This paper presents a general and systematic approach to address decisions in the design and oper... more This paper presents a general and systematic approach to address decisions in the design and operation of offshore oilfields. The approach is based on the formulation of mathematical models that are formulated to accommodate multiple production profiles. The profiles can be used to assess either the best strategy or, instead, possible implications in changing policies during the operation. The work decomposes the problem in two stages: the determination of the optimum drilling centre and the determination of the optimum drilling schedule to meet a specified production profile. The proposed method simultaneously addresses and optimizes the operation of the main production facility and an arbitrary number of satellite fields. Fields and wells are selected to give the overall lowest CAPEX for the development. The method is an improvement over previous work and provides a full optimisation of life-cycle drilling costs.
... Contents Foreword Congressman John Lewis xiii Introduction Chester Hartman xv Part 1. Integra... more ... Contents Foreword Congressman John Lewis xiii Introduction Chester Hartman xv Part 1. Integration Civil Rights, Now and Then Julian Bond 3 ... Kairys 171 New Means for Political Empowerment: Proportional Voting Douglas J. Amy, Fred McBride, and Robert Richie 176 Race ...
Abstract Cerebral malaria is a major form of complicated malaria consequent upon cerebral damage ... more Abstract Cerebral malaria is a major form of complicated malaria consequent upon cerebral damage associated with endothelial cell necrosis. We have used assays of Plasmodium falciparum growth inhibition in vitro to study serum inhibitory factors in patients with cerebral malaria. Serum from children with cerebral malaria inhibited parasite growth in a non-synchronised 72-hour assay to a greater extent than did sera from immune adults or asymptomatic children (p < 0.001). The high level of non-specific inhibition of parasite growth was particularly evident when sera were tested against three P. falciparum isolates, and contrasted with the inhibitory effect of sera from non-malaria febrile controls. In this study, serum from patients with cerebral malaria was more inhibitory than serum from the other groups (p < 0.001) and its between-isolate variation, when tested against a panel of P. falciparum isolates in growth assays, was significantly less than that of the other groups tested (p < 0.005). These results are consistent with the hypothesis of toxin-induced endothelial cell damage, with the sequence of pathogenic events involving host-derived serum factors capable of damaging P. falciparum.
This paper presents a general and systematic approach to address decisions in the design and oper... more This paper presents a general and systematic approach to address decisions in the design and operation of offshore oilfields. The approach is based on the formulation of mathematical models that are formulated to accommodate multiple production profiles. The profiles can be used to assess either the best strategy or, instead, possible implications in changing policies during the operation. The work decomposes the problem in two stages: the determination of the optimum drilling centre and the determination of the optimum drilling schedule to meet a specified production profile. The proposed method simultaneously addresses and optimizes the operation of the main production facility and an arbitrary number of satellite fields. Fields and wells are selected to give the overall lowest CAPEX for the development. The method is an improvement over previous work and provides a full optimisation of life-cycle drilling costs.
... Contents Foreword Congressman John Lewis xiii Introduction Chester Hartman xv Part 1. Integra... more ... Contents Foreword Congressman John Lewis xiii Introduction Chester Hartman xv Part 1. Integration Civil Rights, Now and Then Julian Bond 3 ... Kairys 171 New Means for Political Empowerment: Proportional Voting Douglas J. Amy, Fred McBride, and Robert Richie 176 Race ...
Abstract Cerebral malaria is a major form of complicated malaria consequent upon cerebral damage ... more Abstract Cerebral malaria is a major form of complicated malaria consequent upon cerebral damage associated with endothelial cell necrosis. We have used assays of Plasmodium falciparum growth inhibition in vitro to study serum inhibitory factors in patients with cerebral malaria. Serum from children with cerebral malaria inhibited parasite growth in a non-synchronised 72-hour assay to a greater extent than did sera from immune adults or asymptomatic children (p < 0.001). The high level of non-specific inhibition of parasite growth was particularly evident when sera were tested against three P. falciparum isolates, and contrasted with the inhibitory effect of sera from non-malaria febrile controls. In this study, serum from patients with cerebral malaria was more inhibitory than serum from the other groups (p < 0.001) and its between-isolate variation, when tested against a panel of P. falciparum isolates in growth assays, was significantly less than that of the other groups tested (p < 0.005). These results are consistent with the hypothesis of toxin-induced endothelial cell damage, with the sequence of pathogenic events involving host-derived serum factors capable of damaging P. falciparum.
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