The Correspondence Section serves as a forum for opinion exxhange about subjects of general inter... more The Correspondence Section serves as a forum for opinion exxhange about subjects of general interest such as dermatologic training, relations between dermatologists and pharmaeeutieal houses, governmental eontrol of dermatology and medical practice in general, peculiarities of dermatology related to geographic, climatic, or racial factors, the flow of information and publications, as well as other concerns the readership migbt bave. Originality is higbly desirable and repetitious eontributions or minutiae are discouraged. We wisb also to foster submission of bypotheses marked accordingly. Tbese should be based on reality and sbould stimulate tbougbt. Gontributions should conform to tbe format for eorrespondence as outlined in, "Notice to Contributors." Manuscripts will undergo standard editorial procedures. Submit all correspondence to Mauricio GoibmanYabr, M.D., Pb.D., Section Editor, Jet International M-154, P.O. Box 020010, Miami, FL 33102.
Respiratory viruses (RVs) are known to be major causes of morbidity and mortality in recipients o... more Respiratory viruses (RVs) are known to be major causes of morbidity and mortality in recipients of hematopoietic stem cell transplants (HSCTs), but prospective long-term studies are lacking. We prospectively screened all adult HSCT recipients (172 allogeneic [alloHSCT] and 240 autologous [autoHSCT]) who underwent transplantation during a 4-year period (1999 to 2003) for the development of a first episode of symptomatic upper respiratory tract infections and/or lower respiratory tract infections (LRTI) by an RV. RVs studied were influenza A and B viruses (n 39), human respiratory syncytial virus (n 19), human adenoviruses (n 11), human parainfluenza viruses 1 to 3 (n 8), human enteroviruses (n 5), human rhinoviruses (n 3), and the recently discovered human metapneumoviruses (n 19). During the study, 51 and 32 cases of RV symptomatic infections were identified of alloHSCT and autoHSCT recipients (2-year incidence, 29% and 14%, respectively). Risk factors for progression of upper respi...
Remission of progressive multifocal leucoencephalopathy after antiretroviral therapy. By - Pere D... more Remission of progressive multifocal leucoencephalopathy after antiretroviral therapy. By - Pere Domingo, Josep Maria Guardiola, Alex Iranzo, Nuria Margall.
Rapid, reliable diagnosis of tuberculosis is essential to initiate correct treatment, avoid sever... more Rapid, reliable diagnosis of tuberculosis is essential to initiate correct treatment, avoid severe complications, and prevent transmission. Conventional microbiological methods may not be an option if samples are formalin-fixed and paraffin-embedded (FFPE) for histopathological examination. With the demonstration of necrotizing granulomatous inflammation, tuberculosis becomes an important differential diagnosis, although it was not initially suspected. Following paraffin extraction, BDProbeTec ET strand displacement amplification for detection of Mycobacterium tuberculosis complex (MTC) was applied to 47 prospectively and 19 retrospectively collected FFPE samples from various sources with granulomatous inflammation and results were compared to tuberculosis notification. Of the prospective samples, 20 were from patients who were notified as having tuberculosis and the assay was positive in 18 (90%). Specificity was 100%. For 27 of the patients with prospectively collected FFPE specimens, culture was performed on a specimen collected at a later date from the same location. Culture revealed MTC in 14 and nontuberculous mycobacteria in four. BDProbeTec ET was positive in 13 (92.8%) of the patients with positive MTC culture and negative in the remaining. The sensitivity and specificity in 19 archival samples was 40% and 100%, respectively, compared to notification data. The assay provided rapid, correct diagnosis on different sources of FFPE samples collected prospectively and therefore offers an important supplementary method for patients where tuberculosis was not initially suspected.
The Correspondence Section serves as a forum for opinion exxhange about subjects of general inter... more The Correspondence Section serves as a forum for opinion exxhange about subjects of general interest such as dermatologic training, relations between dermatologists and pharmaeeutieal houses, governmental eontrol of dermatology and medical practice in general, peculiarities of dermatology related to geographic, climatic, or racial factors, the flow of information and publications, as well as other concerns the readership migbt bave. Originality is higbly desirable and repetitious eontributions or minutiae are discouraged. We wisb also to foster submission of bypotheses marked accordingly. Tbese should be based on reality and sbould stimulate tbougbt. Gontributions should conform to tbe format for eorrespondence as outlined in, "Notice to Contributors." Manuscripts will undergo standard editorial procedures. Submit all correspondence to Mauricio GoibmanYabr, M.D., Pb.D., Section Editor, Jet International M-154, P.O. Box 020010, Miami, FL 33102.
Respiratory viruses (RVs) are known to be major causes of morbidity and mortality in recipients o... more Respiratory viruses (RVs) are known to be major causes of morbidity and mortality in recipients of hematopoietic stem cell transplants (HSCTs), but prospective long-term studies are lacking. We prospectively screened all adult HSCT recipients (172 allogeneic [alloHSCT] and 240 autologous [autoHSCT]) who underwent transplantation during a 4-year period (1999 to 2003) for the development of a first episode of symptomatic upper respiratory tract infections and/or lower respiratory tract infections (LRTI) by an RV. RVs studied were influenza A and B viruses (n 39), human respiratory syncytial virus (n 19), human adenoviruses (n 11), human parainfluenza viruses 1 to 3 (n 8), human enteroviruses (n 5), human rhinoviruses (n 3), and the recently discovered human metapneumoviruses (n 19). During the study, 51 and 32 cases of RV symptomatic infections were identified of alloHSCT and autoHSCT recipients (2-year incidence, 29% and 14%, respectively). Risk factors for progression of upper respi...
Remission of progressive multifocal leucoencephalopathy after antiretroviral therapy. By - Pere D... more Remission of progressive multifocal leucoencephalopathy after antiretroviral therapy. By - Pere Domingo, Josep Maria Guardiola, Alex Iranzo, Nuria Margall.
Rapid, reliable diagnosis of tuberculosis is essential to initiate correct treatment, avoid sever... more Rapid, reliable diagnosis of tuberculosis is essential to initiate correct treatment, avoid severe complications, and prevent transmission. Conventional microbiological methods may not be an option if samples are formalin-fixed and paraffin-embedded (FFPE) for histopathological examination. With the demonstration of necrotizing granulomatous inflammation, tuberculosis becomes an important differential diagnosis, although it was not initially suspected. Following paraffin extraction, BDProbeTec ET strand displacement amplification for detection of Mycobacterium tuberculosis complex (MTC) was applied to 47 prospectively and 19 retrospectively collected FFPE samples from various sources with granulomatous inflammation and results were compared to tuberculosis notification. Of the prospective samples, 20 were from patients who were notified as having tuberculosis and the assay was positive in 18 (90%). Specificity was 100%. For 27 of the patients with prospectively collected FFPE specimens, culture was performed on a specimen collected at a later date from the same location. Culture revealed MTC in 14 and nontuberculous mycobacteria in four. BDProbeTec ET was positive in 13 (92.8%) of the patients with positive MTC culture and negative in the remaining. The sensitivity and specificity in 19 archival samples was 40% and 100%, respectively, compared to notification data. The assay provided rapid, correct diagnosis on different sources of FFPE samples collected prospectively and therefore offers an important supplementary method for patients where tuberculosis was not initially suspected.
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Papers by NURIA MARGALL