Papers by Simin Dadparvar
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 1985
Malignant soft-tissue neoplasms may be demonstrated in the course of triple-phase skeletal scinti... more Malignant soft-tissue neoplasms may be demonstrated in the course of triple-phase skeletal scintigraphy due to the presence of either abnormal vascularity or calcifications. We report the unusual case of a malignant lymphoma which was detected in the vascular phases of a triple-phase skeletal scintigraphic study but was not visualized utilizing conventional radioangiographic techniques. Lymphoma should be included in the differential diagnosis of soft-tissue neoplasms demonstrable by scintiangiography.
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Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 1993
We present the findings on iodine-131 (131I) scintigraphy, thallium-201 (201Tl) scintigraphy and ... more We present the findings on iodine-131 (131I) scintigraphy, thallium-201 (201Tl) scintigraphy and quantitative thyroglobulin (QTG) estimation in two patients with follicular carcinoma of the thyroid with extensive metastases. The lesions were initially seen on 131I scintigraphs, but were not subsequently visualized with scanning doses of 131I (5 mCi), while retaining their ability to produce increasing amounts of thyroglobulin and take up 201Tl. Implications in choosing the appropriate diagnostic tests in the management of differentiated thyroid cancer are discussed.
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Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 1994
A patient with a history of cardiac transplant presented with a fever of undetermined etiology. T... more A patient with a history of cardiac transplant presented with a fever of undetermined etiology. The patient had been on multiple medications, including phenytoin, which can occasionally cause allergic or hypersensitivity pneumonitis. A chest x-ray and CT scan of the chest revealed no active disease. A 67Ga study was obtained after intravenous administration of 377.4 MBq (10.2 mCi) of 67Ga-citrate. The images showed diffuse intense lung uptake bilaterally. Bronchoscopic biopsy revealed hypersensitivity pneumonitis. Phenytoin was withdrawn and corticosteroid was started in therapeutic doses. A follow-up gallium study obtained 25 days after the baseline demonstrated marked improvement in the lungs with concurrent clinical recovery. This case illustrates the usefulness of 67Ga in the detection of drug-induced pneumonitis and in the follow-up of response to therapy.
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Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 1990
Markedly altered biodistribution of [67Ga]citrate was observed in a 66-yr-old hemodialysis patien... more Markedly altered biodistribution of [67Ga]citrate was observed in a 66-yr-old hemodialysis patient imaged at 48 hr postinjection. A review of the patient's hospital records revealed toxic serum levels of aluminum, treated with the chelating agent desferoxamine. Based on what is known about the biologic interactions between gallium, aluminum, transferrin, and desferoxamine, we believe that both toxic serum aluminum levels and desferoxamine therapy may cause altered biodistribution on [67Ga]citrate scintigraphy.
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Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 1992
A 56-yr-old man with a prior history of renal cell carcinoma had moderately intense abnormal loca... more A 56-yr-old man with a prior history of renal cell carcinoma had moderately intense abnormal localization of 201Tl-chloride in a solitary brain lesion which was discovered to be a bacterial abscess. The organisms isolated by culture included Actinomycosis odontolyticus, Peptostreptococcus and Hemophilus aphrophilus. Because of the clinical presentation, MRI characteristics and thallium scintigraphic findings, the lesion had been felt to represent either a primary or a metastatic neoplasm. This case illustrates the need for caution in the interpretation of thallium brain scintigram.
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Radiation Oncology Investigations, 1995
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The Cancer Journal, 2002
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Journal of Immunotherapy, 1994
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International Journal of Radiation Oncology*Biology*Physics, 1992
Twenty-five patients with primary presentation of malignant astrocytoma, astrocytoma with anaplas... more Twenty-five patients with primary presentation of malignant astrocytoma, astrocytoma with anaplastic foci, and glioblastoma multiforme were treated with surgical resection and definitive radiation therapy followed by intravenous or intra-arterial administration of Iodine-125 labeled monoclonal antibody-425, which binds specifically to human epidermal growth factor receptor. The patients presented with primary untreated disease, positive contrast enhanced computed tomography scans of the brain, and compatible clinical symptoms. In this Phase II clinical trial, the patients had surgical debulking or biopsy followed by definitively administered external beam radiation therapy and one or multiple doses (35 to 90 mCi per infusion) of radiolabeled antibody. The total cumulative doses ranged from 40 to 224 mCi. The administrations of the radiolabeled antibody were performed in most cases 4-6 weeks following completion of the primary surgery and radiation therapy. Ten patients had astrocytoma with anaplastic foci and 15 had glioblastoma multiforme. No significant life-threatening toxicities were observed during this trial. At 1 year 60% of the patients with astrocytoma with anaplastic foci or glioblastoma multiforme are alive. The median survival for both groups was 15.6 months.
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Clinical Nuclear Medicine, 1983
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CLINICAL NUCLEAR MEDICINE, 1997
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CLINICAL NUCLEAR MEDICINE, 1997
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Clinical Nuclear Medicine, 1996
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Clinical Nuclear Medicine, 1994
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Cancer, 1994
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s from the ACNP 34th Annual Meeting, February 15–18, 2007, San Antonio, Texas
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Journal of Nuclear Medicine, 2019
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Society of Nuclear Medicine Annual Meeting Abstracts, May 1, 2006
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Society of Nuclear Medicine Annual Meeting Abstracts, May 1, 2006
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Society of Nuclear Medicine Annual Meeting Abstracts, May 1, 2008
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Papers by Simin Dadparvar