Objective: Triple-negative breast cancers (TNBCs) are associated with younger age, advanced stage... more Objective: Triple-negative breast cancers (TNBCs) are associated with younger age, advanced stage at diagnosis, ethnicity, lower socioeconomic status (SES), and poor prognosis. The aim of the study was to investigate clinicopathologic features of TNBC patients living in Southeastern Anatolia, and the association between socioeconomic and cultural factors and TNBC. Material and Methods: A total of 875 women were included in the study. The effects of socioeconomic factors and cultural factors on clinicopathologic features of TNBC patients were evaluated. The SES of the patients was categorized as lower and higher according to educational and health insurance status, and household income. Patients’ age at diagnosis, living area (rural or urban), SES, and ethnicity (Arabic, Armenian, Kurdish, and Turkish) were recorded. Results: Median age was 47 (20-85) and 10% (n=87) of the patients were diagnosed TNBC. TNBC rates were higher in patients ≤40 years. Younger age, lower SES, and Arabic a...
Background : Our purpose was to invesgate propolis and its component caffeic acid phenethyl ester... more Background : Our purpose was to invesgate propolis and its component caffeic acid phenethyl ester (CAPE) for their anoxidant effects on the brainssue of rats exposed to ionizing radiaon (IR). Materials and Methods : Fi&y-four male albino Sprague-Dawley rats, divided into six groups, were designed as normal control group, cranial irradiaon of 5 Gray alone, irradiaon plus CAPE, irradiaon plus propolis, control groups of propolis and CAPE. Oxidave/anoxidave status indicators, lipid peroxidaon and anoxidant enzyme s, were determined by biochemical methods in homogenized brainssue of rats. Results : Malondialdehyde level, the lipid peroxidaon index, in the irradiaon alone group was found to be significantly increased compared to all of the other groups (p<0.001). Enzyme acvies of superoxide dismutase (SOD) were 504.93, 720.70 and 659.98 for irradiaon alone group, irradiaon p lus CAPE group and irradiaon plus propolis group, respecvely. Enzyme acvity of SOD in the irradiaon alone group...
Journal of B.U.ON. : official journal of the Balkan Union of Oncology
Hormone receptor (HR) status is a prognostic factor in women with breast cancer and differs among... more Hormone receptor (HR) status is a prognostic factor in women with breast cancer and differs among different ethnic groups. HR status among Turkish, Kurdish and Arabic women with breast cancer living in Turkey is unknown and in this study we investigated the relationship between HR and HER2 status and race. FA total of 648 women with breast cancer (Turkish 438, Kurdish 174, Arabic 35 and Armenian 1) living in southeastern Turkey and referred to the Department of Radiation Oncology between July 2006-July 2012 were included in the study. Patients were categorized into 4 groups according to their HR status. Estrogen receptor (ER) and progesterone receptor (PR) positive (ER+/PR+), ER positive and PR negative (ER+/PR-), ER negative and PR positive (ER-/PR+) and ER and PR negative (ER-/PR-). Human epidermal growth factor receptor 2 (HER2) status was recorded immunohistochemically (IHC) as negative (0 and 1+), and positive (3+). Statistical analysis included ER, PR, HER2, triple subtypes (c...
To evaluate the relationship between fluorine 18 fluorodeoxyglucose (FDG) positron emission tomog... more To evaluate the relationship between fluorine 18 fluorodeoxyglucose (FDG) positron emission tomography (PET) maximum standardized uptake value (SUV(max)) and pain response to radiation therapy (RT) in patients with bone metastasis. Institutional ethical board approval for the study was obtained, with informed consent, for this prospective study. Thirty-one patients with metastatic bone pain who underwent FDG PET/computed tomography before RT were included. Patients were diagnosed with lung (n = 16), breast (n = 7), stomach (n = 2), and head and neck cancers (n = 3), as well as unknown primary tumor (n = 3). Eighty-five painful metastatic locations with FDG PET scans geographically corresponding to 40 treatment fields were evaluated. Pain scores using visual analog scale or faces pain rating scale and SUV(max) at each location were recorded. All patients were treated with a single fraction 8 Gy RT. Pain scores after RT were assessed at weeks 2, 4, 8, 12, 16, 20, and 24. The pretreatment pain scores and pain response to RT were compared with FDG PET SUV(max) of each location. Pearson correlation, independent t test, one-way analysis of variance, and χ(2) tests were used for statistical analysis. Median SUV(max) and initial pain scores for all locations were 7.2 (range, 1.5-22.5) and 6 (range, 2-8), respectively. Median follow-up time was 24 (range, 3-112) weeks. Median SUV(max) was 4.5 (range, 3.1-7.3), 4.75 (range, 1.5-10.3), 8.8 (range, 5.2-11.9), and 12.1 (range, 7-22.5) for pretreatment pain scores of 2, 4, 6, and 8, respectively. SUV(max) was correlated with pretreatment pain scores (P &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; .0001). SUV(max) and pretreatment pain scores were also significantly associated with pain response to RT. Median SUV(max) for locations with complete response, partial response, pain progression, and indeterminate response was 5.2, 9.75, 10.8, and 6.4, respectively (P ≤ .001). FDG PET SUV(max) correlated with initial pain severity and pain response to RT and can be used as a predictive factor for treatment response in patients with painful bone metastasis treated with palliative RT.
Journal of Medical Imaging and Radiation Oncology, 2010
SummaryThe aim of this study was to assess the effect of Trendelenburg position in comparison to ... more SummaryThe aim of this study was to assess the effect of Trendelenburg position in comparison to prone position on small bowel volume and treatment dose in gynecologic pelvic external beam radiotherapy using three‐dimensional conformal treatment plans. Eight patients with gynecologic cancers, treated with definitive or postoperative pelvic radiotherapy were investigated. Pelvic computerized tomography (CT) scans for treatment planning were performed in prone and 25 degree Trendelenburg positions for each patient. The dose‐volume histograms of small bowel within the treatment fields were obtained and compared for both positions. The clinical target volume (CTV) and the planning target volume (PTV) were also defined and evaluated in the subjects. Treatment dose was 5040 cGy to PTV with 180 cGy daily fraction doses in both techniques for all patients. The average irradiated small bowel volume was 726 cc for prone position and 458 cc for the Trendelenburg position. The average irradiate...
Objective: Triple-negative breast cancers (TNBCs) are associated with younger age, advanced stage... more Objective: Triple-negative breast cancers (TNBCs) are associated with younger age, advanced stage at diagnosis, ethnicity, lower socioeconomic status (SES), and poor prognosis. The aim of the study was to investigate clinicopathologic features of TNBC patients living in Southeastern Anatolia, and the association between socioeconomic and cultural factors and TNBC. Material and Methods: A total of 875 women were included in the study. The effects of socioeconomic factors and cultural factors on clinicopathologic features of TNBC patients were evaluated. The SES of the patients was categorized as lower and higher according to educational and health insurance status, and household income. Patients’ age at diagnosis, living area (rural or urban), SES, and ethnicity (Arabic, Armenian, Kurdish, and Turkish) were recorded. Results: Median age was 47 (20-85) and 10% (n=87) of the patients were diagnosed TNBC. TNBC rates were higher in patients ≤40 years. Younger age, lower SES, and Arabic a...
Background : Our purpose was to invesgate propolis and its component caffeic acid phenethyl ester... more Background : Our purpose was to invesgate propolis and its component caffeic acid phenethyl ester (CAPE) for their anoxidant effects on the brainssue of rats exposed to ionizing radiaon (IR). Materials and Methods : Fi&y-four male albino Sprague-Dawley rats, divided into six groups, were designed as normal control group, cranial irradiaon of 5 Gray alone, irradiaon plus CAPE, irradiaon plus propolis, control groups of propolis and CAPE. Oxidave/anoxidave status indicators, lipid peroxidaon and anoxidant enzyme s, were determined by biochemical methods in homogenized brainssue of rats. Results : Malondialdehyde level, the lipid peroxidaon index, in the irradiaon alone group was found to be significantly increased compared to all of the other groups (p<0.001). Enzyme acvies of superoxide dismutase (SOD) were 504.93, 720.70 and 659.98 for irradiaon alone group, irradiaon p lus CAPE group and irradiaon plus propolis group, respecvely. Enzyme acvity of SOD in the irradiaon alone group...
Journal of B.U.ON. : official journal of the Balkan Union of Oncology
Hormone receptor (HR) status is a prognostic factor in women with breast cancer and differs among... more Hormone receptor (HR) status is a prognostic factor in women with breast cancer and differs among different ethnic groups. HR status among Turkish, Kurdish and Arabic women with breast cancer living in Turkey is unknown and in this study we investigated the relationship between HR and HER2 status and race. FA total of 648 women with breast cancer (Turkish 438, Kurdish 174, Arabic 35 and Armenian 1) living in southeastern Turkey and referred to the Department of Radiation Oncology between July 2006-July 2012 were included in the study. Patients were categorized into 4 groups according to their HR status. Estrogen receptor (ER) and progesterone receptor (PR) positive (ER+/PR+), ER positive and PR negative (ER+/PR-), ER negative and PR positive (ER-/PR+) and ER and PR negative (ER-/PR-). Human epidermal growth factor receptor 2 (HER2) status was recorded immunohistochemically (IHC) as negative (0 and 1+), and positive (3+). Statistical analysis included ER, PR, HER2, triple subtypes (c...
To evaluate the relationship between fluorine 18 fluorodeoxyglucose (FDG) positron emission tomog... more To evaluate the relationship between fluorine 18 fluorodeoxyglucose (FDG) positron emission tomography (PET) maximum standardized uptake value (SUV(max)) and pain response to radiation therapy (RT) in patients with bone metastasis. Institutional ethical board approval for the study was obtained, with informed consent, for this prospective study. Thirty-one patients with metastatic bone pain who underwent FDG PET/computed tomography before RT were included. Patients were diagnosed with lung (n = 16), breast (n = 7), stomach (n = 2), and head and neck cancers (n = 3), as well as unknown primary tumor (n = 3). Eighty-five painful metastatic locations with FDG PET scans geographically corresponding to 40 treatment fields were evaluated. Pain scores using visual analog scale or faces pain rating scale and SUV(max) at each location were recorded. All patients were treated with a single fraction 8 Gy RT. Pain scores after RT were assessed at weeks 2, 4, 8, 12, 16, 20, and 24. The pretreatment pain scores and pain response to RT were compared with FDG PET SUV(max) of each location. Pearson correlation, independent t test, one-way analysis of variance, and χ(2) tests were used for statistical analysis. Median SUV(max) and initial pain scores for all locations were 7.2 (range, 1.5-22.5) and 6 (range, 2-8), respectively. Median follow-up time was 24 (range, 3-112) weeks. Median SUV(max) was 4.5 (range, 3.1-7.3), 4.75 (range, 1.5-10.3), 8.8 (range, 5.2-11.9), and 12.1 (range, 7-22.5) for pretreatment pain scores of 2, 4, 6, and 8, respectively. SUV(max) was correlated with pretreatment pain scores (P &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; .0001). SUV(max) and pretreatment pain scores were also significantly associated with pain response to RT. Median SUV(max) for locations with complete response, partial response, pain progression, and indeterminate response was 5.2, 9.75, 10.8, and 6.4, respectively (P ≤ .001). FDG PET SUV(max) correlated with initial pain severity and pain response to RT and can be used as a predictive factor for treatment response in patients with painful bone metastasis treated with palliative RT.
Journal of Medical Imaging and Radiation Oncology, 2010
SummaryThe aim of this study was to assess the effect of Trendelenburg position in comparison to ... more SummaryThe aim of this study was to assess the effect of Trendelenburg position in comparison to prone position on small bowel volume and treatment dose in gynecologic pelvic external beam radiotherapy using three‐dimensional conformal treatment plans. Eight patients with gynecologic cancers, treated with definitive or postoperative pelvic radiotherapy were investigated. Pelvic computerized tomography (CT) scans for treatment planning were performed in prone and 25 degree Trendelenburg positions for each patient. The dose‐volume histograms of small bowel within the treatment fields were obtained and compared for both positions. The clinical target volume (CTV) and the planning target volume (PTV) were also defined and evaluated in the subjects. Treatment dose was 5040 cGy to PTV with 180 cGy daily fraction doses in both techniques for all patients. The average irradiated small bowel volume was 726 cc for prone position and 458 cc for the Trendelenburg position. The average irradiate...
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