(Q70309713)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:6361463%20AND%20SRC:MED&resulttype=core&format=json

10 October 2019

title

Inhibitors of lysosomal function (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:6361463%20AND%20SRC:MED&resulttype=core&format=json

10 October 2019

59 Inhibitors of lysosomal function (English)

1 reference

https://api.crossref.org/works/10.1016/S0076-6879(83)96063-9

7 October 2023

P. O. Seglen

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A6361463

7 October 2023

language of work or name

English

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=6361463

7 October 2023

publication date

1 January 1983

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:6361463%20AND%20SRC:MED&resulttype=core&format=json

10 October 2019

published in

Methods in Enzymology

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:6361463%20AND%20SRC:MED&resulttype=core&format=json

10 October 2019

volume

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:6361463%20AND%20SRC:MED&resulttype=core&format=json

10 October 2019

page(s)

737-764

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:6361463%20AND%20SRC:MED&resulttype=core&format=json

Amino acid inhibition of the autophagic/lysosomal pathway of protein degradation in isolated rat hepatocytes

10 October 2019

cites work

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7 January 2021

Inhibition of autophagic vacuole formation and protein degradation by amino acids in isolated hepatocytes

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7 January 2021

Inhibition of protein breakdown in cultured cells is a consistent response to growth factors

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7 January 2021

Commentary. Lysosomotropic agents

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7 January 2021

Cytoplasmic vacuolation of mouse peritoneal macrophages and the uptake into lysosomes of weakly basic substances

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7 January 2021

Effect of weak bases on the intralysosomal pH in mouse peritoneal macrophages

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7 January 2021

Protein degradation in isolated rat hepatocytes is inhibited by ammonia

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7 January 2021

Ammonia inhibition of protein degradation in isolated rat hepatocytes. Quantitative ultrastructural alterations in the lysosomal system

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7 January 2021

Relationship between medium pH and that of the lysosomal matrix as studied by two independent methods

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7 January 2021

125I-labeled human epidermal growth factor. Binding, internalization, and degradation in human fibroblasts

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7 January 2021

The transport of NH3 and NH4+ across biological membranes

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7 January 2021

Cellular and lysosomal uptake of methylamine in isolated rat hepatocytes

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7 January 2021

Transglutaminase is essential in receptor-mediated endocytosis of α2-macroglobulin and polypeptide hormones

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7 January 2021

Effects of local anesthetics and related compounds on the endocytosis and catabolism of asialo-glycoproteins in isolated hepatocytes.

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7 January 2021

Uptake and intracellular distribution of neutral red in cultured fibroblasts

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7 January 2021

Protein degradation in cultured cells. II. The uptake of chloroquine by rat fibroblasts and the inhibition of cellular protein degradation and cathepsin B1.

1 reference

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7 January 2021

Inhibition of the Lysosomal Pathway of Protein Degradation in Isolated Rat Hepatocytes by Ammonia, Methylamine, Chloroquine and Leupeptin

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7 January 2021

Primary amines induce selective release of lysosomal enzymes from mouse macrophages

1 reference

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7 January 2021

Inhibition of receptor-mediated uptake of a lysosomal enzyme into fibroblasts by chloroquine, procaine and ammonia

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7 January 2021

Primary amines inhibit recycling of α2M receptors in fibroblasts

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7 January 2021

Alterations in surface carbohydrates and in some functional properties of liver lysosomal membrane in vitamin A-deficient rat

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7 January 2021

The ATP-dependent proton pump in lysosome membranes: still a valid hypothesis

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7 January 2021

Inhibition of cell spreading by lysosomotropic amines

1 reference

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7 January 2021

Membrane adsorption and internalization of [14C]chloroquine by cultured human fibroblasts

1 reference

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7 January 2021

The effects of ammonium ions and chloroquine on uptake and degradation of 125I-labeled asialo-fetuin in isolated rat hepatocytes

1 reference

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7 January 2021

Effects of weak bases on the degradation of endogenous and exogenous proteins by rat yolk sacs

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2883%2996063-9

7 January 2021

Amines inhibit the clustering of α2-macroglobulin and EGF on the fibroblast cell surface

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2883%2996063-9

7 January 2021

Reversible and irreversible inhibitors of clustering of alpha 2M in clathrin-coated pits on the surface of fibroblasts

1 reference

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7 January 2021

Primary amines do not prevent the endocytosis of epidermal growth factor into 3T3 fibroblasts

1 reference

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7 January 2021

Lysosomotropic agents. 1. Synthesis and cytotoxic action of lysosomotropic detergents

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2883%2996063-9

7 January 2021

Chloroquine inhibits lysosomal enzyme pinocytosis and enhances lysosomal enzyme secretion by impairing receptor recycling

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2883%2996063-9

7 January 2021

Inhibition of reticulocyte iron uptake by NH4Cl and CH3NH2

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2883%2996063-9

7 January 2021

Chloroquine reduces the number of asialo-glycoprotein receptors in the hepatocyte plasma membrane

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2883%2996063-9

7 January 2021

Mannose-specific endocytosis receptor of alveolar macrophages: demonstration of two functionally distinct intracellular pools of receptor and their roles in receptor recycling

1 reference

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7 January 2021

Analysis of the effect of amines on inhibition of receptor-mediated and fluid-phase pinocytosis in rabbit alveolar macrophages

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2883%2996063-9

7 January 2021

Monensin interrupts the recycling of low density lipoprotein receptors in human fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2883%2996063-9

7 January 2021

Coated pits, coated vesicles, and receptor-mediated endocytosis

1 reference

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7 January 2021

The receptosome: an intermediate organelle of receptor mediated endocytosis in cultured fibroblasts

1 reference

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7 January 2021

The galactose-specific recognition system of mammalian liver: the route of ligand internalization in rat hepatocytes

1 reference

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7 January 2021

Immunocytochemical localization of the receptor for asialoglycoprotein in rat liver cells

1 reference

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7 January 2021

Intracellular membrane traffic

1 reference

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7 January 2021

Rapid acidification of endocytic vesicles containing alpha 2-macroglobulin

1 reference

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7 January 2021

Effect of methylamine on internalization, processing and biological activation of epidermal growth factor receptor

1 reference

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7 January 2021

Degradation of the acetylcholine receptor in cultured muscle cells: selective inhibitors and the fate of undegraded receptors

1 reference

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7 January 2021

Accumulation of autophagosomes after inhibition of hepatocytic protein degradation by vinblastine, leupeptin or a lysosomotropic amine

1 reference

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7 January 2021

Ammonia inhibits phagosome–lysosome fusion in macrophages

1 reference

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7 January 2021

Temporal changes of lysosome and phagosome pH during phagolysosome formation in macrophages: studies by fluorescence spectroscopy

1 reference

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7 January 2021

Infectious entry pathway of influenza virus in a canine kidney cell line

1 reference

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7 January 2021

Fusion of Semliki forest virus with the plasma membrane can be induced by low pH.

1 reference

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7 January 2021

Inhibitory effect of ammonium chloride and chloroquine on the entry of the toxic lectin modeccin into HeLa cells

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2883%2996063-9

7 January 2021

Diphtheria toxin entry into cells is facilitated by low pH.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2883%2996063-9

7 January 2021

Ammonia inhibits protein secretion in isolated rat hepatocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2883%2996063-9

7 January 2021

Inhibition of protein degradation in isolated rat hepatocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2883%2996063-9

7 January 2021

Selective control of the degradation of normal and aberrant proteins in Reuber H35 hepatoma cells

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2883%2996063-9

7 January 2021

Specific inhibition by NH4CL of autophagy-associated proteloysis in cultured fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2883%2996063-9

7 January 2021

Macrophage protein turnover. Evidence for lysosomal participation in basal proteolysis

1 reference

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7 January 2021

Protein synthesis and degradation during expression of the temperature-sensitive defect ints A1S9 mouse L-cells

1 reference

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7 January 2021

Interference with lysosomal proteolysis fails to reduce cardiac myosin degradation

1 reference

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7 January 2021

The starvation induced increase in muscle protein degradation is non-lysosomal in origin

1 reference

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7 January 2021

Effect of dexamethasone, ammonium lons, and serum‐deprivation on intracellular proteolysis in cultured muscle cells

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2883%2996063-9

7 January 2021

Mechanisms of protein turnover in cultured fibroblasts. Differential inhibition of two lysosomal mechanisms with insulin and NH4Cl

1 reference

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7 January 2021

Calcium-dependent proteolytic activity in rat liver: identification of two proteases with different calcium requirements

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2883%2996063-9

7 January 2021

Participation of the inner mitochondrial membrane in the inactivation of carbamyl phosphate synthase and of adenosine triphosphatase by lysosomes

1 reference

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7 January 2021

Differential effects of proteinase inhibitors and amines on the lysosomal and non-lysosomal pathways of protein degradation in isolated rat hepatocytes

1 reference

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7 January 2021

Effects of leupeptin and pepstatin on protein turnover in adult rat hepatocytes in primary culture

1 reference

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7 January 2021

Selective inhibition of lysosomal protein degradation by the thiol proteinase inhibitors E-64, Ep-459 and Ep-457 in isolated rat hepatocytes

1 reference

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7 January 2021

The thiol proteinase inhibitors, Z-Phe-PheCHN2 and Z-Phe-AlaCHN2, inhibit lysosomal protein degradation in isolated rat hepatocytes

1 reference

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7 January 2021

Autophagic sequestration of [14C]sucrose, introduced into rat hepatocytes by reversible electro-permeabilization

1 reference

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7 January 2021

Inhibition of hepatocytic protein degradation by methylaminopurines and inhibitors of protein synthesis.

1 reference

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7 January 2021

6-substituted purines: a novel class of inhibitors of endogenous protein degradation in isolated rat hepatocytes

1 reference

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7 January 2021

Role of Microtubuli in the Lysosomal Degradation of Endogenous and Exogenous Protein in Isolated Rat Hepatocytes

1 reference

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7 January 2021

The effect of Ca2+ and the trifluoperazine on the processing of human acetylated low density lipoprotein by non-parenchymal liver cells

1 reference

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7 January 2021

Uptake and degradation of iodine-labelled chylomicron remnant particles by monolayers of rat hepatocytes

1 reference

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7 January 2021

The effect of ammonia, chloroquine, leupeptin, colchicine and cytochalasin B on degradation of high density lipoproteins in isolated rat hepatocytes

1 reference

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7 January 2021

Comparative studies of intracellular transport of secretory proteins

1 reference

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7 January 2021

Monensin inhibits the conversion of proalbumin to serum albumin in cultured rat hepatocytes

1 reference

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7 January 2021

Inhibition of pinocytosis in rat embryo fibroblasts treated with monensin

1 reference

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7 January 2021

Biological applications of ionophores

1 reference

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7 January 2021

The effect of leupeptin on intracellular digestion of asialofetuin in rat hepatocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2883%2996063-9

7 January 2021

Inhibition of basal and deprivation-induced proteolysis by leupeptin and pepstatin in perfused rat liver and heart

1 reference

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7 January 2021

Direct evidence of importance of lysosomes in degradation of intracellular proteins

1 reference

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7 January 2021

Effects of chymostatin and other proteinase inhibitors on protein breakdown and proteolytic activities in muscle

1 reference

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7 January 2021

Effects of microbial proteinase inhibitors on the degradation of endogenous and internalized proteins by rat yolk sacs

1 reference

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7 January 2021

Effects of protein-degradation inhibitors on the inactivation of tyrosine aminotransferase, tryptophan oxygenase and benzopyrene hydroxylase in isolated rat hepatocytes

1 reference

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7 January 2021

The effect of protease inhibitors and decreased temperature on the degradation of different classes of proteins in cultured hepatocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2883%2996063-9

7 January 2021

Comparison of the control and pathways for degradation of the acetylcholine receptor and average protein in cultured muscle cells

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2883%2996063-9

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2883%2996063-9

7 January 2021

Leupeptin, a Protease Inhibitor, Decreases Protein Degradation in Normal and Diseased Muscles

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2883%2996063-9

7 January 2021

Rapid inactivation of cathepsin L by Z-Phe-PheCHN2 and Z-Phe-AlaCHN2

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2883%2996063-9

7 January 2021

The inhibition of macrophage protein turnover by a selective inhibitor of thiol proteinases

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2883%2996063-9

7 January 2021

The effects of orthovanadate on fatty acid synthesis in isolated rat hepatocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2883%2996063-9

7 January 2021

Vanadate enhances the stimulatory action of insulin on DNA synthesis in cultured mouse mammary gland.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2883%2996063-9

7 January 2021

Vanadate, epidermal growth factor and the stimulation of DNA synthesis

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2883%2996063-9

7 January 2021

Electron paramagnetic resonance studies and insulin-like effects of vanadium in rat adipocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2883%2996063-9

7 January 2021

Human breast tumor estrogen receptor: effects of molybdate and electrophoretic analyses

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2883%2996063-9

7 January 2021

Inhibition of progesterone receptor activation by sodium molybdate

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2883%2996063-9

7 January 2021

Protection of steroid hormone receptors by protease inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2883%2996063-9

7 January 2021

Studies on cellular autophagocytosis. Vinblastine-induced autophagy in the rat liver

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2883%2996063-9

7 January 2021

Effects of concanavalin A on mouse peritoneal macrophages. I. Stimulation of endocytic activity and inhibition of phago-lysosome formation

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2883%2996063-9

7 January 2021

Binding of concanavalin A to isolated hepatocytes and its effect on uptake and degradation of asialo-fetuin by the cells

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2883%2996063-9

7 January 2021

Lectin-induced accumulation of large lysosomes in cultured fibroblasts.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2883%2996063-9

7 January 2021

Site of action of a polyanion inhibitor of phagosome-lysosome fusion in cultured macrophages

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2883%2996063-9

7 January 2021

The effect of inhibitors and enhancers of phagosome-lysosome fusion in cultured macrophages on the phagosome membranes of ingested yeasts

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2883%2996063-9

7 January 2021

Effect of microtubular or translational inhibitors on general cell protein degradation. Evidence for a dual catabolic pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2883%2996063-9

7 January 2021

Requirement for protein synthesis in the regulation of protein breakdown in cultured hepatoma cells

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2883%2996063-9

7 January 2021

Effect of extreme amino acid starvation on the protein synthetic machinery of CHO cells

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2883%2996063-9

7 January 2021

Does the regulation of intracellular protein degradation require protein synthesis?

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2883%2996063-9

7 January 2021

Inhibition of basal protein degradation in rat embryo fibroblasts by cycloheximide: correlation with activities of lysosomal proteases

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2883%2996063-9

7 January 2021

Isolation and characterization of an enkephalin-degrading aminopeptidase from rat brain

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7 January 2021

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7 October 2023

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7 October 2023

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ATP-dependent acidification of intact and disrupted lysosomes. Evidence for an ATP-driven proton pump.

7 October 2023

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7 October 2023

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In Vitro Inhibition of Diphtheria Toxin Action by Ammonium Salts and Amines

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7 October 2023

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American Journal of Physiology

7 October 2023

150

239

F97

Grantham

1980

1 reference

https://api.crossref.org/works/10.1016/S0076-6879(83)96063-9

7 October 2023

Identifiers

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:6361463%20AND%20SRC:MED&resulttype=core&format=json

10 October 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:6361463%20AND%20SRC:MED&resulttype=core&format=json