(Q14905279)

http://www.ebi.ac.uk/interpro/protein/P53762

PAS domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P53762

Helix-loop-helix DNA-binding domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P53762

Myc-type, basic helix-loop-helix (bHLH) domain, protein family

1 reference

PAS fold family

1 reference

PAC motif domain, protein family

1 reference

PAS domain, protein family

1 reference

1 reference

25 May 2022

1 reference

25 May 2022

A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular development

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53762

14 February 2019

Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53762

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53762

14 February 2019

protein dimerization activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53762

1 reference

14 February 2019

transcription coactivator activity

1 reference

7 November 2018

LE-PAS, a novel Arnt-dependent HLH-PAS protein, is expressed in limbic tissues and transactivates the CNS midline enhancer element

http://www.ebi.ac.uk/QuickGO/annotations?protein=P53762&geneProductId=UniProtKB:P53762

protein binding

8 references

14 February 2019

NPAS1-ARNT and NPAS3-ARNT crystal structures implicate the bHLH-PAS family as multi-ligand binding transcription factors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53762

14 February 2019

Structural Basis for Aryl Hydrocarbon Receptor-Mediated Gene Activation.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53762

14 February 2019

Structure and Dimerization Properties of the Aryl Hydrocarbon Receptor PAS-A Domain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53762

14 February 2019

Differential activities of murine single minded 1 (SIM1) and SIM2 on a hypoxic response element. Cross-talk between basic helix-loop-helix/per-Arnt-Sim homology transcription factors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53762

14 February 2019

Hypoxia-inducible factor-1alpha regulates beta cell function in mouse and human islets

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53762

14 February 2019

Induction of phosphoglycerate kinase 1 gene expression by hypoxia. Roles of Arnt and HIF1alpha

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53762

14 February 2019

Two murine homologs of the Drosophila single-minded protein that interact with the mouse aryl hydrocarbon receptor nuclear translocator protein

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53762

14 February 2019

Structural integration in hypoxia-inducible factors

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53762

protein heterodimerization activity

3 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P53762&geneProductId=UniProtKB:P53762

ISO

24 April 2018

A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular development

http://www.ebi.ac.uk/QuickGO/annotations?protein=P53762&geneProductId=UniProtKB:P53762

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P53762&geneProductId=UniProtKB:P53762

DNA-binding transcription factor activity

Isolation and characterization of AINT: a novel ARNT interacting protein expressed during murine embryonic development

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53762

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53762

14 February 2019

14 February 2019

Structural Basis for Aryl Hydrocarbon Receptor-Mediated Gene Activation.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53762

14 February 2019

LE-PAS, a novel Arnt-dependent HLH-PAS protein, is expressed in limbic tissues and transactivates the CNS midline enhancer element

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53762

sequence-specific DNA binding

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53762

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53762

14 February 2019

Structural integration in hypoxia-inducible factors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53762

protein heterodimerization activity

7 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53762

ISO

14 February 2019

A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53762

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53762

14 February 2019

NPAS1-ARNT and NPAS3-ARNT crystal structures implicate the bHLH-PAS family as multi-ligand binding transcription factors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53762

14 February 2019

Structural integration in hypoxia-inducible factors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53762

14 February 2019

Structural Basis for Aryl Hydrocarbon Receptor-Mediated Gene Activation.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53762

14 February 2019

Structure and Dimerization Properties of the Aryl Hydrocarbon Receptor PAS-A Domain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53762

protein homodimerization activity

sequence-specific double-stranded DNA binding

ISO

ISS

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53762

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53762

14 February 2019

Structural Basis for Aryl Hydrocarbon Receptor-Mediated Gene Activation.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53762

nuclear receptor activity

1 reference

14 February 2019

Conditional disruption of the aryl hydrocarbon receptor nuclear translocator (Arnt) gene leads to loss of target gene induction by the aryl hydrocarbon receptor and hypoxia-inducible factor 1alpha

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53762

cell component

cytoplasm

Expression and subcellular localization of the aryl hydrocarbon receptor nuclear translocator (ARNT) protein in mouse and chicken over developmental time

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53762

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53762

14 February 2019

14 February 2019

Isolation and characterization of AINT: a novel ARNT interacting protein expressed during murine embryonic development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53762

14 February 2019

Expression and subcellular localization of the aryl hydrocarbon receptor nuclear translocator (ARNT) protein in mouse and chicken over developmental time

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53762

transcription regulator complex

Isolation and characterization of AINT: a novel ARNT interacting protein expressed during murine embryonic development

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53762

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53762

14 February 2019

14 February 2019

Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53762

nucleus

Expression and subcellular localization of the aryl hydrocarbon receptor nuclear translocator (ARNT) protein in mouse and chicken over developmental time

8 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53762

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53762

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53762

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53762

14 February 2019

Superoxide dismutase-3 promotes full expression of the EPO response to hypoxia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53762

14 February 2019

Hypoxia-inducible factor-1alpha regulates beta cell function in mouse and human islets

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53762

14 February 2019

Isolation and characterization of AINT: a novel ARNT interacting protein expressed during murine embryonic development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53762

14 February 2019

Expression and subcellular localization of the aryl hydrocarbon receptor nuclear translocator (ARNT) protein in mouse and chicken over developmental time

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53762

biological process

cell differentiation

1 reference

14 February 2019

Hypoxia-inducible factors 1alpha and 2alpha regulate trophoblast differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53762

response to hypoxia

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53762

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53762

14 February 2019

Induction of phosphoglycerate kinase 1 gene expression by hypoxia. Roles of Arnt and HIF1alpha

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53762

regulation of transcription, DNA-templated

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53762

1 reference

14 February 2019

embryonic placenta development

1 reference

14 February 2019

Hypoxia-inducible factors 1alpha and 2alpha regulate trophoblast differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53762

positive regulation of protein sumoylation

1 reference

14 February 2019

SUMO modification regulates the transcriptional repressor function of aryl hydrocarbon receptor repressor

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53762

transcription, DNA-templated

http://www.ebi.ac.uk/QuickGO/annotations?protein=P53762&geneProductId=UniProtKB:P53762

1 reference

21 June 2018

positive regulation of transcription, DNA-templated

Differential activities of murine single minded 1 (SIM1) and SIM2 on a hypoxic response element. Cross-talk between basic helix-loop-helix/per-Arnt-Sim homology transcription factors

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53762

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53762

14 February 2019

LE-PAS, a novel Arnt-dependent HLH-PAS protein, is expressed in limbic tissues and transactivates the CNS midline enhancer element

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53762

response to toxic substance

TAS

1 reference

14 February 2019

Isolation and characterization of AINT: a novel ARNT interacting protein expressed during murine embryonic development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53762

positive regulation of transcription by RNA polymerase II

TAS

3 references

14 February 2019

A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53762

14 February 2019

Retinoic acid, hypoxia, and GATA factors cooperatively control the onset of fetal liver erythropoietin expression and erythropoietic differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53762

14 February 2019

Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53762

intracellular receptor signaling pathway

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53762

Identifiers

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

25 May 2022

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

10 August 2016

1 reference

10 August 2016

1 reference

10 August 2016

1 reference

10 August 2016

1 reference

10 August 2016