Diazinon is the most commonly used pesticide in Indonesia. It may increase the production of free... more Diazinon is the most commonly used pesticide in Indonesia. It may increase the production of free radicals that triggers the lipid peroxidation process which will produce the final product, MDA, which can damage cells and tissues, especially the kidneys. Neem gum with its high polysaccharide is a good antioxidant agent to neutralize free radicals. The purpose of this study was to determine the effect of neem gum administration to prevent the increase in kidney MDA levels of wistar rats induced by diazinon. Thirty wistar rats were divided into 6 groups, K0 (given cornoil), K1 (induced DZN 40 mg/kgBW), groups P1, P2, P3, and P4, administered with neem gum as a drinking water at a dose 3.75 g/kgBW, 7.5 g/kgBW, 15 g/kgBW, and 30 g/kgBW and induced by DZN 40 mg/kgBW. The treatment was carried out for 8 days, in which diazinon induction and neem gum solution were administered simultaneously. The average renal MDA levels are K0=20.85±1.10; K1=26.98±5.87; P1=26.84±3.75; P2=21.43±3.44; P3=20...
Background: Kyphosis is vertebrae disorder characterized with increased of vertebrae curve in sa... more Background: Kyphosis is vertebrae disorder characterized with increased of vertebrae curve in sagital line of 40o Cobb angle. Kyphosis is caused by degenerative proces,, neuromuscular disease, tumor, trauma, congenital abnormalities and unergonomic posture at the moment of carriying weights. One of kyphosis risk factor is excessive weights on the back in long duration. The complication of kyphosis such as vertebrae compression fracture could cause pain and deformities. Objective: Purpose of this research is to describe the correlation between workload level in carrier workers towards kyphosis at Tanjung Market, Jember. Methods: This research was observational analitic, cross sectional method, and total sampling. The respondents were 32 male carrier workers and 32 controls.. Data was obtained by interview and Cobb angle measurement on 1st and 12th thoracal vertebrae using inclinometer. Statistical test was done by Spearman correlation test. Results: The data analysis showed that p v...
ABSTRAK Kanker merupakan penyebab kematian utama di seluruh dunia. Kemoterapi doxorubicin sering ... more ABSTRAK Kanker merupakan penyebab kematian utama di seluruh dunia. Kemoterapi doxorubicin sering digunakan dalam pengobatan kanker, namun sebanding dengan efektifitasnya doxo-rubicin memiliki banyak efek samping, salah satunya doxorubicin dapat mengakibatkan kerusakan ginjal melalui proses interstitial fibrosis. Pemanfaatan ekstrak bawang kucai (Allium tuberosum) sebagai ko kemoterapi untuk mengurangi keruskan ginjal akibat doxo-rubicin merupakan peluang yang prospektif. Penelitian ini bertujuan untuk mencari efek nefroprotektif ekstrak bawang kucai terhadap kadar BUN dan kreatinin tikus wistar yang diinduksi doxorubicin. Metode yang digunakan dalam penelitian adalah quasi experimental design dengan randomized post test only controlled grup. Hasil penelitian menunjukkan bahwa ekstrak bawang kucai dapat menurunkan kadar BUN dan kreatinin (p<0,05) pada kelompok yang hanya diinduksi doxorubicin. Dapat disimpulkan bahwa terdapat efek nefroprotektif dalam ekstrak bawang kucai pada tik...
Journal of Agromedicine and Medical Sciences, 2020
Soil-Transmitted Helmithiasis is an infection caused by intestinal nematode worms which in the pr... more Soil-Transmitted Helmithiasis is an infection caused by intestinal nematode worms which in the process of transmission requires soil as media to fullfil its life cycle from non-infective forms to infective forms. The number of infections is influenced by personal hygiene. Personal hygiene consists of the habit of washing hands, cutting nails, eating, defecating and ownership of latrines, and the use of personal protective equipment. This study used a cross sectional research design conducted at Widodaren Plantation with 68 people of samples. Stool examination was determined by kato-katz method, sedimentation, and floatation to detect the presence of Soil-Transmitted Helminth (STH) eggs, while personal hygiene was assessed using questionnaires. Questionnaire and stool examination datas were processed using SPSS data analysis with chi-square method. The results of this study found 26 respondents who were positive for soil-trasmitted helminthiasis infection. The most frequent worm spec...
Acute appendicitis is one of the most common causes of surgery worldwide. Appendectomy is a skept... more Acute appendicitis is one of the most common causes of surgery worldwide. Appendectomy is a skeptical surgical intervention associated with the risk of Surgical Site Infection (SSI). The purpose of this analysis was to describe the relationship between delayed appendectomy in acute appendicitis and the incidence of SSI. Reviewers selected articles containing data on the incidence of SSI due to appendectomy delays for 3 to 48 hours from seven databases, namely Pubmed, Nature, SpringerLink, Science Direct, ProQuest, Oxford Open Access Journal, and Cochrane Library. The data source was secondary data from international articles published in 2011 to 2020 based on the PICO criteria. The data obtained were then grouped and synthesized without meta-analysis/Synthesis Without Metaanalysis (SWiM) descriptively. A total of 2,778 articles were collected, of which 24 studies met the inclusion criteria. A total of 4 articles showed an association between appendectomy delay and SSI while the othe...
Jellyfish is one of the animals that is responsible for poisoning in human. The poisoning jellyfi... more Jellyfish is one of the animals that is responsible for poisoning in human. The poisoning jellyfish commonly found is Physalia utriculus. Jellyfish poison is potential to cause hemolysis on blood. The purpose of this study was to determine the influence of jellyfish (Physalia utriculus) poisoning induction toward the oxygenation function of the male mice erythrocytes. The method was true experimental design with post test only control group design. Eight male mice were devided into two groups: control and treatment groups with a dose of jellyfish poison 30 mg/kgBW. The observation was conducted by using a pulse oxymeter. The result showed average level of oxygen saturation in the control group minute 0; 15; 30; 60; 120; 240; 480; 720; 1440 were 55%; 54%; 63,75%; 70%; 65,25%; 67,5%; 65,75%; 72%; 55%, respectively. While in the treatment group were 61,25%; 62,75%; 59,75%; 58,5%; 51,75%; 58%; 57%; 75,75%; 47%, respectively. The statistical bivariate correlation test has a correlation c...
Journal of Agromedicine and Medical Sciences, 1970
Coronary heart disease (CHD) is the cause of 7,3 million death globally in 2008. The main pathoph... more Coronary heart disease (CHD) is the cause of 7,3 million death globally in 2008. The main pathophysiology process that leads to CHD is atherosclerosis which is caused by high LDL cholesterol level. The aim of this study was to explore bay leaf and celery leaf infusion effect on reducing LDL cholesterol level in dyslipidemic rat model. The type of this study was true experimental research using wistar rat (Rattus novergicus) as the sample. The rats were induced by high fat diet and PTU for two weeks then each of the group were given either bay leaf infusion, celery leaf infusion, simvastatin (positive control), or aquadest (negative control) for a week. The measurement of LDL level used Friedewald formulation. Data was analyzed using paired sample t test and one way ANOVA. As the result there was a significance reduction on LDL level after treatment with bay leaf (p=0,013) and celery leaf infusion (p=0,035) but there was no significance difference between groups (p=0,293). It was con...
P hysalia physalis adalah salah satu jenis ubur-ubur beracun yang dapat menimbulkan dyspnea setel... more P hysalia physalis adalah salah satu jenis ubur-ubur beracun yang dapat menimbulkan dyspnea setelah tersengat . Hal ini menunjukkan adanya efek pneumotoxic toksin Physalia physalis . Penelitian ini bertujuan untuk mengetahui efek pneumotoxic protein toksin ubur-ubur Physalia physalis secara i n vivo pada tikus Wistar . Penelitian menggunakan sampel tikus galur Wistar jantan dengan berat rata-rata 150 gram dengan 1 kelompok kontrol (K) dan 3 kelompok perlakuan (P), masing-masing kelompok terdiri atas 6 ekor tikus. Kelompok K diinjeksi dengan larutan PZ; P1, P2 dan P3 masing-masing diinjeksi protein toksin ubur-ubur Physalia physalis dengan dosis 10 mg/KgBB, 20 mg/KgBB dan 30 mg/KgBB. Setelah 6 jam organ paru-paru tikus diambil dan direndam dengan formalin 10% dan dilakukan pembuatan preparat histologi, kemudian dilakukan pengamatan secara mikroskopik dan ditentukan tingkat perubahan histopatologi paru-paru dengan menggunakan skor. Hasil penelitian menunjukkan terjadinya perubahan his...
e-Jurnal Pustaka Kesehatan, vol. 4 (no. 2), Mei 2016 222 Pulmonary tuberculosis is a respiratory ... more e-Jurnal Pustaka Kesehatan, vol. 4 (no. 2), Mei 2016 222 Pulmonary tuberculosis is a respiratory infection disease caused by Mycobacterium tuberculosis infection in lung tissue. Mycobacterium tuberculosis could inhibit macrophage activation by inducing an increase of SOCS1 which can inhibit IFN-γ signaling process. Meanwhile, IFN-γ production continues as long as Mycobacterium tuberculosis still exist, so the IFN-γ levels stay high. This study aimed to investigate the effect of albumin snakehead fish (Chana striata) extract to decrease IFN-γ level. The study design was a quasy experimental design. The study subject was 24 tuberculosis patients during intensive phase medication, were divided into 2 groups. Experimental group was given 1500 mg/day albumin snakehead fish (Chana striata) extract while control group was placebo for 30 days. This study showed that albumin snakehead fish (Chana striata) extraxt can decrease significanly IFN-γ levels in the experimental group (p=0.006) but ...
Pulmonary tuberculosis is a respiratory infection disease caused by Mycobacterium tuberculosis in... more Pulmonary tuberculosis is a respiratory infection disease caused by Mycobacterium tuberculosis infection in lung tissue. Mycobacterium tuberculosis could inhibit macrophage activation by inducing an increase of SOCS1 which can inhibit IFN-γ signaling process. Meanwhile, IFN-γ production continues as long as Mycobacterium tuberculosis still exist, so the IFN-γ levels stay high. This study aimed to investigate the effect of albumin snakehead fish (Chana striata) extract to decrease IFN-γ level. The study design was a quasy experimental design. The study subject was 24 tuberculosis patients during intensive phase medication, were divided into 2 groups. Experimental group was given 1500 mg/day albumin snakehead fish (Chana striata) extract while control group was placebo for 30 days. This study showed that albumin snakehead fish (Chana striata) extraxt can decrease significanly IFN-γ levels in the experimental group (p=0.006) but not statistically signicant if compared with the decrease...
Diazinon is the most commonly used pesticide in Indonesia. It may increase the production of free... more Diazinon is the most commonly used pesticide in Indonesia. It may increase the production of free radicals that triggers the lipid peroxidation process which will produce the final product, MDA, which can damage cells and tissues, especially the kidneys. Neem gum with its high polysaccharide is a good antioxidant agent to neutralize free radicals. The purpose of this study was to determine the effect of neem gum administration to prevent the increase in kidney MDA levels of wistar rats induced by diazinon. Thirty wistar rats were divided into 6 groups, K0 (given cornoil), K1 (induced DZN 40 mg/kgBW), groups P1, P2, P3, and P4, administered with neem gum as a drinking water at a dose 3.75 g/kgBW, 7.5 g/kgBW, 15 g/kgBW, and 30 g/kgBW and induced by DZN 40 mg/kgBW. The treatment was carried out for 8 days, in which diazinon induction and neem gum solution were administered simultaneously. The average renal MDA levels are K0=20.85±1.10; K1=26.98±5.87; P1=26.84±3.75; P2=21.43±3.44; P3=20...
Background: Kyphosis is vertebrae disorder characterized with increased of vertebrae curve in sa... more Background: Kyphosis is vertebrae disorder characterized with increased of vertebrae curve in sagital line of 40o Cobb angle. Kyphosis is caused by degenerative proces,, neuromuscular disease, tumor, trauma, congenital abnormalities and unergonomic posture at the moment of carriying weights. One of kyphosis risk factor is excessive weights on the back in long duration. The complication of kyphosis such as vertebrae compression fracture could cause pain and deformities. Objective: Purpose of this research is to describe the correlation between workload level in carrier workers towards kyphosis at Tanjung Market, Jember. Methods: This research was observational analitic, cross sectional method, and total sampling. The respondents were 32 male carrier workers and 32 controls.. Data was obtained by interview and Cobb angle measurement on 1st and 12th thoracal vertebrae using inclinometer. Statistical test was done by Spearman correlation test. Results: The data analysis showed that p v...
ABSTRAK Kanker merupakan penyebab kematian utama di seluruh dunia. Kemoterapi doxorubicin sering ... more ABSTRAK Kanker merupakan penyebab kematian utama di seluruh dunia. Kemoterapi doxorubicin sering digunakan dalam pengobatan kanker, namun sebanding dengan efektifitasnya doxo-rubicin memiliki banyak efek samping, salah satunya doxorubicin dapat mengakibatkan kerusakan ginjal melalui proses interstitial fibrosis. Pemanfaatan ekstrak bawang kucai (Allium tuberosum) sebagai ko kemoterapi untuk mengurangi keruskan ginjal akibat doxo-rubicin merupakan peluang yang prospektif. Penelitian ini bertujuan untuk mencari efek nefroprotektif ekstrak bawang kucai terhadap kadar BUN dan kreatinin tikus wistar yang diinduksi doxorubicin. Metode yang digunakan dalam penelitian adalah quasi experimental design dengan randomized post test only controlled grup. Hasil penelitian menunjukkan bahwa ekstrak bawang kucai dapat menurunkan kadar BUN dan kreatinin (p<0,05) pada kelompok yang hanya diinduksi doxorubicin. Dapat disimpulkan bahwa terdapat efek nefroprotektif dalam ekstrak bawang kucai pada tik...
Journal of Agromedicine and Medical Sciences, 2020
Soil-Transmitted Helmithiasis is an infection caused by intestinal nematode worms which in the pr... more Soil-Transmitted Helmithiasis is an infection caused by intestinal nematode worms which in the process of transmission requires soil as media to fullfil its life cycle from non-infective forms to infective forms. The number of infections is influenced by personal hygiene. Personal hygiene consists of the habit of washing hands, cutting nails, eating, defecating and ownership of latrines, and the use of personal protective equipment. This study used a cross sectional research design conducted at Widodaren Plantation with 68 people of samples. Stool examination was determined by kato-katz method, sedimentation, and floatation to detect the presence of Soil-Transmitted Helminth (STH) eggs, while personal hygiene was assessed using questionnaires. Questionnaire and stool examination datas were processed using SPSS data analysis with chi-square method. The results of this study found 26 respondents who were positive for soil-trasmitted helminthiasis infection. The most frequent worm spec...
Acute appendicitis is one of the most common causes of surgery worldwide. Appendectomy is a skept... more Acute appendicitis is one of the most common causes of surgery worldwide. Appendectomy is a skeptical surgical intervention associated with the risk of Surgical Site Infection (SSI). The purpose of this analysis was to describe the relationship between delayed appendectomy in acute appendicitis and the incidence of SSI. Reviewers selected articles containing data on the incidence of SSI due to appendectomy delays for 3 to 48 hours from seven databases, namely Pubmed, Nature, SpringerLink, Science Direct, ProQuest, Oxford Open Access Journal, and Cochrane Library. The data source was secondary data from international articles published in 2011 to 2020 based on the PICO criteria. The data obtained were then grouped and synthesized without meta-analysis/Synthesis Without Metaanalysis (SWiM) descriptively. A total of 2,778 articles were collected, of which 24 studies met the inclusion criteria. A total of 4 articles showed an association between appendectomy delay and SSI while the othe...
Jellyfish is one of the animals that is responsible for poisoning in human. The poisoning jellyfi... more Jellyfish is one of the animals that is responsible for poisoning in human. The poisoning jellyfish commonly found is Physalia utriculus. Jellyfish poison is potential to cause hemolysis on blood. The purpose of this study was to determine the influence of jellyfish (Physalia utriculus) poisoning induction toward the oxygenation function of the male mice erythrocytes. The method was true experimental design with post test only control group design. Eight male mice were devided into two groups: control and treatment groups with a dose of jellyfish poison 30 mg/kgBW. The observation was conducted by using a pulse oxymeter. The result showed average level of oxygen saturation in the control group minute 0; 15; 30; 60; 120; 240; 480; 720; 1440 were 55%; 54%; 63,75%; 70%; 65,25%; 67,5%; 65,75%; 72%; 55%, respectively. While in the treatment group were 61,25%; 62,75%; 59,75%; 58,5%; 51,75%; 58%; 57%; 75,75%; 47%, respectively. The statistical bivariate correlation test has a correlation c...
Journal of Agromedicine and Medical Sciences, 1970
Coronary heart disease (CHD) is the cause of 7,3 million death globally in 2008. The main pathoph... more Coronary heart disease (CHD) is the cause of 7,3 million death globally in 2008. The main pathophysiology process that leads to CHD is atherosclerosis which is caused by high LDL cholesterol level. The aim of this study was to explore bay leaf and celery leaf infusion effect on reducing LDL cholesterol level in dyslipidemic rat model. The type of this study was true experimental research using wistar rat (Rattus novergicus) as the sample. The rats were induced by high fat diet and PTU for two weeks then each of the group were given either bay leaf infusion, celery leaf infusion, simvastatin (positive control), or aquadest (negative control) for a week. The measurement of LDL level used Friedewald formulation. Data was analyzed using paired sample t test and one way ANOVA. As the result there was a significance reduction on LDL level after treatment with bay leaf (p=0,013) and celery leaf infusion (p=0,035) but there was no significance difference between groups (p=0,293). It was con...
P hysalia physalis adalah salah satu jenis ubur-ubur beracun yang dapat menimbulkan dyspnea setel... more P hysalia physalis adalah salah satu jenis ubur-ubur beracun yang dapat menimbulkan dyspnea setelah tersengat . Hal ini menunjukkan adanya efek pneumotoxic toksin Physalia physalis . Penelitian ini bertujuan untuk mengetahui efek pneumotoxic protein toksin ubur-ubur Physalia physalis secara i n vivo pada tikus Wistar . Penelitian menggunakan sampel tikus galur Wistar jantan dengan berat rata-rata 150 gram dengan 1 kelompok kontrol (K) dan 3 kelompok perlakuan (P), masing-masing kelompok terdiri atas 6 ekor tikus. Kelompok K diinjeksi dengan larutan PZ; P1, P2 dan P3 masing-masing diinjeksi protein toksin ubur-ubur Physalia physalis dengan dosis 10 mg/KgBB, 20 mg/KgBB dan 30 mg/KgBB. Setelah 6 jam organ paru-paru tikus diambil dan direndam dengan formalin 10% dan dilakukan pembuatan preparat histologi, kemudian dilakukan pengamatan secara mikroskopik dan ditentukan tingkat perubahan histopatologi paru-paru dengan menggunakan skor. Hasil penelitian menunjukkan terjadinya perubahan his...
e-Jurnal Pustaka Kesehatan, vol. 4 (no. 2), Mei 2016 222 Pulmonary tuberculosis is a respiratory ... more e-Jurnal Pustaka Kesehatan, vol. 4 (no. 2), Mei 2016 222 Pulmonary tuberculosis is a respiratory infection disease caused by Mycobacterium tuberculosis infection in lung tissue. Mycobacterium tuberculosis could inhibit macrophage activation by inducing an increase of SOCS1 which can inhibit IFN-γ signaling process. Meanwhile, IFN-γ production continues as long as Mycobacterium tuberculosis still exist, so the IFN-γ levels stay high. This study aimed to investigate the effect of albumin snakehead fish (Chana striata) extract to decrease IFN-γ level. The study design was a quasy experimental design. The study subject was 24 tuberculosis patients during intensive phase medication, were divided into 2 groups. Experimental group was given 1500 mg/day albumin snakehead fish (Chana striata) extract while control group was placebo for 30 days. This study showed that albumin snakehead fish (Chana striata) extraxt can decrease significanly IFN-γ levels in the experimental group (p=0.006) but ...
Pulmonary tuberculosis is a respiratory infection disease caused by Mycobacterium tuberculosis in... more Pulmonary tuberculosis is a respiratory infection disease caused by Mycobacterium tuberculosis infection in lung tissue. Mycobacterium tuberculosis could inhibit macrophage activation by inducing an increase of SOCS1 which can inhibit IFN-γ signaling process. Meanwhile, IFN-γ production continues as long as Mycobacterium tuberculosis still exist, so the IFN-γ levels stay high. This study aimed to investigate the effect of albumin snakehead fish (Chana striata) extract to decrease IFN-γ level. The study design was a quasy experimental design. The study subject was 24 tuberculosis patients during intensive phase medication, were divided into 2 groups. Experimental group was given 1500 mg/day albumin snakehead fish (Chana striata) extract while control group was placebo for 30 days. This study showed that albumin snakehead fish (Chana striata) extraxt can decrease significanly IFN-γ levels in the experimental group (p=0.006) but not statistically signicant if compared with the decrease...
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