Encuentro Internacional de Educación en Ingeniería ACOFI 2016, Aug 19, 2016
Dada la importancia de la seguridad vial a nivel mundial se resalta la necesidad de generar inves... more Dada la importancia de la seguridad vial a nivel mundial se resalta la necesidad de generar investigaciones dedicadas a analizar posibles soluciones que contribuyan a mitigar el alto indice de mortalidad existente, con el fin de que abarquen no solo medidas ejecutadas y enfocadas a mejorar la seguridad dentro del vehiculo sino tambien a generar cambio a partir de metodos dirigidos a optimizar la seguridad en el entorno del vehiculo y de los peatones. En cuanto a la movilidad y la accidentalidad en la capital del pais se indica que para el ano 2014 se presento una disminucion del 2% con relacion a las cifras del ano 2013. Aun asi por su parte la Secretaria Distrital de Movilidad presenta un registro de 10.596 eventos de accidentes con heridos. Los eventos representativos de accidentes fatales tuvieron un aumento con relacion a las cifras del ano anterior, pasando de 283 eventos en el ano 2013 a 383 para el ano 2014, lo que refleja un descuido en relacion a las victimas de los accidentes viales en Bogota. Estudios revelan una disminucion significativa en los casos de accidentes de transito fatal y no fatal con las camaras de foto deteccion. Los resultados presentados ante este tipo de metodologia indican que el indice de mortalidad por cada 100.000 vehiculos se reduce aproximadamente en un 21%, mientras que la disminucion de los accidentes de transito no fatales muestra una reduccion del 26,2%. En el ano 2014 el tramo 2 de la via Briceno – Tunja presento 194 eventos implicando un alto indice de accidentalidad, el 28.4% se presenta por colision de vehiculos, el 25% corresponde accidentes con motos involucradas, un 24.5% salida de calzada y el 5.6% atropello de peaton, y el restante se identifica como atropellos de peaton, colision de vehiculos – Animal, otros. Es decir el 54.1% es presentado por fallas humanas y el 35.1% por exceso de velocidad. A partir del estudio con camaras de velocidad en el tramo se observa la influencia subjetiva de las mismas en la reduccion de velocidad, previniendo la accidentalidad vial.
In this paper, one linear and two non linear regulation controllers are designed, tested and eval... more In this paper, one linear and two non linear regulation controllers are designed, tested and evaluated for the rotary inverted pendulum system. The state feedback controller, the sliding mode controller, and the super-twisting sliding mode controller are implemented. Their performance, robustness and energy consumption are evaluated showing their capabilities and drawbacks. In addition, a tracking controller based on Lyapunov theory is implemented to place the pendulum on its upward position.
Proceedings of the 18th LACCEI International Multi-Conference for Engineering, Education, and Technology: Engineering, Integration, And Alliances for A Sustainable Development” “Hemispheric Cooperation for Competitiveness and Prosperity on A Knowledge-Based Economy”, 2020
2017 IEEE 3rd Colombian Conference on Automatic Control (CCAC), 2017
In this paper, one linear and two non linear regulation controllers are designed, tested and eval... more In this paper, one linear and two non linear regulation controllers are designed, tested and evaluated for the rotary inverted pendulum system. The state feedback controller, the sliding mode controller, and the super-twisting sliding mode controller are implemented. Their performance, robustness and energy consumption are evaluated showing their capabilities and drawbacks. In addition, a tracking controller based on Lyapunov theory is implemented to place the pendulum on its upward position.
Cómo citar este artículo / To reference this article / Para citar este artigo: Parra, O., Barrios... more Cómo citar este artículo / To reference this article / Para citar este artigo: Parra, O., Barrios, H. y Díaz, V. (2016). La didáctica y el encanto de las Matemáticas. Revista UNIMAR, 34(1), 13-28. Fecha de recepción: 30 de noviembre de 2015 Fecha de revisión: 02 de febrero de 2016 Fecha de aprobación: 17 de marzo de 2016 El presente producto investigativo aporta herramientas metodológicas y didácticas a los docentes e investigadores para su consecuente trabajo de aula y para el fortalecimiento de las competencias investigativas y matemáticas. La metodología utilizada fue la exploratoria y hermenéutica analítica, centrada en el análisis documental a partir de la búsqueda de textos que planteen elementos teórico-prácticos en la utilización de instrumentos didácticos, experiencias, juegos y desafíos. Con base en el análisis, se plantea una propuesta de apoyo a la creación del pensamiento matemático desde la lectura, la narrativa, la visualización, el juego, la concepción ética y la res...
Fibroblast growth factor receptors (FGFRs) belong to a larger family of receptor tyrosine-kinase ... more Fibroblast growth factor receptors (FGFRs) belong to a larger family of receptor tyrosine-kinase (RTK) cell-surface receptors which phosphorylate specific tyrosine residues to trigger downstream responses such as cell proliferation, migration, and differentiation. The study of the EGL-15 FGFR in the nematode Caenorhabditis elegans has long been used as a paradigm to understand principles of RTK signaling, since defects in the processes mediated by EGL-15 result in striking phenotypes that provide powerful genetic tools. One such process is the regulation of fluid homeostasis. EGL-15 hyperactivation causes excessive accumulation of clear fluid inside the worm’s body (the Clear (Clr) phenotype). The isolation of Clr suppressors, termed suppressor of clr (soc) mutants, has led to the identification of many of the core components of EGL-15 signaling. For example, the original set of soc mutations identified the Grb2/SEM-5 adaptor protein that links RTK activation to the activation of the RAS/MAPK pathway. Although SEM-5 is required for EGL-15 signaling, a key component that links activated EGL-15 to SEM-5 has yet to be identified, since an egl-15 mutation, n1457, that eliminates the known SEM-5 binding sites on EGL-15 does not confer a Soc phenotype. To identify these missing components, we conducted a modified “enhancer” Soc screen in an egl- 15(n1457) background. This screen identified new soc mutations, defining up to four new soc genes that potentially function as the additional link between EGL-15 and SEM-5. Of sixteen characterized enhancers, six have been shown to be autosomal. Two are alleles of the known, major soc gene soc-1. Using complementation tests, we have shown that the remaining four autosomal mutations (ay157, ay169, ay174, and ay195) are allelic to one another, and are not alleles of any of the known major soc genes. To demonstrate that this is a novel soc gene, we need to determine whether or not these are alleles of one of the minor soc genes. Genetic mapping experiments can both locate this gene as well as determine whether or not it maps to a region where there are known, minor soc genes. The initial experiments to accomplish this seek to assign this complementation group to a specific chromosome, and we are using ay195 as the representative allele of this complementation group. 2-factor mapping of ay195 has shown that it does not map near the center of either chromosome IV or V. Additional mapping experiments are currently being conducted to determine if ay195 maps to the other chromosomes (I, II, or III). Further characterization of this autosomal complementation group may lead to the discovery of a new autosomal soc gene
Desarrollo de un modelo para el pronostico de precipitacion a partir de datos meteorologicos del ... more Desarrollo de un modelo para el pronostico de precipitacion a partir de datos meteorologicos del periodo mayo de 2014 hasta junio de 2017 en la zona urbana de Cuenca, a traves de Redes Neuronales Recurrentes de tipo Long Short Term Memory (LSTM).
Fibroblast growth factor receptors (FGFRs) belong to a family of receptor tyrosine-kinase (RTK) c... more Fibroblast growth factor receptors (FGFRs) belong to a family of receptor tyrosine-kinase (RTK) cell-surface receptors which phosphorylate specific tyrosine residues to trigger downstream responses such as cell proliferation, migration, and differentiation. The study of the EGL-15 FGFR in the nematode Caenorhabditis elegans has long been used as a paradigm to understand principles of RTK signaling, since defects in the processes mediated by EGL-15 result in striking phenotypes that provide powerful genetic tools. One such process is the regulation of fluid homeostasis. EGL-15 hyperactivation causes excessive accumulation of clear fluid inside the worm’s body (the Clear (Clr) phenotype). The isolation of Clr suppressors, termed Suppressor of Clr (soc) mutants, has led to the identification of many of the core components of EGL-15 signaling. For example, the original set of soc mutations identified the Grb2/SEM-5 adaptor protein that links RTK signaling to the activation of the RAS/MAPK pathway. EGL-15 can directly bind SEM-5 via a pair of binding sites on its carboxy-terminal domain (CTD). Although SEM-5 is required for EGL-15 signaling, the egl-15(n1457) mutation that truncates the CTD (ΔCTD) and eliminates the known SEM-5 binding sites on EGL-15 does not confer a Soc phenotype. These data suggest the existence of an alternate pathway that links EGL-15 to SEM-5/Grb2 in its role in mediating fluid homeostasis. To identify components of this alternative pathway, we repeated the genetic screen for Soc mutants, this time with the ΔCTD mutation in the background. This “enhancer” screen resulted in the isolation of 33 mutations. 17 of these mutations have been initially characterized and assigned to complementation groups. Seven of these enhancer mutations are new alleles of the known soc genes egl-15 (5 alleles) and soc-1 (2 alleles). Five enhancer mutations define a new soc gene on the X chromosome, soc-3; another enhancer mutation, soc(ay167), maps to another novel position on the X chromosome, potentially identifying an additional new soc gene. Four other mutations define an autosomal soc complementation group that is not one of the major soc genes identified in the original Soc screen. Sixteen enhancer mutations are still being characterized. Our preliminary characterization of these enhancer alleles indicates that the screen was successful in two ways. First, the behavior of the enhancer alleles supports two cooperative pathways that transduce EGL-15 signaling: egl-15(ay150), soc-1(ay172), and all alleles of soc-3 show only partial effects on fluid homeostasis on their own and are enhanced by the ΔCTD mutation. Second, the characterization of an initial subset of these soc enhancer mutations suggests that they define up to four new soc genes that potentially define the alternate pathway. These results are consistent with the original hypothesis that two downstream pathways collaborate to affect fluid homeostasis regulation mediated by the EGL-15 FGFR. Further genetic analysis and whole-genome sequencing will be used to identify the molecular identities of these new FGFR signaling genes
En el presente trabajo se describe un estudio realizado durante dos anos, en el cual se evaluaron... more En el presente trabajo se describe un estudio realizado durante dos anos, en el cual se evaluaron las concentraciones de aluminio presentes en el agua suministrada por el Instituto Nacional de Obras Sanitarias (INOS) a Maracaibo, Cabimas y Ciudad Ojeda (Estado Zulia, Venezuela). La ciudad de Maracaibo fue dividida en tres sectores, efectuandose 16 muestreos. En Cabimas se efectuaron cinco muestreos, en dos areas diferentes, mientras que en Ciudad Ojeda solamente se efectuo un muestreo, en seis sectores. Las determinaciones de aluminio se realizaron mediante la tecnica de la espectrometria de absorcion atomica con horno de grafito. Los resultados senalaron la ausencia de diferencias significativas en las concentraciones de aluminio con respecto al sitio va la epoca de muestreo (lluvia y sequia), encontrandose niveles del metal superiores a los optimos recomendables para agua de consumo humano.
A method of allowing fault tolerance in a client process (306) running on a system of distributed... more A method of allowing fault tolerance in a client process (306) running on a system of distributed computing (200), the method comprising: (a) instantiating a runtime environment (316) in response to a call a client process (306), the runtime environment (316) associated with the client process (306) running on distributed computing system (200); (B) executing instructions in said execution environment (316), causing said instructions to said execution environment (316) to issue new instructions to the system distributed computing (200), said additional instructions relating to actions to be taken respect to data stored in said system distributed computing (200); and (c) receiving said additional instructions via a proxy interface objects (320), wherein at least one of said additional instruction is an instruction to save the state which causes said interface proxy object (320) store a current state of the execution environment (316) in a data warehouse.
La incursión de las nuevas herramientas pedagógicas en el contexto educativo en matemáticas; gen... more La incursión de las nuevas herramientas pedagógicas en el contexto educativo en matemáticas; genera una transformación socio-cultural concerniente a la praxis pedagógica y didáctica actual. La investigación que derivó en el presente artículo pretende resaltar y fundamentar los procesos de incidencia de las TIC sobre la resolución de problemas en el marco de la didáctica de las matemáticas. Desde esta perspectiva; se realizó una revisión bibliográfica de fuentes especializadas a partir de una metodología descriptiva basada en la sistematización y clasificación de textos para dar un sustento crítico-argumentativo. Se identificaron unos núcleos de trabajo: Historia y didáctica de las matemáticas; resolución de problemas y tecnologías de la información y la comunicación. El marco cuestionador se enfocó hacia el acercamiento a una reestructuración curricular en las matemáticas; retomando la vinculación del pensamiento matemático y una didaxis hacia la comprensión mediada por las t...
Because regulatory networks of transcription factors drive embryonic patterning, it is possible t... more Because regulatory networks of transcription factors drive embryonic patterning, it is possible that chromatin accessibility states impact how networks interact with information encoded in DNA. To determine the interplay between chromatin states and regulatory network function, we performed ATAC seq onDrosophilaembryos over the period spanning the establishment of the segmentation network, from zygotic genome activation to gastrulation. Chromatin accessibility states are dynamic over this period, and establishment of the segmentation network requires maturation of the ground chromatin state. Elimination of all maternal patterning information allows identification of patterning-dependent and -independent dynamic chromatin regions. A significant proportion of patterning-dependent accessibility stems from pioneer activity of the pair-rule factor Odd-paired (opa). Whileopais necessary to drive late opening of segmentation network cis-regulatory elements, competence foropato pioneer is r...
Encuentro Internacional de Educación en Ingeniería ACOFI 2016, Aug 19, 2016
Dada la importancia de la seguridad vial a nivel mundial se resalta la necesidad de generar inves... more Dada la importancia de la seguridad vial a nivel mundial se resalta la necesidad de generar investigaciones dedicadas a analizar posibles soluciones que contribuyan a mitigar el alto indice de mortalidad existente, con el fin de que abarquen no solo medidas ejecutadas y enfocadas a mejorar la seguridad dentro del vehiculo sino tambien a generar cambio a partir de metodos dirigidos a optimizar la seguridad en el entorno del vehiculo y de los peatones. En cuanto a la movilidad y la accidentalidad en la capital del pais se indica que para el ano 2014 se presento una disminucion del 2% con relacion a las cifras del ano 2013. Aun asi por su parte la Secretaria Distrital de Movilidad presenta un registro de 10.596 eventos de accidentes con heridos. Los eventos representativos de accidentes fatales tuvieron un aumento con relacion a las cifras del ano anterior, pasando de 283 eventos en el ano 2013 a 383 para el ano 2014, lo que refleja un descuido en relacion a las victimas de los accidentes viales en Bogota. Estudios revelan una disminucion significativa en los casos de accidentes de transito fatal y no fatal con las camaras de foto deteccion. Los resultados presentados ante este tipo de metodologia indican que el indice de mortalidad por cada 100.000 vehiculos se reduce aproximadamente en un 21%, mientras que la disminucion de los accidentes de transito no fatales muestra una reduccion del 26,2%. En el ano 2014 el tramo 2 de la via Briceno – Tunja presento 194 eventos implicando un alto indice de accidentalidad, el 28.4% se presenta por colision de vehiculos, el 25% corresponde accidentes con motos involucradas, un 24.5% salida de calzada y el 5.6% atropello de peaton, y el restante se identifica como atropellos de peaton, colision de vehiculos – Animal, otros. Es decir el 54.1% es presentado por fallas humanas y el 35.1% por exceso de velocidad. A partir del estudio con camaras de velocidad en el tramo se observa la influencia subjetiva de las mismas en la reduccion de velocidad, previniendo la accidentalidad vial.
In this paper, one linear and two non linear regulation controllers are designed, tested and eval... more In this paper, one linear and two non linear regulation controllers are designed, tested and evaluated for the rotary inverted pendulum system. The state feedback controller, the sliding mode controller, and the super-twisting sliding mode controller are implemented. Their performance, robustness and energy consumption are evaluated showing their capabilities and drawbacks. In addition, a tracking controller based on Lyapunov theory is implemented to place the pendulum on its upward position.
Proceedings of the 18th LACCEI International Multi-Conference for Engineering, Education, and Technology: Engineering, Integration, And Alliances for A Sustainable Development” “Hemispheric Cooperation for Competitiveness and Prosperity on A Knowledge-Based Economy”, 2020
2017 IEEE 3rd Colombian Conference on Automatic Control (CCAC), 2017
In this paper, one linear and two non linear regulation controllers are designed, tested and eval... more In this paper, one linear and two non linear regulation controllers are designed, tested and evaluated for the rotary inverted pendulum system. The state feedback controller, the sliding mode controller, and the super-twisting sliding mode controller are implemented. Their performance, robustness and energy consumption are evaluated showing their capabilities and drawbacks. In addition, a tracking controller based on Lyapunov theory is implemented to place the pendulum on its upward position.
Cómo citar este artículo / To reference this article / Para citar este artigo: Parra, O., Barrios... more Cómo citar este artículo / To reference this article / Para citar este artigo: Parra, O., Barrios, H. y Díaz, V. (2016). La didáctica y el encanto de las Matemáticas. Revista UNIMAR, 34(1), 13-28. Fecha de recepción: 30 de noviembre de 2015 Fecha de revisión: 02 de febrero de 2016 Fecha de aprobación: 17 de marzo de 2016 El presente producto investigativo aporta herramientas metodológicas y didácticas a los docentes e investigadores para su consecuente trabajo de aula y para el fortalecimiento de las competencias investigativas y matemáticas. La metodología utilizada fue la exploratoria y hermenéutica analítica, centrada en el análisis documental a partir de la búsqueda de textos que planteen elementos teórico-prácticos en la utilización de instrumentos didácticos, experiencias, juegos y desafíos. Con base en el análisis, se plantea una propuesta de apoyo a la creación del pensamiento matemático desde la lectura, la narrativa, la visualización, el juego, la concepción ética y la res...
Fibroblast growth factor receptors (FGFRs) belong to a larger family of receptor tyrosine-kinase ... more Fibroblast growth factor receptors (FGFRs) belong to a larger family of receptor tyrosine-kinase (RTK) cell-surface receptors which phosphorylate specific tyrosine residues to trigger downstream responses such as cell proliferation, migration, and differentiation. The study of the EGL-15 FGFR in the nematode Caenorhabditis elegans has long been used as a paradigm to understand principles of RTK signaling, since defects in the processes mediated by EGL-15 result in striking phenotypes that provide powerful genetic tools. One such process is the regulation of fluid homeostasis. EGL-15 hyperactivation causes excessive accumulation of clear fluid inside the worm’s body (the Clear (Clr) phenotype). The isolation of Clr suppressors, termed suppressor of clr (soc) mutants, has led to the identification of many of the core components of EGL-15 signaling. For example, the original set of soc mutations identified the Grb2/SEM-5 adaptor protein that links RTK activation to the activation of the RAS/MAPK pathway. Although SEM-5 is required for EGL-15 signaling, a key component that links activated EGL-15 to SEM-5 has yet to be identified, since an egl-15 mutation, n1457, that eliminates the known SEM-5 binding sites on EGL-15 does not confer a Soc phenotype. To identify these missing components, we conducted a modified “enhancer” Soc screen in an egl- 15(n1457) background. This screen identified new soc mutations, defining up to four new soc genes that potentially function as the additional link between EGL-15 and SEM-5. Of sixteen characterized enhancers, six have been shown to be autosomal. Two are alleles of the known, major soc gene soc-1. Using complementation tests, we have shown that the remaining four autosomal mutations (ay157, ay169, ay174, and ay195) are allelic to one another, and are not alleles of any of the known major soc genes. To demonstrate that this is a novel soc gene, we need to determine whether or not these are alleles of one of the minor soc genes. Genetic mapping experiments can both locate this gene as well as determine whether or not it maps to a region where there are known, minor soc genes. The initial experiments to accomplish this seek to assign this complementation group to a specific chromosome, and we are using ay195 as the representative allele of this complementation group. 2-factor mapping of ay195 has shown that it does not map near the center of either chromosome IV or V. Additional mapping experiments are currently being conducted to determine if ay195 maps to the other chromosomes (I, II, or III). Further characterization of this autosomal complementation group may lead to the discovery of a new autosomal soc gene
Desarrollo de un modelo para el pronostico de precipitacion a partir de datos meteorologicos del ... more Desarrollo de un modelo para el pronostico de precipitacion a partir de datos meteorologicos del periodo mayo de 2014 hasta junio de 2017 en la zona urbana de Cuenca, a traves de Redes Neuronales Recurrentes de tipo Long Short Term Memory (LSTM).
Fibroblast growth factor receptors (FGFRs) belong to a family of receptor tyrosine-kinase (RTK) c... more Fibroblast growth factor receptors (FGFRs) belong to a family of receptor tyrosine-kinase (RTK) cell-surface receptors which phosphorylate specific tyrosine residues to trigger downstream responses such as cell proliferation, migration, and differentiation. The study of the EGL-15 FGFR in the nematode Caenorhabditis elegans has long been used as a paradigm to understand principles of RTK signaling, since defects in the processes mediated by EGL-15 result in striking phenotypes that provide powerful genetic tools. One such process is the regulation of fluid homeostasis. EGL-15 hyperactivation causes excessive accumulation of clear fluid inside the worm’s body (the Clear (Clr) phenotype). The isolation of Clr suppressors, termed Suppressor of Clr (soc) mutants, has led to the identification of many of the core components of EGL-15 signaling. For example, the original set of soc mutations identified the Grb2/SEM-5 adaptor protein that links RTK signaling to the activation of the RAS/MAPK pathway. EGL-15 can directly bind SEM-5 via a pair of binding sites on its carboxy-terminal domain (CTD). Although SEM-5 is required for EGL-15 signaling, the egl-15(n1457) mutation that truncates the CTD (ΔCTD) and eliminates the known SEM-5 binding sites on EGL-15 does not confer a Soc phenotype. These data suggest the existence of an alternate pathway that links EGL-15 to SEM-5/Grb2 in its role in mediating fluid homeostasis. To identify components of this alternative pathway, we repeated the genetic screen for Soc mutants, this time with the ΔCTD mutation in the background. This “enhancer” screen resulted in the isolation of 33 mutations. 17 of these mutations have been initially characterized and assigned to complementation groups. Seven of these enhancer mutations are new alleles of the known soc genes egl-15 (5 alleles) and soc-1 (2 alleles). Five enhancer mutations define a new soc gene on the X chromosome, soc-3; another enhancer mutation, soc(ay167), maps to another novel position on the X chromosome, potentially identifying an additional new soc gene. Four other mutations define an autosomal soc complementation group that is not one of the major soc genes identified in the original Soc screen. Sixteen enhancer mutations are still being characterized. Our preliminary characterization of these enhancer alleles indicates that the screen was successful in two ways. First, the behavior of the enhancer alleles supports two cooperative pathways that transduce EGL-15 signaling: egl-15(ay150), soc-1(ay172), and all alleles of soc-3 show only partial effects on fluid homeostasis on their own and are enhanced by the ΔCTD mutation. Second, the characterization of an initial subset of these soc enhancer mutations suggests that they define up to four new soc genes that potentially define the alternate pathway. These results are consistent with the original hypothesis that two downstream pathways collaborate to affect fluid homeostasis regulation mediated by the EGL-15 FGFR. Further genetic analysis and whole-genome sequencing will be used to identify the molecular identities of these new FGFR signaling genes
En el presente trabajo se describe un estudio realizado durante dos anos, en el cual se evaluaron... more En el presente trabajo se describe un estudio realizado durante dos anos, en el cual se evaluaron las concentraciones de aluminio presentes en el agua suministrada por el Instituto Nacional de Obras Sanitarias (INOS) a Maracaibo, Cabimas y Ciudad Ojeda (Estado Zulia, Venezuela). La ciudad de Maracaibo fue dividida en tres sectores, efectuandose 16 muestreos. En Cabimas se efectuaron cinco muestreos, en dos areas diferentes, mientras que en Ciudad Ojeda solamente se efectuo un muestreo, en seis sectores. Las determinaciones de aluminio se realizaron mediante la tecnica de la espectrometria de absorcion atomica con horno de grafito. Los resultados senalaron la ausencia de diferencias significativas en las concentraciones de aluminio con respecto al sitio va la epoca de muestreo (lluvia y sequia), encontrandose niveles del metal superiores a los optimos recomendables para agua de consumo humano.
A method of allowing fault tolerance in a client process (306) running on a system of distributed... more A method of allowing fault tolerance in a client process (306) running on a system of distributed computing (200), the method comprising: (a) instantiating a runtime environment (316) in response to a call a client process (306), the runtime environment (316) associated with the client process (306) running on distributed computing system (200); (B) executing instructions in said execution environment (316), causing said instructions to said execution environment (316) to issue new instructions to the system distributed computing (200), said additional instructions relating to actions to be taken respect to data stored in said system distributed computing (200); and (c) receiving said additional instructions via a proxy interface objects (320), wherein at least one of said additional instruction is an instruction to save the state which causes said interface proxy object (320) store a current state of the execution environment (316) in a data warehouse.
La incursión de las nuevas herramientas pedagógicas en el contexto educativo en matemáticas; gen... more La incursión de las nuevas herramientas pedagógicas en el contexto educativo en matemáticas; genera una transformación socio-cultural concerniente a la praxis pedagógica y didáctica actual. La investigación que derivó en el presente artículo pretende resaltar y fundamentar los procesos de incidencia de las TIC sobre la resolución de problemas en el marco de la didáctica de las matemáticas. Desde esta perspectiva; se realizó una revisión bibliográfica de fuentes especializadas a partir de una metodología descriptiva basada en la sistematización y clasificación de textos para dar un sustento crítico-argumentativo. Se identificaron unos núcleos de trabajo: Historia y didáctica de las matemáticas; resolución de problemas y tecnologías de la información y la comunicación. El marco cuestionador se enfocó hacia el acercamiento a una reestructuración curricular en las matemáticas; retomando la vinculación del pensamiento matemático y una didaxis hacia la comprensión mediada por las t...
Because regulatory networks of transcription factors drive embryonic patterning, it is possible t... more Because regulatory networks of transcription factors drive embryonic patterning, it is possible that chromatin accessibility states impact how networks interact with information encoded in DNA. To determine the interplay between chromatin states and regulatory network function, we performed ATAC seq onDrosophilaembryos over the period spanning the establishment of the segmentation network, from zygotic genome activation to gastrulation. Chromatin accessibility states are dynamic over this period, and establishment of the segmentation network requires maturation of the ground chromatin state. Elimination of all maternal patterning information allows identification of patterning-dependent and -independent dynamic chromatin regions. A significant proportion of patterning-dependent accessibility stems from pioneer activity of the pair-rule factor Odd-paired (opa). Whileopais necessary to drive late opening of segmentation network cis-regulatory elements, competence foropato pioneer is r...
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