(Q40429882)

20 September 2017

1 reference

title

Molecular foundations of cancer: new targets for intervention (English)

1 reference

20 September 2017

Molecular foundations of cancer: New targets for intervention (English)

1 reference

25 May 2024

J. E. Karp

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A7585060

25 May 2024

S. Broder

series ordinal

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A7585060

25 May 2024

language of work or name

English

0 references

publication date

1 April 1995

1 reference

full work available at URL

20 September 2017

https://www.nature.com/articles/nm0495-309.pdf

file format

Portable Document Format

online access status

open access

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A7585060

http://www.nature.com/articles/nm0495-309

25 May 2024

1 reference

http://www.nature.com/articles/nm0495-309.pdf

25 May 2024

file format

Portable Document Format

1 reference

25 May 2024

1 reference

20 September 2017

1 reference

20 September 2017

1 reference

20 September 2017

page(s)

309-320

1 reference

Universal control mechanism regulating onset of M-phase

20 September 2017

cites work

1 reference

https://api.crossref.org/works/10.1038%2FNM0495-309

Acceleration of the G1/S phase transition by expression of cyclins D1 and E with an inducible system

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0495-309

Colony-stimulating factor 1 regulates novel cyclins during the G1 phase of the cell cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0495-309

Physical interaction of the retinoblastoma protein with human D cyclins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0495-309

Regulation of retinoblastoma protein functions by ectopic expression of human cyclins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0495-309

A novel cyclin encoded by a bcl1-linked candidate oncogene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0495-309

Herpesvirus saimiri encodes homologues of G protein-coupled receptors and cyclins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0495-309

The p53 tumour suppressor gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0495-309

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0495-309

WAF1, a potential mediator of p53 tumor suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0495-309

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0495-309

p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0495-309

p21 is a universal inhibitor of cyclin kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0495-309

The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0495-309

A novel inhibitor of cyclin-Cdk activity detected in transforming growth factor beta-arrested epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0495-309

A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0495-309

Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0495-309

p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0495-309

Hereditary nonpolyposis colorectal cancer (Lynch syndromes I & II). Genetics, pathology, natural history, and cancer control, Part I.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0495-309

Risks of cancer in BRCA1-mutation carriers. Breast Cancer Linkage Consortium

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0495-309

Genetic alterations during colorectal-tumor development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0495-309

Hereditary gastrointestinal polyposis and nonpolyposis syndromes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0495-309

APC mutations occur early during colorectal tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0495-309

The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0495-309

Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0495-309

Hypermutability and mismatch repair deficiency in RER+ tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0495-309

Mutation in the DNA mismatch repair gene homologue hMLH1 is associated with hereditary non-polyposis colon cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0495-309

Mutations of two PMS homologues in hereditary nonpolyposis colon cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0495-309

Molecular diagnosis of familial adenomatous polyposis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0495-309

Potential role of tamoxifen in prevention of breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0495-309

Angiogenesis in cancer, vascular, rheumatoid and other disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0495-309

Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0495-309

Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0495-309

Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0495-309

Processing, secretion, and biological properties of a novel growth factor of the fibroblast growth factor family with oncogenic potential

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0495-309

Tumor angiogenesis: a new significant and independent prognostic indicator in early-stage breast carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0495-309

Angiostatin: A novel angiogenesis inhibitor that mediates the suppression of metastases by a lewis lung carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0495-309

Interferon alfa-2a therapy for life-threatening hemangiomas of infancy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0495-309

Synthetic analogues of fumagillin that inhibit angiogenesis and suppress tumour growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0495-309

Vascular targeting--a new approach to the therapy of solid tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0495-309

Integrin alpha v beta 3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0495-309

Antisense c-myb oligonucleotides inhibit intimal arterial smooth muscle cell accumulation in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0495-309

Recombinant fibroblast growth factor-1 promotes intimal hyperplasia and angiogenesis in arteries in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0495-309

G1-specific cyclins: in search of an S-phase-promoting factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0495-309

7 January 2021

Association of human cyclin E with a periodic G1-S phase protein kinase

1 reference

https://api.crossref.org/works/10.1038%2FNM0495-309

7 January 2021

Cyclin D and oncogenesis

1 reference

https://api.crossref.org/works/10.1038%2FNM0495-309

7 January 2021

Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma

1 reference

https://api.crossref.org/works/10.1038%2FNM0495-309

7 January 2021

Clinical relevance of the i(12p) marker chromosome in germ cell tumors

1 reference

https://api.crossref.org/works/10.1038%2FNM0495-309

7 January 2021

Prognostic subgroups in B-cell chronic lymphocytic leukemia defined by specific chromosomal abnormalities

1 reference

https://api.crossref.org/works/10.1038%2FNM0495-309

7 January 2021

Molecular cloning and chromosomal mapping of CCND genes encoding human D-type cyclins

1 reference

https://api.crossref.org/works/10.1038%2FNM0495-309

7 January 2021

Redundant cyclin overexpression and gene amplification in breast cancer cells

1 reference

https://api.crossref.org/works/10.1038%2FNM0495-309

7 January 2021

Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms

1 reference

https://api.crossref.org/works/10.1038%2FNM0495-309

7 January 2021

Viral interactions with the p53 gene in human cancer: NCI workshop

1 reference

https://api.crossref.org/works/10.1038%2FNM0495-309

7 January 2021

Potential role of human cytomegalovirus and p53 interaction in coronary restenosis

1 reference

https://api.crossref.org/works/10.1038%2FNM0495-309

7 January 2021

Ataxia-Telangiectasia: A Multisystem Hereditary Disease with Immunodeficiency, Impaired Organ Maturation, X-Ray Hypersensitivity, and a High Incidence of Neoplasia

1 reference

https://api.crossref.org/works/10.1038%2FNM0495-309

7 January 2021

p53-dependent G1 arrest involves pRB-related proteins and is disrupted by the human papillomavirus 16 E7 oncoprotein

1 reference

https://api.crossref.org/works/10.1038%2FNM0495-309

7 January 2021

Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen

1 reference

https://api.crossref.org/works/10.1038%2FNM0495-309

7 January 2021

Proliferating cell nuclear antigen (PCNA) immunolocalization in paraffin sections: an index of cell proliferation with evidence of deregulated expression in some neoplasms.

1 reference

https://api.crossref.org/works/10.1038%2FNM0495-309

7 January 2021

Sequential increases in proliferating cell nuclear antigen expression in head and neck tumorigenesis: a potential biomarker

1 reference

https://api.crossref.org/works/10.1038%2FNM0495-309

7 January 2021

p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest

1 reference

https://api.crossref.org/works/10.1038%2FNM0495-309

7 January 2021

Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals

1 reference

https://api.crossref.org/works/10.1038%2FNM0495-309

7 January 2021

A cell cycle-regulated inhibitor of cyclin-dependent kinases

1 reference

https://api.crossref.org/works/10.1038%2FNM0495-309

7 January 2021

A cell cycle regulator potentially involved in genesis of many tumor types

1 reference

https://api.crossref.org/works/10.1038%2FNM0495-309

7 January 2021

Stifled by inhibitions

1 reference

https://api.crossref.org/works/10.1038%2FNM0495-309

7 January 2021

Negative regulation of G1 in mammalian cells: inhibition of cyclin E-dependent kinase by TGF-beta.

1 reference

https://api.crossref.org/works/10.1038%2FNM0495-309

7 January 2021

Identification of FAP locus genes from chromosome 5q21

1 reference

https://api.crossref.org/works/10.1038%2FNM0495-309

7 January 2021

Clues to the pathogenesis of familial colorectal cancer

1 reference

https://api.crossref.org/works/10.1038%2FNM0495-309

7 January 2021

Genetic mapping of a locus predisposing to human colorectal cancer

1 reference

https://api.crossref.org/works/10.1038%2FNM0495-309

7 January 2021

Microsatellite instability in cancer of the proximal colon

1 reference

https://api.crossref.org/works/10.1038%2FNM0495-309

7 January 2021

The risk of endometrial cancer in hereditary nonpolyposis colorectal cancer.

1 reference

https://api.crossref.org/works/10.1038%2FNM0495-309

7 January 2021

Mutation of a mutL homolog in hereditary colon cancer

1 reference

https://api.crossref.org/works/10.1038%2FNM0495-309

7 January 2021

Mismatch repair gene defects in sporadic colorectal cancers with microsatellite instability

1 reference

https://api.crossref.org/works/10.1038%2FNM0495-309

7 January 2021

Microsatellite alterations as clonal markers for the detection of human cancer

1 reference

https://api.crossref.org/works/10.1038%2FNM0495-309

7 January 2021

Association of the APC gene product with beta-catenin

1 reference

https://api.crossref.org/works/10.1038%2FNM0495-309

7 January 2021

Linkage of early-onset familial breast cancer to chromosome 17q21

1 reference

https://api.crossref.org/works/10.1038%2FNM0495-309

7 January 2021

BRCA1 mutations in primary breast and ovarian carcinomas

1 reference

https://api.crossref.org/works/10.1038%2FNM0495-309

7 January 2021

A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1

1 reference

https://api.crossref.org/works/10.1038%2FNM0495-309

7 January 2021

Localization of a breast cancer susceptibility gene, BRCA2, to chromosome 13q12-13.

1 reference

https://api.crossref.org/works/10.1038%2FNM0495-309

7 January 2021

Susceptibility genes for breast cancer

1 reference

https://api.crossref.org/works/10.1038%2FNM0495-309

7 January 2021

A Large Kindred With 17q-Linked Breast and Ovarian Cancer: Genetic, Phenotypic, and Genealogical Analysis

1 reference

https://api.crossref.org/works/10.1038%2FNM0495-309

7 January 2021

Mutations in the BRCA1 gene in families with early-onset breast and ovarian cancer

1 reference

https://api.crossref.org/works/10.1038%2FNM0495-309

7 January 2021

Common origins of BRCA1 mutations in Canadian breast and ovarian cancer families

1 reference

https://api.crossref.org/works/10.1038%2FNM0495-309

7 January 2021

Cytidine methylation of regulatory sequences near the pi-class glutathione S-transferase gene accompanies human prostatic carcinogenesis

1 reference

https://api.crossref.org/works/10.1038%2FNM0495-309

7 January 2021

Expression of p160erbB-3 and p185erbB-2 in prostatic intraepithelial neoplasia and prostatic adenocarcinoma

1 reference

https://api.crossref.org/works/10.1038%2FNM0495-309

7 January 2021

Identification of the von Hippel-Lindau disease tumor suppressor gene

1 reference

https://api.crossref.org/works/10.1038%2FNM0495-309

7 January 2021

Mutations of the VHL tumour suppressor gene in renal carcinoma

1 reference

https://api.crossref.org/works/10.1038%2FNM0495-309

7 January 2021

Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma

1 reference

https://api.crossref.org/works/10.1038%2FNM0495-309

7 January 2021

Hereditary papillary renal cell carcinoma

1 reference

https://api.crossref.org/works/10.1038%2FNM0495-309

7 January 2021

Interleukin-8 as a macrophage-derived mediator of angiogenesis

1 reference

https://api.crossref.org/works/10.1038%2FNM0495-309

7 January 2021

AIDS-Kaposi's sarcoma-derived cells express cytokines with autocrine and paracrine growth effects.

1 reference

https://api.crossref.org/works/10.1038%2FNM0495-309

7 January 2021

Elevated levels of the angiogenic peptide basic fibroblast growth factor in urine of bladder cancer patients

1 reference

https://api.crossref.org/works/10.1038%2FNM0495-309

7 January 2021

Elevated levels of an angiogenic peptide, basic fibroblast growth factor, in the urine of patients with a wide spectrum of cancers

1 reference

https://api.crossref.org/works/10.1038%2FNM0495-309

7 January 2021

Tumor microvessel density, p53 expression, tumor size, and peritumoral lymphatic vessel invasion are relevant prognostic markers in node-negative breast carcinoma

1 reference

https://api.crossref.org/works/10.1038%2FNM0495-309

7 January 2021

Microvessel density and distribution in ductal carcinoma in situ of the breast

1 reference

https://api.crossref.org/works/10.1038%2FNM0495-309

7 January 2021

Control of angiogenesis in fibroblasts by p53 regulation of thrombospondin-1

1 reference

https://api.crossref.org/works/10.1038%2FNM0495-309

7 January 2021

Identification of endosialin, a cell surface glycoprotein of vascular endothelial cells in human cancer

1 reference

https://api.crossref.org/works/10.1038%2FNM0495-309

7 January 2021

Requirement of vascular integrin alpha v beta 3 for angiogenesis

1 reference

https://api.crossref.org/works/10.1038%2FNM0495-309

7 January 2021

Eradication of large solid tumors in mice with an immunotoxin directed against tumor vasculature

1 reference

https://api.crossref.org/works/10.1038%2FNM0495-309

7 January 2021

Cytostatic gene therapy for vascular proliferative disorders with a constitutively active form of the retinoblastoma gene product

1 reference

https://api.crossref.org/works/10.1038%2FNM0495-309

7 January 2021

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Identifiers

DOI

10.1038/NM0495-309

1 reference

20 September 2017

1 reference