(Q14906044)

English

Bruton agammaglobulinemia tyrosine kinase

mammalian protein found in Mus musculus

ATK
bruton tyrosine kinase
Tyrosine-protein kinase BTK (Brutons tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB)
tyrosine-protein kinase BTK
agammaglobulinemia tyrosine kinase
kinase EMB
X-linked immune deficiency
Btk
B-cell progenitor kinase
Bruton's tyrosine kinase
agammaglobulinaemia tyrosine kinase
BPK

In more languages

default for all languages

No label defined

No description defined

Statements

1 reference

25 May 2022

UniProt protein ID

SH3-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P35991

Protein kinase-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P35991

PH-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P35991

SH2 domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P35991

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

pleckstrin homology domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

SH2 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Tyrosine-protein kinase BTK, SH3 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

SH3 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Protein kinase domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Protein kinase, ATP binding site, protein family

1 reference

based on heuristic

inferred from protein domain or family

Tyrosine-protein kinase, catalytic domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Tyrosine-protein kinase, active site, protein family

1 reference

based on heuristic

inferred from protein domain or family

Zinc finger, Btk motif, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

transferase activity

determination method or standard

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35991

determination method or standard

protein kinase activity

determination method or standard

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35991

determination method or standard

nucleotide binding

determination method or standard

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35991

determination method or standard

metal ion binding

determination method or standard

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35991

determination method or standard

kinase activity

determination method or standard

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35991

determination method or standard

protein binding

determination method or standard

5 references

14 February 2019

Mutations in the DNA-binding domain of the transcription factor Bright act as dominant negative proteins and interfere with immunoglobulin transactivation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35991

determination method or standard

14 February 2019

The forkhead genes, Foxc1 and Foxc2, regulate paraxial versus intermediate mesoderm cell fate

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35991

determination method or standard

14 February 2019

Identification and characterization of a molecule, BAM11, that associates with the pleckstrin homology domain of mouse Btk

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35991

determination method or standard

14 February 2019

Intracellular MHC class II molecules promote TLR-triggered innate immune responses by maintaining activation of the kinase Btk

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35991

determination method or standard

14 February 2019

Bioinformatics and cellular signaling

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35991

determination method or standard

protein tyrosine kinase activity

determination method or standard

6 references

10 September 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35991&geneProductId=UniProtKB:P35991

determination method or standard

10 September 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35991&geneProductId=UniProtKB:P35991

determination method or standard

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35991&geneProductId=UniProtKB:P35991

determination method or standard

10 September 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35991&geneProductId=UniProtKB:P35991

determination method or standard

10 September 2018

Molecular cloning of the mouse APS as a member of the Lnk family adaptor proteins

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35991&geneProductId=UniProtKB:P35991

determination method or standard

10 September 2018

Identification and characterization of a molecule, BAM11, that associates with the pleckstrin homology domain of mouse Btk

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35991&geneProductId=UniProtKB:P35991

determination method or standard

signaling receptor binding

determination method or standard

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35991&geneProductId=UniProtKB:P35991

determination method or standard

determination method or standard

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35991

determination method or standard

protein tyrosine kinase activity

determination method or standard

8 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35991

determination method or standard

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35991

determination method or standard

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35991

determination method or standard

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35991

determination method or standard

14 February 2019

Molecular cloning of the mouse APS as a member of the Lnk family adaptor proteins

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35991

determination method or standard

14 February 2019

Identification and characterization of a molecule, BAM11, that associates with the pleckstrin homology domain of mouse Btk

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35991

determination method or standard

14 February 2019

Regulation of Btk function by a major autophosphorylation site within the SH3 domain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35991

determination method or standard

14 February 2019

Src family protein tyrosine kinases induce autoactivation of Bruton's tyrosine kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35991

determination method or standard

determination method or standard

determination method or standard

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35991

determination method or standard

extrinsic component of cytoplasmic side of plasma membrane

determination method or standard

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35991&geneProductId=UniProtKB:P35991

determination method or standard

plasma membrane

determination method or standard

cytoplasmic vesicle

determination method or standard

1 reference

14 February 2019

Hormone-sensitive lipase is required for high-density lipoprotein cholesteryl ester-supported adrenal steroidogenesis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35991

determination method or standard

mast cell granule

determination method or standard

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35991

determination method or standard

biological process

intracellular signal transduction

determination method or standard

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35991

determination method or standard

regulation of transcription, DNA-templated

determination method or standard

1 reference

24 April 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35991&geneProductId=UniProtKB:P35991

determination method or standard

adaptive immune response

determination method or standard

1 reference

24 April 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35991&geneProductId=UniProtKB:P35991

determination method or standard

phosphorylation

determination method or standard

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35991

determination method or standard

transmembrane receptor protein tyrosine kinase signaling pathway

determination method or standard

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35991&geneProductId=UniProtKB:P35991

determination method or standard

immune system process

determination method or standard

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35991

determination method or standard

cell maturation

determination method or standard

1 reference

14 February 2019

Cellular maturation defects in Bruton's tyrosine kinase-deficient immature B cells are amplified by premature B cell receptor expression and reduced by receptor editing

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35991

determination method or standard

transcription, DNA-templated

determination method or standard

1 reference

24 April 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35991&geneProductId=UniProtKB:P35991

determination method or standard

peptidyl-tyrosine autophosphorylation

determination method or standard

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35991

determination method or standard

peptidyl-tyrosine phosphorylation

determination method or standard

3 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35991

determination method or standard

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35991

determination method or standard

14 February 2019

Molecular cloning of the mouse APS as a member of the Lnk family adaptor proteins

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35991

determination method or standard

I-kappaB kinase/NF-kappaB signaling

determination method or standard

1 reference

14 February 2019

B cell receptor directs the activation of NFAT and NF-kappaB via distinct molecular mechanisms

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35991

determination method or standard

negative regulation of cytokine production

determination method or standard

1 reference

14 February 2019

The tyrosine kinase Btk regulates the macrophage response to Listeria monocytogenes infection

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35991

determination method or standard

apoptotic process

determination method or standard

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35991

determination method or standard

B cell affinity maturation

determination method or standard

1 reference

14 February 2019

B cell developmental defects in X-linked immunodeficiency

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35991

determination method or standard

negative regulation of B cell proliferation

determination method or standard

1 reference

14 February 2019

B cell developmental defects in X-linked immunodeficiency

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35991

determination method or standard

cellular response to interleukin-7

determination method or standard

1 reference

14 February 2019

B cell developmental defects in X-linked immunodeficiency

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35991

determination method or standard

innate immune response

determination method or standard

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35991

determination method or standard

T cell receptor signaling pathway

determination method or standard

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35991

determination method or standard

B cell receptor signaling pathway

determination method or standard

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35991

determination method or standard

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P35991

tyrosine-protein kinase, catalytic domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P35991

tyrosine-protein kinase, active site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P35991

serine-threonine/tyrosine-protein kinase, catalytic domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P35991

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P35991

Zinc finger, Btk motif

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P35991

pleckstrin homology domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P35991

protein kinase, ATP binding site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P35991

protein kinase domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P35991

Tyrosine-protein kinase BTK, SH3 domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P35991

Identifiers

RefSeq protein ID

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSMUSP00000033617

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000033617

ENSMUSP00000108839

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000108839

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q14906044&oldid=2023070342"