Papers by aleksandra pikula
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature, Feb 24, 2010
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F1000 - Post-publication peer review of the biomedical literature, 2009
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F1000 - Post-publication peer review of the biomedical literature, 2012
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F1000 - Post-publication peer review of the biomedical literature, 2011
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F1000 - Post-publication peer review of the biomedical literature, 2013
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BMJ Open
ObjectiveHistorically, neurology research has demonstrated a sex bias with mainly male subjects i... more ObjectiveHistorically, neurology research has demonstrated a sex bias with mainly male subjects included in clinical trials as well as lack of reporting of data by sex. In recent years, emphasis has been placed on increased participation of female participants and explicit declaration/evaluation of sex differences in clinical research.We aimed to review the available literature examining sex differences across four subspecialty areas in neurology (demyelination, headache, stroke, epilepsy) and whether sex and gender terms have been used appropriately.DesignThis scoping review was performed by searching Ovid MEDLINE, Cochrane Central Registry of Controlled Trials, EMBASE, Ovid Emcare and APA PsycINFO databases from 2014 to 2020. Four independent pairs of reviewers screened titles, abstracts and full texts. Studies whose primary objective was to assess sex or gender differences among adults with one of four neurological conditions were included. We report the scope, content and trends...
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F1000 - Post-publication peer review of the biomedical literature, 2009
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The Lancet
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Journal of Stroke and Cerebrovascular Diseases, 2021
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Stroke, 2020
In the past decade, stroke medicine has evolved from discovery of innovative diagnostic tools to ... more In the past decade, stroke medicine has evolved from discovery of innovative diagnostic tools to implementation of new treatments. These advances are projected to increase the demand for stroke neurologists in academic and clinical practices, but hopefully with equitable opportunities for everyone across the gender spectrum. Academic medicine provides opportunities to participate in clinical care, teaching, research, and administration. The early career stage is short-focused on finding an academic niche and developing new skills that will help you navigate the academic environment. A recent InterSECT article emphasized the critical role of women’s leadership in stroke medicine. In this article, we reflect on workforce gender disparities and provide 5 practical strategies that may help women overcome barriers and advance their work mission.
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JAMA Neurology, 2022
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Neurology, 2022
Background and Objectives There is a worldwide increase in the incidence of stroke in young adult... more Background and Objectives There is a worldwide increase in the incidence of stroke in young adults, with major regional and ethnic differences. Advancing knowledge of ethnic and regional variation in causes and outcomes will be beneficial in implementation of regional health care services. We studied the global distribution of risk factors, causes, and 3-month mortality of young patients with ischemic stroke, by performing a patient data meta-analysis from different cohorts worldwide. Methods We performed a pooled analysis of individual patient data from cohort studies that included consecutive patients with ischemic stroke aged 18–50 years. We studied differences in prevalence of risk factors and causes of ischemic stroke between different ethnic and racial groups, geographic regions, and countries with different income levels. We investigated differences in 3-month mortality by mixed-effects multivariable logistic regression. Results We included 17,663 patients from 32 cohorts in ...
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F1000 - Post-publication peer review of the biomedical literature, 2010
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F1000 - Post-publication peer review of the biomedical literature, 2012
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F1000 - Post-publication peer review of the biomedical literature, 2010
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F1000 - Post-publication peer review of the biomedical literature, 2011
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Stroke, 2009
Background and Purpose— Asymmetrical dimethylarginine (ADMA), an inhibitor of endothelial nitric ... more Background and Purpose— Asymmetrical dimethylarginine (ADMA), an inhibitor of endothelial nitric oxide synthase, is a marker of endothelial dysfunction. Elevated circulating ADMA concentrations have been associated with systemic and carotid atherosclerosis, an elevated risk of developing stroke, and magnetic resonance imaging white-matter hyperintensities (WMHs). The relation of plasma ADMA to subclinical vascular brain injury has not been previously studied in a middle-aged, community-based sample. Methods— In 2013 stroke-free Framingham offspring (mean±SD age, 58±9.5 years; 53% women), we related baseline plasma ADMA levels (1995–1998) to subsequent brain magnetic resonance imaging measures (1999–2004) of subclinical vascular injury: presence of silent brain infarcts (SBIs) and large white-matter hyperintensity volumes (LWMHs; defined as >1 SD above the age-specific mean). Results— Prevalences of SBIs and LWMHs were 10.7% and 12.6%, respectively. In multivariable analyses adjus...
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Journal of Neuroimaging, 2011
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Nature genetics, Jan 15, 2012
Aging is associated with reductions in hippocampal volume that are accelerated by…
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Alzheimer's & Dementia, 2010
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Papers by aleksandra pikula