Papers by Cristiana Tanase
Romanian Journal of Neurology, 2014
Objectives. Muscle contusion is the most common form of muscle injury and the muscle endogenous r... more Objectives. Muscle contusion is the most common form of muscle injury and the muscle endogenous regenerative capacity can compensate for non-extensive damage. However, severe traumatic injuries may overcome this capacity. More effective therapeutic strategies are still needed, so the exploration of the molecular context during muscle regeneration might provide new insights. Materials and methods. We investigated the expression pattern of a reputed angiogenic molecule, CD105/endoglin, by measuring the tissue and serum concentration by multiplex assay in normal and Dmdmdx dystrophic mice by following the distribution of the cellular sources by immunofluorescence in a mouse model of acute muscle contusion. Results. Maximal tissue concentration in normal animals was obtained 48h post-injury, and then started to decline, with only one other significantly increased value 5 days after injury. In dystrophic mice, tissue levels were globally much higher than in normal animals and started ris...
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Elsevier eBooks, 2012
Publisher Summary This chapter presents a classification of pituitary tumors based on their funct... more Publisher Summary This chapter presents a classification of pituitary tumors based on their functionality, invasiveness, and aggressiveness. Pituitary tumors, often called adenomas, are among the most frequent intracranial tumors after meningiomas and gliomas. From their epidemiology to their molecular aspects, pituitary adenomas represent a broad spectrum of disorders that can be analyzed and classified according to autonomous secretion, clinical aspects in diagnosis and treatment, pathology in terms of light microscopy (LM) and electron microscopy (EM) features, and special issues such as the clinical impact of aggressive pituitary adenomas or rare pituitary carcinoma cases. Pituitary adenomas can be classified as secreting tumors (such as growth hormone (GH), adrenocorticotropic hormone (ACTH), prolactin (PRL) in women, or the rare thyroid-stimulating hormone (TSH)-secreting adenomas) or clinically nonfunctional adenomas. The remaining pituitary adenomas, representing approximately a third, are clinically silent and are known as nonfunctioning pituitary adenomas (NFPAs), meaning that they only cause symptoms due to tumor growth. GH-producing adenomas represent 20% of pituitary tumors in surgical material, and they show no sex predilection. Corticotroph adenomas are the most frequent form (two-thirds) of the Cushing syndrome in adults, leading to the clinical and biochemical features known as Cushing's disease.
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Elsevier eBooks, 2012
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Publisher Summary This chapter outlines various therapeutic approaches for treatment of pituitary... more Publisher Summary This chapter outlines various therapeutic approaches for treatment of pituitary adenomas. Future perspectives and therapeutic implications in pituitary adenomas are also explored in this chapter. Despite being considered as benign, excess hormone secretion or hypopituitarism implies a major impact upon health, with increased cardiovascular events and mortality. With the exception of pituitary incidentalomas, increasing incidence of pituitary adenomas (secreting or nonfunctional) requires specific intervention. Main therapeutic approaches for treatment of pituitary adenomas include drug, surgical, and radiotherapy. The main principles regarding the surgical indication in pituitary adenomas recommend surgical resection as the primary treatment in tumors that are endocrinologically active as well as in tumors accompanied by pituitary insufficiency. In prolactinomas and GH-PRL secreting adenomas, dopamine agonists are the first line therapy, with improvement/normalization of PRL levels and restore of pituitary function. Temozolomide, drugs targeting angiogenesis, or gene therapy are in the front line research and treatment in trials involving patients with pituitary adenomas. Radiotherapy is generally regarded as the last treatment resource for pituitary adenomas.
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Elsevier eBooks, 2012
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Molecular Pathology of Pituitary Adenomas, 2012
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Romanian Biotechnological Letters, Jun 29, 2021
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Elsevier eBooks, 2012
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Elsevier eBooks, 2012
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International Journal of Molecular Sciences, Feb 24, 2022
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Gels, Jan 7, 2023
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Elsevier eBooks, 2012
Publisher Summary This chapter introduces genomics and proteomics as the new generic tools for di... more Publisher Summary This chapter introduces genomics and proteomics as the new generic tools for diagnosis of pituitary adenomas. The development of tumor-associated serum protein biomarkers over the past few decades has not been much effective for diagnosing primary neoplasia. There is a considerable pressure to discover new disease-related biomarkers. These markers are quantitative measures of biological effects that provide informative links between the mechanism of action and clinical effectiveness. They can provide new insights into a drug's mechanism of action, metabolism, efficacy, and safety, and into disease mechanisms and disease course. Protein biomarkers show a high potential of conversion into paraclinical diagnostic tests. Genomic analysis is one of the most intensively exploited “instrument” in biomarker discovery. Large-scale sequencing of candidate genes provides new biomarkers for tumor diagnosis and prognosis. Somatic DNA sequence analysis has expanded to genome-wide high-performance DNA sequencing leading to whole genome analysis of DNA sequence variations in tumors.
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Gels
Healthcare professionals face an ongoing challenge in managing both acute and chronic wounds, giv... more Healthcare professionals face an ongoing challenge in managing both acute and chronic wounds, given the potential impact on patients’ quality of life and the limited availability of expensive treatment options. Hydrogel wound dressings offer a promising solution for effective wound care due to their affordability, ease of use, and ability to incorporate bioactive substances that enhance the wound healing process. Our study aimed to develop and evaluate hybrid hydrogel membranes enriched with bioactive components such as collagen and hyaluronic acid. We utilized both natural and synthetic polymers and employed a scalable, non-toxic, and environmentally friendly production process. We conducted extensive testing, including an in vitro assessment of moisture content, moisture uptake, swelling rate, gel fraction, biodegradation, water vapor transmission rate, protein denaturation, and protein adsorption. We evaluated the biocompatibility of the hydrogel membranes through cellular assays...
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Biocompatibility of several implantable materials - silica wafers (used for implantable probes fo... more Biocompatibility of several implantable materials - silica wafers (used for implantable probes for measurements of electrical activities of living tissue) and titanium implants was tested in vitro. The testing strategy comprised 2 approaches, derived from the recommendations of the ISO 10993 standard. Thus, a first set of tests was carried with potential extractable components in Balb/c 3T3 cells in culture. A second set of tests was performed in human monocytes for the assessment of cell activation and secretion of proinflammatory cytokines (IL1b and TNF a), measured by an immunoenzymatic method in culture supernatants. Parallel negative control and specific positive controls were run. 24 hrs exposures of 70% confluent cultures were applied in the experiments. Additional assays for 3T3 cells sensitivity tests to TNFa were performed. All assays demonstrated the lack of cytotoxic and proinflammatory effects of silica wafers and titanium implants. Only on uncoated titanium a statis...
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International Immunology, 2010
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European Journal of Cancer, 2016
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Journal of the mechanical behavior of biomedical materials, 2015
Bioactive glasses are currently considered the suitable candidates to stir the quest for a new ge... more Bioactive glasses are currently considered the suitable candidates to stir the quest for a new generation of osseous implants with superior biological/functional performance. In congruence with this vision, this contribution aims to introduce a reliable technological recipe for coating fairly complex 3D-shaped implants (e.g. dental screws) with uniform and mechanical resistant bioactive glass films by the radio-frequency magnetron sputtering method. The mechanical reliability of the bioactive glass films applied to real Ti dental implant fixtures has been evaluated by a procedure comprised of "cold" implantation in pig mandibular bone from a dead animal, followed by immediate tension-free extraction tests. The effects of the complex mechanical strains occurring during implantation were analysed by scanning electron microscopy coupled with electron dispersive spectroscopy. Extensive biocompatibility assays (MTS, immunofluorescence, Western blot) revealed that the bioactive ...
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Toxicology Letters, 2008
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Papers by Cristiana Tanase