Background Long-acting injectable (LAI) antipsychotics provide some advantages in treatment compl... more Background Long-acting injectable (LAI) antipsychotics provide some advantages in treatment compliance of psychotic disorders. However, information about their effects during pregnancy is still very limited. We expose a clinical case of aripiprazole LAI use in a pregnant woman diagnosed of schizophrenia. Methods A non-systematic review using Pubmed was conducted using the following terms: schizophrenia, pregnancy, aripiprazole and aripiprazole LAI. A clinical record review was performed for the clinical case report. Results We report the case of a 30-year-old woman diagnosed of schizophrenia. She required several hospital admissions in the past because of the mental disorder and the lack of treatment adherence, what was the consequence of having no insight of illness and her pregnancy desires. She was initially treated with risperidone, suffering from some adverse effects like prolactine elevation and amenorrhea. In the last hospital admission, she started treatment with aripiprazol...
Background Bipolar Disorder (BD) is a major psychiatric illness defined by episodic mood changes,... more Background Bipolar Disorder (BD) is a major psychiatric illness defined by episodic mood changes, which in approximately 50% of cases is associated with psychotic features. Over the past decades, a large amount of research has identified brain structural and functional alterations in patients with this mental disorder. Some findings have been found to be specific to patients with psychotic symptoms, raising suggestions that this could represent a biological subtype of the disorder. Recent interest has been addressed to Early-Onset Bipolar Disorder (EOBD, onset prior to age 18). Latest reviews in EOBD samples have pointed to abnormalities in the frontal lobe and limbic structures, with some inconsistencies in the reported results possibly caused by differences in the methodology. In addition, no study so far has examined the neural structural correlates of psychotic symptoms in adolescent-onset bipolar disorder (AOBD). The aim of the present study is to examine the impact of psychosi...
Background: Some previous studies in high-functioning austim spectrum disorders (HF-ASD) have sho... more Background: Some previous studies in high-functioning austim spectrum disorders (HF-ASD) have showed impairments in executive functions, as in planning, inhibitory control, flexibility and working memory (Ozonoff, et al. 2004; Robinson, et al., 2009). However, no conclusive results have been obtained (Hill et al., 2004) and the study of executive dysfunction in these children has been amply critized for its excessive reliance in laboratory measures (Gilotty, et al., 2002). Others measures have been used for evaluating executive functioning, as parent’s rated questionnaires which assess the child's daily functioning. By using these questionnaires, it have been founded great impairments in executive functioning, especially in flexibility (Gioia, et al., 2002) and it have been reported that the areas most associated with adaptive functioning were initiative and working memory (Gilotty, et al., 2002; Janusz, et al., 2002). Preliminary results of a large cognitive study in HF-ASD chi...
European Archives of Psychiatry and Clinical Neuroscience, 2010
Early-onset bipolar disorder is an impairing condition that is strongly associated with genetic i... more Early-onset bipolar disorder is an impairing condition that is strongly associated with genetic inheritance. Neurocognitive deficits are core traits of this disorder which seem to be present in both young and adult forms. Deficits in verbal memory and attention are persistent within euthymic phases in bipolar adults, adolescents, and children. In younger samples, including type I or II and not otherwise specified patients, executive functions are not widely impaired and the existence of visual-spatial deficits remains unclear. The main aim of this study was to compare the neurocognitive performance in young stabilized type I or II bipolar patients and healthy controls. Fifteen medicated adolescents with bipolar disorder and 15 healthy adolescents, matched in age and gender, were compared on visual-spatial skills (reasoning, memory, visual-motor accuracy) and executive functioning (attention and working memory, set-shifting, inhibition) using t-tests and MANCOVA. Correcting for verbal competence, MANCOVA showed that patients performed significantly worse than controls in letters and numbers sequencing (P = 0.003), copy (P < 0.001) and immediate recall (P = 0.007) of the Rey Complex Figure Test, interference of the Stroop Color-Word Test (P = 0.007) and non-perseverative errors on the Wisconsin Card Sorting Test (P = 0.038). Impaired cognitive performance was found in young bipolar patients in working memory, visual-motor skills, and inhibitory control.
Rev Esp Reumatol. 2005; 32 (3): 99-105 99 las diferencias estadísticamente significativas. Conclu... more Rev Esp Reumatol. 2005; 32 (3): 99-105 99 las diferencias estadísticamente significativas. Conclusiones: Estos resultados sugieren que el TM puede ser una opción válida para conseguir una mejora de la calidad de vida y en la adaptación psicológica de las ...
Multidisciplinary treatments (MTs) are usually recommended for reducing fibromyalgia (FM) symptom... more Multidisciplinary treatments (MTs) are usually recommended for reducing fibromyalgia (FM) symptoms and include physical exercise, drug management, education, and cognitive behavior therapy (CBT). However, there is no evidence that CBT adds efficacy to the other therapeutic components. This randomized controlled trial analyzed the response of FM patients to two MTs, with and without CBT, according to the presence of concurrent symptoms.
Background Long-acting injectable (LAI) antipsychotics provide some advantages in treatment compl... more Background Long-acting injectable (LAI) antipsychotics provide some advantages in treatment compliance of psychotic disorders. However, information about their effects during pregnancy is still very limited. We expose a clinical case of aripiprazole LAI use in a pregnant woman diagnosed of schizophrenia. Methods A non-systematic review using Pubmed was conducted using the following terms: schizophrenia, pregnancy, aripiprazole and aripiprazole LAI. A clinical record review was performed for the clinical case report. Results We report the case of a 30-year-old woman diagnosed of schizophrenia. She required several hospital admissions in the past because of the mental disorder and the lack of treatment adherence, what was the consequence of having no insight of illness and her pregnancy desires. She was initially treated with risperidone, suffering from some adverse effects like prolactine elevation and amenorrhea. In the last hospital admission, she started treatment with aripiprazol...
Background Bipolar Disorder (BD) is a major psychiatric illness defined by episodic mood changes,... more Background Bipolar Disorder (BD) is a major psychiatric illness defined by episodic mood changes, which in approximately 50% of cases is associated with psychotic features. Over the past decades, a large amount of research has identified brain structural and functional alterations in patients with this mental disorder. Some findings have been found to be specific to patients with psychotic symptoms, raising suggestions that this could represent a biological subtype of the disorder. Recent interest has been addressed to Early-Onset Bipolar Disorder (EOBD, onset prior to age 18). Latest reviews in EOBD samples have pointed to abnormalities in the frontal lobe and limbic structures, with some inconsistencies in the reported results possibly caused by differences in the methodology. In addition, no study so far has examined the neural structural correlates of psychotic symptoms in adolescent-onset bipolar disorder (AOBD). The aim of the present study is to examine the impact of psychosi...
Background: Some previous studies in high-functioning austim spectrum disorders (HF-ASD) have sho... more Background: Some previous studies in high-functioning austim spectrum disorders (HF-ASD) have showed impairments in executive functions, as in planning, inhibitory control, flexibility and working memory (Ozonoff, et al. 2004; Robinson, et al., 2009). However, no conclusive results have been obtained (Hill et al., 2004) and the study of executive dysfunction in these children has been amply critized for its excessive reliance in laboratory measures (Gilotty, et al., 2002). Others measures have been used for evaluating executive functioning, as parent’s rated questionnaires which assess the child's daily functioning. By using these questionnaires, it have been founded great impairments in executive functioning, especially in flexibility (Gioia, et al., 2002) and it have been reported that the areas most associated with adaptive functioning were initiative and working memory (Gilotty, et al., 2002; Janusz, et al., 2002). Preliminary results of a large cognitive study in HF-ASD chi...
European Archives of Psychiatry and Clinical Neuroscience, 2010
Early-onset bipolar disorder is an impairing condition that is strongly associated with genetic i... more Early-onset bipolar disorder is an impairing condition that is strongly associated with genetic inheritance. Neurocognitive deficits are core traits of this disorder which seem to be present in both young and adult forms. Deficits in verbal memory and attention are persistent within euthymic phases in bipolar adults, adolescents, and children. In younger samples, including type I or II and not otherwise specified patients, executive functions are not widely impaired and the existence of visual-spatial deficits remains unclear. The main aim of this study was to compare the neurocognitive performance in young stabilized type I or II bipolar patients and healthy controls. Fifteen medicated adolescents with bipolar disorder and 15 healthy adolescents, matched in age and gender, were compared on visual-spatial skills (reasoning, memory, visual-motor accuracy) and executive functioning (attention and working memory, set-shifting, inhibition) using t-tests and MANCOVA. Correcting for verbal competence, MANCOVA showed that patients performed significantly worse than controls in letters and numbers sequencing (P = 0.003), copy (P < 0.001) and immediate recall (P = 0.007) of the Rey Complex Figure Test, interference of the Stroop Color-Word Test (P = 0.007) and non-perseverative errors on the Wisconsin Card Sorting Test (P = 0.038). Impaired cognitive performance was found in young bipolar patients in working memory, visual-motor skills, and inhibitory control.
Rev Esp Reumatol. 2005; 32 (3): 99-105 99 las diferencias estadísticamente significativas. Conclu... more Rev Esp Reumatol. 2005; 32 (3): 99-105 99 las diferencias estadísticamente significativas. Conclusiones: Estos resultados sugieren que el TM puede ser una opción válida para conseguir una mejora de la calidad de vida y en la adaptación psicológica de las ...
Multidisciplinary treatments (MTs) are usually recommended for reducing fibromyalgia (FM) symptom... more Multidisciplinary treatments (MTs) are usually recommended for reducing fibromyalgia (FM) symptoms and include physical exercise, drug management, education, and cognitive behavior therapy (CBT). However, there is no evidence that CBT adds efficacy to the other therapeutic components. This randomized controlled trial analyzed the response of FM patients to two MTs, with and without CBT, according to the presence of concurrent symptoms.
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