Papers by Michael Adu-Frimpong
Drug Delivery, Jul 31, 2022
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Journal of the Science of Food and Agriculture
BACKGROUNDAstaxanthin (AST) is approved by the US Food and Drug Administration (FDA) as a safe di... more BACKGROUNDAstaxanthin (AST) is approved by the US Food and Drug Administration (FDA) as a safe dietary supplement for humans. As a potent lipid‐soluble keto‐carotenoid, it is widely used in food, cosmetics, and the pharmaceutical industry. However, its low solubility limits its powerful biological activity and its application in these fields. This study aims to develop a delivery system to address the low solubility and bioavailability of AST and to enhance its antioxidant capacity.RESULTSAstaxanthin‐loaded composite micelles were successfully prepared via coaxial electrospray technology. Astaxanthin existed in the amorphous state in the electro‐sprayed formulation with an approximate particle size of 186.28 nm and with a polydispersity index of 0.243. In this delivery system, Soluplus and copovidone (PVPVA 64) were the main polymeric matrix for AST, which then released the drug upon contact with aqueous media, resulting in an overall increase in drug solubility and a release rate o...
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Journal of Nanoparticle Research, May 25, 2022
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Drug Development and Industrial Pharmacy, Nov 2, 2022
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International Journal of Biological Macromolecules, Oct 1, 2018
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Journal of Pharmaceutical Sciences
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Biomedical Materials, May 15, 2023
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Fullerenes Nanotubes and Carbon Nanostructures, Mar 27, 2022
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International Journal of Pharmaceutics, Dec 1, 2019
Myricitrin has many pharmacological effects, such as anti-inflammation, liver protection and anti... more Myricitrin has many pharmacological effects, such as anti-inflammation, liver protection and anti-oxidation. However, its clinical application is limited by poor solubility and low oral bioavailability. The preparation of myricitrin-loaded proliposomes (MPs) was achieved via the combination of thin-film dispersion technique and freeze-drying method. The in vitro release of MPs compared with free myricitrin was measured in different dissolution media while the pharmacokinetic study was also conducted in rats. Moreover, the uric acid-lowering activity of MPs was investigated in the hyperuricemic rat model. The prepared myricitrin appeared to be spherical. Notably, compared with the free myricitrin, the cumulative release in vitro and in vivo oral bioavailability of MPs were markedly increased. Besides, the MPs could significantly lower the serum uric acid level as well as ameliorate liver and kidney damage in hyperuricemic rats compared with the model group. Therefore, the present work supports the fact that MPs improved the oral bioavailability of myricitrin for the prospect of clinical application.
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Aaps Pharmscitech, Mar 22, 2023
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Journal of Chromatography A, Feb 1, 2023
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Journal of Pharmaceutical Sciences, 2023
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Journal of Microencapsulation, May 31, 2023
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Biopharmaceutics & Drug Disposition, Mar 31, 2023
The purpose of this work was to fabricate the microencapsulation of capsaicin using electrospray ... more The purpose of this work was to fabricate the microencapsulation of capsaicin using electrospray technology and polyvinylpyrrolidone (PVP) K30 as a carrier. The morphological characteristics of capsaicin‐PVP electrosprayed microencapsulation complex under different processing parameters were observed by scanning electron microscope (SEM), while the best process was determined, wherein it comprised of 10 KV (voltage), 0.8 ml·h−1 (solution flow rate), 0.9 mm (the inner diameter of the needle), and 10 cm (receiving distance). The X‐ray diffraction results of the electrosprayed complex showed that capsaicin was present in the carrier in an amorphous form. The drug release properties of capsaicin powder and electrosprayed complex in different media were investigated. The results showed that in vitro release rates of the capsaicin complex in different media were much higher than that of capsaicin powder, with correspondingly improved bioavailability, defined by intravenous and oral dosing in rats in vivo, for the electrosprayed complex compared to that of capsacin powder. The dose absorbed of the electrosprayed complex was 2.2‐fold that of the capsaicin powder. In short, electrospray technology can be used to prepare capsaicin‐loaded electrosprayed microencapsulation complex. This technique can improve the solubility and bioavailability of capsaicin, and provide a new idea for the solubilization of other insoluble drugs.
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Aaps Pharmscitech, Oct 8, 2022
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Journal of Pharmaceutical Sciences
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Current Drug Delivery
Objective: To prepare GA-Emo micelle and investigate the feasibility of using GA as both a bifunc... more Objective: To prepare GA-Emo micelle and investigate the feasibility of using GA as both a bifunctional drug and carrier. Methods: The preparation of GA-Emo micelles was accomplished via the thin-film dispersion method with GA as the carrier. Size distribution, entrapment efficiency, and drug loading were used to evaluate the characteristics of micelles. The absorption and transport properties of the micelles in Caco-2 cells were investigated, while their pharmacodynamics in mice were preliminarily studied. Results: The optimal formulation featured a GA/Emo in weight ratio of 2:1 and an encapsulation efficiency of 23.68%. The optimized GA/Emo was characterized as small uniform spheres with an average micellar size of 168.64 ± 5.69 nm, a polydispersity index of 0.17 ± 0.01, and an electrically negative surface (−35.33 ± 0.94 mV). Absorption and transport experiments with Caco-2 cells showed that the absorption of GA-Emo micelles in small intestines was mainly passive transport, amid ...
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Journal of the Science of Food and Agriculture
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SSRN Electronic Journal
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Papers by Michael Adu-Frimpong