Albendazole or praziquantel were measured in plasma and cerebrospinal fluid (CSF) in 29 patients ... more Albendazole or praziquantel were measured in plasma and cerebrospinal fluid (CSF) in 29 patients with neurocysticercosis. Mean levels of albendazole in plasma were 0.918 microgram/ml and in CSF were 0.392 microgram/ml and levels of praziquantel were 1.640 micrograms/ml in plasma and 0.398 microgram/ml in CSF, after doses of 15 and 50 mg/kg, respectively. Drug concentrations in CSF were 43% for albendazole and 24% for praziquantel. The drug levels obtained for both drugs showed ample individual variations that were not related to age, sex, presence of inflammation in the subarachnoid space, or therapeutic effectiveness; such variations seem to be due to individual differences in pharmacokinetics. Both drugs were effective and the doses currently used of each drug seem to be optimal for therapy of neurocysticercosis.
Annals of Mathematics and Artificial Intelligence, 2005
The aim of this paper is to analyze under which conditions Absolute Order-of-Magnitude and Relati... more The aim of this paper is to analyze under which conditions Absolute Order-of-Magnitude and Relative Order-of-Magnitude models may be concordant and to determine the constraints which guarantee concordance. A graphical interpretation of the constraints is provided, bridging the absolute qualitative labels of two quantities into their corresponding relative relation(s), and conversely. The relative order of magnitude relations are then characterized in the absolute order-of-magnitude world.
This paper presents a fuzzy set-based approach for representing and synthesizing information abou... more This paper presents a fuzzy set-based approach for representing and synthesizing information about the different kinds of variables involved in the evaluation of a project's value. The variables considered can be quantitative crisp or fuzzy as well as qualitative ordinal. The ...
Albendazole or praziquantel were measured in plasma and cerebrospinal fluid (CSF) in 29 patients ... more Albendazole or praziquantel were measured in plasma and cerebrospinal fluid (CSF) in 29 patients with neurocysticercosis. Mean levels of albendazole in plasma were 0.918 microgram/ml and in CSF were 0.392 microgram/ml and levels of praziquantel were 1.640 micrograms/ml in plasma and 0.398 microgram/ml in CSF, after doses of 15 and 50 mg/kg, respectively. Drug concentrations in CSF were 43% for albendazole and 24% for praziquantel. The drug levels obtained for both drugs showed ample individual variations that were not related to age, sex, presence of inflammation in the subarachnoid space, or therapeutic effectiveness; such variations seem to be due to individual differences in pharmacokinetics. Both drugs were effective and the doses currently used of each drug seem to be optimal for therapy of neurocysticercosis.
Annals of Mathematics and Artificial Intelligence, 2005
The aim of this paper is to analyze under which conditions Absolute Order-of-Magnitude and Relati... more The aim of this paper is to analyze under which conditions Absolute Order-of-Magnitude and Relative Order-of-Magnitude models may be concordant and to determine the constraints which guarantee concordance. A graphical interpretation of the constraints is provided, bridging the absolute qualitative labels of two quantities into their corresponding relative relation(s), and conversely. The relative order of magnitude relations are then characterized in the absolute order-of-magnitude world.
This paper presents a fuzzy set-based approach for representing and synthesizing information abou... more This paper presents a fuzzy set-based approach for representing and synthesizing information about the different kinds of variables involved in the evaluation of a project's value. The variables considered can be quantitative crisp or fuzzy as well as qualitative ordinal. The ...
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