Two novel complexes, [Zn(L1)(L2)] (1) and [Ni(L3)(L4)·2H2O] (2), have been synthesized by solvoth... more Two novel complexes, [Zn(L1)(L2)] (1) and [Ni(L3)(L4)·2H2O] (2), have been synthesized by solvothermal reactions in different solvents through mixing the carboxylate ligand, imidazole-containing ligand and the metal salt. Compound 1 crystallizes in monoclinic, space group P21/c with a = 9.21400(15), b = 18.1172(3), c = 15.7669(2) A, β = 91.1769(13)o, C30H26N4O4Zn, Mr = 571.92, V = 2631.44(7) A, Z = 4, Dc = 1.444 g·cm, μ = 1.659 mm, F(000) = 1184, λ(CuKα) = 1.54178 A, the final R = 0.048, wR = 0.1442 and S = 1.139. Compound 2 crystallizes in triclinic, space group P1 with a = 7.0664(3), b = 9.5265(4), c = 12.8861(6) A, α = 74.066(4), β = 87.408(3), γ = 83.591(3)o, C34H32N6O6S2Ni, Mr = 743.49, V = 828.83(6) A, Z = 1, Dc = 1.490 g·cm, μ = 2.490 mm, F(000) = 386, λ(CuKα) = 1.54178 A, the final R = 0.0315, wR = 0.0861 and S = 1.022. Complex 1 is the 1D chain which is linked by C–H···O hydrogen bonding interactions to form a 2D supramolecular architecture. Meanwhile, complex 2 is a 2D (4,4) network with the ABCABC stacking mode and then generates a 3D supramolecular architecture through C–H···N and O–H···O hydrogen bonding interactions.
Abstract Observations acquired at ultraviolet wavelengths are uniquely well-suited to investigate... more Abstract Observations acquired at ultraviolet wavelengths are uniquely well-suited to investigate the composition and structure of Enceladus' plume. This paper describes the observations, analysis techniques and results of all the Enceladus occultations observed by Cassini's Ultraviolet Imaging Spectrograph (UVIS) and other observations designed to study the plume. Limits on gas at non-polar latitudes are derived. Constraints on the minor constituents' composition of Enceladus' primarily water vapor plume are evaluated. The overall source rate variability over a time span of 13 years is
Résumé:L’amélioration technologique et informatique explique l’évolution de l’imagerie médicale a... more Résumé:L’amélioration technologique et informatique explique l’évolution de l’imagerie médicale actuelle. Après un bref rappel historique, un état des lieux de l’imagerie actuelle concernant l’échographie cervicale, la TDM et l’IRM cervico-faciale en oncologie, sera exposé. Les développements attendus seront explicités en première partie de chapitre. La place exacte de la TEP qui donne des images fonctionnelles «métaboliques», et des autres techniques d’imagerie, sera discutée en seconde partie d’exposé, en insistant sur l’avenir de la fusion des images entre l’imagerie «anatomique» et l’imagerie «fonctionnelle» en oncologie ORL.Abstract:The advancement of imaging modalities and the availability of high-performance computing are being developed at an impressive rate and provide an entire new dimension for medical imaging of patients with head and neck cancer. Indeed, across a broad front of imaging technologies, rapid advances are being realized. In the first part of the topic, the authors will discuss the recent developments concerning ultrasonography of the neck, head and neck CT and MRI imaging modalities in oncology. Functional imaging modalities like positron emission tomography (PET), may significantly influence the staging and treatment approaches used for head and neck cancer patients. Indications for PET CT, image fusion system for MRI, CT, and PET images will be discussed in the second part of the topic.
Cancer radiothérapie : journal de la Société française de radiothérapie oncologique, 2011
Manual delineation of dental structures is too time-consuming to be feasible in routine practice.... more Manual delineation of dental structures is too time-consuming to be feasible in routine practice. Information on dose risk levels is crucial for dentists following irradiation of the head and neck to avoid postextraction osteoradionecrosis based on empirical dose-effects data established on bidimensional radiation therapy plans. We present an automatic atlas-based segmentation framework of the dental structures, called Dentalmaps, constructed from a patient image-segmentation database. This framework is accurate (within 2 Gy accuracy) and relevant for the routine use. It has the potential to guide dental care in the context of new irradiation techniques. This tool provides a user-friendly interface for dentists and radiation oncologists in the context of irradiated head and neck cancer patients. It will likely improve the knowledge of dose-effect correlations for dental complications and osteoradionecrosis.
Journal of neuroradiology. Journal de neuroradiologie, 2011
The goals of this study is to evaluate and compare the irradiation received by the practitioner w... more The goals of this study is to evaluate and compare the irradiation received by the practitioner when performing percutaneous vertebroplasty or kyphoplasty guided by CT and fluoroscopy, for precise anatomical sites. For each intervention, radiothermoluminescent dosimeters were carefully positioned on both orbitals, both hands, and both ankles of the practitioner. Twenty-four vertebroplasties were performed in 18 patients and nine kyphoplasties on seven patients. The anatomical site that is most exposed to radiation is the right hand. The two other sites subjected to irradiation are the left hand and the left orbital. This study demonstrates a significant correlation between the irradiation dose and fluoroscopy duration, reflecting both the quantity of primary-beam radiation and backscattered radiation. The radiation dose to radiologist is more important for kyphoplasty procedures than vertebroplasty.
The percutaneous treatment of pericardial effusion resulting in cardiac tamponade has undergone a... more The percutaneous treatment of pericardial effusion resulting in cardiac tamponade has undergone an evolution in recent years with the use of less invasive drainage techniques in selected cases. To determine optimal therapy modalities for oncology patients with malignant pericardial tamponade (MPT), the authors review their institutional experience with percutaneous needle puncture routes, means of imaging-guided drainage and percutaneous management of the pericardial fluid effusion (pericardial sclerosis and balloon pericardiotomy). Advantages and limits of the percutaneous techniques will be compared to the surgical treatment.
... Marcy PY, Hericord O, Novellas S, Ettore F Pierre-Yves Marcy Olivier Hericord Sébastien Novel... more ... Marcy PY, Hericord O, Novellas S, Ettore F Pierre-Yves Marcy Olivier Hericord Sébastien Novellas Francette Ettore Centre Antoine Lacassagne Nice, France ... AJR 2001; 177:14871489 4. Sheward SE, Williams AG Jr, Mettler FA Jr, Lacey SR. ...
Journal of the Association for Vascular Access, 2015
Purpose: Various venous access devices are available, including peripheral venous lines, peripher... more Purpose: Various venous access devices are available, including peripheral venous lines, peripherally inserted central catheters lines, and subcutaneous port catheters. The latter provides medium-to long-term venous access and includes medical devices that can be inserted either on the chest (chest ports) or in the arm (arm ports). We report the techniques, dedicated indications, and main complications of arm port insertion using the ultrasonography (US) guidance method. Methods: Tips and tricks of percutaneous real-time US-guided vein access technique in the arm are reviewed, and a brief literature review is reported. Results: Technical feasibility is almost 99%. US guidance allows depiction of anatomic variants, reduces the number of failed attempts, and increases the technical access rate compared with venography-guided access. Comparison of arm ports to chest ports reveals a higher global complication rate. We also report typical (mechanical) complications and dedicated indicati...
Objectifs Demontrer l’utilite du traitement par Radiofrequence des lesions secondaires osseuses e... more Objectifs Demontrer l’utilite du traitement par Radiofrequence des lesions secondaires osseuses en oncologie. Resume L’ablathermie par RF (Electrode perfusee de type Berch-told) a ete effectuee sur un groupe de patients porteurs de lesions soufflantes, lytiques, avec rupture de la corticale osseuse, de primitif varie (Sein, Thyroide, Colon). Le mode de guidage a ete effectue sous controle echographique et TDM, apres verification du bilan de coagulation. L’ablathermie a permis de controler la douleur dans tous les cas et de reduire le volume tumoral, ce qui est particulierement utile pour optimiser la destruction tumorale par IRAtherapie (carcinomes thyroidiens differencies). L’indication est a titre antalgique. Le geste percutane doit etre effectue idealement a distance des structures nerveuses et vasculaires, apres echec ou recidive post-radique. Une cimentoplastie percutanee peut etre eventuellement associee. L’embolisation pre-operatoire est egalement souhaitable pour prevenir l’effet de dispersion de chaleur en cas de lesion hyper vascularisee (tumeurs secondaires de type carcinoide, thyroidienne, renale). Conclusion L’ablathermie par RF est indiquee dans les cas de metastases osteolytiques hyperalgiques de petite taille
Objectifs Rapporter la semiologie de l’imagerie des metastases de la thyroide et l’apport de la c... more Objectifs Rapporter la semiologie de l’imagerie des metastases de la thyroide et l’apport de la cytoponction thyroidienne. Decrire les « patients a risque ». Materiels et methodes Etude retrospective multicentrique recherchant les mots cles suivants : « metastase thyroidienne » en histologie et/ou cytologie [anapath], croises avec echographie thyroidienne +/- cytoponction +/-TDM+/-IRM de la thyroide [Imagerie], a partir des bases de donnees informatiques-patients de cinq centres Saint-Cloud, Tenon, Jules Bordet, Caen et Nice. Resultats L’origine du primitif etait mammaire (8/34), bronchique (7/34), renal (6/34), ORL (8/34), sarcome (2/34), genito-urinaire (1/34). Le stade T (TNM) etait (3) ou (4) dans 70 %. Trois metastases etaient prevalentes, les autres cas sont survenus a 42 mois en moyenne apres le diagnostic oncologique initial, sous forme de nodules isoles ou multiples (11/34), d’hypertrophie unilaterale (15/34), et de goitre (8/34). Les adenopathies (60 %) siegeaient aux secteurs III, IV, VI ; VII. La survie moyenne etait de 10 mois (2, 26). Le pronostic etait moins sombre en cas de tumeur renale, mais le diagnostic cyto-histologique plus difficile. Conclusion Un halo, des calcifications, des tumeurs kystiques recidivantes (sarcome) un envahissement veineux jugulaire (T renale) ont ete (rarement) rencontres. La cytoponction (se = 89,5 %) est a effectuer dans les nodules identiques hypoechogenes, et/ou dans les thyromegalies inhomogenes uni-bilaterales, d’autant qu’il s’agit d’une T3 ou T4 (sein, rein, bronches, sarcome, ORL). La physiopathogenie est discutee.
Objectifs Rapporter la semiologie de l’imagerie metastases a la thyroide et l’apport de la cytopo... more Objectifs Rapporter la semiologie de l’imagerie metastases a la thyroide et l’apport de la cytoponction thyroidienne. Decrire les « patients a risque ». Materiels et methodes Etude retrospective multicentrique recherchant les mots cles suivants : « metastase thyroidienne » en histologie et/ou cytologie [Anapath], croises avec echographie thyroidienne +/-cytoponction +/-TDM+/-IRM de la thyroide [Imagerie], a partir des bases de donnees informatiques-patients de cinq centres Saint-Cloud, Tenon, Jules Bordet, Caen et Nice. Resultats L’origine du primitif etait mammaire (8/34), bronchique (7/34), renal (6/34), ORL (8/34), sarcome (2/34), genito-urinaire (1/ 34). Le stade T (TNM) etait (3) ou (4) dans 70 %. Trois metastases etaient prevalentes, les autres cas sont survenus a 42 mois en moyenne apres le diagnostic oncologique initial, sous forme de nodules isoles ou multiples (11/34), d’hypertrophie unilaterale (15/34), et de goitre (8/34). Les adenopathies (60 %) siegeaient aux secteurs III, IV, VI ; VII. La survie moyenne etait de 10 mois (2, 26). Le pronostic etait moins sombre en cas de tumeur renale, mais le diagnostic cytohistologique plus difficile. Conclusion Un halo, des calcifications, des tumeurs kystiques recidivantes (sarcome) un envahissement veineux jugulaire (T renale) ont ete (rarement) rencontres. La cytoponction (se = 89.5 %) est a effectuer dans les nodules identiques hypoechogenes, et/ou dans les thyromegalies inhomogenes uni-bilaterales, d’autant qu’il s’agit d’une T3 ou T4 (sein, rein, bronches, sarcome, ORL). La physiopathogenie est discutee.
The objective of the study was to determine outcome and satisfaction of cancer patients treated b... more The objective of the study was to determine outcome and satisfaction of cancer patients treated by home-infusions of biphosphonates. 107 patients entered the study and 97 of them chose to receive infusions of zoledronic acid (Z) in the home setting. Patient satisfaction and quality of care (QoC) were assessed by a 22-item questionnaire. Changes from baseline were determined for bone pain using a 0-10 cm visual analogue scale pain score (VAS). Patients expressed a high level of satisfaction specifically with regard to nursing care. Seventy patients experienced a significant decrease in the median pain score during the home-therapy phase not due to an increased use of analgesic therapy (P = 0.03). Z was well tolerated with no major adverse events. The authors conclude that home infusions of biphosphonates, on the condition that the supportive care team is well-organized, is a safe procedure that could be advantageous for patients by increasing satisfaction and compliance with treatment.
Two novel complexes, [Zn(L1)(L2)] (1) and [Ni(L3)(L4)·2H2O] (2), have been synthesized by solvoth... more Two novel complexes, [Zn(L1)(L2)] (1) and [Ni(L3)(L4)·2H2O] (2), have been synthesized by solvothermal reactions in different solvents through mixing the carboxylate ligand, imidazole-containing ligand and the metal salt. Compound 1 crystallizes in monoclinic, space group P21/c with a = 9.21400(15), b = 18.1172(3), c = 15.7669(2) A, β = 91.1769(13)o, C30H26N4O4Zn, Mr = 571.92, V = 2631.44(7) A, Z = 4, Dc = 1.444 g·cm, μ = 1.659 mm, F(000) = 1184, λ(CuKα) = 1.54178 A, the final R = 0.048, wR = 0.1442 and S = 1.139. Compound 2 crystallizes in triclinic, space group P1 with a = 7.0664(3), b = 9.5265(4), c = 12.8861(6) A, α = 74.066(4), β = 87.408(3), γ = 83.591(3)o, C34H32N6O6S2Ni, Mr = 743.49, V = 828.83(6) A, Z = 1, Dc = 1.490 g·cm, μ = 2.490 mm, F(000) = 386, λ(CuKα) = 1.54178 A, the final R = 0.0315, wR = 0.0861 and S = 1.022. Complex 1 is the 1D chain which is linked by C–H···O hydrogen bonding interactions to form a 2D supramolecular architecture. Meanwhile, complex 2 is a 2D (4,4) network with the ABCABC stacking mode and then generates a 3D supramolecular architecture through C–H···N and O–H···O hydrogen bonding interactions.
Abstract Observations acquired at ultraviolet wavelengths are uniquely well-suited to investigate... more Abstract Observations acquired at ultraviolet wavelengths are uniquely well-suited to investigate the composition and structure of Enceladus' plume. This paper describes the observations, analysis techniques and results of all the Enceladus occultations observed by Cassini's Ultraviolet Imaging Spectrograph (UVIS) and other observations designed to study the plume. Limits on gas at non-polar latitudes are derived. Constraints on the minor constituents' composition of Enceladus' primarily water vapor plume are evaluated. The overall source rate variability over a time span of 13 years is
Résumé:L’amélioration technologique et informatique explique l’évolution de l’imagerie médicale a... more Résumé:L’amélioration technologique et informatique explique l’évolution de l’imagerie médicale actuelle. Après un bref rappel historique, un état des lieux de l’imagerie actuelle concernant l’échographie cervicale, la TDM et l’IRM cervico-faciale en oncologie, sera exposé. Les développements attendus seront explicités en première partie de chapitre. La place exacte de la TEP qui donne des images fonctionnelles «métaboliques», et des autres techniques d’imagerie, sera discutée en seconde partie d’exposé, en insistant sur l’avenir de la fusion des images entre l’imagerie «anatomique» et l’imagerie «fonctionnelle» en oncologie ORL.Abstract:The advancement of imaging modalities and the availability of high-performance computing are being developed at an impressive rate and provide an entire new dimension for medical imaging of patients with head and neck cancer. Indeed, across a broad front of imaging technologies, rapid advances are being realized. In the first part of the topic, the authors will discuss the recent developments concerning ultrasonography of the neck, head and neck CT and MRI imaging modalities in oncology. Functional imaging modalities like positron emission tomography (PET), may significantly influence the staging and treatment approaches used for head and neck cancer patients. Indications for PET CT, image fusion system for MRI, CT, and PET images will be discussed in the second part of the topic.
Cancer radiothérapie : journal de la Société française de radiothérapie oncologique, 2011
Manual delineation of dental structures is too time-consuming to be feasible in routine practice.... more Manual delineation of dental structures is too time-consuming to be feasible in routine practice. Information on dose risk levels is crucial for dentists following irradiation of the head and neck to avoid postextraction osteoradionecrosis based on empirical dose-effects data established on bidimensional radiation therapy plans. We present an automatic atlas-based segmentation framework of the dental structures, called Dentalmaps, constructed from a patient image-segmentation database. This framework is accurate (within 2 Gy accuracy) and relevant for the routine use. It has the potential to guide dental care in the context of new irradiation techniques. This tool provides a user-friendly interface for dentists and radiation oncologists in the context of irradiated head and neck cancer patients. It will likely improve the knowledge of dose-effect correlations for dental complications and osteoradionecrosis.
Journal of neuroradiology. Journal de neuroradiologie, 2011
The goals of this study is to evaluate and compare the irradiation received by the practitioner w... more The goals of this study is to evaluate and compare the irradiation received by the practitioner when performing percutaneous vertebroplasty or kyphoplasty guided by CT and fluoroscopy, for precise anatomical sites. For each intervention, radiothermoluminescent dosimeters were carefully positioned on both orbitals, both hands, and both ankles of the practitioner. Twenty-four vertebroplasties were performed in 18 patients and nine kyphoplasties on seven patients. The anatomical site that is most exposed to radiation is the right hand. The two other sites subjected to irradiation are the left hand and the left orbital. This study demonstrates a significant correlation between the irradiation dose and fluoroscopy duration, reflecting both the quantity of primary-beam radiation and backscattered radiation. The radiation dose to radiologist is more important for kyphoplasty procedures than vertebroplasty.
The percutaneous treatment of pericardial effusion resulting in cardiac tamponade has undergone a... more The percutaneous treatment of pericardial effusion resulting in cardiac tamponade has undergone an evolution in recent years with the use of less invasive drainage techniques in selected cases. To determine optimal therapy modalities for oncology patients with malignant pericardial tamponade (MPT), the authors review their institutional experience with percutaneous needle puncture routes, means of imaging-guided drainage and percutaneous management of the pericardial fluid effusion (pericardial sclerosis and balloon pericardiotomy). Advantages and limits of the percutaneous techniques will be compared to the surgical treatment.
... Marcy PY, Hericord O, Novellas S, Ettore F Pierre-Yves Marcy Olivier Hericord Sébastien Novel... more ... Marcy PY, Hericord O, Novellas S, Ettore F Pierre-Yves Marcy Olivier Hericord Sébastien Novellas Francette Ettore Centre Antoine Lacassagne Nice, France ... AJR 2001; 177:14871489 4. Sheward SE, Williams AG Jr, Mettler FA Jr, Lacey SR. ...
Journal of the Association for Vascular Access, 2015
Purpose: Various venous access devices are available, including peripheral venous lines, peripher... more Purpose: Various venous access devices are available, including peripheral venous lines, peripherally inserted central catheters lines, and subcutaneous port catheters. The latter provides medium-to long-term venous access and includes medical devices that can be inserted either on the chest (chest ports) or in the arm (arm ports). We report the techniques, dedicated indications, and main complications of arm port insertion using the ultrasonography (US) guidance method. Methods: Tips and tricks of percutaneous real-time US-guided vein access technique in the arm are reviewed, and a brief literature review is reported. Results: Technical feasibility is almost 99%. US guidance allows depiction of anatomic variants, reduces the number of failed attempts, and increases the technical access rate compared with venography-guided access. Comparison of arm ports to chest ports reveals a higher global complication rate. We also report typical (mechanical) complications and dedicated indicati...
Objectifs Demontrer l’utilite du traitement par Radiofrequence des lesions secondaires osseuses e... more Objectifs Demontrer l’utilite du traitement par Radiofrequence des lesions secondaires osseuses en oncologie. Resume L’ablathermie par RF (Electrode perfusee de type Berch-told) a ete effectuee sur un groupe de patients porteurs de lesions soufflantes, lytiques, avec rupture de la corticale osseuse, de primitif varie (Sein, Thyroide, Colon). Le mode de guidage a ete effectue sous controle echographique et TDM, apres verification du bilan de coagulation. L’ablathermie a permis de controler la douleur dans tous les cas et de reduire le volume tumoral, ce qui est particulierement utile pour optimiser la destruction tumorale par IRAtherapie (carcinomes thyroidiens differencies). L’indication est a titre antalgique. Le geste percutane doit etre effectue idealement a distance des structures nerveuses et vasculaires, apres echec ou recidive post-radique. Une cimentoplastie percutanee peut etre eventuellement associee. L’embolisation pre-operatoire est egalement souhaitable pour prevenir l’effet de dispersion de chaleur en cas de lesion hyper vascularisee (tumeurs secondaires de type carcinoide, thyroidienne, renale). Conclusion L’ablathermie par RF est indiquee dans les cas de metastases osteolytiques hyperalgiques de petite taille
Objectifs Rapporter la semiologie de l’imagerie des metastases de la thyroide et l’apport de la c... more Objectifs Rapporter la semiologie de l’imagerie des metastases de la thyroide et l’apport de la cytoponction thyroidienne. Decrire les « patients a risque ». Materiels et methodes Etude retrospective multicentrique recherchant les mots cles suivants : « metastase thyroidienne » en histologie et/ou cytologie [anapath], croises avec echographie thyroidienne +/- cytoponction +/-TDM+/-IRM de la thyroide [Imagerie], a partir des bases de donnees informatiques-patients de cinq centres Saint-Cloud, Tenon, Jules Bordet, Caen et Nice. Resultats L’origine du primitif etait mammaire (8/34), bronchique (7/34), renal (6/34), ORL (8/34), sarcome (2/34), genito-urinaire (1/34). Le stade T (TNM) etait (3) ou (4) dans 70 %. Trois metastases etaient prevalentes, les autres cas sont survenus a 42 mois en moyenne apres le diagnostic oncologique initial, sous forme de nodules isoles ou multiples (11/34), d’hypertrophie unilaterale (15/34), et de goitre (8/34). Les adenopathies (60 %) siegeaient aux secteurs III, IV, VI ; VII. La survie moyenne etait de 10 mois (2, 26). Le pronostic etait moins sombre en cas de tumeur renale, mais le diagnostic cyto-histologique plus difficile. Conclusion Un halo, des calcifications, des tumeurs kystiques recidivantes (sarcome) un envahissement veineux jugulaire (T renale) ont ete (rarement) rencontres. La cytoponction (se = 89,5 %) est a effectuer dans les nodules identiques hypoechogenes, et/ou dans les thyromegalies inhomogenes uni-bilaterales, d’autant qu’il s’agit d’une T3 ou T4 (sein, rein, bronches, sarcome, ORL). La physiopathogenie est discutee.
Objectifs Rapporter la semiologie de l’imagerie metastases a la thyroide et l’apport de la cytopo... more Objectifs Rapporter la semiologie de l’imagerie metastases a la thyroide et l’apport de la cytoponction thyroidienne. Decrire les « patients a risque ». Materiels et methodes Etude retrospective multicentrique recherchant les mots cles suivants : « metastase thyroidienne » en histologie et/ou cytologie [Anapath], croises avec echographie thyroidienne +/-cytoponction +/-TDM+/-IRM de la thyroide [Imagerie], a partir des bases de donnees informatiques-patients de cinq centres Saint-Cloud, Tenon, Jules Bordet, Caen et Nice. Resultats L’origine du primitif etait mammaire (8/34), bronchique (7/34), renal (6/34), ORL (8/34), sarcome (2/34), genito-urinaire (1/ 34). Le stade T (TNM) etait (3) ou (4) dans 70 %. Trois metastases etaient prevalentes, les autres cas sont survenus a 42 mois en moyenne apres le diagnostic oncologique initial, sous forme de nodules isoles ou multiples (11/34), d’hypertrophie unilaterale (15/34), et de goitre (8/34). Les adenopathies (60 %) siegeaient aux secteurs III, IV, VI ; VII. La survie moyenne etait de 10 mois (2, 26). Le pronostic etait moins sombre en cas de tumeur renale, mais le diagnostic cytohistologique plus difficile. Conclusion Un halo, des calcifications, des tumeurs kystiques recidivantes (sarcome) un envahissement veineux jugulaire (T renale) ont ete (rarement) rencontres. La cytoponction (se = 89.5 %) est a effectuer dans les nodules identiques hypoechogenes, et/ou dans les thyromegalies inhomogenes uni-bilaterales, d’autant qu’il s’agit d’une T3 ou T4 (sein, rein, bronches, sarcome, ORL). La physiopathogenie est discutee.
The objective of the study was to determine outcome and satisfaction of cancer patients treated b... more The objective of the study was to determine outcome and satisfaction of cancer patients treated by home-infusions of biphosphonates. 107 patients entered the study and 97 of them chose to receive infusions of zoledronic acid (Z) in the home setting. Patient satisfaction and quality of care (QoC) were assessed by a 22-item questionnaire. Changes from baseline were determined for bone pain using a 0-10 cm visual analogue scale pain score (VAS). Patients expressed a high level of satisfaction specifically with regard to nursing care. Seventy patients experienced a significant decrease in the median pain score during the home-therapy phase not due to an increased use of analgesic therapy (P = 0.03). Z was well tolerated with no major adverse events. The authors conclude that home infusions of biphosphonates, on the condition that the supportive care team is well-organized, is a safe procedure that could be advantageous for patients by increasing satisfaction and compliance with treatment.
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Papers by P. Marcy