Gabapentin is a γ-aminobutyric acid (GABA) analogue, with GABAmimetic pharmacological properties.... more Gabapentin is a γ-aminobutyric acid (GABA) analogue, with GABAmimetic pharmacological properties. Gabapentin is used for the treatment of seizures, anxiety and neuropathic pain. It has been proposed that gabapentin may be useful in the treatment of cocaine dependence. However, clinical trials with gabapentin have shown conflicting results, while preclinical studies are sparse. In the present study, we investigated the effects
A one-pot procedure for the preparation of ammonia borane from trimethyl borate in 90% yield and ... more A one-pot procedure for the preparation of ammonia borane from trimethyl borate in 90% yield and >99% purity has been reported. This methodology has been modified to prepare a series of trialkylamine-boranes in 70-82% yields from trimethyl borate and lithium hydride/aluminum chloride in the presence of the corresponding trialkylamine.
Ammonia borane (AB) is emerging as a promising solid hydrogen carrier, particularly for power gen... more Ammonia borane (AB) is emerging as a promising solid hydrogen carrier, particularly for power generation in portable devices that employ proton-exchange membrane fuel cells. A preparative-scale synthesis of AB from sodium borohydride and ammonium salts in high yields (> or =95%) and very high purity (> or =98%) has been described. The first systematic study of a transitional metal-catalyzed alcoholysis of AB, comparison of the methanolysis to the hydrolysis of AB, and regeneration of AB from ammonium tetramethoxyborate also has been described.
Gabapentin is a γ-aminobutyric acid (GABA) analogue, with GABAmimetic pharmacological properties.... more Gabapentin is a γ-aminobutyric acid (GABA) analogue, with GABAmimetic pharmacological properties. Gabapentin is used for the treatment of seizures, anxiety and neuropathic pain. It has been proposed that gabapentin may be useful in the treatment of cocaine dependence. However, clinical trials with gabapentin have shown conflicting results, while preclinical studies are sparse. In the present study, we investigated the effects
A one-pot procedure for the preparation of ammonia borane from trimethyl borate in 90% yield and ... more A one-pot procedure for the preparation of ammonia borane from trimethyl borate in 90% yield and >99% purity has been reported. This methodology has been modified to prepare a series of trialkylamine-boranes in 70-82% yields from trimethyl borate and lithium hydride/aluminum chloride in the presence of the corresponding trialkylamine.
Ammonia borane (AB) is emerging as a promising solid hydrogen carrier, particularly for power gen... more Ammonia borane (AB) is emerging as a promising solid hydrogen carrier, particularly for power generation in portable devices that employ proton-exchange membrane fuel cells. A preparative-scale synthesis of AB from sodium borohydride and ammonium salts in high yields (> or =95%) and very high purity (> or =98%) has been described. The first systematic study of a transitional metal-catalyzed alcoholysis of AB, comparison of the methanolysis to the hydrolysis of AB, and regeneration of AB from ammonium tetramethoxyborate also has been described.
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