(Q14905404)

Apoptosis regulator BAX

1 reference

Apoptosis regulator, Bcl-2, BH3 motif, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

Apoptosis regulator, Bcl-2, BH1 motif, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

Apoptosis regulator, Bcl-2, BH2 motif, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

protein homodimerization activity

5 references

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

Bax and Bcl-2 interaction in a transgenic mouse model of familial amyotrophic lateral sclerosis

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

Proapoptotic protein Bax heterodimerizes with Bcl-2 and homodimerizes with Bax via a novel domain (BH3) distinct from BH1 and BH2

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

Proapoptotic protein Bax heterodimerizes with Bcl-2 and homodimerizes with Bax via a novel domain (BH3) distinct from BH1 and BH2

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

protein binding

11 references

8 April 2019

BOK Is a Non-canonical BCL-2 Family Effector of Apoptosis Regulated by ER-Associated Degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Inhibition of both the extrinsic and intrinsic death pathways through nonhomotypic death-fold interactions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

hsp70-DnaJ chaperone pair prevents nitric oxide- and CHOP-induced apoptosis by inhibiting translocation of Bax to mitochondria

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Bcl-2 family interaction with the mitochondrial morphogenesis machinery

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

BID: a novel BH3 domain-only death agonist

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Loss of Bif-1 suppresses Bax/Bak conformational change and mitochondrial apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Mitochondrial rhomboid PARL regulates cytochrome c release during apoptosis via OPA1-dependent cristae remodeling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1alpha

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Upregulation of Bcl2 inhibits apoptosis-driven BAX insertion but favors BAX relocalization in mitochondria

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Bax interacts with the permeability transition pore to induce permeability transition and cytochrome c release in isolated mitochondria

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

MAP-1, a novel proapoptotic protein containing a BH3-like motif that associates with Bax through its Bcl-2 homology domains

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

protein heterodimerization activity

7 references

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

Bcl-XL and Bcl-2 repress a common pathway of cell death

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

Bax can antagonize Bcl-XL during etoposide and cisplatin-induced cell death independently of its heterodimerization with Bcl-XL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

BID: a novel BH3 domain-only death agonist

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

Bax ablation prevents dopaminergic neurodegeneration in the 1-methyl- 4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

lipid binding

1 reference

27 February 2018

hsp70-DnaJ chaperone pair prevents nitric oxide- and CHOP-induced apoptosis by inhibiting translocation of Bax to mitochondria

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

Hsp70 protein binding

1 reference

8 April 2019

hsp70-DnaJ chaperone pair prevents nitric oxide- and CHOP-induced apoptosis by inhibiting translocation of Bax to mitochondria

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

channel activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

4 references

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

identical protein binding

3 references

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

Solution Structure of Apoptotic BAX Oligomer: Oligomerization Likely Precedes Membrane Insertion.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

heat shock protein binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

protein homodimerization activity

6 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Bax and Bcl-2 interaction in a transgenic mouse model of familial amyotrophic lateral sclerosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Proapoptotic protein Bax heterodimerizes with Bcl-2 and homodimerizes with Bax via a novel domain (BH3) distinct from BH1 and BH2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Proapoptotic protein Bax heterodimerizes with Bcl-2 and homodimerizes with Bax via a novel domain (BH3) distinct from BH1 and BH2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

protein-containing complex binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

protein heterodimerization activity

8 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

BID: a novel BH3 domain-only death agonist

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Bcl-XL and Bcl-2 repress a common pathway of cell death

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Bax can antagonize Bcl-XL during etoposide and cisplatin-induced cell death independently of its heterodimerization with Bcl-XL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Bax ablation prevents dopaminergic neurodegeneration in the 1-methyl- 4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

BH domain binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

cell component

cytosol

12 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

The course of etoposide-induced apoptosis from damage to DNA and p53 activation to mitochondrial release of cytochrome c

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Spatial and temporal changes in Bax subcellular localization during anoikis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Genetic inactivation of the transcription factor TIF-IA leads to nucleolar disruption, cell cycle arrest, and p53-mediated apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Bax and Bak can localize to the endoplasmic reticulum to initiate apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Activation of pro-death Bcl-2 family proteins and mitochondria apoptosis pathway in tumor necrosis factor-alpha-induced liver injury

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

BI-1 regulates an apoptosis pathway linked to endoplasmic reticulum stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Loss of Bif-1 suppresses Bax/Bak conformational change and mitochondrial apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Mitochondrial degeneration and not apoptosis is the primary cause of embryonic lethality in ceramide transfer protein mutant mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Intrinsic and extrinsic pathway signaling during neuronal apoptosis: lessons from the analysis of mutant mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Bax in murine thymus is a soluble monomeric protein that displays differential detergent-induced conformations

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

Bcl-2 family protein complex

15 references

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

hsp70-DnaJ chaperone pair prevents nitric oxide- and CHOP-induced apoptosis by inhibiting translocation of Bax to mitochondria

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

Parkin-dependent degradation of the F-box protein Fbw7β promotes neuronal survival in response to oxidative stress by stabilizing Mcl-1

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

The Bax N terminus is required for negative regulation by the mitogen-activated protein kinase kinase and Akt signaling pathways in T cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

Mitochondrial degeneration and not apoptosis is the primary cause of embryonic lethality in ceramide transfer protein mutant mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

Bax and Bak can localize to the endoplasmic reticulum to initiate apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

A mitochondrial protein compendium elucidates complex I disease biology

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

The course of etoposide-induced apoptosis from damage to DNA and p53 activation to mitochondrial release of cytochrome c

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

Caspases 3 and 7: key mediators of mitochondrial events of apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

BI-1 regulates an apoptosis pathway linked to endoplasmic reticulum stress

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

Activation of pro-death Bcl-2 family proteins and mitochondria apoptosis pathway in tumor necrosis factor-alpha-induced liver injury

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

Bcl-2 family interaction with the mitochondrial morphogenesis machinery

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

nucleus

mitochondrial permeability transition pore complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

4 references

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

MAP-1, a novel proapoptotic protein containing a BH3-like motif that associates with Bax through its Bcl-2 homology domains

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

endoplasmic reticulum

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Bax and Bak can localize to the endoplasmic reticulum to initiate apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

pore complex

intracellular anatomical structure

2 references

27 February 2018

Bcl-2 lies downstream of parathyroid hormone-related peptide in a signaling pathway that regulates chondrocyte maturation during skeletal development

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

Pro- and anti-apoptotic members of the Bcl-2 family in skeletal muscle: a distinct role for Bcl-2 in later stages of myogenesis

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

endoplasmic reticulum membrane

mitochondrial outer membrane

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

4 references

27 February 2018

27 February 2018

Loss of Bif-1 suppresses Bax/Bak conformational change and mitochondrial apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

Cidea-deficient mice have lean phenotype and are resistant to obesity

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

Spatial and temporal changes in Bax subcellular localization during anoikis

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

mitochondrial membranes

3 references

27 February 2018

Intrinsic and extrinsic pathway signaling during neuronal apoptosis: lessons from the analysis of mutant mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

Bax-induced cytochrome c release from mitochondria depends on alpha-helices-5 and -6

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

Activation of pro-death Bcl-2 family proteins and mitochondria apoptosis pathway in tumor necrosis factor-alpha-induced liver injury

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

cytoplasm

10 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

hsp70-DnaJ chaperone pair prevents nitric oxide- and CHOP-induced apoptosis by inhibiting translocation of Bax to mitochondria

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

The Bax N terminus is required for negative regulation by the mitogen-activated protein kinase kinase and Akt signaling pathways in T cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Caspases 3 and 7: key mediators of mitochondrial events of apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Apoptosis in the pattern formation of the ventricular wall during mouse heart organogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

p53 and Bax: putative death factors in taste cell turnover

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Gustatory innervation and bax-dependent caspase-2: participants in the life and death pathways of mouse taste receptor cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Bax ablation prevents dopaminergic neurodegeneration in the 1-methyl- 4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

1 reference

8 April 2019

mitochondrion

15 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Parkin-dependent degradation of the F-box protein Fbw7β promotes neuronal survival in response to oxidative stress by stabilizing Mcl-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

hsp70-DnaJ chaperone pair prevents nitric oxide- and CHOP-induced apoptosis by inhibiting translocation of Bax to mitochondria

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

The course of etoposide-induced apoptosis from damage to DNA and p53 activation to mitochondrial release of cytochrome c

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

The Bax N terminus is required for negative regulation by the mitogen-activated protein kinase kinase and Akt signaling pathways in T cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Bax and Bak can localize to the endoplasmic reticulum to initiate apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Activation of pro-death Bcl-2 family proteins and mitochondria apoptosis pathway in tumor necrosis factor-alpha-induced liver injury

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Bcl-2 family interaction with the mitochondrial morphogenesis machinery

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

BI-1 regulates an apoptosis pathway linked to endoplasmic reticulum stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Caspases 3 and 7: key mediators of mitochondrial events of apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Mitochondrial degeneration and not apoptosis is the primary cause of embryonic lethality in ceramide transfer protein mutant mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

HDA

8 April 2019

A mitochondrial protein compendium elucidates complex I disease biology

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

mitochondrial outer membrane

HDA

7 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Spatial and temporal changes in Bax subcellular localization during anoikis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Cidea-deficient mice have lean phenotype and are resistant to obesity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Loss of Bif-1 suppresses Bax/Bak conformational change and mitochondrial apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

mitochondrial membranes

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Bax-induced cytochrome c release from mitochondria depends on alpha-helices-5 and -6

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Intrinsic and extrinsic pathway signaling during neuronal apoptosis: lessons from the analysis of mutant mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Activation of pro-death Bcl-2 family proteins and mitochondria apoptosis pathway in tumor necrosis factor-alpha-induced liver injury

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

perinuclear region of cytoplasm

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

negative regulation of neuron apoptotic process

biological process

1 reference

8 April 2019

Bax promotes neuronal survival and antagonises the survival effects of neurotrophic factors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

response to ionizing radiation

germ cell development

1 reference

8 April 2019

Bcl-x and Bax regulate mouse primordial germ cell survival and apoptosis during embryogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

positive regulation of calcium ion transport into cytosol

1 reference

8 April 2019

Proapoptotic BAX and BAK regulate the type 1 inositol trisphosphate receptor and calcium leak from the endoplasmic reticulum

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

glycosphingolipid metabolic process

1 reference

8 April 2019

Male germ cells require polyenoic sphingolipids with complex glycosylation for completion of meiosis: a link to ceramide synthase-3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

B cell apoptotic process

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Essential role of BAX,BAK in B cell homeostasis and prevention of autoimmune disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

response to salt stress

1 reference

8 April 2019

Susceptibility to metanephric apoptosis in bradykinin B2 receptor null mice via the p53-Bax pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

Sertoli cell proliferation

1 reference

8 April 2019

BCLW mediates survival of postmitotic Sertoli cells by regulating BAX activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

thymocyte apoptotic process

1 reference

8 April 2019

Combined loss of proapoptotic genes Bak or Bax with Bim synergizes to cause defects in hematopoiesis and in thymocyte apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

post-embryonic development

1 reference

8 April 2019

Bcl-2 and Bax function independently to regulate cell death

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

negative regulation of protein binding

regulation of mitochondrial membrane permeability involved in apoptotic process

regulation of mitochondrial membrane permeability involved in programmed necrotic cell death

1 reference

8 April 2019

Bax regulates primary necrosis through mitochondrial dynamics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

odontogenesis of dentin-containing tooth

1 reference

8 April 2019

Combined loss of proapoptotic genes Bak or Bax with Bim synergizes to cause defects in hematopoiesis and in thymocyte apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

positive regulation of extrinsic apoptotic signaling pathway in absence of ligand

1 reference

27 February 2018

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

blood vessel remodeling

1 reference

8 April 2019

Persistent fetal ocular vasculature in mice deficient in bax and bak

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

positive regulation of neuron apoptotic process

20 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Bok Is Not Pro-Apoptotic But Suppresses Poly ADP-Ribose Polymerase-Dependent Cell Death Pathways and Protects against Excitotoxic and Seizure-Induced Neuronal Injury

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

BAX is required for neuronal death after trophic factor deprivation and during development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Susceptibility to neurodegeneration in a glaucoma is modified by Bax gene dosage

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Development of pontine noradrenergic A5 neurons requires brain-derived neurotrophic factor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Effects of Bax gene deletion on muscle and motoneuron degeneration in a sexually dimorphic neuromuscular system

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Widespread elimination of naturally occurring neuronal death in Bax-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Differences in bcl-2- and bax-independent function in regulating apoptosis in sensory neuron populations

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Neuromuscular development in the absence of programmed cell death: phenotypic alteration of motoneurons and muscle

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Suppression of developmental retinal cell death but not of photoreceptor degeneration in Bax-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Bcl-X(L)-caspase-9 interactions in the developing nervous system: evidence for multiple death pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Programmed cell death of adult-generated hippocampal neurons is mediated by the proapoptotic gene Bax

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Ethanol-induced neuronal apoptosis in vivo requires BAX in the developing mouse brain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Bax limits adult neural stem cell persistence through caspase and IP3 receptor activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Reversible physiological alterations in sympathetic neurons deprived of NGF but protected from apoptosis by caspase inhibition or Bax deletion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Bax inactivation in lurcher mutants rescues cerebellar granule cells but not purkinje cells or inferior olivary neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Subtle shifts in the ratio between pro- and antiapoptotic molecules after activation of corticosteroid receptors decide neuronal fate

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Bax deficiency prevents the increased cell death of immature neurons in bcl-x-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Atm and Bax cooperate in ionizing radiation-induced apoptosis in the central nervous system

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

apoptotic process involved in blood vessel morphogenesis

1 reference

8 April 2019

Persistent fetal ocular vasculature in mice deficient in bax and bak

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Bax and Bak independently promote cytochrome C release from mitochondria

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Bax directly induces release of cytochrome c from isolated mitochondria

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

spermatogenesis

Bax-deficient mice with lymphoid hyperplasia and male germ cell death

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Bax-dependent spermatogonia apoptosis is required for testicular development and spermatogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Bcl-x and Bax regulate mouse primordial germ cell survival and apoptosis during embryogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

intrinsic apoptotic signaling pathway in response to DNA damage

Integral role of Noxa in p53-mediated apoptotic response

3 references

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

Combined loss of proapoptotic genes Bak or Bax with Bim synergizes to cause defects in hematopoiesis and in thymocyte apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

apoptotic signaling pathway

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Enhanced Oligodendrocyte Survival after Spinal Cord Injury in Bax-Deficient Mice and Mice with Delayed Wallerian Degeneration

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Spatial and temporal changes in Bax subcellular localization during anoikis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

cell population proliferation

mitochondrion morphogenesis

1 reference

8 April 2019

Bcl-2 family interaction with the mitochondrial morphogenesis machinery

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

activation of cysteine-type endopeptidase activity involved in apoptotic process

7 references

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

Olfactory neurons in bax knockout mice are protected from bulbectomy-induced apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

Ethanol-induced neuronal apoptosis in vivo requires BAX in the developing mouse brain

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

Bax and Bak can localize to the endoplasmic reticulum to initiate apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

Proapoptotic BAX and BAK control multiple initiator caspases

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

Neuronal apoptosis inhibitory protein is expressed in developing kidney and is regulated by PAX2

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

negative regulation of cell population proliferation

1 reference

8 April 2019

Differences in bcl-2- and bax-independent function in regulating apoptosis in sensory neuron populations

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

apoptotic process

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Overexpression of Bcl-2 in transgenic mice decreases apoptosis and improves survival in sepsis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Bax directly induces release of cytochrome c from isolated mitochondria

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

regulation of apoptotic process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

1 reference

8 April 2019

cellular response to organic substance

1 reference

8 April 2019

Apoptosis and related proteins in placenta of intrauterine fetal death in prostaglandin f receptor-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

B cell homeostatic proliferation

1 reference

8 April 2019

Bax-deficient mice with lymphoid hyperplasia and male germ cell death

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

limb morphogenesis

1 reference

8 April 2019

The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

release of matrix enzymes from mitochondria

1 reference

8 April 2019

Bcl-2 and Bax function independently to regulate cell death

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

1 reference

8 April 2019

Bax-dependent caspase-3 activation is a key determinant in p53-induced apoptosis in neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

negative regulation of apoptotic signaling pathway

1 reference

8 April 2019

Nanos3 maintains the germ cell lineage in the mouse by suppressing both Bax-dependent and -independent apoptotic pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

myeloid cell homeostasis

1 reference

8 April 2019

Combined loss of proapoptotic genes Bak or Bax with Bim synergizes to cause defects in hematopoiesis and in thymocyte apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

regulation of neuron apoptotic process

1 reference

8 April 2019

A differential developmental pattern of spinal interneuron apoptosis during synaptogenesis: insights from genetic analyses of the protocadherin-gamma gene cluster

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

regulation of cysteine-type endopeptidase activity involved in apoptotic process

1 reference

8 April 2019

Enhanced Oligodendrocyte Survival after Spinal Cord Injury in Bax-Deficient Mice and Mice with Delayed Wallerian Degeneration

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

response to wounding

1 reference

8 April 2019

Enhanced Oligodendrocyte Survival after Spinal Cord Injury in Bax-Deficient Mice and Mice with Delayed Wallerian Degeneration

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

intrinsic apoptotic signaling pathway by p53 class mediator

1 reference

8 April 2019

Bax-dependent caspase-3 activation is a key determinant in p53-induced apoptosis in neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

hypothalamus development

1 reference

8 April 2019

Deletion of Bax eliminates sex differences in the mouse forebrain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

protein homooligomerization

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Spatial and temporal changes in Bax subcellular localization during anoikis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

response to gamma radiation

1 reference

8 April 2019

Radiation-induced gastric epithelial apoptosis occurs in the proliferative zone and is regulated by p53, bak, bax, and bcl-2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

negative regulation of fibroblast proliferation

1 reference

8 April 2019

Integral role of Noxa in p53-mediated apoptotic response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

positive regulation of intrinsic apoptotic signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

4 references

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Ethanol-induced neuronal apoptosis in vivo requires BAX in the developing mouse brain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

response to toxic substance

B cell negative selection

1 reference

8 April 2019

Essential role of BAX,BAK in B cell homeostasis and prevention of autoimmune disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

mitochondrial fusion

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

5 references

27 February 2018

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

The mitochondrial protein Bak is pivotal for gliotoxin-induced apoptosis and a critical host factor of Aspergillus fumigatus virulence in mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

Role of Bax and Bak in mitochondrial morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

neuron apoptotic process

Bax-dependent caspase-3 activation is a key determinant in p53-induced apoptosis in neurons

9 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Neuromuscular development after the prevention of naturally occurring neuronal death by Bax deletion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Critical function of endogenous XIAP in regulating caspase activation during sympathetic neuronal apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Gamma protocadherins are required for synaptic development in the spinal cord

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Epistatic and independent functions of caspase-3 and Bcl-X(L) in developmental programmed cell death

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Bax ablation prevents dopaminergic neurodegeneration in the 1-methyl- 4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Changes in cortical and striatal neurons predict behavioral and electrophysiological abnormalities in a transgenic murine model of Huntington's disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Differences in bcl-2- and bax-independent function in regulating apoptosis in sensory neuron populations

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

NMDA receptors promote survival in somatosensory relay nuclei by inhibiting Bax-dependent developmental cell death

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

positive regulation of B cell apoptotic process

1 reference

8 April 2019

Bax loss impairs Myc-induced apoptosis and circumvents the selection of p53 mutations during Myc-mediated lymphomagenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

cellular response to UV

1 reference

8 April 2019

Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

sex differentiation

1 reference

8 April 2019

Deletion of Bax eliminates sex differences in the mouse forebrain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

neuron migration

1 reference

8 April 2019

Programmed cell death of adult-generated hippocampal neurons is mediated by the proapoptotic gene Bax

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

B cell homeostasis

positive regulation of release of sequestered calcium ion into cytosol

1 reference

8 April 2019

Bax limits adult neural stem cell persistence through caspase and IP3 receptor activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

positive regulation of apoptotic process involved in mammary gland involution

1 reference

8 April 2019

Gain of Bcl-2 is more potent than bax loss in regulating mammary epithelial cell survival in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

nervous system development

1 reference

8 April 2019

Brn3a regulation of TrkA/NGF receptor expression in developing sensory neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

spermatid differentiation

1 reference

8 April 2019

Concomitant loss of proapoptotic BH3-only Bcl-2 antagonists Bik and Bim arrests spermatogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

development of secondary sexual characteristics

1 reference

8 April 2019

Effects of Bax gene deletion on muscle and motoneuron degeneration in a sexually dimorphic neuromuscular system

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

positive regulation of developmental pigmentation

1 reference

8 April 2019

Bcl-2 and Bax function independently to regulate cell death

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

retina development in camera-type eye

1 reference

8 April 2019

Suppression of developmental retinal cell death but not of photoreceptor degeneration in Bax-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

response to axon injury

1 reference

8 April 2019

Susceptibility to neurodegeneration in a glaucoma is modified by Bax gene dosage

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

positive regulation of mitochondrial membrane permeability involved in apoptotic process

1 reference

8 April 2019

Combined loss of proapoptotic genes Bak or Bax with Bim synergizes to cause defects in hematopoiesis and in thymocyte apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

fertilization

1 reference

8 April 2019

Bcl-x and Bax regulate mouse primordial germ cell survival and apoptosis during embryogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

ectopic germ cell programmed cell death

The pro-apoptotic gene Bax is required for the death of ectopic primordial germ cells during their migration in the mouse embryo

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

The pro-apoptotic gene Bax is required for the death of ectopic primordial germ cells during their migration in the mouse embryo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Steel factor controls midline cell death of primordial germ cells and is essential for their normal proliferation and migration

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

positive regulation of release of cytochrome c from mitochondria

negative regulation of endoplasmic reticulum calcium ion concentration

1 reference

8 April 2019

Proapoptotic BAX and BAK regulate the type 1 inositol trisphosphate receptor and calcium leak from the endoplasmic reticulum

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

regulation of protein homodimerization activity

protein insertion into mitochondrial membrane involved in apoptotic signaling pathway

1 reference

8 April 2019

Integral role of Noxa in p53-mediated apoptotic response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

apoptotic process involved in embryonic digit morphogenesis

1 reference

8 April 2019

Combined loss of proapoptotic genes Bak or Bax with Bim synergizes to cause defects in hematopoiesis and in thymocyte apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

leukocyte homeostasis

mitochondrial fragmentation involved in apoptotic process

positive regulation of endoplasmic reticulum unfolded protein response

establishment or maintenance of transmembrane electrochemical gradient

homeostasis of number of cells

vagina development

1 reference

8 April 2019

The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

post-embryonic camera-type eye morphogenesis

1 reference

8 April 2019

Persistent fetal ocular vasculature in mice deficient in bax and bak

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

regulation of mammary gland epithelial cell proliferation

1 reference

8 April 2019

Gain of Bcl-2 is more potent than bax loss in regulating mammary epithelial cell survival in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

retinal cell programmed cell death

1 reference

8 April 2019

Major role of BAX in apoptosis during retinal development and in establishment of a functional postnatal retina

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

regulation of cell cycle

1 reference

8 April 2019

Essential role of BAX,BAK in B cell homeostasis and prevention of autoimmune disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

regulation of mitochondrial membrane potential

1 reference

8 April 2019

Bax-induced cytochrome c release from mitochondria depends on alpha-helices-5 and -6

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Bax and Bak can localize to the endoplasmic reticulum to initiate apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Proapoptotic BAX and BAK control multiple initiator caspases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

apoptotic mitochondrial changes

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Spatial and temporal changes in Bax subcellular localization during anoikis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

regulation of nitrogen utilization

1 reference

8 April 2019

Bcl-2 and Bax function independently to regulate cell death

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

negative regulation of peptidyl-serine phosphorylation

1 reference

8 April 2019

Proapoptotic BAX and BAK regulate the type 1 inositol trisphosphate receptor and calcium leak from the endoplasmic reticulum

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

positive regulation of protein oligomerization

positive regulation of apoptotic process

16 references

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

BOK Is a Non-canonical BCL-2 Family Effector of Apoptosis Regulated by ER-Associated Degradation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

Decreased glucose transporter expression triggers BAX-dependent apoptosis in the murine blastocyst

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

Prostaglandin E2 reduces radiation-induced epithelial apoptosis through a mechanism involving AKT activation and bax translocation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

The role of Bax in glutamate-induced nerve cell death

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

Bax-dependent spermatogonia apoptosis is required for testicular development and spermatogenesis

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

Prolongation of ovarian lifespan into advanced chronological age by Bax-deficiency

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

Radiation-induced gastric epithelial apoptosis occurs in the proliferative zone and is regulated by p53, bak, bax, and bcl-2

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

Bcl-2 and Bax function independently to regulate cell death

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

TRPM-2 expression and tunel staining in neurodegenerative diseases: studies in wobbler and rd mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

Bax can antagonize Bcl-XL during etoposide and cisplatin-induced cell death independently of its heterodimerization with Bcl-XL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

Steel factor controls midline cell death of primordial germ cells and is essential for their normal proliferation and migration

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

Susceptibility to metanephric apoptosis in bradykinin B2 receptor null mice via the p53-Bax pathway

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

Mammalian prion protein suppresses Bax-induced cell death in yeast

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

extrinsic apoptotic signaling pathway in absence of ligand

extrinsic apoptotic signaling pathway via death domain receptors

1 reference

8 April 2019

Bis, a Bcl-2-binding protein that synergizes with Bcl-2 in preventing cell death

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

release of cytochrome c from mitochondria

8 references

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

A stapled BID BH3 helix directly binds and activates BAX

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

Bax directly induces release of cytochrome c from isolated mitochondria

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

Bax-induced cytochrome c release from mitochondria depends on alpha-helices-5 and -6

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

Critical function of endogenous XIAP in regulating caspase activation during sympathetic neuronal apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

Spatial and temporal changes in Bax subcellular localization during anoikis

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

ovarian follicle development

cerebral cortex development

1 reference

8 April 2019

Deletion of Bax eliminates sex differences in the mouse forebrain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

release of cytochrome c from mitochondria

9 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

A stapled BID BH3 helix directly binds and activates BAX

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Bax-induced cytochrome c release from mitochondria depends on alpha-helices-5 and -6

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Spatial and temporal changes in Bax subcellular localization during anoikis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Critical function of endogenous XIAP in regulating caspase activation during sympathetic neuronal apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Bax directly induces release of cytochrome c from isolated mitochondria

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

activation of cysteine-type endopeptidase activity involved in apoptotic process

6 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Olfactory neurons in bax knockout mice are protected from bulbectomy-induced apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Ethanol-induced neuronal apoptosis in vivo requires BAX in the developing mouse brain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Bax and Bak can localize to the endoplasmic reticulum to initiate apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Proapoptotic BAX and BAK control multiple initiator caspases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

inner mitochondrial membrane organization

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

outer mitochondrial membrane organization

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

mitochondrial fusion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

6 references

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Role of Bax and Bak in mitochondrial morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

The mitochondrial protein Bak is pivotal for gliotoxin-induced apoptosis and a critical host factor of Aspergillus fumigatus virulence in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

intrinsic apoptotic signaling pathway in response to DNA damage

Integral role of Noxa in p53-mediated apoptotic response

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Combined loss of proapoptotic genes Bak or Bax with Bim synergizes to cause defects in hematopoiesis and in thymocyte apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

viral process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

1 reference

8 April 2019

positive regulation of apoptotic process

17 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

BOK Is a Non-canonical BCL-2 Family Effector of Apoptosis Regulated by ER-Associated Degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

The role of Bax in glutamate-induced nerve cell death

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Bax-dependent spermatogonia apoptosis is required for testicular development and spermatogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Radiation-induced gastric epithelial apoptosis occurs in the proliferative zone and is regulated by p53, bak, bax, and bcl-2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Prostaglandin E2 reduces radiation-induced epithelial apoptosis through a mechanism involving AKT activation and bax translocation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Decreased glucose transporter expression triggers BAX-dependent apoptosis in the murine blastocyst

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Prolongation of ovarian lifespan into advanced chronological age by Bax-deficiency

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Bcl-2 and Bax function independently to regulate cell death

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Susceptibility to metanephric apoptosis in bradykinin B2 receptor null mice via the p53-Bax pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Bax can antagonize Bcl-XL during etoposide and cisplatin-induced cell death independently of its heterodimerization with Bcl-XL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Steel factor controls midline cell death of primordial germ cells and is essential for their normal proliferation and migration

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

TRPM-2 expression and tunel staining in neurodegenerative diseases: studies in wobbler and rd mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Mammalian prion protein suppresses Bax-induced cell death in yeast

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

cellular respiration

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

extrinsic apoptotic signaling pathway in absence of ligand

Combined loss of proapoptotic genes Bak or Bax with Bim synergizes to cause defects in hematopoiesis and in thymocyte apoptosis

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Growth factor regulation of autophagy and cell survival in the absence of apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

negative regulation of mitochondrial membrane potential

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

1 reference

14 February 2019

Apoptosis regulator, Bcl-2, BH2 motif, conserved site

has part(s)

1 reference

Apoptosis regulator, Bcl-2, BH1 motif, conserved site

1 reference

Apoptosis regulator, Bcl-2, BH3 motif, conserved site

1 reference