Papers by nihal hatipoğlu
The Journal of Pediatric Academy, 2021
In childhood and adolescence cancers; survival rates increase with the use of treatment options s... more In childhood and adolescence cancers; survival rates increase with the use of treatment options such as chemotherapy, radiotherapy and hematopoietic stem cell transplantation. One of the long-term effects of primary disease and cancer treatment is the irreversible damage to gonadal tissues, resulting in impaired fertility. Especially chemotherapeutic drugs; causes germ cell defect, affects the secretion of pituitary hormone, and also damages the anatomical structures of internal genital structures such as the uterus. Gonadal preservation methods are limited in prepubertal male patients. It is a good option to place the testicles in a different area before radiotherapy. Before chemotherapy or whole body irradiation, freezing of testicular tissue and ensuring pregnancy from frozen tissue is still in the experimental stage. After the ejaculation begins, obtaining and storing sperm is successfully done. A limited number of pregnancies were obtained oocytes frozen ovaries in the prepuber...
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Journal of Pediatric Endocrinology and Metabolism
Objectives Coronavirus disease 2019 has caused a major epidemic worldwide, and lockdowns became n... more Objectives Coronavirus disease 2019 has caused a major epidemic worldwide, and lockdowns became necessary in all countries to prevent its spread. This study aimed to evaluate the effects of staying-at-home practices on the metabolic control of children and adolescents with type 1 diabetes during the pandemic period. Materials and Methods Eighty-nine patients younger than 18 years old who were diagnosed with type 1 diabetes at least one year before the declaration of the pandemic were included in the study. The last visit data of the patients before and after the declaration of the pandemic, and the frequency of presentation of diabetes-related emergencies from one year after diagnosis of type 1 diabetes to the declaration of the pandemic, and from the declaration of the pandemic to the last visit after the pandemic declaration were compared. Results The total number of patients was 89, and 48 (53.9%) were boys. The mean (± standard deviation [SD]) age at diagnosis was 8.4 ± 3.7 year...
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Güncel Pediatri
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Güncel Pediatri
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Archives of Psychiatric Nursing
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The Turkish Journal of Pediatrics
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Pediatric Pulmonology
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Journal of Nutrition and Dietetics
Amaç: Artmış diyet kalitesi, Tip 1 Diabetes Mellitus’ta (T1DM) iyi bir metabolik kontrol ve azalm... more Amaç: Artmış diyet kalitesi, Tip 1 Diabetes Mellitus’ta (T1DM) iyi bir metabolik kontrol ve azalmış komplikasyon riski ile ilişkili olabilirken, günümüzde sıkça tüketilen Batı tarzı diyetlerin düşük diyet kalitesi ve yüksek diyet asit yüküne sahip olduğu gösterilmiştir. Bu araştırmada, T1DM’li çocuk ve adölesanların diyet kalitesi ve asit yükünün saptanması ve bu parametrelerin metabolik kontrol ile ilişkisinin değerlendirilmesi amaçlanmıştır. Bireyler ve Yöntem: Araştırmaya, 8-18 yaş arasında 75 T1DM’li ve 88 sağlıklı birey dahil edilmiş ve tüm katılımcıların antropometrik ölçümleri yapılmıştır. Diyet kalitesinin ve asit yükünün saptanabilmesi için 24 saatlik geriye dönük besin tüketim kaydı alınmıştır. Diyet kalitesi, Sağlıklı Yeme İndeksi (SYİ)-2015 ve Türkiye Beslenme Rehberi’ne (TÜBER) göre revize edilen SYİ-2015 ile değerlendirilmiştir. Diyet asit yükünün tahmini ise potansiyel renal asit yükü (PRAL) değeri ve net endojen asit üretimi (NEAP) skoru hesaplanarak yapılmıştır. Met...
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Journal of Clinical Research in Pediatric Endocrinology
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Journal of Clinical Research in Pediatric Endocrinology
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The Turkish Journal of Pediatrics
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Journal of Clinical Research in Pediatric Endocrinology
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Journal of clinical research in pediatric endocrinology, Jan 14, 2018
Congenital adrenal hyperplasia (CAH) is the most common form of primary adrenal insufficiency in ... more Congenital adrenal hyperplasia (CAH) is the most common form of primary adrenal insufficiency in children. Neonatal screening for CAH is effective in detecting the salt-wasting form and reducing mortality. To estimate incidence of CAH in Turkey and to assess the characteristics and efficacy of the adopted newborn CAH screening strategy. A pilot newborn CAH screening study was carried out under the authority of Turkish Directorate of Public Health. Newborn babies ≥32 gestational weeks and ≥1500 gr birth weight from four cities between March 27- September 15, 2017 were included. Screening protocol included one sample two-tier testing. In the first step, 17α-hydroxyprogesterone (17-OHP) was measured by fluoroimmunoassay in dried blood spots obtained at 3-5th days of life. The cases with positive initial screening were tested by steroid profiling in dried blood spots using liquid chromatography-tandem mass spectrometry method to measure 17-OHP, 21-deoxycortisol, cortisol, 11-deoxycortis...
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Journal of clinical research in pediatric endocrinology, Jan 29, 2018
İnsulin is an important hormone for intrauterine growth, irisin is also an effective myokine in t... more İnsulin is an important hormone for intrauterine growth, irisin is also an effective myokine in the regulation of physiological insulin resistance in pregnancy. Leptin and insulin are associated with fetal growth and adiposity. In this study, we aimed to investigate the relationship between irisin, insulin and leptin levels and maternal weight gain, newborn anthropometric measurements. Eighty-four mothers and newborns were included in the study. Irisin, leptin and insulin levels were measured in the mother and baby cord blood. The anthropometric measurements of the newborn, the final weight of the mother, the weight at the beginning of the pregnancy were recorded. Birth weight were classified as small for gestational age (SGA), appropriate for gestational age (AGA), and large for gestational age (LGA). There was no difference in irisin between the groups. However, in infants, leptin and insulin levels were significantly changed according to birth weight (p: 0.013, 0.012; respectivel...
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Journal of clinical research in pediatric endocrinology, Jan 9, 2018
Hypopituitarism is defined as a decreased release of hypophysis hormones, which may be caused by ... more Hypopituitarism is defined as a decreased release of hypophysis hormones, which may be caused by pituitary gland disease or hypothalamus disease. Clinical findings for neonatal hypopituitarism depend on causes and hormonal deficiency type and degree. Patients may be asymptomatic or may demonstrate non-specific symptoms, but may still be under risk for development of hypophysis hormone deficiency with time. Anamnesis, physical examination, endocrinological, radiological and genetic evaluations are all important for early diagnosis and treatment. Treatment of hypopituitarism patients is possible through treatment of hypophysis and hypothalamus disorders. The aim of this article is to contribute to the literature through a review of etiological factors, clinical findings, diagnoses and treatment approaches for neonatal hypopituitarism.
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Journal of clinical research in pediatric endocrinology, Jan 22, 2017
Backgroud Metabolic impairment in Type 1 Diabetes Mellitus (DM) with poor glycemic control causes... more Backgroud Metabolic impairment in Type 1 Diabetes Mellitus (DM) with poor glycemic control causes insulin resistance, Non-Alcoholic Fatty Liver Disease (NAFLD) and atherosclerosis; thus, increased Carotid-intima media thickness (CIMT). The Fetuin-A has protective effect in cardiovascular disorders, which is increased in hepatosteatosis. We aimed to investigate reliability of Fetuin-A levels in early detection of diabetic complications in children with T1DM and to identify a cut-off value that may show poor metabolic control. The study included 80 patients who had T1DM for at least 5 years but not chronic complication or auto-immune disorder. Blood samples were drawn to measure HbA1c, biochemical parameters and Fetuin-A. Anthropometric parameters and percent body fat analysis were measured. Hepatosteatosis and CIMT were assessed by sonography. The patients mean age was 13.5 years. Grade 1 hepatosteatosis was detected in 10%. Patients were stratified into 2 groups based on presence of...
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Turkiye Klinikleri Journal of Pediatrics, 2009
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Turkiye Klinikleri Journal of Pediatrical Sciences, 2008
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Turkiye Klinikleri Journal of Pediatrical Sciences, 2007
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Papers by nihal hatipoğlu