(Q40164038)

18 September 2017

title

Akt inhibitor A-443654 induces rapid Akt Ser-473 phosphorylation independent of mTORC1 inhibition (English)

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18 September 2017

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E K-H Han

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18 September 2017

J D Leverson

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18 September 2017

T McGonigal

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18 September 2017

O J Shah

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18 September 2017

K W Woods

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18 September 2017

T Hunter

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18 September 2017

V L Giranda

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18 September 2017

Y Luo

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18 September 2017

language of work or name

English

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publication date

5 March 2007

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18 September 2017

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18 September 2017

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18 September 2017

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18 September 2017

page(s)

5655-5661

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Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha

18 September 2017

cites work

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210343

7 January 2021

Perturbations of the AKT signaling pathway in human cancer

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7 January 2021

PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2.

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7 January 2021

The Akt/PKB family of protein kinases: a review of small molecule inhibitors and progress towards target validation

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7 January 2021

Direct inhibition of the signaling functions of the mammalian target of rapamycin by the phosphoinositide 3-kinase inhibitors, wortmannin and LY294002.

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7 January 2021

The Akt/PKB pathway: molecular target for cancer drug discovery

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7 January 2021

Feedback control of the protein kinase TAK1 by SAPK2a/p38

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7 January 2021

Cellular survival: a play in three Akts

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1210343

7 January 2021

Identification of a PKB/Akt hydrophobic motif Ser-473 kinase as DNA-dependent protein kinase

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7 January 2021

Handicapping the race to develop inhibitors of the phosphoinositide 3-kinase/Akt/mammalian target of rapamycin pathway

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7 January 2021

Paradoxical activation of Raf by a novel Raf inhibitor

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7 January 2021

The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins

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7 January 2021

The Akt-mTOR tango and its relevance to cancer

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7 January 2021

Modulation of insulin receptor substrate-1 tyrosine phosphorylation by an Akt/phosphatidylinositol 3-kinase pathway

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7 January 2021

Potent and selective inhibitors of Akt kinases slow the progress of tumors in vivo

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7 January 2021

mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt

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7 January 2021

Regulation of protein kinase B/Akt-serine 473 phosphorylation by integrin-linked kinase: critical roles for kinase activity and amino acids arginine 211 and serine 343

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1210343

7 January 2021

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

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7 January 2021

Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies

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7 January 2021

Activation of Akt and eIF4E survival pathways by rapamycin-mediated mammalian target of rapamycin inhibition.

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7 January 2021

AKT signaling in normal and malignant cells

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7 January 2021

Putting the rap on Akt.

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1210343

7 January 2021

Akt/protein kinase B is regulated by autophosphorylation at the hypothetical PDK-2 site

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1210343

7 January 2021

Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity

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7 January 2021

The N-terminal ERK-binding site of MEK1 is required for efficient feedback phosphorylation by ERK2 in vitro and ERK activation in vivo

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1210343

7 January 2021

Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-Akt signaling through downregulation of PDGFR

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7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1210343

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Dimensions Publication ID

18 September 2017

1005301084

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1 reference