Papers by karen rommelfanger
Neuroscience, Feb 1, 2009
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CNS spectrums, Oct 7, 2020
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The FASEB Journal, Apr 1, 2011
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The Journal of Neuroscience, Jan 20, 2010
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Oxford University Press eBooks, Sep 21, 2017
Placebo, as a negative control, has become a gold standard of research and clinical trials. “True... more Placebo, as a negative control, has become a gold standard of research and clinical trials. “True” or significant effects must go beyond the placebo control, with the tacit understanding being that placebo achieves nothing significant. Placebo administration need not be synonymous with violating the doctor–patient covenant of trust, however. Ethical arguments around placebo require updating as they are based on premises that ignore data that (1) challenge the inertness of placebo, (2) suggest that patients often deem deceptive placebo use as ethically permissible, and (3) that placebo effects need not require deception. This chapter reviews the history of placebo and related ethical conflicts, discusses competing explanations for the mechanisms of placebo, and concludes by arguing that with rhetorical force, neuroscience should be incorporated into care in a way that does not reduce, but rather enriches the understanding of the complexities of human experience.
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Zenodo (CERN European Organization for Nuclear Research), Dec 21, 2021
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Neuron
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IBRO Neuroscience Reports
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American Journal of Neuroradiology, 2013
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NAM Perspectives, 2019
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Annals of Neurology, Jan 24, 2023
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Springer eBooks, 2023
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Frontiers in Communication
Neuroscience research has been expanding, providing new insights into brain and nervous system fu... more Neuroscience research has been expanding, providing new insights into brain and nervous system function and potentially transformative technological applications. In recent years, there has been a flurry of prominent international scientific academies and intergovernmental organizations calling for engagement with different publics on social, ethical, and regulatory issues related to neuroscience and neurotechnology advances. Neuroscientific activities and outputs are value-laden; they reflect the cultural, ethical, and political values that are prioritized in different societies at a given time and impact a variety of publics beyond the laboratory. The focus on engagement in neuroscience recognizes the breadth and significance of current neuroscience research whilst acknowledging the need for a neuroethical approach that explores the epistemic and moral values influencing the neuroscientific agenda. The field of neuroethics is characterized by its focus on the social, legal, and ph...
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Norepinephrine (NE), and specific adrenoceptors, have been reported to influence distinct aspects... more Norepinephrine (NE), and specific adrenoceptors, have been reported to influence distinct aspects of adult hippocampal neurogenesis, including latent stem cell activation, progenitor proliferation, and differentiation. These findings are predominantly based on the use of pharmacological approaches in both in vitro and in vivo systems. Here, we sought to assess the consequences of genetic ablation of NE on adult hippocampal neurogenesis, by examining dopamine β hydroxylase knockout (Dbh-/-) mice, which lack NE from birth. We find that Dbh-/- mice exhibit no difference in adult hippocampal progenitor proliferation and survival. Further, the number of immature newborn neurons, labeled using stage-specific developmental markers within the hippocampal neurogenic niche, was also unaltered in Dbh -/- mice. In contrast, the noradrenergic neurotoxin DSP-4, which had previously been shown to reduce adult hippocampal neurogenesis in rats, also resulted in a decline in hippocampal progenitor pr...
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Frontiers in Neuroscience
Traditionally, recording from and stimulating the brain with high spatial and temporal resolution... more Traditionally, recording from and stimulating the brain with high spatial and temporal resolution required invasive means. However, recently, the technical capabilities of less invasive and non-invasive neuro-interfacing technology have been dramatically improving, and laboratories and funders aim to further improve these capabilities. These technologies can facilitate functions such as multi-person communication, mood regulation and memory recall. We consider a potential future where the less invasive technology is in high demand. Will this demand match that the current-day demand for a smartphone? Here, we draw upon existing research to project which particular neuroethics issues may arise in this potential future and what preparatory steps may be taken to address these issues.
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Nature Reviews Neuroscience
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Neuron
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The Routledge Handbook of Neuroethics, 2017
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Papers by karen rommelfanger