Sugarcane bagasse is an inexpensive and eco-friendly natural biosorbent for the removal of variou... more Sugarcane bagasse is an inexpensive and eco-friendly natural biosorbent for the removal of various organic pollutants. The adsorption of Remazol Brilliant Violet-5R (RBV-5R) dye on sugarcane bagasse (SCB) was studied. Biosorbent was characterized using EDX and FTIR. The effect of various experimental parameters, such as pH, biosorbent dosage, initial dye concentration, contact time, adsorption with shaking and without shaking, and the temperature, was optimized. At pH 6, maximum biosorption of 92.22% was achieved using 0.15 g of SCB. The equilibrium was attained within 30–40 min for the removal of RBV-5R. The initial dye concentration of 10 µg/mL was determined as an optimum concentration for maximum removal of RBV-5R at 30 °C. Langmuir and Freundlich adsorption isotherms were applied, and it was found that the biosorption of RBV-5R follows Freundlich adsorption isotherms. Kinetic studies were also carried out and it was found that the proposed method followed the pseudo-second-orde...
Through current phytochemical investigation on dichloromethane (DCM) fraction of 80% methanolic e... more Through current phytochemical investigation on dichloromethane (DCM) fraction of 80% methanolic extract of Tricholepis eburnea, seven chemical constituents were isolated and their structures were elucidated by spectroscopic analyses. Two of them were identified as new flavonoids as trichonoide A (1) and trichonoide B (2), while the other five known constituents β-sitosterol (3), 3-O-acetyl-β-stigmastanol (4), 3β,17β,20trihydroxy-l-oxo-(20R, 22R)-witha-5,14,24-trienolide (5), pectolinaringenin (6), and dillenetin (7) were isolated for the first time from this species.
This review sums up recent developments in the syntheses, anti-inflammatory activities, and struc... more This review sums up recent developments in the syntheses, anti-inflammatory activities, and structure–activity relationship (SAR) studies of pyrimidine derivatives.
Nebrodenside A was isolated from the plant Dodonaea viscosa and its chemical structure was elucid... more Nebrodenside A was isolated from the plant Dodonaea viscosa and its chemical structure was elucidated by spectroscopic methods. Molecular docking simulation predicted its strong ability to be tested as a potential anti-inflammatory compound. Carrageen-induced paw model and formalin test were utilized for the assessment of anti-inflammatory and analgesic potential. Nebrodenside A was found to be significantly active in reducing inflammation, when compared with diclofenac as a standard drug. Similarly, the compound also possesses substantial analgesic activity in the formalin-induced writhing test. Thus, nebrodenside A revealed a robust potential to be developed as a possible leading medicinal agent for better management of pain and inflammation.
Plant based materials are considered to have broad applications in the remediation of toxic mater... more Plant based materials are considered to have broad applications in the remediation of toxic materials. In this report, we present an environmental friendly and economic Cicer arietinum, named as (CP) supported for the synthesis of Ni nanoparticles (NPs) designated as Ni@CP. The in situ Ni@CP NPs were obtained using aqueous medium in the presence of sodium borohydride (NaBH4) as a reducing agent. The prepared catalysts were applied for the hydrogenation/degradation of p-nitrophenol (PNP), o-nitrophenol (ONP), and 2,4-dinitrophenol (DNP), as well as congo red (CR), methyl orange (MO), methylene blue (MB) and rhodamine B (RB) dyes. The amount of total metal ions adsorbed onto the CP was evaluated by flame atomic absorption spectroscopy. The Ni@CP catalyst was characterized through PXRD, FTIR, FESEM and EDX analyses.
Eburneolins A (1) and B (2), new withanolide glucosides, have been isolated from the n-butanolic ... more Eburneolins A (1) and B (2), new withanolide glucosides, have been isolated from the n-butanolic fraction of the 75% methanolic extract of aerial parts of Tricholepis eburnea. Their structures were elucidated through spectroscopic analysis including ESI-MS, 2D NMR and acid hydrolysis.
Trichosides A (1) and B (2), new withanolide glucosides, have been isolated from the n-butanolic ... more Trichosides A (1) and B (2), new withanolide glucosides, have been isolated from the n-butanolic fraction of the 75% methanolic extract of aerial parts of Tricholepis eburnea. Their structures were elucidated through spectroscopic analysis including ESI-MS, 2D NMR and acid hydrolysis.
Phytochemical investigation of the whole plant of Marrubium vulgare L., led to the isolation of t... more Phytochemical investigation of the whole plant of Marrubium vulgare L., led to the isolation of three new secondary metabolites, 11-oxomarrubiin (1), vulgarcoside A (2) and 3-hydroxyapigenin-4′- O-(6″- O- p-coumaroyl)-β-D-glucopyranoside (3), along with four known constituents 4–7 from the polar fractions of the methanolic extract. The structures of all compounds were deduced on the basis of NMR data and HRESI-MS measurements. The new constituents 1–3 exhibited moderate to low level of inhibition on nitric oxide (NO) production. The compound 2 also showed a moderate inhibition on pro-inflammatory cytokine TNF-α. The new constituents 1–3 showed no inhibitory effect on Reactive Oxygen Species (ROS) production.
Sugarcane bagasse is an inexpensive and eco-friendly natural biosorbent for the removal of variou... more Sugarcane bagasse is an inexpensive and eco-friendly natural biosorbent for the removal of various organic pollutants. The adsorption of Remazol Brilliant Violet-5R (RBV-5R) dye on sugarcane bagasse (SCB) was studied. Biosorbent was characterized using EDX and FTIR. The effect of various experimental parameters, such as pH, biosorbent dosage, initial dye concentration, contact time, adsorption with shaking and without shaking, and the temperature, was optimized. At pH 6, maximum biosorption of 92.22% was achieved using 0.15 g of SCB. The equilibrium was attained within 30–40 min for the removal of RBV-5R. The initial dye concentration of 10 µg/mL was determined as an optimum concentration for maximum removal of RBV-5R at 30 °C. Langmuir and Freundlich adsorption isotherms were applied, and it was found that the biosorption of RBV-5R follows Freundlich adsorption isotherms. Kinetic studies were also carried out and it was found that the proposed method followed the pseudo-second-orde...
Through current phytochemical investigation on dichloromethane (DCM) fraction of 80% methanolic e... more Through current phytochemical investigation on dichloromethane (DCM) fraction of 80% methanolic extract of Tricholepis eburnea, seven chemical constituents were isolated and their structures were elucidated by spectroscopic analyses. Two of them were identified as new flavonoids as trichonoide A (1) and trichonoide B (2), while the other five known constituents β-sitosterol (3), 3-O-acetyl-β-stigmastanol (4), 3β,17β,20trihydroxy-l-oxo-(20R, 22R)-witha-5,14,24-trienolide (5), pectolinaringenin (6), and dillenetin (7) were isolated for the first time from this species.
This review sums up recent developments in the syntheses, anti-inflammatory activities, and struc... more This review sums up recent developments in the syntheses, anti-inflammatory activities, and structure–activity relationship (SAR) studies of pyrimidine derivatives.
Nebrodenside A was isolated from the plant Dodonaea viscosa and its chemical structure was elucid... more Nebrodenside A was isolated from the plant Dodonaea viscosa and its chemical structure was elucidated by spectroscopic methods. Molecular docking simulation predicted its strong ability to be tested as a potential anti-inflammatory compound. Carrageen-induced paw model and formalin test were utilized for the assessment of anti-inflammatory and analgesic potential. Nebrodenside A was found to be significantly active in reducing inflammation, when compared with diclofenac as a standard drug. Similarly, the compound also possesses substantial analgesic activity in the formalin-induced writhing test. Thus, nebrodenside A revealed a robust potential to be developed as a possible leading medicinal agent for better management of pain and inflammation.
Plant based materials are considered to have broad applications in the remediation of toxic mater... more Plant based materials are considered to have broad applications in the remediation of toxic materials. In this report, we present an environmental friendly and economic Cicer arietinum, named as (CP) supported for the synthesis of Ni nanoparticles (NPs) designated as Ni@CP. The in situ Ni@CP NPs were obtained using aqueous medium in the presence of sodium borohydride (NaBH4) as a reducing agent. The prepared catalysts were applied for the hydrogenation/degradation of p-nitrophenol (PNP), o-nitrophenol (ONP), and 2,4-dinitrophenol (DNP), as well as congo red (CR), methyl orange (MO), methylene blue (MB) and rhodamine B (RB) dyes. The amount of total metal ions adsorbed onto the CP was evaluated by flame atomic absorption spectroscopy. The Ni@CP catalyst was characterized through PXRD, FTIR, FESEM and EDX analyses.
Eburneolins A (1) and B (2), new withanolide glucosides, have been isolated from the n-butanolic ... more Eburneolins A (1) and B (2), new withanolide glucosides, have been isolated from the n-butanolic fraction of the 75% methanolic extract of aerial parts of Tricholepis eburnea. Their structures were elucidated through spectroscopic analysis including ESI-MS, 2D NMR and acid hydrolysis.
Trichosides A (1) and B (2), new withanolide glucosides, have been isolated from the n-butanolic ... more Trichosides A (1) and B (2), new withanolide glucosides, have been isolated from the n-butanolic fraction of the 75% methanolic extract of aerial parts of Tricholepis eburnea. Their structures were elucidated through spectroscopic analysis including ESI-MS, 2D NMR and acid hydrolysis.
Phytochemical investigation of the whole plant of Marrubium vulgare L., led to the isolation of t... more Phytochemical investigation of the whole plant of Marrubium vulgare L., led to the isolation of three new secondary metabolites, 11-oxomarrubiin (1), vulgarcoside A (2) and 3-hydroxyapigenin-4′- O-(6″- O- p-coumaroyl)-β-D-glucopyranoside (3), along with four known constituents 4–7 from the polar fractions of the methanolic extract. The structures of all compounds were deduced on the basis of NMR data and HRESI-MS measurements. The new constituents 1–3 exhibited moderate to low level of inhibition on nitric oxide (NO) production. The compound 2 also showed a moderate inhibition on pro-inflammatory cytokine TNF-α. The new constituents 1–3 showed no inhibitory effect on Reactive Oxygen Species (ROS) production.
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