One of the greatest risk factors for cardiovascular diseases is hypercholesterolemia. Moringa ole... more One of the greatest risk factors for cardiovascular diseases is hypercholesterolemia. Moringa oleifera is a good source of phytochemicals and is well explored for its antioxidant properties. Methods:The main aim of the present study was to assess the potential cholesterol lowering effect of Moringa oleifera leaf polyphenols (MOP) in an animal model. Five groups of male Wister rats were fed for 45 days as follows: a standard diet (GI); high fat-cholesterol diet (GII); high fat-cholesterol with MOP (100 and 200mg/kg body wt GIII & GIV respectively); and high fat-cholesterol with statins (Atorvastatin) (G-V). Results:Administration of MOP rich extract (GII and GIV) significantly (p≤0.05) lowered the serum cholesterol, triglycerides and low-density lipoprotein cholesterol. A significant (p≤0.05) decrease in the activity of the HMG CoA reductase enzyme was observed in GIII, GIV and GV but not in GI & GII. Conclusion: The results demonstrate that the polyphenol extract of Moringa oleifera...
Morus indica- MI-S36 is a potential source of phytochemicals and is well explored for its medicin... more Morus indica- MI-S36 is a potential source of phytochemicals and is well explored for its medicinal properties such as antidiabetic and antioxidant activity. In the present study, Mous indica aqueous (MAq) and dechlorophyllised (MDc) extracts efficacy to protect against the carbon tetrachloride (CCl4) induced hepatotoxicity was studied in rats in comparison with standard drug Liv52. The experimental group rats were pre treated with MAq, MDc and Liv52 for 7days. Healthy control and positive control group animals were fed wth Olive oil and after 7days two doses of CCl4 was given at 12 and 36 hrs intervals to all the animal groups. After 12 hrs of CCl4 dosage animals were sacrificed and biochemical parameters analysed in the serum. The total protein, albumin, urea, creatinine, total bilirubin were within the normal level in all the groups whereas the hepatic enzymes AST, ALT and ALP activity was less in Liv52 and Morus treated groups. Total cholesterol, triglycerides, were determined. ...
Plants rich in antioxidants and phytochemicals especially phenolic groups play a protective role ... more Plants rich in antioxidants and phytochemicals especially phenolic groups play a protective role in health and disease conditions, like cancer, diabetes, heart disease hypertension etc. by counteracting reactive oxygen species and inhibiting the lipid oxidation. Morus indica is non-toxic natural therapeutic plant used as herbal medicine as hypoglycemic, hypotensive, and diuretic properties. In the present study proximate, phytochemical and antioxidant profile in dehydrated leaves powder of Morus indica varieties, M5, V1 and S36 were estimated. The 100 methanol, 80 methanol (methanol & water, 8: 2), dechlorophyllised, aqueous cold and hot extracts were prepared and their polyphenol content, antioxidant activity of inhibiting oxidation in oil emulsion and liver microsomes was evaluated at 300 to 500ìg. There was no significant (PMethanol> 80 methanol > Aq. c old and hot. In oil emulsion, no significant difference in inhibiting oxidation was observed in methanol and 80 methanol extracts, whereas in dechlorophylised, aq. cold and hot extracts V1 and S36 showed higher activity. In microsomes, S36 variety was more potent in inhibiting oxidation in all extracts except Aq. cold. S36 was found to be good source of phytochemicals and showed more potency in inhibiting the oxidation in two food and biological systems
Article can be accessed online on: www.ijpsr.com ABSTRACT: Plants rich in antioxidants and phytoc... more Article can be accessed online on: www.ijpsr.com ABSTRACT: Plants rich in antioxidants and phytochemicals especially phenolic groups play a protective role in health and disease conditions, like cancer, diabetes, heart disease hypertension etc. by counteracting reactive oxygen species and inhibiting the lipid oxidation. Morus indica is non-toxic natural therapeutic plant used as herbal medicine as hypoglycemic, hypotensive, and diuretic properties. In the present study proximate, phytochemical and antioxidant profile in dehydrated leaves powder of Morus indica varieties, M5, V1 and S36 were estimated. The 100 % methanol, 80 % methanol (methanol & water, 8: 2), dechlorophyllised, aqueous cold and hot extracts were prepared and their polyphenol content, antioxidant activity of inhibiting oxidation in oil emulsion and liver microsomes was evaluated at 300 to 500µg. There
International Journal of Medicinal Chemistry, 2014
Natural antioxidants present in foods and other biological materials have attracted considerable ... more Natural antioxidants present in foods and other biological materials have attracted considerable interest because of their presumed safety and potential nutritional and therapeutic effects. Antioxidant constituents of plant materials act as radical scavengers and convert the radicals to less reactive species.Abrus precatorius(AP) was analyzed for its proximate and phytochemical composition. The leaves were extracted with methanol (ME) and analyzed for antioxidant activity by radical scavenging method, reducing power, ferric reducing capacity, andin vitroinhibition of Fenton’s reagent-induced oxidation in oil emulsion and microsomes. In addition, the effect of temperature (100∘C, 15, and 30 min) and pH (4.5, 7, and 9) C on the antioxidant activity of ME was investigated. The leaves were rich in total polyphenols, flavonoids,β-carotene, glutathione,α-tocopherol, and ascorbic acid. The ME exhibited varying degree of antioxidant activity in a dose-dependent manner. The AP exhibited more...
One of the greatest risk factors for cardiovascular diseases is hypercholesterolemia. Moringa ole... more One of the greatest risk factors for cardiovascular diseases is hypercholesterolemia. Moringa oleifera is a good source of phytochemicals and is well explored for its antioxidant properties. Methods:The main aim of the present study was to assess the potential cholesterol lowering effect of Moringa oleifera leaf polyphenols (MOP) in an animal model. Five groups of male Wister rats were fed for 45 days as follows: a standard diet (GI); high fat-cholesterol diet (GII); high fat-cholesterol with MOP (100 and 200mg/kg body wt GIII & GIV respectively); and high fat-cholesterol with statins (Atorvastatin) (G-V). Results:Administration of MOP rich extract (GII and GIV) significantly (p≤0.05) lowered the serum cholesterol, triglycerides and low-density lipoprotein cholesterol. A significant (p≤0.05) decrease in the activity of the HMG CoA reductase enzyme was observed in GIII, GIV and GV but not in GI & GII. Conclusion: The results demonstrate that the polyphenol extract of Moringa oleifera...
Morus indica- MI-S36 is a potential source of phytochemicals and is well explored for its medicin... more Morus indica- MI-S36 is a potential source of phytochemicals and is well explored for its medicinal properties such as antidiabetic and antioxidant activity. In the present study, Mous indica aqueous (MAq) and dechlorophyllised (MDc) extracts efficacy to protect against the carbon tetrachloride (CCl4) induced hepatotoxicity was studied in rats in comparison with standard drug Liv52. The experimental group rats were pre treated with MAq, MDc and Liv52 for 7days. Healthy control and positive control group animals were fed wth Olive oil and after 7days two doses of CCl4 was given at 12 and 36 hrs intervals to all the animal groups. After 12 hrs of CCl4 dosage animals were sacrificed and biochemical parameters analysed in the serum. The total protein, albumin, urea, creatinine, total bilirubin were within the normal level in all the groups whereas the hepatic enzymes AST, ALT and ALP activity was less in Liv52 and Morus treated groups. Total cholesterol, triglycerides, were determined. ...
Plants rich in antioxidants and phytochemicals especially phenolic groups play a protective role ... more Plants rich in antioxidants and phytochemicals especially phenolic groups play a protective role in health and disease conditions, like cancer, diabetes, heart disease hypertension etc. by counteracting reactive oxygen species and inhibiting the lipid oxidation. Morus indica is non-toxic natural therapeutic plant used as herbal medicine as hypoglycemic, hypotensive, and diuretic properties. In the present study proximate, phytochemical and antioxidant profile in dehydrated leaves powder of Morus indica varieties, M5, V1 and S36 were estimated. The 100 methanol, 80 methanol (methanol & water, 8: 2), dechlorophyllised, aqueous cold and hot extracts were prepared and their polyphenol content, antioxidant activity of inhibiting oxidation in oil emulsion and liver microsomes was evaluated at 300 to 500ìg. There was no significant (PMethanol> 80 methanol > Aq. c old and hot. In oil emulsion, no significant difference in inhibiting oxidation was observed in methanol and 80 methanol extracts, whereas in dechlorophylised, aq. cold and hot extracts V1 and S36 showed higher activity. In microsomes, S36 variety was more potent in inhibiting oxidation in all extracts except Aq. cold. S36 was found to be good source of phytochemicals and showed more potency in inhibiting the oxidation in two food and biological systems
Article can be accessed online on: www.ijpsr.com ABSTRACT: Plants rich in antioxidants and phytoc... more Article can be accessed online on: www.ijpsr.com ABSTRACT: Plants rich in antioxidants and phytochemicals especially phenolic groups play a protective role in health and disease conditions, like cancer, diabetes, heart disease hypertension etc. by counteracting reactive oxygen species and inhibiting the lipid oxidation. Morus indica is non-toxic natural therapeutic plant used as herbal medicine as hypoglycemic, hypotensive, and diuretic properties. In the present study proximate, phytochemical and antioxidant profile in dehydrated leaves powder of Morus indica varieties, M5, V1 and S36 were estimated. The 100 % methanol, 80 % methanol (methanol & water, 8: 2), dechlorophyllised, aqueous cold and hot extracts were prepared and their polyphenol content, antioxidant activity of inhibiting oxidation in oil emulsion and liver microsomes was evaluated at 300 to 500µg. There
International Journal of Medicinal Chemistry, 2014
Natural antioxidants present in foods and other biological materials have attracted considerable ... more Natural antioxidants present in foods and other biological materials have attracted considerable interest because of their presumed safety and potential nutritional and therapeutic effects. Antioxidant constituents of plant materials act as radical scavengers and convert the radicals to less reactive species.Abrus precatorius(AP) was analyzed for its proximate and phytochemical composition. The leaves were extracted with methanol (ME) and analyzed for antioxidant activity by radical scavenging method, reducing power, ferric reducing capacity, andin vitroinhibition of Fenton’s reagent-induced oxidation in oil emulsion and microsomes. In addition, the effect of temperature (100∘C, 15, and 30 min) and pH (4.5, 7, and 9) C on the antioxidant activity of ME was investigated. The leaves were rich in total polyphenols, flavonoids,β-carotene, glutathione,α-tocopherol, and ascorbic acid. The ME exhibited varying degree of antioxidant activity in a dose-dependent manner. The AP exhibited more...
Uploads
Papers