Papers by Abdul Kadir Mohammed
Frontiers in Aging Neuroscience, 2019
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Brain research bulletin, Jan 6, 2015
Neuroplasticity can be conceptualized as an intrinsic property of the brain that enables modifica... more Neuroplasticity can be conceptualized as an intrinsic property of the brain that enables modification of function and structure in response to environmental demands. Neuroplastic strengthening of synapses is believed to serve as a critical mechanism underlying learning, memory, and other cognitive functions. Ex vivo work investigating neuroplasticity has been done on hippocampal slices using high frequency stimulation. However, in vivo neuroplasticity in humans has been difficult to demonstrate. Recently, a long-term potentiation-like phenomenon, a form of neuroplastic change, was identified in young adults by differences in visual evoked potentials (VEPs) that were measured before and after tetanic visual stimulation (TVS). The current study investigated whether neuroplastic changes in the visual pathway can persist in older adults. Seventeen healthy subjects, 65 years and older, were recruited from the community. Subjects had a mean age of 77.4 years, mean education of 17 years, m...
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Proceedings of the National Academy of Sciences, 2007
Mitochondrial dysfunction is implicated in the pathophysiology of Parkinson′s disease (PD), a com... more Mitochondrial dysfunction is implicated in the pathophysiology of Parkinson′s disease (PD), a common age-associated neurodegenerative disease characterized by intraneuronal inclusions (Lewy bodies) and progressive degeneration of the nigrostriatal dopamine (DA) system. It has recently been demonstrated that midbrain DA neurons of PD patients and elderly humans contain high levels of somatic mtDNA mutations, which may impair respiratory chain function. However, clinical studies have not established whether the respiratory chain deficiency is a primary abnormality leading to inclusion formation and DA neuron death, or whether generalized metabolic abnormalities within the degenerating DA neurons cause secondary damage to mitochondria. We have used a reverse genetic approach to investigate this question and created conditional knockout mice (termed MitoPark mice), with disruption of the gene for mitochondrial transcription factor A ( Tfam ) in DA neurons. The knockout mice have reduced...
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Physiological psychology, Sep 1, 1985
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Behavior Genetics, 2011
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Scandinavian Journal of Psychology, 1984
... Archer, T., Soderberg, U., Mohammed, A. K., Fredriksson, A. & Ross, S. B.: Active... more ... Archer, T., Soderberg, U., Mohammed, A. K., Fredriksson, A. & Ross, S. B.: Active and passive avoidance performances following bilateral olfactory bulbectomy. Scandinauian Journal ofPsychology, 1984, 25, 179-188. ... 184 T . Archer et a/. ... Table 2 presents the amine uptake data. ...
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Psychopharmacology, 1986
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Pharmacology Biochemistry and Behavior, 1983
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Pharmacology Biochemistry and Behavior, 1986
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Neuroscience, 1990
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Neurobiology of Aging, 1992
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Journal of Chemical Neuroanatomy, 1993
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European Journal of Pharmacology, 1986
The breakdown of inositol phospholipid (PI) stimulated by hippocampal noradrenaline in rat minipr... more The breakdown of inositol phospholipid (PI) stimulated by hippocampal noradrenaline in rat miniprisms in vitro was used as an index of alpha 1-adrenoceptor function after selective noradrenergic denervation. Selective denervation was produced by microinjections of 6-hydroxydopamine (6-OHDA) into either the dorsal noradrenergic bundle (DNAB) or the locus coeruleus (LC), or by systemic treatment with the noradrenergic neurotoxin DSP4 (N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine). Fourteen days after these treatments, there was a large depletion of cortical noradrenaline but no change in the stimulation of hippocampal PI breakdown by noradrenaline. It is concluded that selective noradrenergic denervation under the conditions used here does not lead to hippocampal alpha 1-adrenoceptor supersensitivity as assessed by noradrenaline-stimulated PI breakdown.
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Developmental Brain Research, 1986
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Molecular Brain Research, 1994
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Brain Research, 1993
In the present study we have quantified preprosomatostatin-mRNA and somatostatin levels in rat br... more In the present study we have quantified preprosomatostatin-mRNA and somatostatin levels in rat brain following environmental stimulation. Animals were housed for 30 days in an enriched or impoverished environment prior to analysis. After 30 days of housing half of the rats from each environment were behaviourally tested for 3 days. Housing in enriched environment improved performance in a spatial learning situation. The open-field behaviour of these animals was characterized by initially higher rearing scores and a more rapid habituation to novel environment as measured by spontaneous locomotor activity. We found significantly elevated somatostatin levels in the cortex following enriched environment, compared with impoverished environment. Exposure to behavioural testing of impoverished animals led to increased cortical somatostatin levels. Hypothalamic somatostatin levels increased significantly after housing in enriched environment, while the testing procedure had no influence. Our data shows that the somatostatin system in the rat brain was activated in association with cognitive changes, that were induced by housing in an enriched environment.
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Brain Research Bulletin, 1995
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Papers by Abdul Kadir Mohammed