The recent application of proteomics and metabolomics to clinical medicine has demonstrated their... more The recent application of proteomics and metabolomics to clinical medicine has demonstrated their potential role in complementing genomics for a better understanding of diseases' patho-physiology. These technologies offer the clear opportunity to identify risk factors, disease-specific or stage-specific biomarkers and to predict therapeutic response. This article is an overview of the recent insights obtained by metabolomic and proteomic studies in inherited kidney disorders. Proteomics studies have allowed the definition of a detailed picture of protein composition, post-translational modifications and interactions in kidney-derived samples, improving our understanding of renal physiology, especially of tubular transport and primary cilium-related functions. Studies on patients' urine samples and experimental models of inherited kidney diseases have provided clues suggesting novel potential pathological mechanisms and biomarkers of disease, for example in polycystic kidney ...
Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 1999
Aortopulmonary window (A-P window) is a rare congenital heart disease. The majority of patients c... more Aortopulmonary window (A-P window) is a rare congenital heart disease. The majority of patients come to the hospital with congestive heart failure. If they are left untreated, irreversible pulmonary vascular hypertension inevitably occurs. Although the hemodynamic of this disease resembles large persistent ductus arteriosus, the treatment is quite different. We report one patient of A-P window, a 4 month-old girl, who presented with fever and dyspnea. On investigations, she had A-P window. We successfully treated her by closure the defect under cardiopulmonary bypass. We describe the technique we used.
Acute respiratory distress syndrome (ARDS) is a life-threatening complication of Coronavirus Dise... more Acute respiratory distress syndrome (ARDS) is a life-threatening complication of Coronavirus Disease 2019 (COVID-19) with the mortality rate is as high as 40% Extracorporeal membrane oxygenation (ECMO) can be considered in selected patients with cardiopulmonary failure unresponsive to conventional management We share our experience of using ECMO in severe ARDS secondary to COVID-19 The patient was a 44-year-old male with a confirmed diagnosis of COVID-19 suffering from ARDS and submassive pulmonary embolism requiring mechanical ventilation on day 20 after onset of illness Tocilizumab, low molecular weight heparins, and antiviral agents were promptly administered Despite the optimization of ventilatory support, his condition was deteriorating then ECMO was applied Intravenous methylprednisolone and extracorporeal hemadsorption were started due to cytokine storm Fortunately, the patient showed a significant clinical response to the treatment, and ECMO was eventually discontinued The p...
Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 1999
Aortopulmonary window (A-P window) is a rare congenital heart disease. The majority of patients c... more Aortopulmonary window (A-P window) is a rare congenital heart disease. The majority of patients come to the hospital with congestive heart failure. If they are left untreated, irreversible pulmonary vascular hypertension inevitably occurs. Although the hemodynamic of this disease resembles large persistent ductus arteriosus, the treatment is quite different. We report one patient of A-P window, a 4 month-old girl, who presented with fever and dyspnea. On investigations, she had A-P window. We successfully treated her by closure the defect under cardiopulmonary bypass. We describe the technique we used.
The recent application of proteomics and metabolomics to clinical medicine has demonstrated their... more The recent application of proteomics and metabolomics to clinical medicine has demonstrated their potential role in complementing genomics for a better understanding of diseases' patho-physiology. These technologies offer the clear opportunity to identify risk factors, disease-specific or stage-specific biomarkers and to predict therapeutic response. This article is an overview of the recent insights obtained by metabolomic and proteomic studies in inherited kidney disorders. Proteomics studies have allowed the definition of a detailed picture of protein composition, post-translational modifications and interactions in kidney-derived samples, improving our understanding of renal physiology, especially of tubular transport and primary cilium-related functions. Studies on patients' urine samples and experimental models of inherited kidney diseases have provided clues suggesting novel potential pathological mechanisms and biomarkers of disease, for example in polycystic kidney ...
Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 1999
Aortopulmonary window (A-P window) is a rare congenital heart disease. The majority of patients c... more Aortopulmonary window (A-P window) is a rare congenital heart disease. The majority of patients come to the hospital with congestive heart failure. If they are left untreated, irreversible pulmonary vascular hypertension inevitably occurs. Although the hemodynamic of this disease resembles large persistent ductus arteriosus, the treatment is quite different. We report one patient of A-P window, a 4 month-old girl, who presented with fever and dyspnea. On investigations, she had A-P window. We successfully treated her by closure the defect under cardiopulmonary bypass. We describe the technique we used.
Acute respiratory distress syndrome (ARDS) is a life-threatening complication of Coronavirus Dise... more Acute respiratory distress syndrome (ARDS) is a life-threatening complication of Coronavirus Disease 2019 (COVID-19) with the mortality rate is as high as 40% Extracorporeal membrane oxygenation (ECMO) can be considered in selected patients with cardiopulmonary failure unresponsive to conventional management We share our experience of using ECMO in severe ARDS secondary to COVID-19 The patient was a 44-year-old male with a confirmed diagnosis of COVID-19 suffering from ARDS and submassive pulmonary embolism requiring mechanical ventilation on day 20 after onset of illness Tocilizumab, low molecular weight heparins, and antiviral agents were promptly administered Despite the optimization of ventilatory support, his condition was deteriorating then ECMO was applied Intravenous methylprednisolone and extracorporeal hemadsorption were started due to cytokine storm Fortunately, the patient showed a significant clinical response to the treatment, and ECMO was eventually discontinued The p...
Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 1999
Aortopulmonary window (A-P window) is a rare congenital heart disease. The majority of patients c... more Aortopulmonary window (A-P window) is a rare congenital heart disease. The majority of patients come to the hospital with congestive heart failure. If they are left untreated, irreversible pulmonary vascular hypertension inevitably occurs. Although the hemodynamic of this disease resembles large persistent ductus arteriosus, the treatment is quite different. We report one patient of A-P window, a 4 month-old girl, who presented with fever and dyspnea. On investigations, she had A-P window. We successfully treated her by closure the defect under cardiopulmonary bypass. We describe the technique we used.
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