the mouse Sod I gene makes the hearts vulnerable to ischemic reperfusion injury

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

response to ethanol

1 reference

14 February 2019

Mitochondrial alterations in livers of Sod1-/- mice fed alcohol

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

neurofilament cytoskeleton organization

embryo implantation

1 reference

14 February 2019

Reduced fertility in female mice lacking copper-zinc superoxide dismutase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

locomotory behavior

1 reference

14 February 2019

Hindlimb motor neurons require Cu/Zn superoxide dismutase for maintenance of neuromuscular junctions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

response to antibiotic

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

transmission of nerve impulse

1 reference

14 February 2019

Hindlimb motor neurons require Cu/Zn superoxide dismutase for maintenance of neuromuscular junctions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

myeloid cell homeostasis

Defective hematopoiesis and hepatic steatosis in mice with combined deficiencies of the genes encoding Fancc and Cu/Zn superoxide dismutase

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

14 February 2019

Defective hematopoiesis and hepatic steatosis in mice with combined deficiencies of the genes encoding Fancc and Cu/Zn superoxide dismutase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

reactive oxygen species metabolic process

1 reference

14 February 2019

Drusen, choroidal neovascularization, and retinal pigment epithelium dysfunction in SOD1-deficient mice: a model of age-related macular degeneration

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

hydrogen peroxide biosynthetic process

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

14 February 2019

Pivotal role of Cu,Zn-superoxide dismutase in endothelium-dependent hyperpolarization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

regulation of protein kinase activity

negative regulation of cholesterol biosynthetic process

cellular response to potassium ion

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

retrograde axonal transport

1 reference

14 February 2019

Effects of ALS-related SOD1 mutants on dynein- and KIF5-mediated retrograde and anterograde axonal transport

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

glutathione metabolic process

1 reference

14 February 2019

Phenotypes of mice lacking extracellular superoxide dismutase and copper- and zinc-containing superoxide dismutase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

response to antipsychotic drug

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

cellular response to cadmium ion

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

response to carbon monoxide

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

regulation of blood pressure

1 reference

14 February 2019

Increased superoxide and vascular dysfunction in CuZnSOD-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

response to axon injury

1 reference

14 February 2019

Motor neurons in Cu/Zn superoxide dismutase-deficient mice develop normally but exhibit enhanced cell death after axonal injury

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

ovarian follicle development

1 reference

14 February 2019

Ovarian function in superoxide dismutase 1 and 2 knockout mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

cellular response to ATP

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

response to hydrogen peroxide

1 reference

14 February 2019

Effects of variation in superoxide dismutases (SOD) on oxidative stress and apoptosis in lens epithelium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

superoxide metabolic process

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

14 February 2019

Cellular response of antioxidant metalloproteins in Cu/Zn SOD transgenic mice exposed to hyperoxia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

peripheral nervous system myelin maintenance

1 reference

14 February 2019

Hindlimb motor neurons require Cu/Zn superoxide dismutase for maintenance of neuromuscular junctions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

response to superoxide

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

14 February 2019

Reduced fertility in female mice lacking copper-zinc superoxide dismutase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

14 February 2019

Organ-specific increase in mutation accumulation and apoptosis rate in CuZn-superoxide dismutase-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

14 February 2019

The nature of antioxidant defense mechanisms: a lesson from transgenic studies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

positive regulation of cytokine production

regulation of multicellular organism growth

1 reference

14 February 2019

Phenotypes of mice lacking extracellular superoxide dismutase and copper- and zinc-containing superoxide dismutase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

ageing

1 reference

14 February 2019

Phenotypes of mice lacking extracellular superoxide dismutase and copper- and zinc-containing superoxide dismutase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

hearing

3 references

14 February 2019

Cu/Zn superoxide dismutase and age-related hearing loss

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

14 February 2019

Targeted deletion of the cytosolic Cu/Zn-superoxide dismutase gene (Sod1) increases susceptibility to noise-induced hearing loss

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

14 February 2019

Cu/Zn SOD deficiency potentiates hearing loss and cochlear pathology in aged 129,CD-1 mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

superoxide anion generation

1 reference

14 February 2019

Complex III releases superoxide to both sides of the inner mitochondrial membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

regulation of mitochondrial membrane potential

auditory receptor cell stereocilium organization

cellular iron ion homeostasis

1 reference

14 February 2019

Phenotypes of mice lacking extracellular superoxide dismutase and copper- and zinc-containing superoxide dismutase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

negative regulation of apoptotic process

Accelerated impairment of spermatogenic cells in SOD1-knockout mice under heat stress

3 references

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08228&geneProductId=UniProtKB:P08228

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08228&geneProductId=UniProtKB:P08228

27 February 2018

Copper/zinc superoxide dismutase attenuates neuronal cell death by preventing extracellular signal-regulated kinase activation after transient focal cerebral ischemia in mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08228&geneProductId=UniProtKB:P08228

response to oxidative stress

Elevated oxidative stress in erythrocytes due to a SOD1 deficiency causes anaemia and triggers autoantibody production

4 references

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08228&geneProductId=UniProtKB:P08228

27 February 2018

Absence of CuZn superoxide dismutase leads to elevated oxidative stress and acceleration of age-dependent skeletal muscle atrophy

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08228&geneProductId=UniProtKB:P08228

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08228&geneProductId=UniProtKB:P08228

27 February 2018

Copper/zinc superoxide dismutase attenuates neuronal cell death by preventing extracellular signal-regulated kinase activation after transient focal cerebral ischemia in mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08228&geneProductId=UniProtKB:P08228

response to copper ion

1 reference

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08228&geneProductId=UniProtKB:P08228

removal of superoxide radicals

In vitro photochemical cataract in mice lacking copper-zinc superoxide dismutase

12 references

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08228&geneProductId=UniProtKB:P08228

27 February 2018

The nature of antioxidant defense mechanisms: a lesson from transgenic studies

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08228&geneProductId=UniProtKB:P08228

27 February 2018

Targeted disruption of the mouse Sod I gene makes the hearts vulnerable to ischemic reperfusion injury

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08228&geneProductId=UniProtKB:P08228

27 February 2018

Motor neurons in Cu/Zn superoxide dismutase-deficient mice develop normally but exhibit enhanced cell death after axonal injury

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08228&geneProductId=UniProtKB:P08228

27 February 2018

Defective hematopoiesis and hepatic steatosis in mice with combined deficiencies of the genes encoding Fancc and Cu/Zn superoxide dismutase

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08228&geneProductId=UniProtKB:P08228

27 February 2018

Increased superoxide and vascular dysfunction in CuZnSOD-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08228&geneProductId=UniProtKB:P08228

27 February 2018

Reduced fertility in female mice lacking copper-zinc superoxide dismutase

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08228&geneProductId=UniProtKB:P08228

27 February 2018

Exacerbation of delayed cell injury after transient global ischemia in mutant mice with CuZn superoxide dismutase deficiency

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08228&geneProductId=UniProtKB:P08228

27 February 2018

Mitochondrial alterations in livers of Sod1-/- mice fed alcohol

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08228&geneProductId=UniProtKB:P08228

27 February 2018

Targeted deletion of the cytosolic Cu/Zn-superoxide dismutase gene (Sod1) increases susceptibility to noise-induced hearing loss

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08228&geneProductId=UniProtKB:P08228

27 February 2018

Defective hematopoiesis and hepatic steatosis in mice with combined deficiencies of the genes encoding Fancc and Cu/Zn superoxide dismutase

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08228&geneProductId=UniProtKB:P08228

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08228&geneProductId=UniProtKB:P08228

response to nutrient levels

1 reference

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08228&geneProductId=UniProtKB:P08228

response to reactive oxygen species

1 reference

14 February 2019

Elevated oxidative stress in erythrocytes due to a SOD1 deficiency causes anaemia and triggers autoantibody production

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

cellular response to oxidative stress

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

response to oxidative stress

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

14 February 2019

Elevated oxidative stress in erythrocytes due to a SOD1 deficiency causes anaemia and triggers autoantibody production

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

14 February 2019

Absence of CuZn superoxide dismutase leads to elevated oxidative stress and acceleration of age-dependent skeletal muscle atrophy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

14 February 2019

Copper/zinc superoxide dismutase attenuates neuronal cell death by preventing extracellular signal-regulated kinase activation after transient focal cerebral ischemia in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

removal of superoxide radicals

In vitro photochemical cataract in mice lacking copper-zinc superoxide dismutase

14 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

14 February 2019

Motor neurons in Cu/Zn superoxide dismutase-deficient mice develop normally but exhibit enhanced cell death after axonal injury

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

14 February 2019

Targeted deletion of the cytosolic Cu/Zn-superoxide dismutase gene (Sod1) increases susceptibility to noise-induced hearing loss

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

14 February 2019

Increased superoxide and vascular dysfunction in CuZnSOD-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

14 February 2019

Exacerbation of delayed cell injury after transient global ischemia in mutant mice with CuZn superoxide dismutase deficiency

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

14 February 2019

The nature of antioxidant defense mechanisms: a lesson from transgenic studies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

14 February 2019

Targeted disruption of the mouse Sod I gene makes the hearts vulnerable to ischemic reperfusion injury

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

14 February 2019

Defective hematopoiesis and hepatic steatosis in mice with combined deficiencies of the genes encoding Fancc and Cu/Zn superoxide dismutase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

14 February 2019

Mitochondrial alterations in livers of Sod1-/- mice fed alcohol

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

14 February 2019

Reduced fertility in female mice lacking copper-zinc superoxide dismutase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

14 February 2019

Defective hematopoiesis and hepatic steatosis in mice with combined deficiencies of the genes encoding Fancc and Cu/Zn superoxide dismutase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

negative regulation of apoptotic process

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

14 February 2019

Accelerated impairment of spermatogenic cells in SOD1-knockout mice under heat stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

14 February 2019

Copper/zinc superoxide dismutase attenuates neuronal cell death by preventing extracellular signal-regulated kinase activation after transient focal cerebral ischemia in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

negative regulation of inflammatory response

1 reference

14 February 2019

Targeting miR-155 restores abnormal microglia and attenuates disease in SOD1 mice.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

positive regulation of phagocytosis

1 reference

14 February 2019

Targeting miR-155 restores abnormal microglia and attenuates disease in SOD1 mice.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08228

Superoxide dismutase, copper/zinc binding domain

has part(s)

1 reference

Superoxide dismutase, copper/zinc, binding site

1 reference