Dithranol is one of the oldest and most efficient drugs used in the treatment of psoriasis. One o... more Dithranol is one of the oldest and most efficient drugs used in the treatment of psoriasis. One of the challenges with using dithranol is its photostability, because it easily degrades when exposed to light. This study investigated the potential of coaxial core-sheath PCL/PVA nanofibers as a dual-functional system for enhancing dithranol photostability and remote-controlled drug delivery for psoriasis therapy. We have shown that coaxial nanofibers with titanium oxide nanoparticles (reflecting and absorbing ultra-violet light) in the PVA-based sheath part of the nanofibers can increase dithranol photostability. Incorporation of dithranol and magnetic nanoparticles into a PCL-based core of the nanofibers enables dithranol release control via an external radio-frequency field. The application of a radio-frequency field generates heat that can be used to control the release rate of drugs. Our approach therefore offers a non-invasive and remotely controlled drug release system that hold ...
We have evaluated heating capabilities of new magnetic nanoparticles. In in vitro experiments the... more We have evaluated heating capabilities of new magnetic nanoparticles. In in vitro experiments they were exposed to an alternating magnetic field with frequency 3.5 MHz and induction 1.5 mT produced in three turn pancake coil. In in vivo experiments rats with injected magnetic nanoparticles were also exposed to an ac field. An optimal increase of temperature of the tumor to 44 degrees C was achieved after 10 minutes of exposure. Obtained results showed that magnetic nanoparticles may be easily heated in vitro as well as in vivo, and may be therefore useful for hyperthermic therapy of cancer.
There is substantial evidence regarding enhanced antitumor cytotoxicity of selected chemotherapeu... more There is substantial evidence regarding enhanced antitumor cytotoxicity of selected chemotherapeutic agents by appropriate heat exposure (40–44°C). Based upon these results, the integration of hyperthermia as an additional treatment modality given simultaneously with systemic chemotherapy is currently of considerable interest. Hyperthermia can be induced by alternating magnetic field and magnetic nanoparticles. Thus, we have used thermosensitive magnetoliposomes that contained superparamagnetic iron oxide nanoparticles and doxorubicin for in vitro and in vivo therapy of rat glioma C6. The results showed that magnetoliposomes can be specifically heated to 43°C (phase transition temperature of a used lipid composition) in a few minutes, and during this, the encapsulated doxorubicin is released in a controllable manner. The in vitro experiments showed that the cell viability decreased to 79.2% after heat treatment alone and to 47.4% for doxorubicin-loaded magnetoliposomes without application of alternating magnetic field, while the combined treatment resulted in 17.3% cell viability. Also, in vivo results demonstrated that magnetic drug targeting has a strong antiglioma effect with a tumor volume growth inhibition and complete regression. Such targeted delivery and controlled release of anticancer agents would provide clinical advantages compared with currently available methods.
A novel platform has been developed for combined cancer chemotherapy and hyperthermia based on ir... more A novel platform has been developed for combined cancer chemotherapy and hyperthermia based on iron oxide magnetic nanoparticles functionalized with cis-diamminedichloroplatinum(II) (cisplatin). The capabilities of this system for heating and controlled drug release were investigated, and the system was tested in vitro by the treatment of BP6 rat sarcoma cells, where we demonstrated a synergism between the effects of cisplatin-targetMAG nanoparticles and the application of electromagnetic field.
Abstract Lungs are used as an attractive possibility for administration of different therapeutic ... more Abstract Lungs are used as an attractive possibility for administration of different therapeutic substances for a long time. An innovative method of such administration widely studied nowadays is the application of aerosolized magnetic particles as the carriers to the lungs in the external non-homogeneous magnetic field. For these reasons we have studied dynamics of such a system on a level of particle trajectory in air in the presence of magnetic force as a driving force exerted on micrometric magnetic particle. On two typical examples of magnetically driven systems—motion of magnetic particle in a gradient magnetic field and cyclotron-like motion of a charged particle in homogeneous magnetic field in microscale, where the external accelerating forces are very large and the relevant time scale is of the order from fraction of milliseconds to seconds, we have examined the importance of these forces. As has been shown, for particles with high initial acceleration, not only the commonly used Stokes force but also the Basset history force should be used for correct description of the motion.
The purpose of this study was to apply functionalized magnetic nanoparticles for the treatment of... more The purpose of this study was to apply functionalized magnetic nanoparticles for the treatment of amyloidosis, a disease characterized by the accumulation of aberrant protein forms with an insoluble amyloid structure. The dissolution and clearance of these extremely stable fibrils from lesions is very complicated. For this purpose, we examined the possibility of using magnetic nanoparticles that generate heat in an external alternating magnetic field with a frequency of 3.5 MHz. As a convenient model system, we used lysozyme fibrils. For the quantification of fibrillar status, we used Thioflavin T and Congo red, specific dyes which change their spectroscopic properties upon binding with the cross-beta structure of fibrils. We found that by using fluorescence, and polarization microscopy, as well as absorption spectrophotometry, the amyloid-like fibrils can be almost completely dissolved. The obtained results suggest that the application of magnetic nanoparticles could be a possible ...
It was shown on the Frank autocatalytic reaction-diffusion scheme that strong environmental fluct... more It was shown on the Frank autocatalytic reaction-diffusion scheme that strong environmental fluctuations, conditioned by external noise (e.g. sunlight fluctuation) and external macroscopic flows (e.g. ebb and flow), typical for conditions on prebiotic earth, may have been beneficial for chiral symmetry breaking and formation and stabilization of biomolecular homochirality.
International Journal of Nonlinear Sciences and Numerical Simulation
Magnetic carriers for guiding, delivery, and capturing of drugs to desired place attract interest... more Magnetic carriers for guiding, delivery, and capturing of drugs to desired place attract interest in the field of smart treatment of various pathological conditions. Presented paper, therefore, deals with one such application with the theoretical model of magnetic fluid flow through vessel bifurcation with one arm treated with ferromagnetic vascular stent placed in an external originally homogeneous magnetic field. This flow was described as laminar Newtonian incompressible continuum of the magnetic many-bead system, with Reynolds number ≈ 1 $\approx 1$ , using magnetic force variant of the Nernst–Planck equation coupled with the Navier–Stokes equations, solved numerically by the finite element method (FEM). This approach allowed us to quantify capturing efficiency of magnetic beads in each arm of bifurcation vessels. Results show reduction of the number of magnetic beads entering as well as leaving the arm treated with stent in comparison with the untreated one. For stented bifurca...
Dithranol is one of the oldest and most efficient drugs used in the treatment of psoriasis. One o... more Dithranol is one of the oldest and most efficient drugs used in the treatment of psoriasis. One of the challenges with using dithranol is its photostability, because it easily degrades when exposed to light. This study investigated the potential of coaxial core-sheath PCL/PVA nanofibers as a dual-functional system for enhancing dithranol photostability and remote-controlled drug delivery for psoriasis therapy. We have shown that coaxial nanofibers with titanium oxide nanoparticles (reflecting and absorbing ultra-violet light) in the PVA-based sheath part of the nanofibers can increase dithranol photostability. Incorporation of dithranol and magnetic nanoparticles into a PCL-based core of the nanofibers enables dithranol release control via an external radio-frequency field. The application of a radio-frequency field generates heat that can be used to control the release rate of drugs. Our approach therefore offers a non-invasive and remotely controlled drug release system that hold ...
We have evaluated heating capabilities of new magnetic nanoparticles. In in vitro experiments the... more We have evaluated heating capabilities of new magnetic nanoparticles. In in vitro experiments they were exposed to an alternating magnetic field with frequency 3.5 MHz and induction 1.5 mT produced in three turn pancake coil. In in vivo experiments rats with injected magnetic nanoparticles were also exposed to an ac field. An optimal increase of temperature of the tumor to 44 degrees C was achieved after 10 minutes of exposure. Obtained results showed that magnetic nanoparticles may be easily heated in vitro as well as in vivo, and may be therefore useful for hyperthermic therapy of cancer.
There is substantial evidence regarding enhanced antitumor cytotoxicity of selected chemotherapeu... more There is substantial evidence regarding enhanced antitumor cytotoxicity of selected chemotherapeutic agents by appropriate heat exposure (40–44°C). Based upon these results, the integration of hyperthermia as an additional treatment modality given simultaneously with systemic chemotherapy is currently of considerable interest. Hyperthermia can be induced by alternating magnetic field and magnetic nanoparticles. Thus, we have used thermosensitive magnetoliposomes that contained superparamagnetic iron oxide nanoparticles and doxorubicin for in vitro and in vivo therapy of rat glioma C6. The results showed that magnetoliposomes can be specifically heated to 43°C (phase transition temperature of a used lipid composition) in a few minutes, and during this, the encapsulated doxorubicin is released in a controllable manner. The in vitro experiments showed that the cell viability decreased to 79.2% after heat treatment alone and to 47.4% for doxorubicin-loaded magnetoliposomes without application of alternating magnetic field, while the combined treatment resulted in 17.3% cell viability. Also, in vivo results demonstrated that magnetic drug targeting has a strong antiglioma effect with a tumor volume growth inhibition and complete regression. Such targeted delivery and controlled release of anticancer agents would provide clinical advantages compared with currently available methods.
A novel platform has been developed for combined cancer chemotherapy and hyperthermia based on ir... more A novel platform has been developed for combined cancer chemotherapy and hyperthermia based on iron oxide magnetic nanoparticles functionalized with cis-diamminedichloroplatinum(II) (cisplatin). The capabilities of this system for heating and controlled drug release were investigated, and the system was tested in vitro by the treatment of BP6 rat sarcoma cells, where we demonstrated a synergism between the effects of cisplatin-targetMAG nanoparticles and the application of electromagnetic field.
Abstract Lungs are used as an attractive possibility for administration of different therapeutic ... more Abstract Lungs are used as an attractive possibility for administration of different therapeutic substances for a long time. An innovative method of such administration widely studied nowadays is the application of aerosolized magnetic particles as the carriers to the lungs in the external non-homogeneous magnetic field. For these reasons we have studied dynamics of such a system on a level of particle trajectory in air in the presence of magnetic force as a driving force exerted on micrometric magnetic particle. On two typical examples of magnetically driven systems—motion of magnetic particle in a gradient magnetic field and cyclotron-like motion of a charged particle in homogeneous magnetic field in microscale, where the external accelerating forces are very large and the relevant time scale is of the order from fraction of milliseconds to seconds, we have examined the importance of these forces. As has been shown, for particles with high initial acceleration, not only the commonly used Stokes force but also the Basset history force should be used for correct description of the motion.
The purpose of this study was to apply functionalized magnetic nanoparticles for the treatment of... more The purpose of this study was to apply functionalized magnetic nanoparticles for the treatment of amyloidosis, a disease characterized by the accumulation of aberrant protein forms with an insoluble amyloid structure. The dissolution and clearance of these extremely stable fibrils from lesions is very complicated. For this purpose, we examined the possibility of using magnetic nanoparticles that generate heat in an external alternating magnetic field with a frequency of 3.5 MHz. As a convenient model system, we used lysozyme fibrils. For the quantification of fibrillar status, we used Thioflavin T and Congo red, specific dyes which change their spectroscopic properties upon binding with the cross-beta structure of fibrils. We found that by using fluorescence, and polarization microscopy, as well as absorption spectrophotometry, the amyloid-like fibrils can be almost completely dissolved. The obtained results suggest that the application of magnetic nanoparticles could be a possible ...
It was shown on the Frank autocatalytic reaction-diffusion scheme that strong environmental fluct... more It was shown on the Frank autocatalytic reaction-diffusion scheme that strong environmental fluctuations, conditioned by external noise (e.g. sunlight fluctuation) and external macroscopic flows (e.g. ebb and flow), typical for conditions on prebiotic earth, may have been beneficial for chiral symmetry breaking and formation and stabilization of biomolecular homochirality.
International Journal of Nonlinear Sciences and Numerical Simulation
Magnetic carriers for guiding, delivery, and capturing of drugs to desired place attract interest... more Magnetic carriers for guiding, delivery, and capturing of drugs to desired place attract interest in the field of smart treatment of various pathological conditions. Presented paper, therefore, deals with one such application with the theoretical model of magnetic fluid flow through vessel bifurcation with one arm treated with ferromagnetic vascular stent placed in an external originally homogeneous magnetic field. This flow was described as laminar Newtonian incompressible continuum of the magnetic many-bead system, with Reynolds number ≈ 1 $\approx 1$ , using magnetic force variant of the Nernst–Planck equation coupled with the Navier–Stokes equations, solved numerically by the finite element method (FEM). This approach allowed us to quantify capturing efficiency of magnetic beads in each arm of bifurcation vessels. Results show reduction of the number of magnetic beads entering as well as leaving the arm treated with stent in comparison with the untreated one. For stented bifurca...
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Papers by Peter Babinec