Introduction: β-Thalassemia is an inherited abnormal condition that results in hemolytic anemia. ... more Introduction: β-Thalassemia is an inherited abnormal condition that results in hemolytic anemia. It is the most common monogenic disorder in the world. The Mediterranean countries have the highest prevalence of β-thalassemia (2%-18%), and in Egypt, it is 9% to 10%. Regular multiblood transfusion and iron chelation are the major line of therapy for thalassemic patients. There are relatively low blood transfusion safety standards in the Third World countries. Hepatitis C virus (HCV) has the highest risk of transfusion transmitted diseases and Egypt has the highest HCV prevalence worldwide. Method: Our study is aimed to assess the risk of HCV transmitted to thalassemic patients that receive regular blood transfusions by focusing on the statistics of this population. The study covered most Egyptian governorates from Nile Delta and Upper Egypt by collecting patients’ data between 2015 and 2018. Results: Consecutive studies were done on 946 β-thalassemic patients as demonstrated from the ...
Smart grid (SG) is the solution to solve existing problems of energy security from generation to ... more Smart grid (SG) is the solution to solve existing problems of energy security from generation to utilization. Examples of such problems are disruptions in the electric grid and disturbances in the transmission. SG is a premium source of Big Data. The data should be processed to reveal hidden patterns and secret correlations to extrapolate the needed values. Such useful information obtained by the so-called data analytics is an essential element for energy management and control decision towards improving energy security, efficiency, and decreasing costs of energy use. For that reason, different techniques have been developed to process Big Data. This paper presents an overview of these techniques and discusses their advantages and challenges. The contribution of this paper is building a recommender system using different techniques to overcome the most obstacles encountering the Big Data processes in SG. The proposed system achieves the goals of the future SG by (i) analyzing data a...
This study was designed to investigate the potential effects and underlying mechanism of adipose ... more This study was designed to investigate the potential effects and underlying mechanism of adipose tissue-derived mesenchymal stem cells (MSCs) on allergic inflammation compared to Montelukast as an antileukotriene drug in a rat model of allergic rhinitis (AR). The effect of MSCs was evaluated in albino rats that were randomly divided into four (control, AR, AR + Montelukast, and AR + MSCs) groups. Rats of AR group were sensitized by ovalbumin (OVA) and then challenged with daily nasal drops of OVA diluted in sterile physiological saline (50 μL/nostril, 100 mg/mL, 10% OVA) from day 15 to day 21 of treatment with/without Montelukast (1 h before each challenge) or MSCs I/P injection (1 × 106 MCSs; weekly for three constitutive weeks). Both Montelukast and MSCs treatment started from day 15 of the experiment. At the end of the 5th week, blood samples were collected from all rats for immunological assays, histological, and molecular biology examinations. Both oral Montelukast and intraper...
β-thalassemia major (β-TM) patients had an increased incidence of cardiovascular complications se... more β-thalassemia major (β-TM) patients had an increased incidence of cardiovascular complications secondary to iron overload. They showed early carotid atherosclerosis as showed by increased carotid intima media thickness (CIMT) that may occur early even when significant iron overload is absent. We aimed to test the diagnostic performance of CIMT measurement by Doppler ultrasonography as a structural indicator for premature atherosclerosis in β-TM patients. Case-control study included 42 β-TM patients (24 males and 18 females) aged from 3 to 30 years and 36 age- and sex-matched healthy controls. Carotid Duplex was used for measurement of CIMT in all subjects. The frequency of abnormal CIMT among patients was 19%. Mean CIMT of right anterior wall was 0.8 ± 0.16 (range 0.5-1.2) mm, of right posterior wall was 0.80 ± 0.17 (range 0.5-1.2), of right lateral wall was 0.8 ± 0.17 (range 0.5-1.1) mm. CIMT of left anterior wall ranged from 0.5 to 1.2 with mean 0.81 ± 0.17, CIMT of left posterior...
We report the case of a 21-year old woman presenting with high blood pressure and raised normetan... more We report the case of a 21-year old woman presenting with high blood pressure and raised normetanephrine levels. Indium-111-pentetreotide single photon-emission computed tomography with computed tomography (SPECT/CT) and 2-deoxy-2-[fluorine-18]fluoro-d-glucose (FDG) positron emission tomography/computed tomography (PET/CT) imaging showing isolated tracer-uptake by a 2 cm tumor close to the costovertebral angle of the third thoracic vertebra. Thoracic surgery led to normalization of normetanephrine levels. Histological findings were consistent with the presence of a paraganglioma. Mutations in , , , , , , , , , , , and were absent, but a heterozygous missense mutation, c.311G > T, was found in exon 1 of the von Hippel-Lindau gene, , resulting in a glycine to valine substitution in the VHL protein at position 104, p.Gly104Val. This same mutation was found in both the mother and the 17-year old sister in whom a small retinal hemangioblastoma was also found. We diagnose an unusual fu...
The Journal of clinical endocrinology and metabolism, Jan 18, 2018
Multiple Endocrine Neoplasia type 1 (MEN1) is an autosomal dominant disease caused by mutations i... more Multiple Endocrine Neoplasia type 1 (MEN1) is an autosomal dominant disease caused by mutations in the MEN1 gene characterized by a broad spectrum of clinical manifestations, of which the most frequent are primary hyperparathyroidism, pituitary adenomas, and neuroendocrine tumors. The aim of this work is to facilitate interpretation of variants and improve the genetic counseling and medical care of MEN1-patients' families. The TENGEN network (French oncogenetics network of neuroendocrine tumors) has interpreted and collected all allelic variants and clinical characteristics of the MEN1-positive patients identified through genetic testing performed in the French population from 1997 to 2015. They were registered in a locus-specific database called the UMD-MEN1 database (www.umd.be/MEN1/). variant classification, age-related penetrance, odds ratio. Three hundred seventy distinct variants reported in 1,676 patients, including 181 unpublished variants, have currently been registered...
Hyponatremia is a common electrolyte abnormality, however, encountering a patient with serum sodi... more Hyponatremia is a common electrolyte abnormality, however, encountering a patient with serum sodium level below 100 mEq/L and minimal symptoms is unusual. We present the case of an 86-year-old woman who was found to have serum sodium levels of 99 mEq/L. Her only complaint was difficulty in walking. On admission, and throughout her hospital stay, she did not have altered mental status, focal neurological deficits, or adverse outcomes. Her history, blood work, and urine studies pointed towards a diagnosis of thiazide-associated hyponatremia. Thiazide-associated hyponatremia can occur at any time during the course of thiazide administration. The first step that should be taken to manage this condition is discontinuing the medication. The lesson learned from this case is that the degree of hyponatremia does not always correlate with the severity of symptoms.
... rule-based duration models was in 1970s [2]. More recently, a rule-based duration model was d... more ... rule-based duration models was in 1970s [2]. More recently, a rule-based duration model was developed for a text-to-speech system for the ... to study, due to complex inter-action among the linguistic features at various levels [4]. Therefore the rule inference process is restricted ...
Introduction: β-Thalassemia is an inherited abnormal condition that results in hemolytic anemia. ... more Introduction: β-Thalassemia is an inherited abnormal condition that results in hemolytic anemia. It is the most common monogenic disorder in the world. The Mediterranean countries have the highest prevalence of β-thalassemia (2%-18%), and in Egypt, it is 9% to 10%. Regular multiblood transfusion and iron chelation are the major line of therapy for thalassemic patients. There are relatively low blood transfusion safety standards in the Third World countries. Hepatitis C virus (HCV) has the highest risk of transfusion transmitted diseases and Egypt has the highest HCV prevalence worldwide. Method: Our study is aimed to assess the risk of HCV transmitted to thalassemic patients that receive regular blood transfusions by focusing on the statistics of this population. The study covered most Egyptian governorates from Nile Delta and Upper Egypt by collecting patients’ data between 2015 and 2018. Results: Consecutive studies were done on 946 β-thalassemic patients as demonstrated from the ...
Smart grid (SG) is the solution to solve existing problems of energy security from generation to ... more Smart grid (SG) is the solution to solve existing problems of energy security from generation to utilization. Examples of such problems are disruptions in the electric grid and disturbances in the transmission. SG is a premium source of Big Data. The data should be processed to reveal hidden patterns and secret correlations to extrapolate the needed values. Such useful information obtained by the so-called data analytics is an essential element for energy management and control decision towards improving energy security, efficiency, and decreasing costs of energy use. For that reason, different techniques have been developed to process Big Data. This paper presents an overview of these techniques and discusses their advantages and challenges. The contribution of this paper is building a recommender system using different techniques to overcome the most obstacles encountering the Big Data processes in SG. The proposed system achieves the goals of the future SG by (i) analyzing data a...
This study was designed to investigate the potential effects and underlying mechanism of adipose ... more This study was designed to investigate the potential effects and underlying mechanism of adipose tissue-derived mesenchymal stem cells (MSCs) on allergic inflammation compared to Montelukast as an antileukotriene drug in a rat model of allergic rhinitis (AR). The effect of MSCs was evaluated in albino rats that were randomly divided into four (control, AR, AR + Montelukast, and AR + MSCs) groups. Rats of AR group were sensitized by ovalbumin (OVA) and then challenged with daily nasal drops of OVA diluted in sterile physiological saline (50 μL/nostril, 100 mg/mL, 10% OVA) from day 15 to day 21 of treatment with/without Montelukast (1 h before each challenge) or MSCs I/P injection (1 × 106 MCSs; weekly for three constitutive weeks). Both Montelukast and MSCs treatment started from day 15 of the experiment. At the end of the 5th week, blood samples were collected from all rats for immunological assays, histological, and molecular biology examinations. Both oral Montelukast and intraper...
β-thalassemia major (β-TM) patients had an increased incidence of cardiovascular complications se... more β-thalassemia major (β-TM) patients had an increased incidence of cardiovascular complications secondary to iron overload. They showed early carotid atherosclerosis as showed by increased carotid intima media thickness (CIMT) that may occur early even when significant iron overload is absent. We aimed to test the diagnostic performance of CIMT measurement by Doppler ultrasonography as a structural indicator for premature atherosclerosis in β-TM patients. Case-control study included 42 β-TM patients (24 males and 18 females) aged from 3 to 30 years and 36 age- and sex-matched healthy controls. Carotid Duplex was used for measurement of CIMT in all subjects. The frequency of abnormal CIMT among patients was 19%. Mean CIMT of right anterior wall was 0.8 ± 0.16 (range 0.5-1.2) mm, of right posterior wall was 0.80 ± 0.17 (range 0.5-1.2), of right lateral wall was 0.8 ± 0.17 (range 0.5-1.1) mm. CIMT of left anterior wall ranged from 0.5 to 1.2 with mean 0.81 ± 0.17, CIMT of left posterior...
We report the case of a 21-year old woman presenting with high blood pressure and raised normetan... more We report the case of a 21-year old woman presenting with high blood pressure and raised normetanephrine levels. Indium-111-pentetreotide single photon-emission computed tomography with computed tomography (SPECT/CT) and 2-deoxy-2-[fluorine-18]fluoro-d-glucose (FDG) positron emission tomography/computed tomography (PET/CT) imaging showing isolated tracer-uptake by a 2 cm tumor close to the costovertebral angle of the third thoracic vertebra. Thoracic surgery led to normalization of normetanephrine levels. Histological findings were consistent with the presence of a paraganglioma. Mutations in , , , , , , , , , , , and were absent, but a heterozygous missense mutation, c.311G > T, was found in exon 1 of the von Hippel-Lindau gene, , resulting in a glycine to valine substitution in the VHL protein at position 104, p.Gly104Val. This same mutation was found in both the mother and the 17-year old sister in whom a small retinal hemangioblastoma was also found. We diagnose an unusual fu...
The Journal of clinical endocrinology and metabolism, Jan 18, 2018
Multiple Endocrine Neoplasia type 1 (MEN1) is an autosomal dominant disease caused by mutations i... more Multiple Endocrine Neoplasia type 1 (MEN1) is an autosomal dominant disease caused by mutations in the MEN1 gene characterized by a broad spectrum of clinical manifestations, of which the most frequent are primary hyperparathyroidism, pituitary adenomas, and neuroendocrine tumors. The aim of this work is to facilitate interpretation of variants and improve the genetic counseling and medical care of MEN1-patients' families. The TENGEN network (French oncogenetics network of neuroendocrine tumors) has interpreted and collected all allelic variants and clinical characteristics of the MEN1-positive patients identified through genetic testing performed in the French population from 1997 to 2015. They were registered in a locus-specific database called the UMD-MEN1 database (www.umd.be/MEN1/). variant classification, age-related penetrance, odds ratio. Three hundred seventy distinct variants reported in 1,676 patients, including 181 unpublished variants, have currently been registered...
Hyponatremia is a common electrolyte abnormality, however, encountering a patient with serum sodi... more Hyponatremia is a common electrolyte abnormality, however, encountering a patient with serum sodium level below 100 mEq/L and minimal symptoms is unusual. We present the case of an 86-year-old woman who was found to have serum sodium levels of 99 mEq/L. Her only complaint was difficulty in walking. On admission, and throughout her hospital stay, she did not have altered mental status, focal neurological deficits, or adverse outcomes. Her history, blood work, and urine studies pointed towards a diagnosis of thiazide-associated hyponatremia. Thiazide-associated hyponatremia can occur at any time during the course of thiazide administration. The first step that should be taken to manage this condition is discontinuing the medication. The lesson learned from this case is that the degree of hyponatremia does not always correlate with the severity of symptoms.
... rule-based duration models was in 1970s [2]. More recently, a rule-based duration model was d... more ... rule-based duration models was in 1970s [2]. More recently, a rule-based duration model was developed for a text-to-speech system for the ... to study, due to complex inter-action among the linguistic features at various levels [4]. Therefore the rule inference process is restricted ...
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