ABSTRACTBACKGROUNDGut microbiota have been implicated in atherosclerotic disease, but their relat... more ABSTRACTBACKGROUNDGut microbiota have been implicated in atherosclerotic disease, but their relation with subclinical coronary atherosclerosis is unclear. This study aimed to identify associations between the gut microbiome and computed tomography-based measures of coronary atherosclerosis, and to explore relevant clinical correlates.METHODSWe conducted a cross-sectional study of 8973 participants aged 50 to 65 without overt atherosclerotic disease from the population-based Swedish Cardiopulmonary BioImage Study (SCAPIS). Coronary atherosclerosis was measured using coronary artery calcium score (CACS) and coronary computed tomography angiography (CCTA). Gut microbiota species abundance and functional potential were assessed with shotgun metagenomics sequencing of stool samples, and their association with coronary atherosclerosis was evaluated with multivariable regression models adjusted for cardiovascular risk factors. Associated species were evaluated for association with inflamma...
Headlines An increased prevalence and severity of periodontitis in RA patients has been reported ... more Headlines An increased prevalence and severity of periodontitis in RA patients has been reported in several studies RA and periodontitis have many pathological features in common, of which inflammation and bone destruction are the most prominent Risk factors in both conditions are smoking and genetic susceptibility A possible mutual effect of treatment of the diseases is not ascertained There is currently limited evidence to support that periodontitis is a risk factor for RA
Hyaluronan (HY) har pa grund av sina egenskaper (bakteriostatiska, antiin ammatoriska et cetera) ... more Hyaluronan (HY) har pa grund av sina egenskaper (bakteriostatiska, antiin ammatoriska et cetera) nyligen introducerats for anvandning i parodon- tal terapi. Denna litteraturgenomgang bygger del- vis pa en nyligen publicerad systematisk oversikt, och har kompletterats med gingivitstudier och de senast publicerade vetenskapliga arbetena med HY inom parodontitbehandling. Artikeln ger en sammanfattning av de terapeutiska mojligheterna med HY-applikation som monoterapi eller som ett tillagg till behandling av gingivit och parodontit. Vid sokning i tre litteraturdatabaser fann vi 18 kontrollerade studier. I majoriteten av dessa stu- dier beskrivs for HY-testgruppen jamfort med kontrollgruppen ● en statistiskt signi kant forbattring i gingivalin- dex for gingivitpatienter ● en statistiskt signi kant minskning i blodning vid sondering och fickdjup vid icke-kirurgisk parodontal behandling ( gur I), dock i mattligt kliniskt relevant utstrackning. Att erhalla nagon ytterligare vinst i klinisk ...
To evaluate the potential use of quantitative computed tomography (QCT) for the assessment of bon... more To evaluate the potential use of quantitative computed tomography (QCT) for the assessment of bone mineral density of the edentulous mandible prior to implant placement. Ten 2 mm thick CT slices of anterior and posterior edentulous sections from 15 mandibles were obtained perpendicular to the buccal and lingual plates. The bone mineral density, expressed as the amount of calcium hydroxyapatite (mg cm-3) of the trabecular bone, was calculated using a method that takes into account the influence of fat. The variation of bone mineral density between mandibles was high. Anterior sections showed higher values than posterior sections and a variation was found within sections of the same mandible. CT provides a site-related measure of the bone mineral density in the mandible and appears potentially useful as a non-invasive method to determine a parameter that may reflect bone quality prior to implant placement.
Nationella samordningsgruppens aktiviteter syftar till att: - identifiera forskningsmiljoer som k... more Nationella samordningsgruppens aktiviteter syftar till att: - identifiera forskningsmiljoer som kan starkas genom nationell koordinering - sammanfora yngre forskare fran olika forskningsmiljoer - sammanfora etablerade forskare men yngre forskare - stimulera till forskningssamarbete pa ett nationellt plan
The aim of this study was to evaluate patients' experiences of oral implant surgery when perf... more The aim of this study was to evaluate patients' experiences of oral implant surgery when performed in a student clinic setting and the potential impact on patients'daily life. Patient selection was carried out during a round, to which undergraduate students in semester 9 and 10 could bring patients that they considered eligible for one or two implants. Partial edentulous patients that fulfilled the inclusion criteria for implant installation at the student's clinic were consequently enrolled to implant surgery with either Astra Tech or 3i implants. The same surgeon accomplished all implant installations and the students were involved in the treatment, initially by assisting during the surgery and subsequently by performing the prosthetic restoration. After the surgery, a study-specific questionnaire was sent to patients for evaluation of discomfort, pain during the surgical procedure and postoperative symptoms. Thirty-six patients were included in the study, 30 patients ...
The aim of the present study was to record and describe the oral condition of homeless adults in ... more The aim of the present study was to record and describe the oral condition of homeless adults in Stockholm, Sweden. There have been no clinical studies of the oral health of the homeless in Sweden since the 1970s. The study population comprised 147 homeless individuals (110 M, 37 F) in the age range 22-77 years. All underwent oral examination, including registration of periodontal status and caries data. The results show that homeless adults in Stockholm have fewer remaining teeth than the general population. Because conservative periodontal treatment is expensive and time-consuming, teeth with doubtful prognoses are usually extracted and only those with optimal periodontal health are retained. Another consequence of inadequate periodontal treatment, including insufficient oral hygiene instruction, is the high percentage of tooth surfaces with plaque accumulation. Heavy plaque accumulation will also have an effect on caries progression, expressed in this study as high DMFT values. Loss of teeth is likely to create dental and chewing problems, possibly resulting in increased dental and medical treatment needs.
Periodontal disease is caused by a chronic infection inducing an inflammatory reaction that leads... more Periodontal disease is caused by a chronic infection inducing an inflammatory reaction that leads to a breakdown of tooth-supporting tissue. The maintenance of an equilibrium between the host defence and microorganisms in the sulcus is essential to preserve health. All multicellular organisms have mechanisms for killing their own cells, and use physiological cell death for defence, development, homeostasis and ageing. Apoptosis and proliferation are very important phenomena in regulating this and a disturbance is often associated with disease e.g. cancer, AIDS, Alzheimer's disease, rheumatoid arthritis. The aim of this study was to determine whether the number of apoptotic and proliferative gingival keratinocytes differed between patients with gingivitis and those with periodontitis. The distribution of neutrophil elastase, PCNA/cyclin, DNA fragmentation (apoptosis) and p53 was determined with immunocytochemical techniques. We used paraffin-embedded sections from gingival biopsies and did quantitative analyses. These showed that 5-12% of the keratinocytes in the basal layers of the epithelium proliferated in the two groups. Fewer apoptotic cells were seen in the oral epithelium than in the sulcus in all subjects in both groups. Only in the most apical part of the sulcus, close to the junctional epithelium, did the number of apoptotic keratinocytes exceed the proliferative ones in patients with periodontitis.
The cleaning effectiveness of different treatment methods for titanium abutments was evaluated us... more The cleaning effectiveness of different treatment methods for titanium abutments was evaluated using scanning electron microscopy (SEM). In the mandible of 4 beagle dogs, 25 titanium abutments were installed (modum Brånemark). After 16 weeks of plaque accumulation, mineralized deposits had formed on 23 abutments. Each of these abutments was subjected to one of the following treatment methods: scaling with (1) metal, (2) plastic, or (3) ultrasonic instruments;(4) air‐polishing, (5) weekly rubber cup polishing or (6) daily brushing with a conventional toothbrush. Fourteen abutments were removed immediately after treatment. On 9 abutments, the scaling procedures and air‐polishing were repeated after another 16 weeks of plaque accumulation. The abutments were prepared for SEM, and each of them was viewed and photographed at 3 different magnifications. The photomicrographs were evaluated by 3 examiners who, guided by reference pictures, gave each abutment a “cleanliness” score, ranking f...
ABSTRACTBACKGROUNDGut microbiota have been implicated in atherosclerotic disease, but their relat... more ABSTRACTBACKGROUNDGut microbiota have been implicated in atherosclerotic disease, but their relation with subclinical coronary atherosclerosis is unclear. This study aimed to identify associations between the gut microbiome and computed tomography-based measures of coronary atherosclerosis, and to explore relevant clinical correlates.METHODSWe conducted a cross-sectional study of 8973 participants aged 50 to 65 without overt atherosclerotic disease from the population-based Swedish Cardiopulmonary BioImage Study (SCAPIS). Coronary atherosclerosis was measured using coronary artery calcium score (CACS) and coronary computed tomography angiography (CCTA). Gut microbiota species abundance and functional potential were assessed with shotgun metagenomics sequencing of stool samples, and their association with coronary atherosclerosis was evaluated with multivariable regression models adjusted for cardiovascular risk factors. Associated species were evaluated for association with inflamma...
Headlines An increased prevalence and severity of periodontitis in RA patients has been reported ... more Headlines An increased prevalence and severity of periodontitis in RA patients has been reported in several studies RA and periodontitis have many pathological features in common, of which inflammation and bone destruction are the most prominent Risk factors in both conditions are smoking and genetic susceptibility A possible mutual effect of treatment of the diseases is not ascertained There is currently limited evidence to support that periodontitis is a risk factor for RA
Hyaluronan (HY) har pa grund av sina egenskaper (bakteriostatiska, antiin ammatoriska et cetera) ... more Hyaluronan (HY) har pa grund av sina egenskaper (bakteriostatiska, antiin ammatoriska et cetera) nyligen introducerats for anvandning i parodon- tal terapi. Denna litteraturgenomgang bygger del- vis pa en nyligen publicerad systematisk oversikt, och har kompletterats med gingivitstudier och de senast publicerade vetenskapliga arbetena med HY inom parodontitbehandling. Artikeln ger en sammanfattning av de terapeutiska mojligheterna med HY-applikation som monoterapi eller som ett tillagg till behandling av gingivit och parodontit. Vid sokning i tre litteraturdatabaser fann vi 18 kontrollerade studier. I majoriteten av dessa stu- dier beskrivs for HY-testgruppen jamfort med kontrollgruppen ● en statistiskt signi kant forbattring i gingivalin- dex for gingivitpatienter ● en statistiskt signi kant minskning i blodning vid sondering och fickdjup vid icke-kirurgisk parodontal behandling ( gur I), dock i mattligt kliniskt relevant utstrackning. Att erhalla nagon ytterligare vinst i klinisk ...
To evaluate the potential use of quantitative computed tomography (QCT) for the assessment of bon... more To evaluate the potential use of quantitative computed tomography (QCT) for the assessment of bone mineral density of the edentulous mandible prior to implant placement. Ten 2 mm thick CT slices of anterior and posterior edentulous sections from 15 mandibles were obtained perpendicular to the buccal and lingual plates. The bone mineral density, expressed as the amount of calcium hydroxyapatite (mg cm-3) of the trabecular bone, was calculated using a method that takes into account the influence of fat. The variation of bone mineral density between mandibles was high. Anterior sections showed higher values than posterior sections and a variation was found within sections of the same mandible. CT provides a site-related measure of the bone mineral density in the mandible and appears potentially useful as a non-invasive method to determine a parameter that may reflect bone quality prior to implant placement.
Nationella samordningsgruppens aktiviteter syftar till att: - identifiera forskningsmiljoer som k... more Nationella samordningsgruppens aktiviteter syftar till att: - identifiera forskningsmiljoer som kan starkas genom nationell koordinering - sammanfora yngre forskare fran olika forskningsmiljoer - sammanfora etablerade forskare men yngre forskare - stimulera till forskningssamarbete pa ett nationellt plan
The aim of this study was to evaluate patients' experiences of oral implant surgery when perf... more The aim of this study was to evaluate patients' experiences of oral implant surgery when performed in a student clinic setting and the potential impact on patients'daily life. Patient selection was carried out during a round, to which undergraduate students in semester 9 and 10 could bring patients that they considered eligible for one or two implants. Partial edentulous patients that fulfilled the inclusion criteria for implant installation at the student's clinic were consequently enrolled to implant surgery with either Astra Tech or 3i implants. The same surgeon accomplished all implant installations and the students were involved in the treatment, initially by assisting during the surgery and subsequently by performing the prosthetic restoration. After the surgery, a study-specific questionnaire was sent to patients for evaluation of discomfort, pain during the surgical procedure and postoperative symptoms. Thirty-six patients were included in the study, 30 patients ...
The aim of the present study was to record and describe the oral condition of homeless adults in ... more The aim of the present study was to record and describe the oral condition of homeless adults in Stockholm, Sweden. There have been no clinical studies of the oral health of the homeless in Sweden since the 1970s. The study population comprised 147 homeless individuals (110 M, 37 F) in the age range 22-77 years. All underwent oral examination, including registration of periodontal status and caries data. The results show that homeless adults in Stockholm have fewer remaining teeth than the general population. Because conservative periodontal treatment is expensive and time-consuming, teeth with doubtful prognoses are usually extracted and only those with optimal periodontal health are retained. Another consequence of inadequate periodontal treatment, including insufficient oral hygiene instruction, is the high percentage of tooth surfaces with plaque accumulation. Heavy plaque accumulation will also have an effect on caries progression, expressed in this study as high DMFT values. Loss of teeth is likely to create dental and chewing problems, possibly resulting in increased dental and medical treatment needs.
Periodontal disease is caused by a chronic infection inducing an inflammatory reaction that leads... more Periodontal disease is caused by a chronic infection inducing an inflammatory reaction that leads to a breakdown of tooth-supporting tissue. The maintenance of an equilibrium between the host defence and microorganisms in the sulcus is essential to preserve health. All multicellular organisms have mechanisms for killing their own cells, and use physiological cell death for defence, development, homeostasis and ageing. Apoptosis and proliferation are very important phenomena in regulating this and a disturbance is often associated with disease e.g. cancer, AIDS, Alzheimer's disease, rheumatoid arthritis. The aim of this study was to determine whether the number of apoptotic and proliferative gingival keratinocytes differed between patients with gingivitis and those with periodontitis. The distribution of neutrophil elastase, PCNA/cyclin, DNA fragmentation (apoptosis) and p53 was determined with immunocytochemical techniques. We used paraffin-embedded sections from gingival biopsies and did quantitative analyses. These showed that 5-12% of the keratinocytes in the basal layers of the epithelium proliferated in the two groups. Fewer apoptotic cells were seen in the oral epithelium than in the sulcus in all subjects in both groups. Only in the most apical part of the sulcus, close to the junctional epithelium, did the number of apoptotic keratinocytes exceed the proliferative ones in patients with periodontitis.
The cleaning effectiveness of different treatment methods for titanium abutments was evaluated us... more The cleaning effectiveness of different treatment methods for titanium abutments was evaluated using scanning electron microscopy (SEM). In the mandible of 4 beagle dogs, 25 titanium abutments were installed (modum Brånemark). After 16 weeks of plaque accumulation, mineralized deposits had formed on 23 abutments. Each of these abutments was subjected to one of the following treatment methods: scaling with (1) metal, (2) plastic, or (3) ultrasonic instruments;(4) air‐polishing, (5) weekly rubber cup polishing or (6) daily brushing with a conventional toothbrush. Fourteen abutments were removed immediately after treatment. On 9 abutments, the scaling procedures and air‐polishing were repeated after another 16 weeks of plaque accumulation. The abutments were prepared for SEM, and each of them was viewed and photographed at 3 different magnifications. The photomicrographs were evaluated by 3 examiners who, guided by reference pictures, gave each abutment a “cleanliness” score, ranking f...
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