BackgroundPoor air and mask quality in the work environment increase the risks of inflammation, r... more BackgroundPoor air and mask quality in the work environment increase the risks of inflammation, reactive oxygen species (ROS) production, ongoing oxidative stress, and superoxide dismutase 3 (SOD3) levels in the airways. The study aimed to investigate the effect of the Nephrolepis exaltata - Hibiscus rosa-sinensis (NE-HRS) combination herbal mask on the airways, as measured by ROS and SOD3 levels in the nasal wash of textile industry workers.MethodsThis was a pre- and post-test randomized controlled trial, consisting of 30 subjects with ³5-year working time, conducted for eight weeks and monitored every ten days. Subjects were randomized into 3 groups, regular surgical mask group (n=10), NE-HRS combination herbal mask group (n=10) and factory mask group (n=10). SOD3 and ROS levels were determined using ELISA. Data were analyzed with One-way ANOVA and multiple comparison tests.Results ROS levels decreased significantly in all groups (p=0.004). Regular surgical masks decreased ROS lev...
Latar Belakang: Squamous Cell Carcinoma (SCC) adalah keganasan paling umum dari kepala dan leher ... more Latar Belakang: Squamous Cell Carcinoma (SCC) adalah keganasan paling umum dari kepala dan leher (sekitar 3%), tetapi hanya <1% dari seluruh jenis keganasan (insidensi jarang), yang dibagi menjadi jenis keratinizing dan non-keratinizing. Nonkeratinizing squamous cell carcinoma mempunyai berbagai nama lain, salah satunya Schneiderian carcinoma. Dahulu, Schneiderian carcinoma disebut sebagai Carcinoma Ex-Schneiderian Papilloma (malignant transformation). Atas kelangkaan dan keberagaman penamaan kasus ini, maka penulis tertarik untuk menyajikan kasus ini. Laporan Kasus: Seorang laki-laki 68 tahun datang dengan keluhan utama benjolan di leher kanan. Dilakukan tindakan wide eksisi dan rekontruksi, kemudian dikirimkan sampel untuk pemeriksaan histopatologi, didapatkan gambaran kelompok-kelompok sel epithelial ganas, dengan inti bulat oval, pleomorfik, hiperkromatik, berkromatin kasar, sitoplasma eosinofilik, mitosis dapat ditemukan, tumbuh papilifer, infiltratif diantara dalam stroma j...
Latar belakang Meningioma merupakan tumor jinak intrakranial primer yang dipengaruhi oleh keseimb... more Latar belakang Meningioma merupakan tumor jinak intrakranial primer yang dipengaruhi oleh keseimbangan hormon estrogen dan progesteron. Digit Ratio (2D : 4D) sangat dipengaruhi oleh paparan hormon androgen prenatal khususnya estrogen dan testosteron. Tujuan Mengetahui hubungan reseptor estrogen (ER) dan reseptor progesteron (PR) dengan Digit Ratio (2D : 4D) pada pasien meningioma. Metode Penelitian observasional analitik dengan desain cross sectional study. Jumlah sampel sebesar 25 pasien meningioma yang dilakukan pemeriksaan ER dan PR. Pengukuran Digit Ratio dilakukan di poliklinik dan bangsal bedah syaraf RSUP Dr. Kariadi Semarang. Uji statistik menggunakan uji spearman. Hasil Digit Ratio kanan, kiri dan selisih kanan-kiri dengan nilai rerata 1,0046; 1,0021 dan 0,0492. Uji spearman, hubungan Digit Ratio kanan, Digit Ratio kiri dan Selisih Digit Ratio kanan kiri dengan PR didapatkan masin–masing nilai p = 0,5 (r = 0,1), p = 0,8 ( r = 0,1), dan p = 0,3 (r = 0,2). Hubungan Digit Rati...
Introduction: A periodical database is important including for skin cancer. Periodical registrati... more Introduction: A periodical database is important including for skin cancer. Periodical registration is needed to acknowledge changes in pattern and frequencies of skin lesion. Objective: The purpose of this study was to describe the pattern and the frequency of skin lesion in RSUD Kariadi.Method: A cross-sectional study was conducted through analysis of the medical records of patients diagnosed skin lesion in the pathology labolatory of RSUD Kariadi between 2008 and 2009. The variables were secondary data including age, gender, specimen area, dan histopathology diagnosis. Data was choosen by consecutive sampling from 381 medical records of skin tissues examined at laboratorium of pathology anatomy of Dr. Kariadi general hospital during 2008-2009.Result: 381 cases were recorded comprising of 246 (65%) neoplastic and 135 (35%) non neoplastic lesion. 120 patients presented with skin cancer, and 126 with benign skin lesion. Most malignancy was observed among female patients (62.5%) on a...
Introduction Smoking is one of the most important causes of mortality and morbidity in the world,... more Introduction Smoking is one of the most important causes of mortality and morbidity in the world, as it is related to the risk factor and etiology of respiratory-tract diseases. Long-term smoking causes both structural and functional damage in the respiratory airways, leading to changes in nasal mucociliary clearance (NMC). Objectives The aim of the present study was to look systematically into the current literature and carefully collect and analyze results to explore NMC in smokers. Data Synthesis Two independent reviewers conducted a literature search on some Electronic database: Pubmed, Medline, Ebsco, Springer Link, Science Direct, Scopus, and Proquest searching for articles fulfilling the inclusion and exclusion criteria. The lead author independently assessed the risk of bias of each of the included studies and discussed their assessments with the other two authors to achieve consensus. Of the 1,654 articles identified in the database search, 16 met the criteria for this revi...
Infeksi Helicobacter pylorii (Hp) telah menjadi masalah kesehatan yang mendunia, sebagai penyebab... more Infeksi Helicobacter pylorii (Hp) telah menjadi masalah kesehatan yang mendunia, sebagai penyebab utama gastritis kronik, tukak lambung dan keganasan, akan tetapi mekanismenya dalam menimbulkan gastritis kronik masih belum sepenuhnya dimengerti. Penelitian ini bertujuan untuk mengetahui pengaruh kepadatan kuman Helicobacter spp dan derajad inflamasi terhadap derajat kerusakan histopatologik pada penderita gastritis kronik serta prevalensinya di RSUP dr.Kariadi. Penelitian ini adalah penelitianobservasional dengan pendekatan potong lintang dengan sampel sebanyak 70 slide arsip dari laboratorium Patologi Anatomi RSUP dr.Kariadi mulai 1 Januari 2011 – 31 Desember 2013 yang telah didiagnosis sebagai gastritis kronik disertai kuman Helicobacter spp positif oleh dokter spesialis Patologi Anatomi. Data kepadatan kuman Helicobacter spp, derajat inflamasi dan derajat kerusakan histopatologik gaster dianalisa dengan uji Kruskal Wallis, dilanjutkan dengan uji Mann-Whitney U dan uji korelasi Sp...
Endometriosis ovarium memiliki resiko keganasan epithelial ovarium (resiko relatif 1.9 sampai 4.2... more Endometriosis ovarium memiliki resiko keganasan epithelial ovarium (resiko relatif 1.9 sampai 4.2). Karsinoma endometrioid adalah salah satu jenis keganasan yang paling sering berhubungan dengan endometriosis, sementara karsinoma serosum merupakan keganasan epitelial terbanyak pada ovarium.Serum sitokin pro-inflamasi interleukin-1 (IL-1) β telah ditemukan berperan pada endometriosis dan karsinogenesis.Penelitian Keita, 2010, menemukan bahwa karsinoma endometrioid memiliki kadar IL-1β yang lebih tinggi secara bermakna dibandingkan jenis lainnya. Penelitian ini bertujua untuk mengetahui perbedaan ekspresi IL-1β pada jaringan endometriosis, karsinoma endometrioid dan karsinoma serosum ovarium. Desain penelitian ini adalah cross sectional design. Sampel adalah tiga puluh 33 blok parafin yang telah didiagnosis dan dire-evaluasi sebagai endometriosis (kelompok A), karsinoma endometrioid (kelompok B) dan karsinoma serosum ovarium (kelompok C) dan dilakukan pemeriksaan imunohistokimia IL-1β...
Prevalence of Helicobacter pylori infection in Indonesia was 36-46%. In Jakarta and Surabaya, the... more Prevalence of Helicobacter pylori infection in Indonesia was 36-46%. In Jakarta and Surabaya, the prevalence were 85,7%-93,9%. Helicobacter pylori infection play role in pathogenesis of pectic ulcers, chronic gastritis, carcinoma of gaster and gastric lymphoma. Epidemiologic study showed 80% of carcinoma of gaster related with H pylori infection.This study analyzed expression of anti-Helicobacter pylori in chronic gastritis, precancer lesion , and carcinoma of gaster. This study was a observational descriptive study with case control design. Thirty (30) samples from paraffin bloc that were diagnosed with chronic gastritis, precancer lesion, and carcinoma of gaster at Dokter Kariadi hospital in 2013 was stained by hematoxylin eosin, giemsa and immunohistochemistry of anti-helicobacter pylori. Data was analyzed by descriptive analysis. Thirty (30) samples were diagnosed as gastritis chronis 13 (43,3% ), pra cancer lesion(36.6%), and carcinoma(20.1%). Chronic gastritis can be occurred ...
BackgroundPoor air and mask quality in the work environment increase the risks of inflammation, r... more BackgroundPoor air and mask quality in the work environment increase the risks of inflammation, reactive oxygen species (ROS) production, ongoing oxidative stress, and superoxide dismutase 3 (SOD3) levels in the airways. The study aimed to investigate the effect of the Nephrolepis exaltata - Hibiscus rosa-sinensis (NE-HRS) combination herbal mask on the airways, as measured by ROS and SOD3 levels in the nasal wash of textile industry workers.MethodsThis was a pre- and post-test randomized controlled trial, consisting of 30 subjects with ³5-year working time, conducted for eight weeks and monitored every ten days. Subjects were randomized into 3 groups, regular surgical mask group (n=10), NE-HRS combination herbal mask group (n=10) and factory mask group (n=10). SOD3 and ROS levels were determined using ELISA. Data were analyzed with One-way ANOVA and multiple comparison tests.Results ROS levels decreased significantly in all groups (p=0.004). Regular surgical masks decreased ROS lev...
Latar Belakang: Squamous Cell Carcinoma (SCC) adalah keganasan paling umum dari kepala dan leher ... more Latar Belakang: Squamous Cell Carcinoma (SCC) adalah keganasan paling umum dari kepala dan leher (sekitar 3%), tetapi hanya <1% dari seluruh jenis keganasan (insidensi jarang), yang dibagi menjadi jenis keratinizing dan non-keratinizing. Nonkeratinizing squamous cell carcinoma mempunyai berbagai nama lain, salah satunya Schneiderian carcinoma. Dahulu, Schneiderian carcinoma disebut sebagai Carcinoma Ex-Schneiderian Papilloma (malignant transformation). Atas kelangkaan dan keberagaman penamaan kasus ini, maka penulis tertarik untuk menyajikan kasus ini. Laporan Kasus: Seorang laki-laki 68 tahun datang dengan keluhan utama benjolan di leher kanan. Dilakukan tindakan wide eksisi dan rekontruksi, kemudian dikirimkan sampel untuk pemeriksaan histopatologi, didapatkan gambaran kelompok-kelompok sel epithelial ganas, dengan inti bulat oval, pleomorfik, hiperkromatik, berkromatin kasar, sitoplasma eosinofilik, mitosis dapat ditemukan, tumbuh papilifer, infiltratif diantara dalam stroma j...
Latar belakang Meningioma merupakan tumor jinak intrakranial primer yang dipengaruhi oleh keseimb... more Latar belakang Meningioma merupakan tumor jinak intrakranial primer yang dipengaruhi oleh keseimbangan hormon estrogen dan progesteron. Digit Ratio (2D : 4D) sangat dipengaruhi oleh paparan hormon androgen prenatal khususnya estrogen dan testosteron. Tujuan Mengetahui hubungan reseptor estrogen (ER) dan reseptor progesteron (PR) dengan Digit Ratio (2D : 4D) pada pasien meningioma. Metode Penelitian observasional analitik dengan desain cross sectional study. Jumlah sampel sebesar 25 pasien meningioma yang dilakukan pemeriksaan ER dan PR. Pengukuran Digit Ratio dilakukan di poliklinik dan bangsal bedah syaraf RSUP Dr. Kariadi Semarang. Uji statistik menggunakan uji spearman. Hasil Digit Ratio kanan, kiri dan selisih kanan-kiri dengan nilai rerata 1,0046; 1,0021 dan 0,0492. Uji spearman, hubungan Digit Ratio kanan, Digit Ratio kiri dan Selisih Digit Ratio kanan kiri dengan PR didapatkan masin–masing nilai p = 0,5 (r = 0,1), p = 0,8 ( r = 0,1), dan p = 0,3 (r = 0,2). Hubungan Digit Rati...
Introduction: A periodical database is important including for skin cancer. Periodical registrati... more Introduction: A periodical database is important including for skin cancer. Periodical registration is needed to acknowledge changes in pattern and frequencies of skin lesion. Objective: The purpose of this study was to describe the pattern and the frequency of skin lesion in RSUD Kariadi.Method: A cross-sectional study was conducted through analysis of the medical records of patients diagnosed skin lesion in the pathology labolatory of RSUD Kariadi between 2008 and 2009. The variables were secondary data including age, gender, specimen area, dan histopathology diagnosis. Data was choosen by consecutive sampling from 381 medical records of skin tissues examined at laboratorium of pathology anatomy of Dr. Kariadi general hospital during 2008-2009.Result: 381 cases were recorded comprising of 246 (65%) neoplastic and 135 (35%) non neoplastic lesion. 120 patients presented with skin cancer, and 126 with benign skin lesion. Most malignancy was observed among female patients (62.5%) on a...
Introduction Smoking is one of the most important causes of mortality and morbidity in the world,... more Introduction Smoking is one of the most important causes of mortality and morbidity in the world, as it is related to the risk factor and etiology of respiratory-tract diseases. Long-term smoking causes both structural and functional damage in the respiratory airways, leading to changes in nasal mucociliary clearance (NMC). Objectives The aim of the present study was to look systematically into the current literature and carefully collect and analyze results to explore NMC in smokers. Data Synthesis Two independent reviewers conducted a literature search on some Electronic database: Pubmed, Medline, Ebsco, Springer Link, Science Direct, Scopus, and Proquest searching for articles fulfilling the inclusion and exclusion criteria. The lead author independently assessed the risk of bias of each of the included studies and discussed their assessments with the other two authors to achieve consensus. Of the 1,654 articles identified in the database search, 16 met the criteria for this revi...
Infeksi Helicobacter pylorii (Hp) telah menjadi masalah kesehatan yang mendunia, sebagai penyebab... more Infeksi Helicobacter pylorii (Hp) telah menjadi masalah kesehatan yang mendunia, sebagai penyebab utama gastritis kronik, tukak lambung dan keganasan, akan tetapi mekanismenya dalam menimbulkan gastritis kronik masih belum sepenuhnya dimengerti. Penelitian ini bertujuan untuk mengetahui pengaruh kepadatan kuman Helicobacter spp dan derajad inflamasi terhadap derajat kerusakan histopatologik pada penderita gastritis kronik serta prevalensinya di RSUP dr.Kariadi. Penelitian ini adalah penelitianobservasional dengan pendekatan potong lintang dengan sampel sebanyak 70 slide arsip dari laboratorium Patologi Anatomi RSUP dr.Kariadi mulai 1 Januari 2011 – 31 Desember 2013 yang telah didiagnosis sebagai gastritis kronik disertai kuman Helicobacter spp positif oleh dokter spesialis Patologi Anatomi. Data kepadatan kuman Helicobacter spp, derajat inflamasi dan derajat kerusakan histopatologik gaster dianalisa dengan uji Kruskal Wallis, dilanjutkan dengan uji Mann-Whitney U dan uji korelasi Sp...
Endometriosis ovarium memiliki resiko keganasan epithelial ovarium (resiko relatif 1.9 sampai 4.2... more Endometriosis ovarium memiliki resiko keganasan epithelial ovarium (resiko relatif 1.9 sampai 4.2). Karsinoma endometrioid adalah salah satu jenis keganasan yang paling sering berhubungan dengan endometriosis, sementara karsinoma serosum merupakan keganasan epitelial terbanyak pada ovarium.Serum sitokin pro-inflamasi interleukin-1 (IL-1) β telah ditemukan berperan pada endometriosis dan karsinogenesis.Penelitian Keita, 2010, menemukan bahwa karsinoma endometrioid memiliki kadar IL-1β yang lebih tinggi secara bermakna dibandingkan jenis lainnya. Penelitian ini bertujua untuk mengetahui perbedaan ekspresi IL-1β pada jaringan endometriosis, karsinoma endometrioid dan karsinoma serosum ovarium. Desain penelitian ini adalah cross sectional design. Sampel adalah tiga puluh 33 blok parafin yang telah didiagnosis dan dire-evaluasi sebagai endometriosis (kelompok A), karsinoma endometrioid (kelompok B) dan karsinoma serosum ovarium (kelompok C) dan dilakukan pemeriksaan imunohistokimia IL-1β...
Prevalence of Helicobacter pylori infection in Indonesia was 36-46%. In Jakarta and Surabaya, the... more Prevalence of Helicobacter pylori infection in Indonesia was 36-46%. In Jakarta and Surabaya, the prevalence were 85,7%-93,9%. Helicobacter pylori infection play role in pathogenesis of pectic ulcers, chronic gastritis, carcinoma of gaster and gastric lymphoma. Epidemiologic study showed 80% of carcinoma of gaster related with H pylori infection.This study analyzed expression of anti-Helicobacter pylori in chronic gastritis, precancer lesion , and carcinoma of gaster. This study was a observational descriptive study with case control design. Thirty (30) samples from paraffin bloc that were diagnosed with chronic gastritis, precancer lesion, and carcinoma of gaster at Dokter Kariadi hospital in 2013 was stained by hematoxylin eosin, giemsa and immunohistochemistry of anti-helicobacter pylori. Data was analyzed by descriptive analysis. Thirty (30) samples were diagnosed as gastritis chronis 13 (43,3% ), pra cancer lesion(36.6%), and carcinoma(20.1%). Chronic gastritis can be occurred ...
Uploads
Papers by udadi sadhana