Papers by Rosalinda Allegro
UNIPA Springer Series, 2020
Journal of Clinical Oncology, Jun 20, 2006
20092 Background: Circulating serum levels of the extracellular domain of the HER-2/neu receptor ... more 20092 Background: Circulating serum levels of the extracellular domain of the HER-2/neu receptor have been described in up to 15–30% of pre-surgical BC pts and 45% of metastatic BC (MBC) pts. S-HER2 has been reported to have a potential prognostic and predictive role in BC pts. Methods: We conducted a prospective evaluation of the S-HER2 levels in BC pts with the aim of studying its prognostic role and correlation with the clinical situation.The S-HER-2 levels were measured by an ELISA immunometric test (cut-off 13 ng/ml) at the first visit and then every 3 months.All pts gave a written informed consent. Results: From Jan ‘05 97 consecutive BC pts [68 st I-III; 29 (1 male) st.IV; median age at entry: 60y (28–83)] have been accrued and a total of 196 serum samples have been tested for S-HER2 (mean = 2/pt).Preliminary results are reported.Elevated S-HER2 levels at the first dosage (bS-HER2) were present in 25% of primary and 52% of MBC pts.In 68 primary BC pts the tumor HER2 status was 0/1+ in 54% (bS-HER2 >13 ng/ml = 22%) and 2+/3+ in 22% (bS-HER2 >13 ng/ml = 27%); there was no correlation between bS-HER2 with tumor HER2 status, size,axillary nodes, ER status, grading according to the Fisher’s exact test. In 29 MBC pts the tumor HER2 status was 0/1+ in 24% (bS-HER2 >13 ng/ml = 24%) and 2+/3+ in 48% (bS-HER2 >13 ng/ml = 21%); there was no correlation between S-HER2 and sites of metastases/n.of sites even if the S-HER2 median value was 18 and 12.5 ng/ml in visceral vs no visceral metastases.We also observed in 35% of MBC pts experiencing progression of disease that S-HER2 sequential values increased from baseline;in 21% of MBC pts that experienced complete remission the S-HER2 values decreased <13 from baseline. Conclusions: This analysis showed no definite association between bS-HER-2 and clinical parameters.Further evaluations in a larger group of pts and association with response,survival and changes of S-HER2 status will be conducted. No significant financial relationships to disclose.
Urologia, 2004
As a preliminary approach to define the object of larger case-control studies, the distribution o... more As a preliminary approach to define the object of larger case-control studies, the distribution of potential risk factors coming from environmental pollution among patients affected by superficial bladder cancer (TGGB) has been analyzed. MATERIAL E METHODS. The analysis included only patients affected by medium risk superficial TGGB. Forty Italian urological centres joined the study. Detailed information about age, sex, residency, employment, active and passive cigarette smoking, water resource, hair-dye use were centralized. All patients underwent TUR and early intravesical chemotherapy. The distribution of the above mentioned environmental factors was related to tumor characteristics such as multiplicity and previous natural history. RESULTS. Until today 474 patients have been recruited, 182 (38.4%) with primary tumors and 293 (61.8%) with multiple lesions. Over 80% of the patients lived in urban areas, 20% were employed in industry at risk for bladder cancer and 8% used hair dye. Forty percent of the patients were smokers, with a median smoking period of 30 years. Bottled water was the only water resource in 42% of cases. At multivariate statistical analysis a significant correlation between tumor multiplicity and employment in industry (p<0.01) and between past natural history and period of cigarette smoking (p<0.05) was found. Preliminarly, an interesting trend was detected for a correlation between water resource and bladder cancer in © Wichtig Editore, 2004 0391-5603/203-05$15.00/0 Fattori di rischio ambientali nel carcinoma vescicale a medio rischio di recidiva non-smoking patients. The municipal water system was the main water resource more frequently in non-smokers (75% vs 53%). This might imply a pathogenic role of water pollution and chlorination. (Urologia 2004; 71: 203-7)
Rivista Urologia, Jul 1, 2004
The diagnosis of prostate carcinoma has been monitored in Sicily and Calabria for one year. Mater... more The diagnosis of prostate carcinoma has been monitored in Sicily and Calabria for one year. Material e Methods Twenty-seven urological centres of Sicily and Calabria joined the study. Detailed informations about age, familiarity, PSA, Gleason score and TNM stage at diagnosis were centralized between november 2001 and november 2002. Results 721 patients have been recruited. The median age was 73 years. More than 80% of the patients were older than 65 years. Median PSA was 14 ng/ml. The clinical stage at diagnosis was T1c in 33% of patients and 67% had an organ confined prostate cancer (T1-T2). Familiarity was detected in 8% of cases. Age and PSA at diagnosis in these patients were similar to those of the remaining population. However, only 18% of them had a T1 tumor, emphasizing the delay in diagnosis in these patients. Although only 10% of the patients shows at diagnosis a metastatic tumor, 29% only are fit for radical prostatectomy in according to age, PSA and stage.
Bull. Inst. Natn. Scien. Tech. Mer de Salammbô, 2016
Heavy metals are chemical contaminants in the environment that may end up in all the feed that we... more Heavy metals are chemical contaminants in the environment that may end up in all the feed that we consume.
The objective of this study is a risk assessment according to the methodology developed by the European Food Safety Authority (EFSA) which consist in estimating the concentration of three heavy metals (cadmium, lead, mercury) in feed consumed by a population, determining the absorbed doses and comparing them to absorption limits.
The estimation of the weekly intake (EWI) of heavy metals gave the following values (in μg/kg/week) Cadmium 1.42; Lead 1.57; Mercury 0.42.
We can conclude that the doses absorbed by the consumer are below the tolerable limits. In addition, veterinary services ensure effective measures for monitoring heavy metals in farmed fish in accordance with European standards.
UNIPA Springer series, 2020
UNIPA Springer series, 2020
Evidence from several developed economies has shown that skill mismatch and overeducation are wid... more Evidence from several developed economies has shown that skill mismatch and overeducation are widespread phenomena and that they typically affect about one-third of the higher educated employed population.
UNIPA Springer series, 2020
In this study, the multi-criteria approach is used to obtain rankings for a number of Italian uni... more In this study, the multi-criteria approach is used to obtain rankings for a number of Italian universities, according to certain curricular and job placement graduate characteristics.
Introduction: A general awareness of the most common genitourinary diseases is often lacking.The ... more Introduction: A general awareness of the most common genitourinary diseases is often lacking.The aim of the present study was to investigate the attention of the general practitioner and of the patient to the genitourinary diseases. An incomplete medical history and/or an inadequate physical examination might be responsible of late diagnosis and improper management. Patients and Methods: A self administered questionnaire was obtained by our outpatients before the urological visit. As a preliminary step we administered a very simple questionnaire consisting of four multiple choice questions: 1) Did your general practitioner examine your external genitalia in the last five years? Did you ask for this examination? 2) Did your general practitioner prescribe any clinical investigations? 3) Have you ever seen blood in your urine? Did you advise your doctor? 4) How long time did elapse between the first symptom and our councelling? The study should be closed if less than 5 patients among the first 20 showed an improper attention to genitourinary pathology, otherwise, 200 consecutive patients at least should be entered. A further structured interview was planned in the case of doubtful results. Results: From December 2011 to February 2012, 327 questionnaires were obtained from 358 patients with a compliance of 91.3%. The median age of the patients was 61 years (range: 15-91). Two hundred fiftyfive (78%) were men. Out of 327 patients only 72 (22%) underwent a physical examination comprehensive of the external genitalia in the previous five years. The remaining 250 (76.4%) patients were not examined and, more relevant, they did not ask for. Forty-nine (63.6%) out of the 77 patients were examined on their specific request. Only 172 (52.6%) patients underwent laboratory and/or imaging assessment before urological councelling. Gross haematuria was the main urological symptom in 91 (27.8%) of cases. The general practitioner was not adviced of patients\u2019 symptom in 13% of cases and, when informed, a urological assessment was required in only 47%. Discussion and Conclusion: Our preliminary survey point out a limited attention to the genitourinary diseases both from the general practitioner and the patient. Noteworthy, in case of gross haematuria 20% of the patients did not inform the family doctor and a urological assessment was indicated in only 50% of cases
European Urology Supplements, Mar 1, 2005
Urologia, 2004
... UROLOGIA, 72(1), 152-154. Autori: C PAVONE; V SERRETTA; A GALUFFO; M VELLA; R ALLEGRO; MORELL... more ... UROLOGIA, 72(1), 152-154. Autori: C PAVONE; V SERRETTA; A GALUFFO; M VELLA; R ALLEGRO; MORELLO V; R PORCASI; TOMASINO RM; M PAVONE-MANCUSO. Titolo: Ruolo prognostico della p53 nel tumore vescicale superficiale. ...
Rivista Urologia, 2009
Introduction The European guidelines classify primary bladder tumors of Ta category and G1–2 grad... more Introduction The European guidelines classify primary bladder tumors of Ta category and G1–2 grade as low risk tumors when single or less than 7 in number and 3 cm in diameter. The aim of the present paper was to evaluate the usefulness of EORTC Risk Tables when applied to non-selected patients in daily clinical practice. Material and Methods In the present retrospective study 129 consecutive patients affected by primary bladder tumors category Ta and Grade G1–2 have been considered. The median follow-up was 48 months. Bladder tumors were TaG1 in 69 (53.5%) patients, TaG2 in 60 (46.5%), single in 82 (63.6%) and multiple in 47 (36.4%) cases. Fifty-one patients (39.5%) received adjuvant intravesical chemotherapy. Results At a median follow-up of 48 months, 70 (41.8%) patients recurred. Recurrence occurred in 43.5% of TaG1 versus 66.7% of TaG2 tumors (p=0.003), in 50% of single tumors versus 61.7% of multiple (p=0.096), in 41.2% of patients receiving adjuvant chemotherapy versus 62.8% of untreated patients (p=0.007). Progression to G3 grade, T1 category and muscle invasive tumor occurred in 3%, 10% and 2% of cases, respectively. Conclusions The EORTC Risk Tables can be applied in common clinical practice to unselected low-risk patients.
TERAPIA ORALE DOMICILIARE PER IL PAZIENTE CON CARCINOMA PROSTATICO ORMONOREFRATTARIO V. Altieri, ... more TERAPIA ORALE DOMICILIARE PER IL PAZIENTE CON CARCINOMA PROSTATICO ORMONOREFRATTARIO V. Altieri, V. Serretta, D. Melloni, R. Allegro, G. Morgia, M. Madonia, M. Ferro, A. Siragusa, G. De Grande, L. Orestano, M. Napoli, E. Membri Fondazione GSTU (Napoli) SCOPO DEL LAVORO: Per preservare la qualit\ue0 di vita del paziente affetto da carcinoma prostatico ormonorefrattario (HRPC) si rendono necessari regimi terapeutici che possano essere eseguiti a domicilio senza frequenti ricoveri ospedalieri, seppur in regime di dayhospital. I vantaggi in termini di sopravvivenza offerti da schemi chemioterapici a base di taxani, pur presenti, sono ad oggi limitati. Scopo del presente studio di fase II \ue8 stato quello di valutare efficacia e tollerabilit\ue0 di un regime totalmente orale di associazione a bassa dose di estramustina fosfato (EMP) ed etoposide (VP16). MATERIALI E METODI: Cinquantasei pazienti affetti da HRPC, et\ue0 media 75 anni, sono stati randomizzati tra: braccio A: EMP (10mg/kg) al giorno, e braccio B: EMP (3mg/kg) pi\uf9 VP16 (50mg) al giorno per 14 giorni per cicli di 28 giorni. Il rapporto di randomizzazione \ue8 stato di 2:3. PSA mediano alla randomizzazione 41.1 ng/ml. Nessuna differenza statisticamente significativa \ue8 emersa tra le caratteristiche dei pazienti. L'analogo LHRH \ue8 stato mantenuto mentre l'eventuale antiandrogeno \ue8 stato sospeso almeno un mese prima dell'inserimento in studio. RISULTATI: Sette pazienti sono usciti dallo studio per violazione del protocollo. Si \ue8 registrata interruzione della terapia per tossicit\ue0 in 6 pazienti (30%) del braccio and 5 (17.2%) del braccio B. La combinazione a bassa dose \ue8 risultata significativamente vantaggiosa in termini di tempo sino ad interruzione del trattamento per qualsiasi causa (p=0.01) e per tossicit\ue0 (6 vs 12 mesi; p=0.02). Riduzione del PSA superiore al 50% si \ue8 manifestata in 3 (15%) and 12 (41.4%) pazienti del braccio A e del braccio B con una sopravvivenza libera da progressione rispettivamente pari a 6 e 15 mesi (p= 0.02), malgrado non sia emerso nessun vantaggio in termini di sopravvivenza globale MESSAGGIO CONCLUSIVO: L'associazione per via orale a bassa dose di EMP e VP16 pu\uf2 essere somministrata a domicilio anche per periodi prolungati in pazienti anziani con un monitoraggio minimo e rappresenta un'alternativa terapeutica per i pazienti che rifiutano frequenti ricoveri ospedalieri. I risultati ottenuti in termini di risposta al PSA e sopravvivenza libera da progressione non sembrano dissimili da quelli ottenuti da altri regimi terapeutici e risultano meglio tollerati rispetto alla somministrazione a piena dose della estramustina fosfato da sola
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Papers by Rosalinda Allegro
The objective of this study is a risk assessment according to the methodology developed by the European Food Safety Authority (EFSA) which consist in estimating the concentration of three heavy metals (cadmium, lead, mercury) in feed consumed by a population, determining the absorbed doses and comparing them to absorption limits.
The estimation of the weekly intake (EWI) of heavy metals gave the following values (in μg/kg/week) Cadmium 1.42; Lead 1.57; Mercury 0.42.
We can conclude that the doses absorbed by the consumer are below the tolerable limits. In addition, veterinary services ensure effective measures for monitoring heavy metals in farmed fish in accordance with European standards.
The objective of this study is a risk assessment according to the methodology developed by the European Food Safety Authority (EFSA) which consist in estimating the concentration of three heavy metals (cadmium, lead, mercury) in feed consumed by a population, determining the absorbed doses and comparing them to absorption limits.
The estimation of the weekly intake (EWI) of heavy metals gave the following values (in μg/kg/week) Cadmium 1.42; Lead 1.57; Mercury 0.42.
We can conclude that the doses absorbed by the consumer are below the tolerable limits. In addition, veterinary services ensure effective measures for monitoring heavy metals in farmed fish in accordance with European standards.